Kavli Affiliate: Justus M Kebschull and Jean Fan | Authors: Manjari M-G Anant, Eli Clemens Zuercher, Maggie Lowman, Caleb Shi, Dylan Z. Faltine-Gonzalez, Michael L. Piacentino, Jean Fan and Justus M. Kebschull | Summary: The cerebellar nuclei, the output regions of the cerebellum, have evolved via repeated duplication of a conserved cell type set to […]
Kavli Affiliate: Robert B. Darnell | Authors: Madison T Jones, Natalie Noble, Robert B Darnell and Ezgi Hacisuleyman | Summary: Neurons rely on localized protein synthesis to rapidly adapt synaptic function to activity, yet how dendritic translation regulates mitochondrial remodeling during synaptic plasticity remains poorly understood. Here, we show that neuronal activity engages a spatially […]
Kavli Affiliate: Ellen J. Hoffman | Authors: April Pruitt, Liang Yang, Seoyeon Lee, Novin Balafkan, Shilin Gao, Carina Seah, Yi Dai, Elizabeth Davidson, Suha Khan, Annabel Sen, Jenny Liu, Isabel Wood, Gang Xu, Xiayuan Huang, Marina Carlson, Dejian Zhao, Priyanka Jamadagni, Grace Dossou, Kayla Retallick-Townsley, Xinyun Liu, Xenophon Papademetris, P.J. Michael Deans, Meilin Fernandez Garcia, […]
Kavli Affiliate: John Reynolds | Authors: Karina Vanadzina, Kaushalya Nagahawatte, Deshan Rupasinghe, George G. Brown, Erin K. Cameron, Sylvain Gérard, Céline Pelosi, John W. Reynolds, Alyssa Rice and Helen R.P. Phillips | Summary: Invasive species constitute one of the most significant threats to biodiversity worldwide, and are responsible for more than $400 billion in losses […]
Kavli Affiliate: Alexander Szalay | Authors: Long Yuan, Xuyang Li, My Le, Stephanie C Hicks, Atul Deshpande, Janis M Taube and Alexander S Szalay | Summary: Single-cell RNA-seq atlases are commonly explored with nonlinear embeddings that preserve neighborhoods but provide limited coordinate-level interpretation. We asked whether projecting the dominant principal components (PCs) of single-cell gene […]
Kavli Affiliate: Karunesh Ganguly | Authors: Aviv D Mizrahi-Kliger, Samantha Coury, Cameron L Woodard and Karunesh Ganguly | Summary: With practice, rapid early gains in performance are followed by a slower phase marked by kinematic refinement, automaticity and enhanced cortical and striatal interactions. While sleep is known to support early learning, its causal role in […]
Kavli Affiliate: Michael Shadlen | Authors: NaYoung So, Ariel Zylberberg and Michael N Shadlen | Summary: Perceptual decisions are widely modeled as the accumulation of evidence to a bound. In the lateral intraparietal area (LIP), this computation is thought to be implemented in a low-dimensional population representation organized around the single action used to report […]
Kavli Affiliate: Stanley Prusiner | Authors: Nicholas L. Yan, Mylan Mayer, Arthur A. Melo, Jacob I. Ayers, Daniel A. Mordes, William W. Seeley, Stanley B. Prusiner, Eric Tse, Vinita G. Chittoor-Vinod and Gregory E Merz | Summary: α-Synuclein (aSyn) aggregation within Lewy bodies underlies Parkinson’s disease and associated dementias. These aggregates are often comprised of […]
Kavli Affiliate: Ann-Shyn Chiang | Authors: Ya-Hui Lin, Chao-Yin Huang, Yin-Hsu Chen, Yen-Hui Chen, Ping-Liang Ko, Heng-Hua Hsu, Yi-Chung Tung, Yu-Fang Chen, Hui-Chi Chen, Ann-Shyn Chiang, Chih-Ming Ho, Da-Jeng Yao, Kimberly L Fiock, Kuo-Chuan Wang, Chin-Hsien Lin, Shang-Hsiu Hu, Bi-Chang Chen and Li-An Chu | Summary: Archived formalin-fixed, paraffin-embedded (FFPE) tissues, including brain-bank specimens, are […]
Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: A challenge in sensory neuroscience is understanding how populations of neurons operate in concert to represent diverse stimuli. To meet this challenge, we have created “encoding manifolds” that reveal the overall responses of brain areas […]