Orchestrating Spatial Transcriptomics Analysis with Bioconductor

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Keri Martinowich | Authors: Helena L Crowell, Yixing Dong, Ilaria Billato, Peiying Cai, Martin Emons, Samuel Gunz, Boyi Guo, Mengbo Li, Alexandru Mahmoud, Artür Manukyan, Hervé Pagès, Pratibha Panwar, Shreya Rao, Callum J Sargeant, Lori Shepherd Kern, Marcel Ramos, Jieran […]


Continue.. Orchestrating Spatial Transcriptomics Analysis with Bioconductor

Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Devanand Manoli | Authors: Mohamed Abuelanin, Gulhan Kaya, Juniper A Lake, Christine Lambert, Melody V Wu, Kristen Berendzen, Ksenia Krasheninnikova, Jonathan MD Wood, Nancy G Solomon, Zoe R Donaldson, Karen L Bales, Kerstin Howe, Jonas Korlach, Devanand S Manoli, Jessica […]


Continue.. Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding

Disruption of theta-timescale spiking impairs learning but spares hippocampal replay

Kavli Affiliate: Loren Frank | Authors: Abhilasha Joshi, Alison E. Comrie, Samuel Bray, Abhijith Mankili, Jennifer A. Guidera, Rhino Nevers, Xulu Sun, Emily Monroe, Viktor Kharazia, Ryan Ly, Daniela Astudillo Maya, Denisse Morales-Rodriguez, Jai Yu, Anna Kiseleva, Victor Perez and Loren M. Frank | Summary: The ability to rapidly learn and retrieve salient information about […]


Continue.. Disruption of theta-timescale spiking impairs learning but spares hippocampal replay

A multimodal interrogation of Broca’s area in the pediatric and adult human brain

Kavli Affiliate: Arturo Alvarez-Buylla, Arnold R. Kriegstein and David Rowitch | Authors: Juan Moriano, Tanzila Mukhtar, Jimmy Tsz Hang Lee, Fani Memi, Jonathan Augustin, Rachel Leonard, Joseph Asfouri, I-Ling Lu, Clara Siebert, Jennifer Ja-Yoon Choi, Guolong Zuo, Yinshui Chang, Stanislaw Makarchuk, Elina Jin, Martin Prete, Shaohui Wang, Qiuli Bi, Yuhan Hao, Liz Tuck, Katy Tudor, […]


Continue.. A multimodal interrogation of Broca’s area in the pediatric and adult human brain

Deep learning design and in vivo validation of Müller glia-specific cis-regulatory elements

Kavli Affiliate: Jin Kang | Authors: Oriol Fornes, Kyung Duk Koh, Rebecca M Marton, Jiapei Chen, Kevin A Marroquin, Gyeong Jin Kang, Avantika Lal, Sören Müller, Gokcen Eraslan, Eliah R Shamir, Pratiksha I Thakore, Heinrich Jasper and David Garfield | Summary: Effective recombinant adeno-associated virus gene therapies require promoters that are compact and cell-type-specific. Ideally, […]


Continue.. Deep learning design and in vivo validation of Müller glia-specific cis-regulatory elements

A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]


Continue.. A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Neural substrates underlying the expectation of rewards resulting from effortful exertio

Kavli Affiliate: Vikram Chib | Authors: Aram Kim and Vikram S. Chib | Summary: Decisions to exert effort for reward are often conceptualized as reflecting a trade-off between anticipated benefits and effort costs. However, economic theories propose that valuation is reference-dependent, such that behavior is shaped relative to expected outcomes rather than absolute reward magnitude. […]


Continue.. Neural substrates underlying the expectation of rewards resulting from effortful exertio

Granule cells reorient cortical trajectories to separate contexts

Kavli Affiliate: Rui Costa | Authors: Martha G Garcia-Garcia, Michal Jozef Wojcik, Srijan Thota, Luke Drake, Amma Otchere, Oluwatobi Akinwale, Lizmaylin Ramos, Rui Ponte Costa and Mark J Wagner | Summary: To learn effectively, animals must generalize across yet distinguish between related contexts. Generalization relies on low-dimensional neural manifolds found throughout neocortex1,2, which accelerate learning […]


Continue.. Granule cells reorient cortical trajectories to separate contexts

Heterogeneous responses to embryonic critical period perturbations within the Drosophila larval locomotor circuit.

Kavli Affiliate: Michael Miller | Authors: Niklas Krick, Jacob Davies, Bramwell Coulson, Daniel Sobrido-Camean, Michael Miller, Matthew C.W. Oswald, Aref Arzan Zarin, Richard Baines and Matthias Landgraf | Summary: As developing neural circuits become functional, they undergo a phase of heightened plasticity that facilitates network tuning in response to intrinsic and/or extrinsic stimuli. These developmental […]


Continue.. Heterogeneous responses to embryonic critical period perturbations within the Drosophila larval locomotor circuit.

Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states

Kavli Affiliate: Philip Starr | Authors: TAO LIU, Jiaang Yao, Bahman Abdi-Sargezeh, Abhinav Sharma, Camille Lasbareilles, Robert Tsi Lok Ho, Jackson Cheung, Timothy Denison, Huiling Tan, Wolf-Julian Neumann, Minghan Max Zhu, Sebastian Liu, Philip Starr, Simon Little and Ashwini Oswal | Summary: Adaptive deep brain stimulation (aDBS) relies on physiological biomarkers to infer motor state […]


Continue.. Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states