Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Graeme Davis | Authors: Jacob Ellegood, Antoine Beauchamp, Yohan Yee, Gabe Devenyi, Justine Ziolkowski, Lily Qiu, Rand Askalan, Muhammad Ayub, Philipp Suetterlin, Alex Donovan, M. Albert Basson, Katherine M Quesnel, Nathalie G Berube, Taeseon Woo, David Beversdorf, Hans Bjornsson, Randy Blakely, Froylan Calderon de Anda, Jacqueline Crawley, Jennifer Crosbie, Brian O Orr, Graeme […]


Continue.. Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

TxNova: recovery of recurrent unannotated intergenic splice loci from existing bulk RNA-seq alignments

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Background Reference catalogs such as GENCODE capture most stably expressed mammalian genes but may not include condition-restricted or low-abundance transcripts. Reads supporting unannotated intergenic splice junctions are generally absent from annotation-restricted gene-count matrices; transcript assemblers may reconstruct a subset as novel […]


Continue.. TxNova: recovery of recurrent unannotated intergenic splice loci from existing bulk RNA-seq alignments

Vangl2 acts in distinct cell types to establish bidirectional hair-bundle polarity and maintains tissue-wide alignment in zebrafish neuromasts

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: A. James Hudspeth | Authors: Swarna Jeewajee, Francesco Gianoli, Maria Jussila, Brian Ciruna, Aaron Steiner, Adrian Jacobo and Albert James Hudspeth | Summary: The conserved core planar cell polarity (PCP) pathway orients cells and subcellular structures within an epithelium through asymmetric protein localization and intercellular communication(1–4). In vestibular organs and lateral-line neuromasts, mechanosensory […]


Continue.. Vangl2 acts in distinct cell types to establish bidirectional hair-bundle polarity and maintains tissue-wide alignment in zebrafish neuromasts

Unifying error and reward action learning: a cerebello-basal ganglia theory

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Rui Costa | Authors:Michele Garibbo, Carolina Filipe, Laurence Aitchison and Rui Ponte Costa | Summary: Learning depends on both reward- and error-based feedback, yet how the brain integrates these distinct signals to guide behaviour remains fundamentally unclear. Here, using a normative computational framework, we derive credit assignment rules for both reward-based learning (RBL) […]


Continue.. Unifying error and reward action learning: a cerebello-basal ganglia theory

SRGAP2 limits experience-dependent structural synaptic plasticity in adult cortical circuits

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Franck Polleux | Authors: Sergio Bernal-Garcia, Regina Jiang and Franck Polleux | Summary: In cortical circuits, synaptic plasticity involves either changes in the weight of pre-existing synapses, referred to as functional synaptic plasticity, or synapse formation and elimination, referred to as structural synaptic plasticity. Experience-dependent structural synaptic plasticity is prominent in juvenile cortical […]


Continue.. SRGAP2 limits experience-dependent structural synaptic plasticity in adult cortical circuits

Criterion-selective neurons in the human medial frontal cortex track decision thresholds during memory-based decision making

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Miller | Authors: Evan Layher, Ivan Skelin, Chrystal M Reed, Jeffrey M Chung, Lisa M Bateman, Taufik A Valiante, Adam N Mamelak, Michael B Miller and Ueli Rutishauser | Summary: The decision criterion is foundational to theories of decision-making, yet little is known about its neural underpinnings. In memory-based decision making, the […]


Continue.. Criterion-selective neurons in the human medial frontal cortex track decision thresholds during memory-based decision making

Central carbon metabolism switching in lytic versus temperate coral reef viral communities

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Robert Edwards | Authors: Jacob Kelman, Meena Khan, Chibundu Umunna, Russell Brainard, Grace Donohue, Robert A Edwards, Natalie A Falta, Emma E. George, Eleanor Gorham, Juris Grasis, Kevin Green, Andreas F Haas, Kimberly Halsey, Eric Hester, Summer Jacob, Aydin Loid Karatas, Yan Wei Lim, Mark Little, Stuart Sandin, Jessie Segnitz, Maya Serota, Natalia […]


Continue.. Central carbon metabolism switching in lytic versus temperate coral reef viral communities

A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]


Continue.. A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Directional alignment of turn-related activity with locomotor dynamics in the superior colliculus

Posted by dbos UCSD / Salk

Kavli Affiliate: Massimo Scanziani and Loren Frank | Authors: Cameron Wilhite, Loren M. Frank and Massimo Scanziani | Summary: Fluid behavior requires temporal coordination across brain systems that orchestrate movement. A clear example is locomotion, in which left and right turns are not only precisely coordinated with the ongoing stepping rhythm but occur at opposite […]


Continue.. Directional alignment of turn-related activity with locomotor dynamics in the superior colliculus

Active gaze behavior organizes V1 activity in freely-moving marmosets

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Cory Miller | Authors: Jingwen Li, Vikram Pal Singh, Jude F. Mitchell, Alexander C. Huk and Cory T. Miller | Summary: Human and nonhuman primates rely heavily on vision to actively explore and navigate their environment. Although primate visual cortex has been studied extensively in head-fixed animals, little is known about how the […]


Continue.. Active gaze behavior organizes V1 activity in freely-moving marmosets