Transcriptional Control of Neocortical Size and Microcephaly

Kavli Affiliate: Kristina Nielsen Loyal Goff | Authors: Soraia Barao, Yijun Xu, Rachel Vistein, Loyal Goff, Kristina Nielsen, Byoung-Il Bae, Richard S. Smith, Christopher A Walsh, Genevieve Stein O Brien and Ulrich Muller | Summary: The mammalian neocortex differs vastly in size and complexity between mammalian species, yet the mechanisms that lead to an increase […]


Continue.. Transcriptional Control of Neocortical Size and Microcephaly

Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts

Kavli Affiliate: Jean Fan | Authors: Jude Marvin Phillip, Pratik Kamat, Nico Macaluso, Chanhong Min, Yukang Li, Anshika Agrawal, Aaron Winston, Lauren Pan, Bartholomew Marvin Starich, Teasia Stewert, Pei-Hsun Wu, Jean Fan and Jeremy Walston | Summary: Cellular senescence is an established driver of aging, exhibiting context-dependent phenotypes across multiple biological length-scales. Despite its mechanistic […]


Continue.. Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts

Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

Kavli Affiliate: Keri Martinowich | Authors: Anthony Dial Ramnauth, Madhavi Tippani, Heena R. Divecha, Alexis R. Papariello, Ryan A Miller, Erik D Nelson, Elizabeth A. Pattie, Joel E. Kleinman, Kristen R. Maynard, Leonardo Collado-Torres, Thomas M. Hyde, Keri Martinowich, Stephanie C Hicks and Stephanie Cerceo Page | Summary: The dentate gyrus of the hippocampus is […]


Continue.. Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

Dark exposure reduces high-frequency hearing loss in C57BL/6J mice

Kavli Affiliate: Hey-Kyoung Lee and Patrick Kanold | Authors: Peter Jendrichovsky, Hey-Kyoung Lee and Patrick O Kanold | Summary: Plastic changes in the brain are primarily limited to early postnatal periods. Recovery of adult brain plasticity is critical for the effective development of therapies. A brief (1-2 week) duration of visual deprivation (dark exposure, DE) […]


Continue.. Dark exposure reduces high-frequency hearing loss in C57BL/6J mice

Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme

Kavli Affiliate: Michael Beer | Authors: Michael Beer, Ana Sofia F. Oliveira, Catherine L. Tooke, Philip Hinchliffe, Angie Tsz Yan Li, Balazs Balega, James Spencer and Adrian J Mulholland | Summary: β-Lactamases, which hydrolyse β-lactam antibiotics, are key determinants of antibiotic resistance. Predicting the sites and effects of distal mutations in enzymes is challenging. For […]


Continue.. Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

Kavli Affiliate: Keri Martinowich | Authors: Erik D. Nelson, Madhavi Tippani, Anthony D. Ramnauth, Heena R. Divecha, Ryan A. Miller, Nicholas J. Eagles, Elizabeth A. Pattie, Sang Ho Kwon, Svitlana V. Bach, Uma M. Kaipa, Jianing Yao, Joel E. Kleinman, Leonardo Collado-Torres, Shizhong Han, Kristen R. Maynard, Thomas M. Hyde, Keri Martinowich, Stephanie C. Page […]


Continue.. An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns from Breast Multiplexed Digital Pathology

Kavli Affiliate: Jeremias Sulam | Authors: Zhenzhen Wang, Cesar A. Santa-Maria, Aleksander S. Popel and Jeremias Sulam | Summary: The tumor microenvironment is widely recognized for its central role in driving cancer progression and influencing prognostic outcomes. Despite extensive research efforts dedicated to characterizing this complex and heterogeneous environment, considerable challenges persist. In this study, […]


Continue.. Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns from Breast Multiplexed Digital Pathology

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species

Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Seyun Oh, Svitlana V Bach, Yufeng Du, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Stephanie C Hicks, Stephanie Cerceo Page and Keri Martinowich | Summary: The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in […]


Continue.. Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]


Continue.. Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis