Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

Kavli Affiliate: Hana El-Samad | Authors: Achal Mahajan, Francesca Ratti, Ban Wang, Hana El-Samad, James H. Kaufman and Vishrawas Gopalakrishnan | Summary: Regulation of gene expression is fundamental for proper cellular function, and is constrained by the local chromatin environment of each gene, which varies spatially along the chromosome and is shaped by epigenetic modifications. […]


Continue.. Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Kavli Affiliate: Robert Edwards | Authors: Mera F. Liccione, Trevor Scobey, Heather M. Froggatt, Camryn Pajon, Boyd L. Yount, Qi Yin, Taylor N. Spence, Emmanuel B. Walter, Kevin O. Saunders, Robert J. Edwards, Ralph S. Baric, Barton F. Haynes, Derek W. Cain, Timothy P. Sheahan and Daniel Wrapp | Summary: HCoV-229E is an endemic Alphacoronavirus […]


Continue.. A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Early development of direction selectivity in higher visual cortex

Kavli Affiliate: Kristina Nielsen | Authors: Dallas C Khamiss, Augusto A Lempel, Brandon R Nanfito and Kristina Juliane Nielsen | Summary: A fundamental aspect of visual motion processing is the computation of motion direction. In ferrets, as in primates, selectivity for motion direction is found both in early cortical stages like the primary visual cortex […]


Continue.. Early development of direction selectivity in higher visual cortex

Condenzymes: Biomolecular condensates with inherent catalytic activities

Kavli Affiliate: Wei Min | Authors: Michael W Chen, Xiao Guo, Mina Farag, Naixin Qian, Xiaowei Song, Anton Ni, Vicky Liu, Xia Yu, Yuefeng Ma, Leshan Yang, Wen Yu, Matthew King, Joonho Lee, Richard N Zare, Wei Min, Rohit V Pappu and Yifan Dai | Summary: We report the discovery that chemical reactions can be […]


Continue.. Condenzymes: Biomolecular condensates with inherent catalytic activities

Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Alexis M Black, Natsumi Komatsu, Jiaxuan Zhao, Scarlet R Taskey, Nicole S Serrano, Ruchira Sharma, Devanand S. Manoli, Markita P Landry and Annaliese Beery | Summary: Friendships, or selective peer relationships, are a vital component of healthy social functioning in humans, while deficits in these relationships are associated with […]


Continue.. Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Kavli Affiliate: Anders Dale and Wesley Thompson | Authors: Pravesh Parekh, Nadine Parker, Diliana Pecheva, Evgeniia Frei, Marc Vaudel, Diana M. Smith, Alison Rigby, Piotr Jahołkowski, Ida Elken Sønderby, Viktoria Birkenæs, Nora Refsum Bakken, Chun Chieh Fan, Carolina Makowski, Jakub Kopal, Robert John Loughnan, Donald J. Hagler, Jr., Dennis van der Meer, Stefan Johansson, Pål […]


Continue.. FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

Kavli Affiliate: Maryam Ziaei | Authors: Shuer Ye, Arjun Dave, Alireza Salami and Maryam Ziaei | Summary: Functional dedifferentiation, a hallmark of brain aging particularly evident within the frontoparietal network (FPN), has been extensively investigated in the context of cognitive decline, yet its implications for late-life mental health remain poorly understood. Leveraging naturalistic fMRI combined […]


Continue.. Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Kavli Affiliate: David Rowitch | Authors: Grant de Jong, Fani Memi, Tannia Gracia, Olga Lazareva, Oliver Gould, Alexander Aivazidis, Manas Dave, Qianqian Zhang, Melanie Jensen, Ahmet Sureyya Rifaioglu, Joao D. Barros-Silva, Sabine Eckert, Di Zhou, Yvette Wood, Elizabeth Tuck, Sezgin Er, Henry Marshall, Kenny Roberts, Andrew L. Trinh, Shreya Rai, Tyler Shaw, Agnes Oszlanczi, Hayden […]


Continue.. A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

Kavli Affiliate: Kay Tye | Authors: Caroline Jia, Andrea Tran, Faith Aloboudi, Ella Say, Nick Thao, Christopher R. Lee, Kanha Batra, Amanda Nguyen, Aneesh Bal, Nathaniel N. Nono, Jeremy Delahanty, May G Chan, Laurel R. Keyes, Reesha R. Patel, Romy Wichmann, Felix Taschbach, Yulong Li, Marcus K. Benna, Talmo D Pereira, Hao Li and Kay […]


Continue.. Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Kavli Affiliate: Tatyana Sharpee and Sreekanth Chalasani | Authors: Iulia Rusu, Zachary T Cecere, Javier J How, Kathleen T Quach, Eviatar Yemini, Tatyana O Sharpee and Sreekanth H Chalasani | Summary: Neurons represent changes in external and internal environments by altering their activity patterns. While coherent brain-wide patterns of neural activity have been observed in […]


Continue.. A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding