Kavli Affiliate: Zachary Knight | Authors: James C. R. Grove, Anna M. Hakimi, Queenie Li, Jingkun Zhang, Heiko Backes, Bojana Kuzmanovic, Jaewon Choi, Violeta Ubadiah, Longhui Qiu, Zhengya Liu, Dana M. Small, Marc Tittgemeyer and Zachary A. Knight | Summary: Animals learn about the external world, in part, via interoceptive signals1,2. For example, the nutrient […]
Kavli Affiliate: Xin Duan and Lily Jan | Authors: Chao Chen, Ruogu Liu, Aijia Yi-Luo, Xiaoyan Cao, Jitao Hu, Shikang Guan, Si-yuan Chang, Xiaoli Cui, Wei Zhou, Fei Zhao, Chun-Teng Huang, Xin Duan, Lily Y. Jan and Tongfei A. Wang | Summary: The brain coordinates animal physiology and behavior via neuronal circuits. To understand and […]
Kavli Affiliate: Zachary Knight and Kevin Yackle | Authors: Naz Dundar, Ilayda Alkislar, Brooke C Jarvie, Ho Namkung, Kathryn Xie, Mahekdeep Kaur, Queenie Li, Anagh S Ravi, Alejandro Lopez, Antionette Spina, Longhui Qui, Truong Ly, Jun Oh, Kevin Yackle and Zachary A Knight | Summary: Digestion requires precisely timed transit of food through the gastrointestinal […]
Kavli Affiliate: Alan David Kaplan | Authors: Arghamitra Talukder and Alan Kaplan | Summary: Genomic foundation models promise to infer regulatory consequences of genetic variants directly from DNA sequence, but how well these predictions translate to clinical utility remains unclear. To probe this question, we evaluate AlphaGenome (AG) for understanding amyotrophic lateral sclerosis (ALS) genetics […]
Kavli Affiliate: Peter Walter | Authors: Chari M Noddings, Rukmini Mukherjee, Carsten Peukert, Thomas G Laughlin, Jing Wang, Benjamin T Walters, Tsan-Wen Lu, Tristan Croll, Deniz Eismann, Shelly Harel, Angela Xu, Kibeom Kim, Meghna Gupta, James Crawford, Christopher P Arthur, Daniel Itzhak, Mauro Costa-Mattioli, Joachim Rudolph, Avi Ashkenazi and Peter Walter | Summary: The endoplasmic […]
Kavli Affiliate: Zachary Knight | Authors: Zhengya Liu, Ho Namkung, Jingkun Zhang, Julianne Davis, Naymalis La Santa Medina, Sophia Laskaris, Anyu Cao, Tianyi Chen, Xinlan Wen and Zachary A Knight | Summary: Drinking quenches thirst long before the ingested water has been absorbed. Here we investigate the mechanism by combining sham drinking, which uncouples water […]
Kavli Affiliate: Joshua Berke | Authors: Seongtak Kang, Dennis A Burke, Caroline Kornbrek, Farah Farouq, Huijeong Jeong, Vijay Mohan K Namboodiri and Joshua Berke | Summary: Dopamine in the nucleus accumbens Core powerfully influences motivation and learning, yet the information encoded by Core dopamine remains unresolved. Competing theories typically assume a spatially uniform signal, […]
Kavli Affiliate: David Rowitch | Authors: Harry JCJ Bulstrode, Adam Young, Ifenya Huysman, Dushanth Seevaratnam, King Ki Man, Ho Lim Pak, Grace Wilson, AthenaStamper, Xinyi Wang, Yujun Wang, Xin Tang, An Truong, Saeed Kayhanian, Francisca Ferreira, Mark Plummer, Adam O’Connell, Dominika Bogusiewicz, Daniel Brown, Danny Godfrey, Ronan Daly, George G Malliaras, David H Rowitch, Peter […]
Kavli Affiliate: Qili Liu | Authors: Qili Liu, Tianji Ma, Guangyan Wu, Lauren Tham, Madison Palarca-Wong, Sharon Vaz, Nick Allen, Carrie Shao, Ashley Tsai, Richard W. Song and Pamela M. England | Summary: Protein is unique among macronutrients due to its nitrogen content and that its building blocks, essential amino acids, cannot be synthesized by […]
Kavli Affiliate: Adam Gazzaley | Authors: Christian Valtierra, Jeremy Hogeveen, Gabriella Mace, Samantha Moreno, Avery Ostrand, Sydney Griffith, Maria Jose Auil, Patrick McConnell, Joseph C.C. Chen, Jennifer Mitchell, Gary R. Turner, Nathan Spreng, Adam Gazzaley and Lorenzo Pasquini | Summary: Social isolation and loneliness are major determinants of well-being in older adults. Shrinking social networks […]