Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons

Kavli Affiliate: Timothy A. Ryan; | Authors: Kirsten Bredvik, Charmaine Liu and Timothy A. Ryan | Summary: The ketogenic diet is an effective treatment for drug-resistant epilepsy, but the therapeutic mechanisms are poorly understood. Although ketones are able to fuel the brain, it is not known whether ketones are directly metabolized by neurons on a […]


Continue.. Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

Kavli Affiliate: Pietro De Camilli; | Authors: Xinbo Wang, Peng Xu, Amanda Bentley-DeSousa, William Hancock-Cerutti, Shujun Cai, Benjamin T Johnson, Francesca Tonelli, Gabriel Talaia, Dario R Alessi, Shawn M Ferguson and Pietro De Camilli | Summary: Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson’s disease (PD). Here we […]


Continue.. Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression

Kavli Affiliate: Steven Siegelbaum; | Authors: Lara M. Boyle, Wanhui Sheng, Felix Leroy, Rhea Sahai, Sarah Irfan, Heon-Jin Lee, Andres Villegas, W. Scott Young and Steven A Siegelbaum | Summary: Although it is well-known that the hippocampus mediates declarative memory (the repository of information of people, places, things and events) and influences behavior, the differential […]


Continue.. The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression

RESPAN: an accurate, unbiased and automated pipeline for analysis of dendritic morphology and dendritic spine mapping

Kavli Affiliate: Franck Polleux; | Authors: Sergio B. Garcia, Alexa P. Schlotter, Daniela Pereira, Franck Polleux and Luke Hammond | Summary: Accurate and unbiased reconstructions of neuronal morphology, including quantification of dendritic spine morphology and distribution, are widely used in neuroscience but remain a major roadblock for large-scale analysis. Traditionally, spine analysis has required labor-intensive […]


Continue.. RESPAN: an accurate, unbiased and automated pipeline for analysis of dendritic morphology and dendritic spine mapping

Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

Kavli Affiliate: Mark H. Tuszynski; | Authors: Pabitra K Sahoo, Nick Hanovice, Patricia Ward, Manasi A Agrawal, Terika P Smith, HaoMin SiMa, Jennifer N Dulin, Lauren S Vaughn, Mark Tuszynski, Kristy Welshhans, Larry Benowitz, Arthur English, John D Houle and Jeffery L Twiss | Summary: Depletion or inhibition of core stress granule proteins, G3BP1 in […]


Continue.. Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

The JADES Transient Survey: Discovery and Classification of Supernovae in the JADES Deep Field

Kavli Affiliate: Roberto Maiolino | First 5 Authors: Christa DeCoursey, Eiichi Egami, Justin D. R. Pierel, Fengwu Sun, Armin Rest | Summary: The JWST Advanced Deep Extragalactic Survey (JADES) is a multi-cycle JWST program that has taken among the deepest near-infrared images to date (down to $sim$30.5 ABmag) over $sim$25 arcmin$^2$ in the GOODS-S field […]


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Programmable Multi-responsive Nanocellulose-based Hydrogels with Embodied Logic

Kavli Affiliate: Chiara Daraio | First 5 Authors: Beatriz Arsuffi, Gilberto Siqueira, Gustav Nyström, Silvia Titotto, Tommaso Magrini | Summary: Programmable materials are desirable for a variety of functional applications that range from biomedical devices, actuators and soft robots to adaptive surfaces and deployable structures. However, current smart materials are often designed to respond to […]


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Scalar Dark Energy Models and Scalar-Tensor Gravity: Theoretical Explanations for the Accelerated Expansion of Present Universe

Kavli Affiliate: Lijing Shao | First 5 Authors: Peixiang Ji, Lijing Shao, , , | Summary: The reason for the present accelerated expansion of the Universe stands as one of the most profound questions in the realm of science, with deep connections to both cosmology and fundamental physics. From a cosmological point of view, physical […]


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$T_c$ and the elastocaloric effect of Sr$_2$RuO$_4$ under $langle 110 rangle$ uniaxial stress: no indications of transition splitting

Kavli Affiliate: Brad J. Ramshaw | First 5 Authors: Fabian Jerzembeck, You-Sheng Li, Grgur Palle, Zhenhai Hu, Mehdi Biderang | Summary: There is considerable evidence that the superconductivity of Sr2RuO4 has two components. Among this evidence is a jump in the shear elastic modulus $c_{66}$ at the critical temperature $T_c$, observed in ultrasound measurements. Such […]


Continue.. $T_c$ and the elastocaloric effect of Sr$_2$RuO$_4$ under $langle 110 rangle$ uniaxial stress: no indications of transition splitting

Electric leakage suppression of phase-transforming ferroelectrics with donor impurities

Kavli Affiliate: Xian Chen | First 5 Authors: Chenbo Zhang, Xiaotong Peng, Bo Liu, Kai Zhang, Xian Chen | Summary: Phase-transforming ferroelectric materials are widely used in energy harvesting and conversion devices. However, the functionality of these devices is significantly impeded by electrical leakage at high temperatures. In this study, we fundamentally study the mechanism […]


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