Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

Kavli Affiliate: Robert Edwards | Authors: Sai Luo, Jun Zhang, Alex J.B. Kreutzberger, Amanda Eaton, Robert J. Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D. Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S. […]


Continue.. Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

Pumping the brakes on RNA velocity – understanding and interpreting RNA velocity estimates

Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field that qualitatively reflects known […]


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White matter and literacy: a dynamic system in flux

Kavli Affiliate: Terry Jernigan | Authors: SEthan Roy, Adam Richie-Halford, John Kruper, Manjari Narayan, David Bloom, Timoty T. Brown, Terry L. Jernigan, Bruce D. McCandliss, Ariel Rokem and Jason D. Yeatman | Summary: Past studies have linked differences in white matter tissue properties to reading skills. However, these studies have reported a range of, sometimes […]


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Targeted cortical stimulation reveals principles of cortical contextual interactions

Kavli Affiliate: Kenneth Miller | Authors: Shen Wang, Agostina Palmigiano, Kenneth D Miller and Stephen David Van Hooser | Summary: Cross-orientation suppression is a classic form of contextual normalization in visual cortex, yet the degree to which cortical circuits participate in the normalization computation is unclear. We visualized orientation maps of individual ferrets, and provided […]


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Cortical ripples during NREM sleep and waking in humans

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for the consolidation of memories in the cortex during non-rapid eye movement […]


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Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer’s Disease

Kavli Affiliate: Menno Witter, Susumu Mori, Michael Miller | Authors: Kaitlin Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno Witter, Can Ceritoglu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael I Miller | Summary: Previous research has emphasized the unique impact of Alzheimer’s Disease (AD) pathology on the medial temporal lobe (MTL), […]


Continue.. Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer’s Disease

A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs

Kavli Affiliate: Jyoti Mishra | Authors: Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, Vigneswaran C, Pragathi Priyadharsini Balasubramani, Jyoti Mishra, Dhaskshin S Ramanathan and V Srinivasa Chakravarthy | Summary: Human cognition is characterized by a wide range of capabilities including goal-oriented selective attention, distractor suppression, decision making, response inhibition, and working memory. Much research has focused […]


Continue.. A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs

Pumping the brakes on RNA velocity — understanding and interpreting RNA velocity estimates

Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field which qualitatively reflects known […]


Continue.. Pumping the brakes on RNA velocity — understanding and interpreting RNA velocity estimates

Dynamic top-down biasing implements rapid adaptive changes to individual movements

Kavli Affiliate: Michael Brainard | Authors: Lucas Y Tian, Timothy L Warren and Michael S Brainard | Summary: Complex behaviors depend on the coordinated activity of neural ensembles in interconnected brain areas. The behavioral function of such coordination, often measured as co-fluctuations in neural activity across areas, is poorly understood. One hypothesis is that rapidly […]


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Phencyclidine and methamphetamine cause cognitive deficits by changing pyramidal neuron transmitter identity in the prefrontal cortex

Kavli Affiliate: Nicholas Spitzer | Authors: Marta Pratelli, Arth Thaker, Huiquan Li, Swetha Godavarthi and Nicholas C. Spitzer | Summary: Decreased cognitive ability is a major consequence of exposure to drugs of abuse, but the underlying neuroplastic changes have been elusive. We show that both phencyclidine and methamphetamine cause a population of prelimbic pyramidal neurons […]


Continue.. Phencyclidine and methamphetamine cause cognitive deficits by changing pyramidal neuron transmitter identity in the prefrontal cortex