Kavli Affiliate: A. James Hudspeth | Authors: Teng Han, Zhen Sun, Matthew Lange, Y Zoe Cho, Patrick Mcgillivray, Maren Buttner, Nathaniel R Kastan, Subhiksha Nandakumar, Huiyong Zhao, Sanyukta Oak, Linda Fong, Wenfei Kang, Ning Fan, Jimmy Zhao, Nazifa Salsabeel, Harmanpreet Kaur, Ninghui Mao, Qing Chang, Eric Rosiek, Eric Chan, Murray Tipping, Nikolaus Schultz, Pierre-Jacques Hamard, […]
Kavli Affiliate: Richard Huganir | Authors: Chih-Ming Chen, Yu-Min Huang, Chih-Ching Chung, Richard C. Johnson, Cheng-Ya Tsai, Yu-Han Chen, Han L. Tan, Fu-Yun Hsiao, Richard L. Huganir and Shu-Ling Chiu | Summary: AMPA receptors (AMPARs) mediate fast excitatory synaptic transmission and are essential for neuronal development and brain function. We investigated the role of a […]
Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Huihui Qi, Craig Washington, Xiaoping Liang and Justus M Kebschull | Summary: The barcoded connectomics tool MAPseq enables highly multiplexed projection mapping of individual neurons by translating neuroanatomy into a format solvable by DNA sequencing. Here we present MAPseq2, a user-friendly protocol with up to ∼10-fold […]
Kavli Affiliate: Stavros Lomvardas | Authors: Martin Escamilla-del-Arenal, Lauren C Tang, Albana Kodra, Hani J Shayya, Aileen C Ugurbil, Olga Stathi, Abdurrahman Keskin, Adan Horta, Joan M Pulupa, Junqiang Ye, Marko Jovanovic, Stavros Lomvardas and Rachel Duffié | Summary: During the switch from progenitor to differentiated cell, cellular physiology must change to accommodate increased translation […]
Kavli Affiliate: Winrich Freiwald | Authors: Lucas Y Tian, Kedar Garzón Gupta, Daniel J. Hanuska, Adam G Rouse, Mark AG Eldridge, Marc H Schieber, Xiao-Jing Wang, Joshua B Tenenbaum and Winrich A Freiwald | Summary: A hallmark of intelligence is proficiency in solving new problems, including those that differ dramatically from problems seen before. Problem-solving, […]
Kavli Affiliate: Alex Pollen | Authors: Alyssa M Yoxsimer, Rhea R Daugherty, Emily E Hare, Yingguang Frank Chan, Felicity C Jones, Garrett A Roberts Kingman, Emma G Offenberg, Timothy R Howes, Haili Zhang, Alex Aaron Pollen, Shannon D Brady, Kathleen T Xie, Heidi I Chen, Craig B Lowe, Eric H Au, Jane Grimwood, Jeremy Schmutz, […]
Kavli Affiliate: Edward Chang | Authors: Jiawei Li, Chunxu Guo, Chao Zhang, Edward F Chang and Yuanning Li | Summary: Reconstructing speech from neural recordings is crucial for understanding speech coding and developing brain-computer interfaces (BCIs). However, existing methods trade off acoustic richness (pitch, prosody) for linguistic intelligibility (words, phonemes). To overcome this limitation, we […]
Kavli Affiliate: Stefano Fusi and Liam Paninski | Authors: Lorenzo Posani, Shuqi Wang, Samuel Muscinelli, Liam Paninski and Stefano Fusi | Summary: A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently (“categorical” representations [1–3]) and the implications for neural computation. Here, we systematically analyzed how […]
Kavli Affiliate: Jean Fan | Authors: Dee Velazquez, Caleb Hallinan, Roujin An, Kalen Clifton and Jean Fan | Summary: Motivation Imaging-based spatially resolved transcriptomics (imSRT) technologies provide high-throughput molecular-resolution spatial characterization of genes within cells. Conventional analysis methods to identify cell-types and states in imSRT data rely on gene count matrices derived from tallying the […]
Kavli Affiliate: Robert Edwards | Authors: Susana Furman, Latifa Zayou, Kate I Inman Tsourmas, Dominic Ibarra Javonillo, Gema M Olivarria, Yuting Cheng, Collin Pachow, Kellie Fernandez, Lucas Le, Robert Andrew Edwards, Dequina Nicholas, Gabriela Pacheco Sanchez, Ralph S. Baric, Kim N Green and Thomas E. Lane | Summary: Alzheimer’s disease (AD) is a progressive neurodegenerative […]