MM-ComBat and MM-CovBat: Multivariate Frameworks for Joint Harmonization of Multi-Metric Neuroimaging Data

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Zheng Ren, Patrick Sadil and Martin Lindquist | Summary: Aggregating neuroimaging data across sites and studies is increasingly common, yet site- and scanner-related batch effects can obscure meaningful biological variation and introduce spurious associations. Although ComBat and its extensions are widely used, they are primarily designed for single-metric harmonization. […]


Continue.. MM-ComBat and MM-CovBat: Multivariate Frameworks for Joint Harmonization of Multi-Metric Neuroimaging Data

Ecotypes, Wolbachia, and urbanization shape Culex pipiens population structure in a West Nile virus hotspot

Posted by dbos Columbia

Kavli Affiliate: Scott Small | Authors: Sonia Cebrián-Camisón, Ángel G. Rivera-Colón, Scott T. Small, Jordi Figuerola, Andrew D. Kern, Peter L. Ralph, Aureliano Bombarely and María José Ruiz-López | Summary: Culex pipiens is a major vector of West Nile Virus (WNV) in Europe and has a complex evolutionary history that has been linked to the […]


Continue.. Ecotypes, Wolbachia, and urbanization shape Culex pipiens population structure in a West Nile virus hotspot

Clustered Inputs Maximize Efficiency for Stable Place Field Encoding in Hippocampal Pyramidal Neurons

Posted by dbos Columbia

Kavli Affiliate: Attila Losonczy | Authors: Simone Tasciotti, Daniel Maxim Iascone, Spyridon Chavlis, Luke Hammond, Yardena Katz, Attila Losonczy, Franck Polleaux and Panayiota Poirazi | Summary: How spatial organization of synaptic inputs along the dendritic tree of neurons influence their feature selectivity is a central question in neuroscience. Here, we mapped the three-dimensional distribution of […]


Continue.. Clustered Inputs Maximize Efficiency for Stable Place Field Encoding in Hippocampal Pyramidal Neurons

Opioids modulate Curiosity-Driven Exploration in Music

Posted by dbos Columbia

Kavli Affiliate: Jacqueline Gottlieb | Authors: Claudia Alvarez-Martin, Raimund Buehler, Xim Cerda-Company, Gemma Cardona, Matthäus Willeit, Jacqueline Pallas Gottlieb, Giorgia Silani and Antoni Rodriguez-Fornells | Summary: Curiosity, a key driver of exploration and learning, is reinforced by reward-related neurochemical systems, yet the role of the opioidergic system in modulating this behavior remains unclear. Music, as […]


Continue.. Opioids modulate Curiosity-Driven Exploration in Music

Compressed Cortical Input Separates Control from Dynamics in Striatum

Posted by dbos UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Sreejan Kumar, Matthieu B Le Cauchois, Alexander Mathis, Lea Duncker, Jonathon R. Howlett and Marcelo G. Mattar | Summary: The dorsolateral striatum (DLS) supports diverse time-sensitive behaviors—action chunking, duration estimation, and motor timing—yet no single framework is able to explain all of these phenomena. Here, we propose that the […]


Continue.. Compressed Cortical Input Separates Control from Dynamics in Striatum

HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease

Posted by dbos Oxford

Kavli Affiliate: Zameel Cader | Authors: Xuewei Qi, Alessandra Granata, Tom Van Agtmael, Sanjay Sinha, Zameel Cader, Hugh S Markus, Stuart M. Allan, Karen Horsburgh and Tao Wang | Summary: Cerebral small vessel disease (cSVD) is a major contributor to stroke and cognitive decline, ultimately leading to vascular dementia (VaD). Genetic factors play a key […]


Continue.. HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease

A family portrait of the genomic factors shaping tandem repeat mutagenesis

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Thomas A Sasani, Michael E Goldberg, Akshay K Avvaru, Thomas J Nicholas, Deborah W Neklason, Egor Dolzhenko, Tom Mokveld, Katherine M Munson, Kendra Hoekzema, Marcelo Ayllon, Eli J Kaufman, David Porubsky, Paul N Valdmanis, Evan E Eichler, Aaron R Quinlan and Harriet Dashnow | Summary: Tandem repeats (TRs) are […]


Continue.. A family portrait of the genomic factors shaping tandem repeat mutagenesis

A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]


Continue.. A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Samantha M Gray, Adam JO Dede, Zachariah R Cross, Ignacio Saez, Fady Girgis, Edward F Chang, Kurtis Auguste, Ammar Shaikhouni, Robert T Knight and Elizabeth L Johnson | Summary: Working memory (WM) enables us to maintain and manipulate information over time, but how the brain organizes sequential information locally […]


Continue.. Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network

Hippocampal theta frequency as a readout of path-integration recalibration

Posted by dbos Hopkins

Kavli Affiliate: James Knierim | Authors: Seong-Beom Park, Manu Madhav, Ravikrishnan P Jayakumar, Noah Cowan and James J Knierim | Summary: Understanding how the brain represents hidden variables is a fundamental challenge. In navigation, the internal path-integration gain is often masked by external landmarks that override the path integrator. Path integration can recalibrate its gain […]


Continue.. Hippocampal theta frequency as a readout of path-integration recalibration