Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes

Posted by dbos Yale

Kavli Affiliate: Ellen J. Hoffman | Authors: April Pruitt, Liang Yang, Seoyeon Lee, Novin Balafkan, Shilin Gao, Carina Seah, Yi Dai, Elizabeth Davidson, Suha Khan, Annabel Sen, Jenny Liu, Isabel Wood, Gang Xu, Xiayuan Huang, Marina Carlson, Dejian Zhao, Priyanka Jamadagni, Grace Dossou, Kayla Retallick-Townsley, Xinyun Liu, Xenophon Papademetris, P.J. Michael Deans, Meilin Fernandez Garcia, […]


Continue.. Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes

Systematic evidence map of research on life-history traits in native and introduced earthworms

Posted by dbos UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Karina Vanadzina, Kaushalya Nagahawatte, Deshan Rupasinghe, George G. Brown, Erin K. Cameron, Sylvain Gérard, Céline Pelosi, John W. Reynolds, Alyssa Rice and Helen R.P. Phillips | Summary: Invasive species constitute one of the most significant threats to biodiversity worldwide, and are responsible for more than $400 billion in losses […]


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Interpretable spherical geometry of single-cell state transitions from dominant principal components

Posted by dbos Hopkins

Kavli Affiliate: Alexander Szalay | Authors: Long Yuan, Xuyang Li, My Le, Stephanie C Hicks, Atul Deshpande, Janis M Taube and Alexander S Szalay | Summary: Single-cell RNA-seq atlases are commonly explored with nonlinear embeddings that preserve neighborhoods but provide limited coordinate-level interpretation. We asked whether projecting the dominant principal components (PCs) of single-cell gene […]


Continue.. Interpretable spherical geometry of single-cell state transitions from dominant principal components

A Novel Cortico-Striatal NREM Sleep Rhythm in Mice and Non-Human Primates

Posted by dbos UCSF

Kavli Affiliate: Karunesh Ganguly | Authors: Aviv D Mizrahi-Kliger, Samantha Coury, Cameron L Woodard and Karunesh Ganguly | Summary: With practice, rapid early gains in performance are followed by a slower phase marked by kinematic refinement, automaticity and enhanced cortical and striatal interactions. While sleep is known to support early learning, its causal role in […]


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Behavioral demands organize a decision process into distinct yet coordinated neural representations in parietal cortex

Posted by dbos Columbia

Kavli Affiliate: Michael Shadlen | Authors: NaYoung So, Ariel Zylberberg and Michael N Shadlen | Summary: Perceptual decisions are widely modeled as the accumulation of evidence to a bound. In the lateral intraparietal area (LIP), this computation is thought to be implemented in a low-dimensional population representation organized around the single action used to report […]


Continue.. Behavioral demands organize a decision process into distinct yet coordinated neural representations in parietal cortex

Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

Posted by dbos UCSF

Kavli Affiliate: Stanley Prusiner | Authors: Nicholas L. Yan, Mylan Mayer, Arthur A. Melo, Jacob I. Ayers, Daniel A. Mordes, William W. Seeley, Stanley B. Prusiner, Eric Tse, Vinita G. Chittoor-Vinod and Gregory E Merz | Summary: α-Synuclein (aSyn) aggregation within Lewy bodies underlies Parkinson’s disease and associated dementias. These aggregates are often comprised of […]


Continue.. Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

Physicochemical balancing facilitates fast cyclic immunolabeling in centimeter-scale FFPE tissues

Posted by dbos UCSD / Salk

Kavli Affiliate: Ann-Shyn Chiang | Authors: Ya-Hui Lin, Chao-Yin Huang, Yin-Hsu Chen, Yen-Hui Chen, Ping-Liang Ko, Heng-Hua Hsu, Yi-Chung Tung, Yu-Fang Chen, Hui-Chi Chen, Ann-Shyn Chiang, Chih-Ming Ho, Da-Jeng Yao, Kimberly L Fiock, Kuo-Chuan Wang, Chin-Hsien Lin, Shang-Hsiu Hu, Bi-Chang Chen and Li-An Chu | Summary: Archived formalin-fixed, paraffin-embedded (FFPE) tissues, including brain-bank specimens, are […]


Continue.. Physicochemical balancing facilitates fast cyclic immunolabeling in centimeter-scale FFPE tissues

Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: A challenge in sensory neuroscience is understanding how populations of neurons operate in concert to represent diverse stimuli. To meet this challenge, we have created “encoding manifolds” that reveal the overall responses of brain areas […]


Continue.. Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds

RNA trans-splicing treatment for Duchenne muscular dystrophy

Posted by dbos UCSD / Salk

Kavli Affiliate: Samuel Pfaff | Authors: Ryan H. Hsu, Claire E. Williams, Geraldine Maier, Miriam Gullo, Karen Lettieri, Cindy J. Alvarez, Kip J. Hermann, Stella Kramer, Satchidananda Panda, Lukas C. Bachmann and Samuel L. Pfaff | Summary: Duchenne muscular dystrophy (DMD) is a fatal disorder caused by dystrophin mutations, leading to progressive muscle degeneration and cardiac failure. […]


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Hippocampo-septal inhibitory feedback controls the medial septal circuit as a function of brain state, pyramidal cell activity and movement speed.

Posted by dbos Columbia

Kavli Affiliate: Attila Losonczy | Authors: Andor Domonkos, Daniel Schlingloff, Balint Kiraly, Litsa Ledri, Marta Jelitai, Gergely Turi, Rita M Karlocai, Edit Papp, Panna Hegedus, Gabor Nyiri, Attila I Gulyas, Tamas F Freund, Karl Deisseroth, Attila Losonczy, Balazs Hangya and Viktor Varga | Summary: Encoding novel experiences and retrieving stored information rely on the hippocampal […]


Continue.. Hippocampo-septal inhibitory feedback controls the medial septal circuit as a function of brain state, pyramidal cell activity and movement speed.