Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Kavli Affiliate: Michael Keiser | Authors: Sina Ghandian, Liane Albarghouthi, Kiana Nava, Shivam R. Rai Sharma, Lise Minaud, Laurel Beckett, Naomi Saito, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger and Michael J. Keiser | Summary: Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of […]


Continue.. Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

Kavli Affiliate: Jin Kang | Authors: Alexandra Nelson and Anatol Kreitzer | Summary: Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is likely altered in PD, but we understand little about […]


Continue.. Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

Kavli Affiliate: Joshua Berke | Authors: Mariana Duhne, Ali Mohebi, Kyoungjun Kim, Lilian Pelattini and Joshua D. Berke; | Summary: Movement, motivation and reward-related learning depend strongly on striatal dopamine and acetylcholine. These neuromodulators each regulate the other, and disturbances to their coordinated signals contribute to human disorders ranging from Parkinson’s Disease to depression and […]


Continue.. A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

Closed-loop modulation of remote hippocampal representations with neurofeedback

Kavli Affiliate: Loren Frank | Authors: Michael E. Coulter, Anna K. Gillespie, Joshua P Chu, Eric L. Denovellis, Trevor T.K. Nguyen, Daniel Liu, Katherine Wadhwani, Biabhav Sharma, Kevin Wang, Xinyi Deng, Uri Eden, Caleb Kemere and Loren M. Frank | Summary: Humans can remember specific events without acting on them and can influence which memories […]


Continue.. Closed-loop modulation of remote hippocampal representations with neurofeedback

RealtimeDecoder: A fast software module for online clusterless decoding

Kavli Affiliate: Loren Frank | Authors: Joshua P Chu, Michael E Coulter, Eric L. Denovellis, Trevor TK Nguyen, Daniel F Liu, Xinyi Deng, Uri T Eden, Caleb T Kemere and Loren M Frank | Summary: Decoding algorithms provide a powerful tool for understanding the firing patterns that underlie cognitive processes such as motor control, learning, […]


Continue.. RealtimeDecoder: A fast software module for online clusterless decoding

Data-driven fine-grained region discovery in the mouse brain with transformers

Kavli Affiliate: Reza Abbasi Asl | Authors: Alex Jihun Lee, Shenqin Yao, Nicholas Lusk, Hongkui Zeng, Bosiljka Tasic and Reza Abbasi-Asl | Summary: Technologies such as spatial transcriptomics offer unique opportunities to define the spatial organization of the mouse brain. We developed an unsupervised training scheme and novel transformer-based deep learning architecture to detect spatial […]


Continue.. Data-driven fine-grained region discovery in the mouse brain with transformers

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Kavli Affiliate: Kira Poskanzer | Authors: Xuelong Mi, Alex Bo-Yuan Chen, Daniela Duarte, Erin Carey, Charlotte R. Taylor, Philipp N. Braaker, Mark Bright, Rafael G. Almeida, Jing-Xuan Lim, Virginia M. Rutten, Wei Zheng, Mengfan Wang, Michael E. Reitman, Yizhi Wang, Kira E. Poskanzer, David A. Lyons, Axel Nimmerjahn, Misha B. Ahrens and Guoqiang Yu | […]


Continue.. Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

The breath shape controls intonation of mouse vocalizations

Kavli Affiliate: Kevin Yackle | Authors: Alastair MacDonald and Kevin Yacklei | Summary: Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct “words”, like the ten sounds in the murine lexicon. A […]


Continue.. The breath shape controls intonation of mouse vocalizations

Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans

Kavli Affiliate: Saul Kato | Authors: Daniel Yutaka Sprague, Kevin Rusch, Raymond L Dunn, Jackson Borchardt, Greg Bubnis, Grace Chiu, Chentao Wen, Ryoga Suzuki, Shivesh Chaudhary, Ben Dichter, Ryan Ly, Shuichi Onami, Hang Lu, Kotaro Kimura, Eviatar I Yemini and Saul Kato | Summary: We develop a data harmonization approach for C. elegans volumetric microscopy […]


Continue.. Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans

Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments

Kavli Affiliate: Robert Edwards | Authors: Linzi Hosohama, Delia F. Tifrea, Kevin Nee, Sung Yun Park, Jie Wu, Amber N. Habowski, Cassandra Van, Marcus M. Seldin, Robert A. Edwards and Marian L. Waterman | Summary: Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that tumor heterogeneity […]


Continue.. Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments