SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Kavli Affiliate: Adam S. Charles and Kathleen Cullen | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Kathleen E Cullen, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology (ephys) […]


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Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

Kavli Affiliate: Keri Martinowich | Authors: Bernard Mulvey, Heena R Divecha, Madhavi Tippani, Svitlana V Bach, Rahul Bharadwaj, Ishbel Del Rosario, Sarah E Maguire, Ryan A Miller, Aaron J Salisbury, Atharv Chandra, Beau A Oster, Kelsey D Montgomery, Sang Ho Kwon, Haya A Algrain, Alexis R Papariello, Louise A Huuki-Myers, Joel E Kleinman, Leonardo Collado-Torres, […]


Continue.. Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

Shared Molecular Landscape of Human Brain Structure and Systemic Metabolism

Kavli Affiliate: Anders Dal | Authors: Dennis van der Meer, Jakub Kopal, Sara Stinson, Olav Smeland, Alexey Shadrin, Julian Fuhrer, Jaroslav Rokicki, Tiril Gurholt, Ida Sonderby, Ibrahim Akkouh, Oleksandr Frei, Kevin O’Connell, Lars T. Westlye, Srdjan Djurovic, Anders Dale and Ole Andreassen | Summary: The human brain is metabolically demanding, yet the causal interplay between […]


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A non-invasive method to genotype cephalopod sex by quantitative PCR

Kavli Affiliate: Scott Small | Authors: Frederick A. Rubino, Gabrielle C. Coffing, Connor J. Gibbons, Scott T. Small, Thomas Desvignes, Jeffery Pessutti, Ann M. Petersen, Alexander Arkhipkin, Zhanna Shcherbich, John H. Postlethwait, Andrew D. Kern and Tessa G. Montague | Summary: Coleoid cephalopods (cuttlefish, octopus, and squid) are emerging model organisms in neuroscience, development, and […]


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Natural Scene Coding Consistency in Genetically-Defined Cell Populations

Kavli Affiliate: Kenneth Miller | Authors: Dennis van der Meer, Jakub Kopal, Sara Stinson, Olav Smeland, Alexey Shadrin, Julian Fuhrer, Jaroslav Rokicki, Tiril Gurholt, Ida Sonderby, Ibrahim Akkouh, Oleksandr Frei, Kevin O’Connell, Lars T. Westlye, Srdjan Djurovic, Anders Dale and Ole Andreassen | Summary: Understanding how genetically-defined cell populations encode visual information remains a fundamental […]


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CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

Kavli Affiliate: Richard Huganir | Authors: Laura Sichlinger, Molly Reilly, Sakshi Arora, Shuo Zhang, Nicolas Marotta, Kiara L. Rodriguez-Acevedo, Marisol Hooks, Kyle S. Czarnecki, Julia J. Winter, Elisa A. Waxman, Lea V. Dungan, Ingie Hong, Yoichi Araki, Richard Johnson, Richard L. Huganir, Giulia Pavani, Deborah L. French, Beverly L. Davidson, Benjamin L. Prosser and Elizabeth […]


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Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry

Kavli Affiliate: Flora Vaccarino | Authors: Abhiram Natu, Mrunal K. Dehankar, Reenal Pattni, Milovan Suvakov, Dmitrii Olisov, Livia Tomasini, Yeongjun Jang, Yiling Huang, Eva Benito-Garragori, Patrick Hasenfeld, Jan Korbel, Alexander E. Urban, Alexej Abyzov and Flora M. Vaccarino | Summary: The role of somatic mutations in human development and disease is obscured by difficulties in […]


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Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most neuroimaging studies in rodents use anesthesia to […]


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Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating

Kavli Affiliate: Roderick MacKinnon | Authors: George Vaisey and Roderick MacKinnon | Summary: Piezo1 ion channels are widely expressed cellular mechanosensors. They adopt an intrinsically curved shape when closed and are thought to open when mechanical forces applied to the membrane favor a more flattened conformation. By reconstituting Piezo1 channels into lipid vesicles, a flattened […]


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Continuous partitioning of neuronal variability

Kavli Affiliate: Adam S. Charles | Authors: Anuththara Rupasinghe, Adam S Charles and Jonathan W Pillow | Summary: Neural variability poses a major challenge to understanding the information content of neural codes. Recent work by Goris et al. (Nat. Neurosci 2014) has provided new insights into variability in the visual pathway by partitioning it into […]


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