Kavli Affiliate: Shawn Ferguson | Authors: Devin Clegg, Amanda Bentley-DeSousa, Agnes Roczniak-Ferguson and Shawn M Ferguson | Summary: Increased activity of leucine-rich repeat kinase 2 (LRRK2) confers Parkinson’ s disease risk. LRRK2 dynamically localizes to lysosomal membranes in response to various stresses, yet the mechanisms by which distinct lysosomal perturbations are communicated to LRRK2 remain […]
Kavli Affiliate: Stefano Fusi and Kenneth Miller | Authors: Mario Dipoppa, Ramon Nogueira, Stéphane Bugeon, Yoni Friedman, Charu B. Reddy, Kenneth D. Harris, Dario L. Ringach, Kenneth D. Miller, Matteo Carandini and Stefano Fusi | Summary: Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic Sensory adaptation dynamically changes neural responses as a […]
Kavli Affiliate: Mark Ellisman | Authors: Hugo Calligaro, Brian Khov, Karina Noel, Aidan Glina, Laura van Rosmalen, Ramesh Ramasamy, Yushi Li, Michael Tun Yin Lam, Hiep Le, Keun-Young Kim, Wonkyu Ju, Mark Ellisman and Satchidananda Panda | Summary: Circadian disruption, notably sleep disturbances, serves as an early indicator of Alzheimer’s disease (AD), preceding cognitive symptoms […]
Kavli Affiliate: Timothy Brown | Authors: Frederike Stock, Saswat Panda, Richard Poire, Timothy Brown, Ayesha Akram, Liang Zheng, Huan Lei, Ruyi Zha, Mingrui Zhao, Sebastien Isabelle, Michele Martel, Marc-Andre Comeau, Louis-Philippe Hamel, Pierre-Olivier Lavoie, Marc Andre D’Aoust, Hannah Reithinger, Pooja Saxena, Eric A. Stone, Hongdong Li, Danielle A. Way and Owen K. Atkin | Summary: […]
Kavli Affiliate: Li Zhao | Authors: Li Na Zhao and Jesper Andersen | Summary: Background The rising burden of metabolic dysfunction-associated steatotic liver disease (MASLD)-associated hepatocellular carcinoma (HCC) underscores the need for innovative therapeutic strategies. Methods We integrated RNA-seq fusion detection, immunopeptidomics, and proteogenomics to systematically prioritize tumor-specific neoantigen candidates arising from gene fusions in MASLD-HCC. Results We […]
Kavli Affiliate: Zachary Knight | Authors: Heeun Jang, Alexis Behne Sharma, Usan Dan, Jasmine H. Wong, Zachary A. Knight and Jennifer L. Garrison | Summary: Chronic dehydration is a leading cause of morbidity for the elderly, but how aging alters the fluid homeostasis system is not well understood. Here, we used a combination of physiologic, […]
Kavli Affiliate: Li Zhao | Authors: UnJin Lee and Li Zhao | Summary: HP6/Umbrea, a rapidly evolving Drosophila (Heterochromatin Protein 1) HP1-family paralog, has well-documented sequence and regulatory evolution but an under-studied molecular function. In this manuscript, we hypothesize that HP6/Umbrea acts as an HP1-recruited plasticizer, providing support for this model using coarse-grained molecular-dynamics simulations of HP1a […]
Kavli Affiliate: Leslie B. Vosshall | Authors: Yael N Tsitohay, Nipun S Basrur, Umberto Palatini, Alexandra E DeFoe, Thomas A Jones, Junhui Peng, Margaret Herre, Li Zhao, Sean R Eddy, Nadav Shai and Leslie B Vossha | Summary: Sex-specific RNA splicing is a conserved mechanism for generating sexual dimorphism in insects, with the beststudied examples […]
Kavli Affiliate: Nathaniel Sawtell | Authors: Qianyun Zhang, Salomon Z Muller, LF Abbott and Nathaniel B Sawtell | Summary: The dorsal cochlear nucleus (DCN) is a cerebellum-like structure in the mammalian auditory brainstem that combines auditory nerve input with diverse auditory and non-auditory signals conveyed by granule cells. Granule cells form excitatory synapses onto inhibitory […]
Kavli Affiliate: Keri Martinowich | Authors: Michael S. Totty, Svitlana V. Bach, Madeline R. Valentine, Madhavi Tippani, Sarah E. Maguire, Ishbel Del Rosario Alvia, Ryan A. Miller, Joel E. Kleinman, Kristen R. Maynard, Stephanie Cerceo Page, Thomas M. Hyde, Stephanie C. Hicks and Keri Martinowich | Summary: The amygdala is a central hub for emotional […]