Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]
Kavli Affiliate: Vikram Chib | Authors: Aram Kim and Vikram S. Chib | Summary: Decisions to exert effort for reward are often conceptualized as reflecting a trade-off between anticipated benefits and effort costs. However, economic theories propose that valuation is reference-dependent, such that behavior is shaped relative to expected outcomes rather than absolute reward magnitude. […]
Kavli Affiliate: Michael Miller | Authors: Niklas Krick, Jacob Davies, Bramwell Coulson, Daniel Sobrido-Camean, Michael Miller, Matthew C.W. Oswald, Aref Arzan Zarin, Richard Baines and Matthias Landgraf | Summary: As developing neural circuits become functional, they undergo a phase of heightened plasticity that facilitates network tuning in response to intrinsic and/or extrinsic stimuli. These developmental […]
Kavli Affiliate: Justus M Kebschull | Authors: Angela Y Fan, Jack T Scott, Noah M Kuehn, Maryam Majeed, Sabrina Y Cheng, Huihui Qi, Mathew T Summers, John Hover, Tye Johnson, Ben Ouellette, Alana A Oyama, Diana Ravens, Huiqing Zhan, Justus M Kebschull, James A Bourne and Xiaoyin Chen | Summary: Across mammals, brain regions can […]
Kavli Affiliate: Alex Kolodkin | Authors: Natalie R Hamilton, Victoria N Neckles, Timour Al-Khindi, Nitya Donthi, Shun Mizutori, Renata Fu, James K Kiraly, Bea C Winship, Alex L Kolodkin and Karina Chaudhari | Summary: The optokinetic reflex (OKR) is an evolutionarily conserved reflexive behavior that ensures image stabilization on the retina during global motion. It […]
Kavli Affiliate: Adam S. Charles and Patricia Janak | Authors: Aamna Lawrence, Eva Yezerets, Patricia H Janak and Adam Charles | Summary: Neural systems exhibit multiple firing states that reflect an organism’s internal state and modulate the relationship between external environmental stimuli and behavior. Several studies have inferred these latent states by supplementing the traditional […]
Kavli Affiliate: Vikram Chib | Authors: Naser Al-Fawakhiri, Vikram S. Chib and Samuel D. McDougle | Summary: Multiple learning signals can shape motor output, including reward and punishment (via value-based reinforcement learning) and sensorimotor error (via motor adaptation). However, it is unclear if action values, learned via reinforcement learning, interact with error-based motor learning. Here, […]
Kavli Affiliate: Alex Kolodkin | Authors: Stephanie L Sarbanes, Jakub Ziak, Alex L Kolodkin and Antonina Roll-Mecak | Summary: Microtubule dynamics regulation is critical for neuronal development, yet how neurons regulate tubulin levels remains poorly understood. Tetratricopeptide repeat domain 5 (TTC5) mediates the co-translational degradation of tubulin transcripts in response to excess soluble tubulin, a.k.a. […]
Kavli Affiliate: David Linden | Authors: Xuelei Wang, Jana Zweerings, Michael Lührs, Fengyu Cong, Klaus Mathiak, David E.J. Linden, Rainer Goebel, Assunta Ciarlo and David M. A. Mehler | Summary: Identifying informative voxels is a critical, yet challenging step in functional magnetic resonance imaging (fMRI), particularly for multivariate analyses involving multiple related conditions. Existing approaches […]
Kavli Affiliate: Keri Martinowich | Authors: Leslie Hassanein, Bernard Mulvey, Harris Blankenship, Margaret M Tish, Anu Korukonda, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Rosa Villalba, Xiangchuan Chen, Khan Hekmatyar, Jenny Yang, Daniel Huddleston, Seong Su Kang, Arielle Segal, Steven A Sloan, Keri Martinowich, Keqiang Ye, Joseph D Dougherty, Katharine E McCann, Yoland Smith, […]