Object representation in a gravitational reference frame

Kavli Affiliate: Kristina Nielsen and Charles Connor | Authors: Alexandriya MX Emonds, Ramanujan Srinath, Kristina J Nielsen and Charles E Connor | Summary: ABSTRACT When your head tilts laterally, as in sports, reaching, and resting, your eyes counterrotate less than 20%, and thus eye images rotate, over a total range of about 180°. Yet, the […]


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Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters

Kavli Affiliate: Patricia Janak | Authors: Kurt M Fraser and Patricia H Janak | Summary: ABSTRACT Reward-seeking in the world is driven by cues that can have ambiguous predictive and motivational value. To produce adaptive, flexible reward-seeking it is necessary to exploit occasion setters, other distinct features in the environment, to resolve the ambiguity of […]


Continue.. Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters

MISPEL: A deep learning approach for harmonizing multi-scanner matched neuroimaging data

Kavli Affiliate: Ciprian Crainiceanu | Authors: Mahbaneh Eshaghzadeh Torbati, Davneet S Minhas, Charles M Laymon, Pauline Maillard, James D Wilson, Chang-Le Chen, Ciprian M Crainiceanu, Charles S DeCarli, Seong Jae Hwang and Dana L Tudorascu | Summary: Abstract Large-scale data obtained from aggregation of already collected multi-site neuroimaging datasets has been brought benefits such as […]


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Suboptimal phenotypic reliability impedes reproducible human neuroscience

Kavli Affiliate: Joshua Vogelstein | Authors: Aki Nikolaidis, Andrew An Chen, Xiaoning He, Russell Shinohara, Joshua Vogelstein, Michael Milham and Haochang Shou | Summary: Biomarkers of behavior and psychiatric illness for cognitive and clinical neuroscience remain out of reach. Suboptimal reliability of biological measurements, such as functional magnetic resonance imaging (fMRI), is increasingly cited as […]


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Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma

Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]


Continue.. Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma

Engineered Adhesion Molecules Drive Synapse Organization

Kavli Affiliate: Richard Huganir | Authors: William Dylan Hale, Thomas C. Sudhof and Richard L. Huganir | Summary: In multicellular organisms, cell-adhesion molecules connect cells into tissues and mediate intercellular signaling between these cells. In vertebrate brains, synaptic cell-adhesion molecules (SAMs) guide the formation, specification, and plasticity of synapses. Some SAMs, when overexpressed in cultured […]


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Pulsatile electrical stimulation creates predictable, correctable disruptions in neural firing

Kavli Affiliate: Kathleen Cullen | Authors: Cynthia R Steinhardt, Diana E Mitchell, Kathleen E Cullen and Gene Y Fridman | Summary: Electrical stimulation of neural responses is used both scientifically in brain mapping studies and in many clinical applications such as cochlear, vestibular, and retinal implants. Due to safety considerations, stimulation of the nervous system […]


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Converging pathways found in copy number variation syndromes with high schizophrenia risk

Kavli Affiliate: David Linden | Authors: Friederike Ehrhart, Ana Silva, Therese Amelsvoort, Emma von Scheibler, Chris Evelo and David E.J. Linden | Summary: Schizophrenia genetics is complex, and the contribution of common and rare variants are not fully understood. Several specific copy number variations (CNVs) confer increased risk for schizophrenia, and the study of their […]


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Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R, and GenePattern Notebook implementations of CoGAPS

Kavli Affiliate: Loyal Goff | Authors: Jeanette Anna Irene Johnson, Ashley Tsang, Jacob T Mitchell, Emily F Davis-Marcisak, Thomas Sherman, Ted Liefeld, Melanie Loth, Loyal Goff, Jacquelyn Zimmerman, Ben Kinny-Köster, Elizabeth Jaffee, Pablo Tamayo, Jill Mesirov, Michael Reich, Elana J Fertig and Genevieve L Stein-O’Brien | Summary: Non-negative matrix factorization (NMF) is an unsupervised learning […]


Continue.. Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R, and GenePattern Notebook implementations of CoGAPS

Dynamics of Borrelia Burgdorferi Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model

Kavli Affiliate: Peter Searson | Authors: Zhaobin Guo, Nan Zhao, Tracy D. Chung, Anjan Singh, Ikshu Pandey, Linus Wang, Xinyue Gu, Aisha Ademola, Raleigh Miller Linville, Utpal Pal, J. Stephen Dumler and Peter C. Searson | Summary: Lyme disease is a tick-borne disease prevalent in North America, Europe, and Asia. Dissemination of vector-borne pathogens, such […]


Continue.. Dynamics of Borrelia Burgdorferi Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model