dbos – Page 5 – Kavli Institute Pre-Print Publications

mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

Posted by dbos January 30, 2026February 10, 2026Yale

Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Rolando Garcia-Milian, Ernestine Giahyue, Sofia Fertuzinhos, Florine Collin, Weiwei Wang, TuKiet Lam, Angus Nairn and Marina R Picciotto | Summary: Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors […]

Continue..

Dynamic Regulation of CD300b, and CD300f on Myeloid Cells in Oral Immunotherapy

Posted by dbos January 30, 2026February 10, 2026Columbia

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Hyun Joo Ji, Edmund Tsou, Steven L Salzberg and Jean Fan | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe […]

Continue..

Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

Posted by dbos January 30, 2026February 10, 2026Hopkins

Continue..

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque

Posted by dbos January 30, 2026February 10, 2026UCSF

Kavli Affiliate: Robert Edwards | Authors: Matthew Clark, Hui Li, Mitchell Martin, Tyler Evangelous, Sophie Gobeil, Madison Berry, Kshitij Wagh, Elena Giorgi, Michael Hogarty, Chengyan Zhao, Shuyi Wang, Lorie Marchitto, Wenge Ding, Younghoon Park, Juliette Rando, John Carey, Andrew Connell, Ashwin Skelly, Yue Chen, Seth Rohr, Chuancang Jiang, Sravani Venkatayogi, Katayoun Mansouri, Robert J. Edwards, […]

Continue..

Nanoscale Protonation Limits and Charge Density in Polymer Films Govern the Activity of Immobilized LacZ under Acid Stress

Posted by dbos January 29, 2026February 10, 2026UCSF

Kavli Affiliate: Yifan Cheng | Authors: Huida Duan, Junxing Chen, Felicia Fianu, Wei Sun and Yifan Cheng | Summary: Under acidic conditions, polycationic polymer coatings function as protective immobilization supports through protonation-mediated local pH buffering. However, it remains unclear how polymer support design parameters, such as film thickness and charge density, govern that vital protonation […]

Continue..

Spyglass: a data analysis framework for reproducible and shareable neuroscience research

Posted by dbos January 29, 2026February 10, 2026UCSF

Kavli Affiliate: Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Samuel R Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Emrey Broyles, Donghoon Shin, Sharon Chiang, Cristofer Holobetz, Andrew Tritt, […]

Continue..

The performance of genetic-constraint metrics varies significantly across the human noncoding genome

Posted by dbos January 28, 2026February 10, 2026Columbia

Kavli Affiliate: Michael Goldberg | Authors: Peter McHale, Michael E Goldberg and Aaron R Quinlan | Summary: A longstanding goal in human genetics is to prioritize noncoding loci that, when disrupted, lead to developmental disorders and other Mendelian traits. In pursuit of this goal, multiple metrics have been developed to distinguish neutrally evolving sequences from […]

Continue..

Attention-like regulation of theta sweeps in the brain’s spatial navigation circuit

Posted by dbos January 28, 2026February 10, 2026NTNU

Kavli Affiliate: Edvard Moser and May-Britt Moser | Authors: Abraham Z. Vollan, Michael F. Schellenberger, May-Britt Moser and Edvard I. Moser | Summary: Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid– and place-cell population activity, which sample nearby space in a left-right-alternating […]

Continue..

C. elegans CED-3 caspase promotes non-apoptotic linker cell dismantling but not death onset

Posted by dbos January 27, 2026February 10, 2026Rockefeller

Kavli Affiliate: Shai Shaham | Authors: Olya Yarychkivska, Lena M Kutscher, Betty Ortiz Bido, Juliana Kagan, Yoon A Kim, Dana Mamriev, Yun Lu, Elli Puscher, Wolfgang Keil, Sarit Larisch and Shai Shaham | Summary: dismantling of the C. elegans linker cell, which undergoes non-apoptotic morphologically-conserved cell death characterized by nuclear envelope crenellations and cell splitting. […]

Continue..

Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy

Posted by dbos January 27, 2026February 10, 2026Hopkins

Kavli Affiliate: Michael Miller | Authors: Sattar Khoshkhoo, Mingyun Bae, Yilan Wang, Ashton Tillett, Rosita B. Ramirez, Benjamin Finander, Emily D. Egan, Linus Marx, Dipan Patel, Zinan Zhou, Yasmine Chahine, Brian Chhouk, Sofia M. Zoullas, Abbe Lai, Roland Coras, Franck Bielle, Vincent Navarro, Bertrand Mathon, Taufik A. Valiante, Homeira Moradi Chameh, Andrew F. Gao, Timo […]

Continue..