A Photoactivatable Norepinephrine for Probing Adrenergic Neural Circuits

Kavli Affiliate: Kira Poskanzer | Authors: Michelle K. Cahill, Yeraldith Rojas Perez, Amara Larpthaveesarp, Roberto Etchenique and Kira E Poskanzer | Summary: Norepinephrine (NE) is a critical neuromodulator that mediates a wide range of behavior and neurophysiology, including attention, arousal, plasticity, and memory consolidation. A major source of NE is the brainstem nucleus the locus […]


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The entropic heart: Tracking the psychedelic state via heart rate dynamics

Kavli Affiliate: Reza Abbasi Asl & Adam Gazzaley | Authors: Fernando E. Rosas, Pedro A.M. Mediano, Christopher Timmermann, Andrea I Luppi, Diego Candia-Rivera, Reza Abbasi-Asl, Adam Gazzaley, Morten L Kringelbach, Suresh Daniel Muthukumaraswamy, Daniel Bor, Sarah Garfinkel and Robin Carhart-Harris | Summary: A growing body of work shows that autonomic signals provide a privileged evidence-stream […]


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Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Robert A Edwards, Michael J. Roach, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Joel Brame, Anna Heintz-Buschart, Timothy R Cavagnaro, Elizabeth A Dinsdale, Michael P Doane, Nico Eisenhauer, Grace Mitchell, Bibishan Rai, Sunita Ramesh and Martin F Breed | Summary: Microbiomes are critical to the […]


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DREDge: robust motion correction for high-density extracellular recordings across species

Kavli Affiliate: Michael Shadlen, Liam Paninski, Mark Churchland, & Edward Chang | Authors: Charlie Windolf, Han Yu, Angelique C. Paulk, Domokos Meszéna, William Muñoz, Julien Boussard, Richard Hardstone, Irene Caprara, Mohsen Jamali, Yoav Kfir, Duo Xu, Jason E. Chung, Kristin K. Sellers, Zhiwen Ye, Jordan Shaker, Anna Lebedeva, Manu Raghavan, Eric Trautmann, Maxwell D. Melin, […]


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Context-invariant socioemotional encoding by prefrontal ensembles

Kavli Affiliate: Vikaas Sohal | Authors: Nicholas A Frost, Kevin C Donohue and Vikaas Sohal | Summary: The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information across different environments? Are contextual and socioemotional representations segregated or intermixed, […]


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Encoding of melody in the human auditory cortex

Kavli Affiliate: Edward Chang | Authors: Narayan Sankaran, Matthew K Leonard, Frederic E Theunissen and Edward F Chang | Summary: Melody is a core component of music in which discrete pitches are serially arranged to convey emotion and meaning. Perception of melody varies along several pitch-based dimensions: (1) the absolute pitch of notes, (2) the […]


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Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Kavli Affiliate: Edward Chang | Authors: Sunada Khadka, Yu-Hsi Lin, Jeffrey J Ackroyd, Yi-An Chen, Yanghui Sheng, Wubin Qian, Sheng Guo, Yining Chen, Eliot Itzkow Behr, Yasaman Barekatin, Md. Nasir Uddin, Kenisha Arthur, Victoria C Yan, Edward Chang, Anton Poral, Theresa Tran, Wen-Hao Hsu, Surendra Chaurasiya, Dimitra K. Georgiou, John M. Asara, Floris P. Barthel, […]


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Development of covalent chemogenetic K2P channel activators

Kavli Affiliate: Daniel Minor | Authors: Parker E Deal, Haerim Lee, Abhisek Mondal, Marco Lolicato, Philipe Ribeiro Furtado de Mandonca, Holly Black, Xochina El-Hilali, Clifford Bryant, Ehud Y Isacoff, Adam Renslo and Daniel L Minor, Jr. | Summary: K2P potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune […]


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The breath shape controls intonation of mouse vocalizations

Kavli Affiliate: Kevin Yackle | Authors: Alastair MacDonald and Kevin Yacklei | Summary: Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct “words”, like the ten sounds in the murine lexicon. A […]


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A Simple Subcortical Feeding Circuit Linking Interoceptive Inputs to Consummatory Behavior

Kavli Affiliate: Zachary Knight & Jeffrey M. Friedman | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: The brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the underlying circuitry linking inputs to outputs is unknown. Here we delineate a subcortical circuit in […]


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