Decoding Chronic Pain States from Distributed Intracranial Recordings

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Ankit N. Khambhati, Edward F. Chang and Prasad Shirvalkar | Summary: Chronic pain engages distributed cortical and subcortical circuits, and large-scale intracranial recordings in humans offer a valuable opportunity to characterize its neural signatures. Here, we recorded multi-day stereoelectroencephalography (sEEG) from six participants with refractory chronic neuropathic […]


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Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport

Posted by dbos UCSF

Kavli Affiliate: David Rowitch | Authors: Guy LAM, Zhaoyang Xu, Adrien M Vaquie, Stavros Vagionitis, Michael Perry, Omar de Faria, Jr., Georgios Solomou, John H Stockley, Gemma C Girdler, Daniel Yamamoto, Juan A Oses, Qianqian Zhang, Gregory Jordan, Laura R Morcom, Jacob Stillman, Hani S Mousa, Alma Burlingame, Murray Stewart, Hauke B. Werner, Andras Lakatos, […]


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Functional segregation of body-brain signals in the area postrema

Posted by dbos UCSF

Kavli Affiliate: Zachary Knight | Authors: Alejandro Lopez-Cruz, Natalie S. Figueredo Burgos, Anna M Hakimi, Kathryn Xie, Mo Mao, Mahekdeep Kaur, Antionette Spina, Katie Choi, Longhui Qui, Teresa E Lever, Fiona M Gribble, Frank Reimann, Martin G Myers, Alice E Adriaenssens and Zachary A Knight | Summary: Nausea arises from activation of specialized neurons in […]


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Sleep to forget: active control of consolidation and forgetting by slow-wave sleep dynamics

Posted by dbos UCSF

Kavli Affiliate: Karunesh Ganguly | Authors: Ryan Golden, Mingxiao Wei, Samantha Coury, Aviv Mizrahi-Kliger, Karunesh Ganguly and Maxim Bazhenov | Summary: Sleep supports both the consolidation of new memories and the forgetting of others, but how the cortex flexibly controls these outcomes remains poorly understood. Recent work has shown that two types of Up states […]


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Shared potential metabolism trends in degraded soils and type 2 diabetes gut microbiomes

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: Global change profoundly impacts microbial systems but cascading effects on human metabolic health remain largely unexplored. Type 2 […]


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Type 1 lymphocytes accumulate in the thalamus and produce interferon-γ to restrict seizure susceptibility after brain injury

Posted by dbos UCSF

Kavli Affiliate: Anna Molofsky and Jeanne Paz | Authors: Nicholas M Mroz, Agnieszka Ciesielska, Nathan A Ewing-Crystal, Leah C Dorman, Rafael T Han, Jerika J Barron, Nicholas J Silva, Audrey Magsig, Anna V Molofsky, Ari B Molofsky and Jeanne T Paz | Summary: Chronic neural circuit hyperexcitability frequently emerges after brain injury, but endogenous mechanisms […]


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The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy

Posted by dbos UCSF

Kavli Affiliate: Xin Duan and Massimo Scanziani | Authors: Xinxin Ge, Xing Wei, Baixi Ruan, Qin Ying Wu, Siyuan Chang, Nicole Tsai, Shaobo Zhang, Xin Duan and Massimo Scanziani | Summary: The hierarchical organization of sensory cortices and the rich molecular taxonomy of their cell types are defining features of the mammalian cortex. Cortical areas […]


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Complexity as a Potential Neurophysiological Correlate of Awe

Posted by dbos UCSF

Kavli Affiliate: Reza Abbasi Asl | Authors: oseph Chih Chien Chen, Gabriella Mace, Avery Ostrand, Christian Valtierra, Sydney Griffith, Richard Campusano, Andrew Li, Erin Vinson, Jonas Schlomberg, Maya Eshel, John Matthew Suntay, Syed Rahim, Roger Anguera-Singla, Bijurika Nandi, Isabella Hartley, Daniel A Brown, Nicole C Swann, Luca Mazzucato, Xin Hu, Dan Zhang, Christopher Timmermann, Maryam […]


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A Neuronal Gene Expression Program Underlying Sustained Network Activity

Posted by dbos UCSF

Kavli Affiliate: Yuh Nung Jan | Authors: J. Wren Kim, Rebecca Eliscu, Adeline JH Yong, Sua Lee, Yuh Nung Jan, Taeyoung Hwang, Liana F Lareau and Nicholas T Ingolia | Summary: Neurons function within interconnected networks and must continuously adjust their firing properties to maintain stable network activity. Although these adjustments require long-lasting molecular changes, […]


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A non-canonical pallidothalamic pathway for motor control

Posted by dbos UCSF

Kavli Affiliate: Jeanne Paz | Authors: Isaac Y.M. Chang and Jeanne T. Paz | Summary: Coordinated movement relies on interactions between the basal ganglia and the thalamus, yet the circuits linking these structures are not fully understood. Here, we dissect a non-canonical basal ganglia output pathway, from the external globus pallidus (GPe) to the nucleus […]


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