Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor

Kavli Affiliate: Richard Huganir | Authors: William Dylan Hale, Richard L. Huganir and Edward C Twomey | Summary: AMPA-subtype glutamate receptors (AMPARs), composed of subunits GluA1-4, mediate fast, excitatory synaptic transmission in the brain. After glutamate binding, AMPAR ion channels exhibit multiple subconductance states that tune neuronal responses to glutamate. GluA4 is the rarest subunit […]


Continue.. Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor

xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales

Kavli Affiliate: Laurent Younes and Michael Miller | Authors: Kaitlin Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouve and Michael I Miller | Summary: Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose […]


Continue.. xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales

Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers

Kavli Affiliate: Michael Miller | Authors: Tyler Santander, Selin Bekir, Theresa Paul, Jessica M Simonson, Valerie M Wiemer, Henri Etel Skinner, Johanna L Hopf, Anna Rada, Friedrich G Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G Bien, Olaf Sporns, Michael S Gazzaniga, Lukas J Volz and Michael B Miller | Summary: The dynamic integration of the […]


Continue.. Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers

Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity

Kavli Affiliate: Alex Kolodkin | Authors: Karina Chaudhari, Luis E Guzman-Clavel and Alex L Kolodkin | Summary: There is great diversity in retinal ganglion cells subtypes in the mouse retina, but little is known about the molecular factors required to generate this subtype diversity. Here, we identify the transcription factor Gfi1 as a conserved driver […]


Continue.. Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity

Fentanyl reinforcement history has sex-specific effects on multi-step decision-making

Kavli Affiliate: Patricia Janak | Authors: Eric Garr, Yifeng Cheng, Andy Dong and Patricia H. Janak | Summary: It is commonly thought that drug addiction involves a transition to habitual control of action, where the choice to consume drugs becomes automatized and reflects a failure to deliberate over possible negative outcomes. Determining whether the pursuit […]


Continue.. Fentanyl reinforcement history has sex-specific effects on multi-step decision-making

Common and distinct neural correlates of social interaction perception and theory of mind

Kavli Affiliate: Martin Lindquist | Authors: Zizhuang Miao, Heejung Jung, Philip A. Kragel, Ke Bo, Patrick Sadil, Martin A. Lindquist and Tor D. Wager | Summary: Social interaction perception and theory of mind (ToM) frequently co-occur, but their commonalities and distinctions at behavioral and neural levels remain unclear. Participants (N = 231) provided moment-by-moment ratings […]


Continue.. Common and distinct neural correlates of social interaction perception and theory of mind

Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang, Travis Babola and Patrick O Kanold | Summary: Sensory information is represented by small neuronal ensembles in sensory cortices. Neuronal activity shows high trial-by-trial variability in that repeated presentation of the same stimulus, e. g., multiple presentations of the same sound activate differing ensembles in the auditory […]


Continue.. Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

Kavli Affiliate: Michael Miller | Authors: Bowen Jin, Katherine S.-M. Brown, Denis S. Smirnov, Samuel M. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey, Guanlan Dong, Shulin Mao, Samadhi P. Wijethunga, Theresa Connors Stewart, Dennis J. Selkoe, Matthew P. Frosh, Derek H. Oakley, Bradley T. Hyman, August Yue Huang and Michael Miller | Summary: Tau deposition […]


Continue.. Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

The shape of attention: How cognitive goals sculpt cortical representation of speech.

Kavli Affiliate: Mounya Elhilali | Authors: Moïra-Phoebé Huet and Mounya Elhilali | Summary: Perception requires more than passive sensing—it involves prioritizing the features most relevant to ongoing cognitive goals, a process guided by selective attention. A central question is whether attention operates by enhancing all features of a selected target, or by optimizing neural encoding […]


Continue.. The shape of attention: How cognitive goals sculpt cortical representation of speech.

Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Kavli Affiliate: Jean Fan | Authors: Srujan Singh, Shishir Kumar Patel, Ryo Matsuura, Dee Velazquez, Zhaoli Sun, Sanjeev Noel, Hamid Rabb and Jean Fan | Summary: Kidney transplantation is the gold standard treatment strategy for end-stage renal disease. Deceased donor kidneys usually undergo cold storage until kidney transplantation, leading to cold ischemia injury that may […]


Continue.. Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes