Kavli Affiliate: Justus M Kebschull and Jean Fan | Authors: Manjari M-G Anant, Eli Clemens Zuercher, Maggie Lowman, Caleb Shi, Dylan Z. Faltine-Gonzalez, Michael L. Piacentino, Jean Fan and Justus M. Kebschull | Summary: The cerebellar nuclei, the output regions of the cerebellum, have evolved via repeated duplication of a conserved cell type set to […]
Kavli Affiliate: Alexander Szalay | Authors: Long Yuan, Xuyang Li, My Le, Stephanie C Hicks, Atul Deshpande, Janis M Taube and Alexander S Szalay | Summary: Single-cell RNA-seq atlases are commonly explored with nonlinear embeddings that preserve neighborhoods but provide limited coordinate-level interpretation. We asked whether projecting the dominant principal components (PCs) of single-cell gene […]
Kavli Affiliate: Michael Miller | Authors: Janine L. Gray, Mia C. Callens, Amelia Henley, Daniel Zaidman, Carmen Jimenez Antunez, Andrew P. Thompson, Zhihe Lei, Rachael Skyner, Michael Miller, Eleanor P. Williams, Anya Robinson, Raina Seupal, Matt T. Fry, Mihajlo Filep, Frank von Delft, Michael P. Willis, Annette R. von Delft, Nir London and Paul E. […]
Kavli Affiliate: Jeremy Nathans | Authors: Jeremy Nathans, Yanshu Wang, Ningyu Zhu, Amir Rattner and Philip M Smallwood | Summary: In CNS endothelial cells (ECs), VEGF signaling promotes vascular permeability, and Wnt/beta-catenin signaling reduces vascular permeability by controlling the gene expression program for the blood-brain barrier. Here we show, using genetic mosaics, that, in mouse […]
Kavli Affiliate: David Linden | Authors: Vikram Joshi, Corey Seavey, Kaitlyn Knutson, Abhilash Sawant, Yasmeen MF Hamed, Mario D’Ambrosio, Emma Laible, Vladimir Dokic, Jason Paul Sinnwell, Yuanhang Liu, Franco F Jin, Colin Thomas, Gwyneth Garramone, Amelia Paul Mazzone, Ferdinando Bonfiglio, Mauro D’Amato, Recep Avci, Peng Du, Madhusudan Grover, Purna C Kashyap, Brooke R Druliner, David […]
Kavli Affiliate: Michael Beer | Authors: Kijin Jang, Kevin Ostacolo, Valdimar Sveinsson, Michael A Beer, Kimberley Jade Anderson and Hans Tomas Bjornsson | Summary: Abstract The mild hypothermia response (MHR) is a conserved mammalian cytoprotective program activated upon exposure to mild hypothermia (32 °C) that contributes to the neuroprotective effects of therapeutic hypothermia following hypoxic […]
Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]
Kavli Affiliate: Denis Wirtz | Authors: Pei-Hsun Wu, Chongguang Jin, Tiffany Chu, Qiming Zhang and Denis Wirtz | Summary: Preclinical drug evaluation relies heavily on two-dimensional (2D) monolayer assays, which fail to recapitulate the structural and functional complexity of the tumor microenvironment and may therefore misrepresent therapeutic efficacy. Here, we present VITAL (Volumetric Imaging-based Toxicity […]
Kavli Affiliate: Jean Fan | Authors: Dee Velazquez, Caleb Hallinan, Roujin An, Kalen Clifton and Jean Fan | Summary: Motivation Imaging-based spatially resolved transcriptomics (imSRT) technologies provide high-throughput molecular-resolution spatial characterization of genes within cells. Conventional analysis methods to identify cell-types and states in imSRT data rely on gene count matrices derived from tallying the […]
Kavli Affiliate: Michael Beer | Authors: Michael Beer, Jim Spencer and Adrian J Mulholland | Summary: Carbapenems are the most potent β-lactams, key antibiotics for healthcare-associated infections by Gram-negative bacteria and evade hydrolysis by most β-lactamases; but are increasingly threatened by emergence of enzymes exhibiting hydrolytic activity towards them. Of the four recognised β-lactamase subclasses, […]