Kavli Affiliate: Daniel Kronauer | Authors: Daniel H. Pastor, Leonora Olivos-Cisneros, Alejandra Hurtado-Giraldo, Anurag Sharma, Patrick K. Piekarski, Giacomo L. Glotzer and Daniel Kronauer | Summary: Ant larvae are blind and immobile, depending heavily on the adults for care in the form of feeding, grooming, and transport. However, they are not inactive colony members but […]
Kavli Affiliate: Michael J Higley | Authors: Yongxu Zhang, Josue Ortega Caro, Rachel Oren, Michael James Higley, Jessica Cardin, Anne Churchland and Shreya Saxena | Summary: Modern recording technologies enable simultaneous measurement of high-dimensional neural activity and rich behavioral variables, creating both an opportunity and a modeling challenge: identifying the shared latent structure that mediates […]
Kavli Affiliate: Rui Costa | Authors: Afonso Lourinho, Marta S. Silva, Emanuel Tahiri, Marco D’Ambrosio, Ana D. Pinto, Saray Calvo Parra, Giovana De Pietro, Guilherme Galvao, Ana B. Caniceiro, Luis Pereira de Almeida, Paulo Pinheiro, Irina S. Moreira, Rui Jorge Nobre, Miranda Mele, Andrzej W. Cwetsch, Carlos B. Duarte and Rui O Costa | Summary: […]
Kavli Affiliate: Xin Duan and Lily Jan | Authors: Chao Chen, Ruogu Liu, Aijia Yi-Luo, Xiaoyan Cao, Jitao Hu, Shikang Guan, Si-yuan Chang, Xiaoli Cui, Wei Zhou, Fei Zhao, Chun-Teng Huang, Xin Duan, Lily Y. Jan and Tongfei A. Wang | Summary: The brain coordinates animal physiology and behavior via neuronal circuits. To understand and […]
Kavli Affiliate: Zachary Knight and Kevin Yackle | Authors: Naz Dundar, Ilayda Alkislar, Brooke C Jarvie, Ho Namkung, Kathryn Xie, Mahekdeep Kaur, Queenie Li, Anagh S Ravi, Alejandro Lopez, Antionette Spina, Longhui Qui, Truong Ly, Jun Oh, Kevin Yackle and Zachary A Knight | Summary: Digestion requires precisely timed transit of food through the gastrointestinal […]
Kavli Affiliate: Charles M. Rice | Authors: Yingpu Yu, Eleftherios Michailidis, Leon Louis Seifert, Mengyin Zhang, Chenhui Zou, Catherine Freije, Georgios Dangas, Antonis Athanasiadis, Andreas Puschnik, Audrey Hanson, Evelyn Rocha, Yi-Pei Chen, Xupeng Hong, Corrine Quirk, Yichen Zhou, Michael A Schmid, Florian A Lempp, Charles M Rice, William Schneider and Ype P De Jong | […]
Kavli Affiliate: Alan David Kaplan | Authors: Arghamitra Talukder and Alan Kaplan | Summary: Genomic foundation models promise to infer regulatory consequences of genetic variants directly from DNA sequence, but how well these predictions translate to clinical utility remains unclear. To probe this question, we evaluate AlphaGenome (AG) for understanding amyotrophic lateral sclerosis (ALS) genetics […]
Kavli Affiliate: Peter Walter | Authors: Chari M Noddings, Rukmini Mukherjee, Carsten Peukert, Thomas G Laughlin, Jing Wang, Benjamin T Walters, Tsan-Wen Lu, Tristan Croll, Deniz Eismann, Shelly Harel, Angela Xu, Kibeom Kim, Meghna Gupta, James Crawford, Christopher P Arthur, Daniel Itzhak, Mauro Costa-Mattioli, Joachim Rudolph, Avi Ashkenazi and Peter Walter | Summary: The endoplasmic […]
Kavli Affiliate: Jin Kang | Authors: Kang Jin, Reuben A. Saunders, Jiahao Zhang, Jiaqi Lu, Aaron A. Halpern, Jaspreet Sandhu, Xingjie Pan, Cosmos Yuqi Wang, Alexander M. Li, William E. Allen, Jonathan S. Weissman and Xiaowei Zhuang | Summary: Genetic perturbations can reshape both the state of a targeted cell and the behavior of neighboring […]
Kavli Affiliate: David Kleinfeld | Authors: Jia-Jin Liu, Hidenobu Mizuno, Emmanuel Than-Trong, Philipp Machler, Hideaki Kubotera, Tony Barbay, Ching-Yao Wang, Qin-Ling To, Yuki Kamijo, Taki Nishimura, Marc Boisvert, Marie-Eve Paquet, Mikhail Drobizhev, Stephanie J Cragg, Jun Nagai, David Kleinfeld, Serge Charpak and Yusuke NASU | Summary: Extracellular L-lactate reports cellular metabolism, but resolving its dynamics […]