Kavli Affiliate: Patrick Kanold | Authors: Yunru Chen and Patrick O Kanold | Summary: Speech has harmonic features and speech perception is impaired in aging. Imaging of auditory cortex (A1) in aged mice shows reduced selectivity to harmonic sounds and impaired temporal integration of component frequencies especially in layers 2/3 but not layer 4, suggesting […]
Kavli Affiliate: Patricia Janak | Authors: Huijeong Jeong, Leo Zsembik, Farah Farouq, Risha Chakraborty, Nishita Belur, Mingkang Zhou, Andrea D. Sanders, Styra X. Wang, Ananya Srinivasan, Sylvia M. L. Cox, Eric Garr, Sara Brooke, Patricia H. Janak, Marco Leyton, Ritchie Chen and Vijay Mohan K. Namboodiri | Summary: Erasing outdated memories is crucial for adaptive […]
Kavli Affiliate: Terrence Sejnowski | Authors: Margot Wagner, Yusi Chen, Arjun Karuvally, Mia Cameron and Terrence J Sejnowski | Summary: The hippocampus must balance stable memory representations with internally generated sequential dynamics underlying replay and prediction. How hippocampal circuitry achieves both remains unclear. Here, we show that recurrent neural networks trained on prediction tasks converge […]
Kavli Affiliate: Marcelo Mattar | Authors: Sreejan Kumar, Matthieu B Le Cauchois, Alexander Mathis, Lea Duncker, Jonathon R. Howlett and Marcelo G. Mattar | Summary: The dorsolateral striatum (DLS) supports diverse time-sensitive behaviors—action chunking, duration estimation, and motor timing—yet no single framework is able to explain all of these phenomena. Here, we propose that the […]
Kavli Affiliate: Scott Small | Authors: Angel G Rivera-Colón, Scott T Small, Erin Jezuit, John P Wares and Andrew D Kern | Summary: Population size is a key factor underlying the mode and tempo of evolution, particularly as it relates to the strength of selection and drift. While the mechanisms underlying the interactions between population […]
Kavli Affiliate: Shreesh P. Mysore | Authors: Xinhao Fan and Shreesh P Mysore | Summary: A cornerstone of our understanding of both biological and artificial neural networks is that they store information in the strengths of synaptic connections among the neurons. However, in contrast to the well-established theory for quantifying information encoded by the firing […]
Kavli Affiliate: John Reynolds | Authors: Emily S King, Liz Jaeschke-Angi, Hakuei Fujiyama, Wickliffe Abraham, Jennifer Rodger, John N Reynolds, Darren Clarke, Jamie L Beros and Alexander Tang | Summary: Repetitive transcranial magnetic stimulation (rTMS) is used widely in neuroscience to study and alter neural plasticity. The cellular mechanisms underlying the effect of rTMS on […]
Kavli Affiliate: Zachary Knight | Authors: Zachary A Knight and Heeun Jang | Summary: The mouse skull serves as the coordinate framework for stereotaxic neurosurgery, yet whether aging alters surgically critical calvarial geometry has not been examined. We measured three parameters in large cohorts of young (2-3 months) and aged (23-30 months) male and female […]
Kavli Affiliate: Jeffrey M. Friedman | Authors: Zhaoyue Zhang, Alexandre Moura-Assis, Shanshan Liu, Alon Millet, Jordan Shaked, Divya Rajan, Hanan Alwaseem, Michael Isay-Del Viscio, Henrik Molina, Kivanc Birsoy and Jeffrey M. Friedman | Summary: While standard high fat diets cause hyperphagia and obesity in mice, high fat-low carbohydrate ketogenic diets (KDs) reduce food intake and […]