Kavli Affiliate: Jonathan Whitlock | Authors: Pearl Saldanha, Martin Bjerke, Benjamin Adric Dunn and Jonathan Robert Whitlock | Summary: Spatial navigation is commonly studied in static environments, but adaptive behavior frequently hinges on tracking moving goals in real time. Active pursuit exemplifies this challenge, since it is an inherently egocentric spatial behavior requiring continual localization […]
Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Xiaqing Lan, Alireza Salami, Heidi Jacobs and Maryam Ziaei | Summary: The locus coeruleus (LC) regulates attention, arousal and adaptive behavior via widespread noradrenergic projections to cortex, yet its large-scale cortical organization and vulnerability to aging remain poorly understood. Using ultra-high-field 7T–MRI during naturalistic viewing […]
Kavli Affiliate: Maryam Ziaei and Menno Witter | Authors: Shuer Ye, Arjun Dave, Xiaqing Lan, Menno P. Witter, Alireza Salami and Maryam Ziaei | Summary: Amygdala-related functional connectivity plays a crucial role in human emotion, cognition, and mental well-being. The amygdala is a highly heterogeneous structure, with subregions that have both distinct and overlapping functions. […]
Kavli Affiliate: Rui Costa | Authors: Akira Fushiki, David Ng, Zachary R. Lewis, Archana Yadav, Tatiana Saraiva, Luke A. Hammand, Christoph Wirblich, Bosiljka Tasic, Vilas Menon, Joaquim Alves da Silva and Rui M. Costa | Summary: In Parkinson′s disease (PD), dopaminergic neurons (DANs) in the midbrain gradually degenerate, with ventral substantia nigra pars compacta (SNc) […]
Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Boyi Guo, Cindy Fang, Madhavi Tippani, Svitlana V Bach, Ryan A Miller, Sarah E Maguire, Artemis Iatrou, Geo Pertea, Nicholas J Eagles, Madeline R Valentine, Seyun Oh, Aarti Jajoo, Vijetha Balakundi, Yufeng Du, Annie B Nguyen, Ruth Zhang, Uma M Kaipa, Heena R Divecha, Jashandeep S. […]
Kavli Affiliate: Zachary Knight | Authors: Truong Ly, Xinyang Yi, Grace R. Lee, James CR Grove, Youssef E. Sibih, Yun Y. Oh, Longhui Qiu, Nilla Sivakumar and Zachary A Knight | Summary: The termination of a meal is triggered by sensory feedback from the stomach and intestines that reports on ingested food1–10 and is relayed […]
Kavli Affiliate: Sarah Woolley | Authors: Logan S James, Benjamin Hoffman, Jen-Yu Liu, Marius Miron, Milad Alizadeh, Emmanuel Fernandez, Matthieu Geist, Diane Kim, Aza Raskin, Jon T Sakata, Emmanuel Chemla, Olivier Pietquin and Sarah C Woolley | Summary: Vocal interactions are widespread across animals and important for many social behaviors (1–4). For example, during human […]
Kavli Affiliate: Martin Lindquist | Authors: Bogdan Petre, Martin A Lindquist and Tor Wager | Summary: Brain maps (e.g. retinotopy, somatotopy) vary across individuals. This is thought to reflect underlying computational differences. However, artificial neural networks (ANNs) show that similar performance and internal representations can coexist with diverse circuit layouts. Consequently, we tested the presumption […]
Kavli Affiliate: Seth Shipman | Authors: Jihoon Han and Seth Shipman | Summary: Here, we introduce Detectrons, modular biosensors that couples programmable toehold switches with retron-mediated reverse transcription to transduce RNA inputs into unique DNA barcodes. The ability to convert dynamic RNA signals into durable DNA records within living cells unlocks powerful new modes of […]
Kavli Affiliate: Xiaoqin Wang | Authors: Chenggang Chen, Zhiyu Yang and Xiaoqin Wang | Summary: Whether the auditory cortex has parallel pathways for sound identification (“what”) and localization (“where”), and whether it contains a map of auditory space, is debated. Here, we examined the low-dimensional structure (manifold) of “what” and “where” representations in deep neural […]