Working memory retention by medial entorhinal cortex low-dimensional neural dynamics

Kavli Affiliate: Jill Leutgeb | Authors: Li Yuan, Jiarui Wang, Xiaohe Li, Wenxi Li, Johnatan Aljadeff, Jill K Leutgeb and Stefan Leutgeb | Summary: The ability to retain information over tens of seconds is essential for carrying out many routine tasks. Recurrently connected circuits are thought to support memory over these timescales, yet how they […]


Continue.. Working memory retention by medial entorhinal cortex low-dimensional neural dynamics

Spatiotemporal Dissociation of Human Amygdala Response to Negative Affect

Kavli Affiliate: Martin Lindquist | Authors: Ke Bo, Martin Lindquist, Peter J Gianaros and Tor Wager | Summary: The amygdala is central to negative affect and a primary target of top-down regulation, yet its temporal dynamics remain poorly characterized. Most fMRI studies model stimulus-evoked amygdala activity with a canonical hemodynamic response function and collapse across […]


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Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD

Kavli Affiliate: A. James Hudspeth | Authors: Teng Han, Zhen Sun, Matthew Lange, Y Zoe Cho, Patrick Mcgillivray, Maren Buttner, Nathaniel R Kastan, Subhiksha Nandakumar, Huiyong Zhao, Sanyukta Oak, Linda Fong, Wenfei Kang, Ning Fan, Jimmy Zhao, Nazifa Salsabeel, Harmanpreet Kaur, Ninghui Mao, Qing Chang, Eric Rosiek, Eric Chan, Murray Tipping, Nikolaus Schultz, Pierre-Jacques Hamard, […]


Continue.. Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD

Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

Kavli Affiliate: Yuh Nung Jan and Lily Jan | Authors: Adeline J.H. Yong, Yayu Wang, Juan A. Oses-Prieto, Tong Cheng, Chao Chen, Lane Domke, Mario V. Zubia, Angelina Koroknay, Jeffrey Simms, Alma L. Burlingame, Lily Y. Jan, Nicholas T. Ingolia, J. Wren Kim and Yuh Nung Jan | Summary: Activity-dependent remodeling of the synaptic proteome […]


Continue.. Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer’s disease-resilience spectrum

Kavli Affiliate: Becky Carlyle | Authors: Helen A. Jolly, Paula Seghers, Kaleah Balcomb, Amelia J. Smith, Laura Pearson, Ishan Agrawal, Bethany Geary, David A. Bennett, Thomas Wisniewski, Stephanie L. Fowler, Eleanor Drummond, Oliver M. Crook and Becky C. Carlyle | Summary: Proteome-wide analyses of human tissue have transformed our understanding of disease, but provide limited […]


Continue.. Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer’s disease-resilience spectrum

Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands

Kavli Affiliate: Joshua Berke and Loren Frank | Authors: Alison E. Comrie, Emily J. Monroe, Ari E. Kahn, Eric L. Denovellis, Abhilasha Joshi, Jennifer A. Guidera, Timothy A. Krausz, Joshua D. Berke, Nathaniel D. Daw and Loren M. Frank | Summary: The cognitive ability to go beyond the present to consider alternative possibilities, including potential […]


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Parametric neural control differentiates top neural network models of primate visual cortex

Kavli Affiliate: George A. Alvarez | Authors: Jacob S. Prince, Binxu Wang, Thomas Fel, Akshay V. Jagadeesh, Parisa A. Vaziri, George A. Alvarez, Margaret S. Livingstone and Talia Konkle | Summary: Leading deep neural network encoding models predict visual cortical responses with nearly indistinguishable accuracy, raising the strong inference that these models have converged on […]


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The structural logic of insect olfactory receptor assembly and gating

Kavli Affiliate: Vanessa Ruta | Authors: Navid Paknejad, Dragana Nesic, Beth Graczyk, Jackson Rogow, Mackenzie A. Yedlin, Chidera Udedibia, Joel Butterwick and Vanessa Ruta | Summary: Insects detect the chemical world using a large family of odorant-gated ion channels, each formed from a variable odorant-binding subunit (OR) and a single conserved co-receptor Orco. This modular […]


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Bile acid signaling as a therapeutically tractable pathway linking early caregiving adversity to social behavior

Kavli Affiliate: Maya Opendak | Authors: Cesar Medina, Pragney Deme, Vishal Win, Isabellah Nikitah, Isaac S McKie, Mingyuan Song, Maria Raudales, Elaina Regier, Emily Amsden, Pranali Bendale, Norman Haughey and Maya Opendak | Summary: Adverse early caregiving produces lasting changes in social behavior and increases vulnerability to psychiatric illness, yet the biological pathways through which […]


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Dendritic spines implement specific connectivity and support neuronal ensembles in cortical circuits

Kavli Affiliate: Rafael Yuste | Authors: Dean Geckt, Netanel Ofer, Michael W Reimann, Rafael Yuste and Idan Segev | Summary: Dendritic spines are the principal postsynaptic targets of excitatory synapses, yet the network logic governing their organization and contribution to cortical computation remains unclear. Here, we combine the MICrONS ultrastructural reconstruction of mouse visual cortex […]


Continue.. Dendritic spines implement specific connectivity and support neuronal ensembles in cortical circuits