Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer disease-related hyperexcitability and brain network dysfunction

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Kelli Lauderdale, Zhaoqi Yan, Andrew S. Mendiola, Yutong Zhang, Dakota Mallen, Pranav Nambiar, Erica Brady, Stephanie R. Miller, Rosa Meza Acevedo, Belinda Cabriga, Fred Jiang, Nick Kaliss, Kevin Shen, Jia Shin, Jessica Herbert, Keran Ma, Jae Kyu Ryu, Ayushi Agrawal, Renaud Schuck, Maria del Pilar S. Alzamora, Jorge Sanz-Ros, […]


Continue.. Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer disease-related hyperexcitability and brain network dysfunction

Accumulation of neural state transitions in dorsomedial striatum predicts patch foraging decisions

Posted by dbos Hopkins

Kavli Affiliate: Marshall Hussain Shuler | Authors: Elissa Sutlief, Shichen Zhang, Kate Forsberg and Marshall G Hussain Shuler | Summary: Activities with temporally distributed returns require deciding not only what to do, but when to stop. Although optimal foraging theory predicts that patch departure should depend on the total time invested in a patch, behavior […]


Continue.. Accumulation of neural state transitions in dorsomedial striatum predicts patch foraging decisions

Notch-driven fate asymmetry dictates hair cell behavior via a fate-specific kinase

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Emily Atlas, Caleb C. Reagor, Brian Frost, Sapna Krishnakumar, A. J. Hudspeth and Adrian Jacobo | Summary: Cell-cell signaling and cell-fate decisions are essential for organ assembly, but how these molecular events translate into the physical properties and cell behaviors that drive development remains poorly understood. In the […]


Continue.. Notch-driven fate asymmetry dictates hair cell behavior via a fate-specific kinase

Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Diane D Shao, Yifan Zhao, Joseph Brew, Yahia Adla, Urmi Ghosh, Vinayak V Viswanadham, Lovelace J Luquette, Sijing Zhao, Andrea J Kriz, Xuyu Qian, Takumi Taketomi, Shannon Coy, Sandro Santagata, Michael B Miller, Fuminori Tsuruta, Peter J Park and Christopher A Walsh | Summary: Human neurons are postmitotic and […]


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Multiscale Hyperbolic Embedding Reveals Hierarchical Structure in Complex Biological Systems

Posted by dbos UCSD / Salk

Kavli Affiliate: Tatyana Sharpee | Authors: Mingchen Yao, Anoop Praturu and Tatyana Sharpee | Summary: The rapid expansion of biological and computational datasets demands scalable methods that support both visualization and quantitative interpretation. Hyperbolic embeddings are well suited to represent hierarchical structure, but existing approaches are limited by fixed curvature assumptions or poor scalability to […]


Continue.. Multiscale Hyperbolic Embedding Reveals Hierarchical Structure in Complex Biological Systems

Fixed human pangenome sequences reveal origins of common human traits

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Chern-sing Goh, Matthew Davenport, Chul Lee and Erich Jarvis | Summary: Humans possess human-specific traits1,2 such as spoken language and lineage-specific traits such as ape-specific taillessness3,4. Previous efforts to identify the DNA sequences responsible for such human traits were limited by necessary accommodations for poor genome assembly quality and […]


Continue.. Fixed human pangenome sequences reveal origins of common human traits

Diversity and divergence of two sympatric, sibling octopus species

Posted by dbos Columbia

Kavli Affiliate: Scott Small | Authors: Gabrielle Coffing, Silas Tittes, Scott T Small and Andrew D. Kern | Summary: Coleoid cephalopods have convergently evolved many traits shared with vertebrates, including camera-type eyes, large brain-to-body size ratios, and complex behaviors. Most evolutionary studies of cephalopods have compared individual genomes of taxa that diverged tens to hundreds […]


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A genetically encoded reporter reveals coordinated interferon responses in neurons and non-neuronal cells in the brain

Posted by dbos UCSF

Kavli Affiliate: Anna Molofsky | Authors: Sarah R Anderson, Pailin Chiaranunt, Nicholas M Mroz, Sarah D Wade, Fathima N Pitchai, Shinya Okamura, Ashley McDonough, Yi-Je Chen, Ari B Molofsky, Jonathan R Weinstein, Raul Andino and Anna V Molofsky | Summary: Interferons (IFNs) are canonical antiviral cytokines with emerging homeostatic functions across tissues, including in the […]


Continue.. A genetically encoded reporter reveals coordinated interferon responses in neurons and non-neuronal cells in the brain

Aging Impairs Temporal Integration in Supragranular but Not Thalamorecipient Layers of Primary Auditory Cortex

Posted by dbos Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Yunru Chen and Patrick O Kanold | Summary: Speech has harmonic features and speech perception is impaired in aging. Imaging of auditory cortex (A1) in aged mice shows reduced selectivity to harmonic sounds and impaired temporal integration of component frequencies especially in layers 2/3 but not layer 4, suggesting […]


Continue.. Aging Impairs Temporal Integration in Supragranular but Not Thalamorecipient Layers of Primary Auditory Cortex

Memory erasure by dopamine-gated retrospective learning

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Authors: Huijeong Jeong, Leo Zsembik, Farah Farouq, Risha Chakraborty, Nishita Belur, Mingkang Zhou, Andrea D. Sanders, Styra X. Wang, Ananya Srinivasan, Sylvia M. L. Cox, Eric Garr, Sara Brooke, Patricia H. Janak, Marco Leyton, Ritchie Chen and Vijay Mohan K. Namboodiri | Summary: Erasing outdated memories is crucial for adaptive […]


Continue.. Memory erasure by dopamine-gated retrospective learning