A reference genome for the Andean cavefish Trichomycterus rosablanca (Siluriformes, Trichomycteridae): building genomic resources to study evolution in cave environments

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Daniel Cadena, Laura Pabon, Carlos DoNascimiento, Linelle Abueg, Tatiana Tiley, Brian O-Toole, Dominic Absolon, Ying Sims, Giulio Formenti, Olivier Fedrigo, Erich Jarvis and Mauricio Torres | Summary: Animals living in caves are of broad relevance to evolutionary biologists interested in understanding the mechanisms underpinning convergent evolution. In the Eastern […]


Continue.. A reference genome for the Andean cavefish Trichomycterus rosablanca (Siluriformes, Trichomycteridae): building genomic resources to study evolution in cave environments

A Photoactivatable Norepinephrine for Probing Adrenergic Neural Circuits

Posted by dbos UCSF

Kavli Affiliate: Kira Poskanzer | Authors: Michelle K. Cahill, Yeraldith Rojas Perez, Amara Larpthaveesarp, Roberto Etchenique and Kira E Poskanzer | Summary: Norepinephrine (NE) is a critical neuromodulator that mediates a wide range of behavior and neurophysiology, including attention, arousal, plasticity, and memory consolidation. A major source of NE is the brainstem nucleus the locus […]


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Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Sonya Kumar Bharathkar, Michael J. Miller and Beth M. Stadtmueller | Summary: Secretory (S) Immunoglobin (Ig) A is the predominant mucosal antibody, which mediates host interactions with commensal and pathogenic microbes, including Clostridioides difficile. SIgA adopts a polymeric IgA structure that is bound by secretory component (SC). Despite significance, […]


Continue.. Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Posted by dbos Hopkins

Kavli Affiliate: Michael Beer | Authors: Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil N. Nurtdinov, Wang Xi, Anthony S. Tan, Hank Jones, X. Rosa Ma, David Yao, Joseph Nasser, Ziga Avsec, Benjamin T. James, Muhammad S. Shamim, Neva C. Durand, Suhas S. P. Rao, Ragini […]


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Investigating egocentric tuning in hippocampal CA1 neurons using simulated data

Posted by dbos NTNU

Kavli Affiliate: Edvard Moser & May-Britt Moser | Authors: Jordan Carpenter, Jan Sigurd Blackstad, David Tingley, Valentin A. Normand, Edvard I. Moser, May-Britt Moser and Benjamin A. Dunn | Summary: Navigation requires integrating sensory information with a stable schema to create a dynamic map of an animal’s position using egocentric and allocentric coordinate systems. In […]


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Microbiota-dependent early life programming of gastrointestinal motility

Posted by dbos Hopkins

Kavli Affiliate: David Linden | Authors: Mary E Frith, Purna C Kashyap, David R Linden, Betty Theriault and Eugene B Chang | Summary: Gastrointestinal microbes modulate peristalsis and stimulate the enteric nervous system (ENS), whose development, as in the central nervous system (CNS), continues into the murine postweaning period. Given that adult CNS function depends […]


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Ammonia-oxidizing archaea and bacteria differentially contribute to ammonia oxidation in soil under precipitation gradients and land legacy

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Soumyadev Sarkar, Anna Kazarina, Paige M. Hansen, Kaitlyn Ward, Christopher Hargreaves, Nicholas Reese, Qinghong Ran, Willow Kessler, Ligia F.T. de Souza, Terry D. Loecke, Marcos V.M. Sarto, Charles W. Rice, Lydia H. Zeglin, Benjamin A. Sikes and Sonny T.M. Lee | Summary: Global change has accelerated the nitrogen […]


Continue.. Ammonia-oxidizing archaea and bacteria differentially contribute to ammonia oxidation in soil under precipitation gradients and land legacy

Abstract representations emerge in human hippocampal neurons during inference behavior

Posted by dbos Columbia

Kavli Affiliate: Stefano Fusi & Daniel Salzman | Authors: Hristos Spiridonos Courellis, Juri Minxha, Araceli Ramirez Cardenas, Daniel L Kimmel, Chrystal M Reed, Taufik A Valiante, C. Daniel Salzman, Adam N Mamelak, Ralph Adolphs, Stefano Fusi and Ueli Rutishauser | Summary: Humans have the remarkable cognitive capacity to rapidly adapt to changing environments. Central to […]


Continue.. Abstract representations emerge in human hippocampal neurons during inference behavior

Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adenoviral expression of Ca2+ indicators

Posted by dbos Columbia

Kavli Affiliate: Rafael Yuste | Authors: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O’Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel and Tony Kelly | Summary: Genetically encoded calcium indicators (GECIs) such as GCaMP are an invaluable tool in neuroscience to monitor neuronal activity using […]


Continue.. Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adenoviral expression of Ca2+ indicators

Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Lila D. Patterson, Benjamin D. Dubansky, Brooke H. Dubansky, Shannon Stone, Mukesh Kumar and Charles D Rice | Summary: The Coronavirus disease 2019 (COVID19) pandemic caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is an ongoing threat to global public health. To this end, intense efforts are underway to […]


Continue.. Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment