Dendritic spines implement specific connectivity and support neuronal ensembles in cortical circuits

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Rafael Yuste | Authors: Dean Geckt, Netanel Ofer, Michael W Reimann, Rafael Yuste and Idan Segev | Summary: Dendritic spines are the principal postsynaptic targets of excitatory synapses, yet the network logic governing their organization and contribution to cortical computation remains unclear. Here, we combine the MICrONS ultrastructural reconstruction of mouse visual cortex […]


Continue.. Dendritic spines implement specific connectivity and support neuronal ensembles in cortical circuits

Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Yifan Cheng | Authors: Maureen A McGargill, Beiyun C Liu, Michael S Kuhns, Daniel Mucida, Isabella Rauch, Lauren B Rodda, Meghan A Koch, Hugo Gonzalez Velozo, Ken Cadwell, Tanya S Freedman, Tiffany C Scharschmidt, Richard Sever, Jose Ordovas-Montanes, Sara Suliman, Andrew Oberst, Brooke Runnette and Matthew F Krummel | Summary: Peer review serves […]


Continue.. Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact

ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Yifan Cheng | Authors: Hao Wu, Upneet Kaur, Chengmin Li, Elise N. Munoz, Geeta J. Narlikar and Yifan Cheng | Summary: ATP-dependent chromatin remodeling enzymes play central roles in genome regulation by mobilizing nucleosomes. All remodelers except for one, position their core ATPase at an internal nucleosome location, superhelical location (SHL) 2, and […]


Continue.. ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

Posted by dbos This Week: Neuroscience, Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most fMRI studies in rodents use anesthesia to […]


Continue.. Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Arturo Alvarez-Buylla and Arnold R. Kriegstein | Authors: Arantxa Cebrian-Silla, Fiona R Dale-Huang, Stephanie A Redmond, Carmen Elena Aragon Ortiz, Juan Morianos, Marcos Assis Nascimento, Zhenmeiyu Li, Cristina Guinto, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Cathryn R Cadwell, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Arnold Kriegstein, Eric Huang and Arturo Alvarez-Buylla | Summary: Ependymal (E1) cells, […]


Continue.. Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Charles M. Rice | Authors: Antonis Athanasiadis, Georgios Dangas, Ansgar F. Stenzel, Paul Park, Anthi Maslarinou, Evgenia Moschogianni, Allan Henrique Depieri Cataneo, Catherine A Freije, Yichen Zhou, Kenneth C Levenson, Corrine Quirk, Chenhui Zou, William Matthew Schneider, Adriano Aguzzi, Charles M Rice, Ype P De Jong and Eleftherios Michailidis | Summary: More than […]


Continue.. A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors

scFair: Geometry-Aware Gene Budgets and Same-Rank Extension for Highly Variable Gene Selection

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Background Highly variable gene (HVG) selection begins almost every single-cell RNA-seq analysis. While ranking formulas have been compared extensively, the integer gene budget at which any ranking must be truncated is typically left to the user and habitually fixed near 2,000. […]


Continue.. scFair: Geometry-Aware Gene Budgets and Same-Rank Extension for Highly Variable Gene Selection

Chromosome-level genome assembly of the European leaf-toed gecko, Euleptes europaea

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Erich Jarvis | Authors: Josephine R Paris, Linelle Abueg, Sarah Pelan, Ying Sims, Tatiana Tilley, Jacquelyn Mountcastle, Jennifer Balacco, Brian O’Toole, Olivier Fedrigo, Giulio Formenti, Erich D Jarvis, Daniele Canestrelli and Daniele Salvi | Summary: The European leaf-toed gecko (Euleptes europaea) is a small, nocturnal gecko endemic to the western Mediterranean. As a […]


Continue.. Chromosome-level genome assembly of the European leaf-toed gecko, Euleptes europaea

Phylogeny of cortical-hippocampal projections reveals selective elimination of input from sensory regions

Posted by dbos NTNU, This Week: Neuroscience

Kavli Affiliate: Menno Witter | Authors: Daniel Reznik, Piotr Majka, Marcello GP Rosa, Menno P Witter and Christian F Doeller | Summary: The study of cross-species differences in the organization of the cerebral cortex received significant attention during the past century. However, the evolutionary principles governing changes in brain connectivity and their impact on cognition […]


Continue.. Phylogeny of cortical-hippocampal projections reveals selective elimination of input from sensory regions

GIAnT: a Glutamate Imaging Analysis Toolbox

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Adam S. Charles | Authors: Michael E. Xie, Johannes Friedrich, Elizabeth Wirsching, Caleb Jones Shibu, Maedeh Seyedolmohadesin, Naveen Ouellette, Tim Wang, Karel Svoboda, Adam S Charles and Kaspar Podgorski | Summary: Recent advances in fluorescent indicators and optical microscopy now enable in vivo synaptic imaging of glutamate, which transmits the majority of signals between neurons […]


Continue.. GIAnT: a Glutamate Imaging Analysis Toolbox