MERFISH-based pooled genetic screening reveals cell non-autonomous phenotypes in intact tissue

Kavli Affiliate: Jin Kang | Authors: Kang Jin, Reuben A. Saunders, Jiahao Zhang, Jiaqi Lu, Aaron A. Halpern, Jaspreet Sandhu, Xingjie Pan, Cosmos Yuqi Wang, Alexander M. Li, William E. Allen, Jonathan S. Weissman and Xiaowei Zhuang | Summary: Genetic perturbations can reshape both the state of a targeted cell and the behavior of neighboring […]


Continue.. MERFISH-based pooled genetic screening reveals cell non-autonomous phenotypes in intact tissue

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise

Kavli Affiliate: Michael Miller | Authors: MoTrPAC Study Group, Anna R Brandt, Jerome Fleg, Bret H Goodpaster, Byron Jaeger, Christopher A Jin, Neil M Johannsen, Dan Katz, Hasmik Keshishian, Wendy M Kohrt, William E Kraus, Bridget Lester, Edward L Melanson, Michael E Miller, Samuel Montalvo, W Jack Rejeski, Samiya M Shimly, Gregory R Smith, Cynthia […]


Continue.. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise

Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium

Kavli Affiliate: Michael Miller | Authors: MoTrPAC Study Group, Daniel H. Katz, Christopher A. Jin, Gina M. Many, Gregory R. Smith, Hasmik Keshishian, Natalie M. Clark, Gayatri Iyer, Cheehoon Ahn, Malene E. Lindholm, Tyler J. Sagendorf, David Amar, Jacob L. Barber, Anna R. Brandt, Paul M. Coen, Yongchao Ge, Patrick Hart, Fang-Chi Hsu, Byron C. […]


Continue.. Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium

Adversity severity shapes caregiving predictors and neural correlates of infant social behavior

Kavli Affiliate: Maya Opendak | Authors: Allison Su, Elaina Regier, Chloe Lim, Isaac McKie, Ben Perez-Flesler, Vishal Win, Isabellah Nikitah, Damaris Chacon, Brianna C. Bullock, Lucy Sparks Mendez, Keita Fogus, Kellie L.K. Tamashiro, Patrese A. Robinson and Maya Opendak | Summary: Early-life adversity is associated with highly variable developmental outcomes, but identifying sources of this […]


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Pervasive Somatic Mutations in NF1 Drive Cell Type and Spatially Specific Clonal Selection in Neurofibromatosis

Kavli Affiliate: Michael Miller | Authors: Daniel A Snellings, Kow Essuman, Benjamin Finander, Eitan Goodman, Christie Cambridge, Jannis Buecking, Brian Chhouk, Chunhui Cai, Liang Sun, Urmi Ghosh, Michael B. Miller and Christopher A. Walsh | Summary: Tumorigenesis is a multi-step process shaped by the accumulation of somatic driver mutations, but identifying the earliest steps and […]


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Real-time AI integration for MR to detect artifacts and guide pulse sequence adaptations

  Kavli Affiliate: Jeremias Sulam | Authors: Aaron T. Gudmundson, Zahra Shams, Abdelrahman Gad, Shuyuan Wang, Dunja Simicic, Saipavitra Murali-Manohar, Gizeaddis Lamesgin Simegn, Ipek Özdemir, Christopher W. Davies-Jenkins, Yulu Song, Vivek Yedavalli, Georg Oeltzschner, Omer Burak Demirel, Jeremias Sulam, Michael schär, Sandeep Ganji and Richard A. E. Edden | Summary: This work presents a first-of-its-kind […]


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Three dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis

Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Jianing Yao, Svitlana V Bach, Ishbel Del Rosario Alvia, Yufeng Du, Sarah E Maguire, Ruth Zhang, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Keri Martinowich, Kristen R Maynard and Stephanie C Hicks | Summary: Spatial transcriptomics has transformed molecular characterization of the human […]


Continue.. Three dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis

SCREWx: A Screwless, Chronic, Recoverable, and Lightweight Neuropixels fixture for freely-moving rodents

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: James Knierim and Kathleen Cullen | Authors: Alexandra Cheng, Tate DeWeese, Yueqing Zhou, Yotaro Sueoka, Sai Koukuntla, Merrill Green, Kathleen Cullen, James Knierim, Austin Graves and Timothy Harris | Summary: High-density Neuropixels probes enable the study of large neural populations […]


Continue.. SCREWx: A Screwless, Chronic, Recoverable, and Lightweight Neuropixels fixture for freely-moving rodents

Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning

Kavli Affiliate: Vikram Chib | Authors: Naser Al-Fawakhiri, Vikram S. Chib and Samuel D. McDougle | Summary: Motor learning depends on the integration of several, often competing signals, including reward and punishment (which guide learning the value of actions via reinforcement learning) and sensorimotor errors (which refine the execution of actions via motor adaptation). If […]


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Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging

Kavli Affiliate: Michael Miller | Authors: Emre Caglayan, Ishaan Lamba, Monica Devi Manam, Benjamin Finander, Lovelace J. Luquette, David Exposito-Alonso, Sijing Zhao, Bowen Jin, Michael B Miller, Peter J Park, Chet C. Sherwood and Christopher A Walsh | Summary: Human brain aging is frequently studied in model mammals that rarely show the natural age-related neurodegenerative […]


Continue.. Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging