Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

Kavli Affiliate: Hana El-Samad | Authors: Achal Mahajan, Francesca Ratti, Ban Wang, Hana El-Samad, James H. Kaufman and Vishrawas Gopalakrishnan | Summary: Regulation of gene expression is fundamental for proper cellular function, and is constrained by the local chromatin environment of each gene, which varies spatially along the chromosome and is shaped by epigenetic modifications. […]


Continue.. Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Kavli Affiliate: Robert Edwards | Authors: Mera F. Liccione, Trevor Scobey, Heather M. Froggatt, Camryn Pajon, Boyd L. Yount, Qi Yin, Taylor N. Spence, Emmanuel B. Walter, Kevin O. Saunders, Robert J. Edwards, Ralph S. Baric, Barton F. Haynes, Derek W. Cain, Timothy P. Sheahan and Daniel Wrapp | Summary: HCoV-229E is an endemic Alphacoronavirus […]


Continue.. A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Alexis M Black, Natsumi Komatsu, Jiaxuan Zhao, Scarlet R Taskey, Nicole S Serrano, Ruchira Sharma, Devanand S. Manoli, Markita P Landry and Annaliese Beery | Summary: Friendships, or selective peer relationships, are a vital component of healthy social functioning in humans, while deficits in these relationships are associated with […]


Continue.. Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Kavli Affiliate: David Rowitch | Authors: Grant de Jong, Fani Memi, Tannia Gracia, Olga Lazareva, Oliver Gould, Alexander Aivazidis, Manas Dave, Qianqian Zhang, Melanie Jensen, Ahmet Sureyya Rifaioglu, Joao D. Barros-Silva, Sabine Eckert, Di Zhou, Yvette Wood, Elizabeth Tuck, Sezgin Er, Henry Marshall, Kenny Roberts, Andrew L. Trinh, Shreya Rai, Tyler Shaw, Agnes Oszlanczi, Hayden […]


Continue.. A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Kavli Affiliate: Philip Starr | Authors: Jin-Xiao Zhang, Clay Smyth, Md Fahim Anjum, Yue Leng, Andrew D. Krystal, Philip A. Starr and Simon Little | Summary: Sleep disturbance is involved in the progression of neurodegenerative diseases, but the neurophysiological mechanisms remain unclear in humans. We recorded sleep at home using portable polysomnography for multiple nights […]


Continue.. A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Working memory by distributed neural oscillators in a simple nervous system

Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: Working memory allows an animal to gather sensory evidence over time, integrate it with evolving internal needs, and make informed decisions about […]


Continue.. Working memory by distributed neural oscillators in a simple nervous system

Separable global and local beta burst dynamics in motor cortex of primates

Kavli Affiliate: Karunesh Ganguly | Authors: Preeya Khanna, behraz farrokhi, Hoseok Choi, Sandon Griffin, Ian Heimbuch, Lisa Novik, Katherina Thiesen, John H Morrison, Robert Morecraft and Karunesh Ganguly | Summary: Sensorimotor beta band oscillations are known to modulate during normal movement control and abnormal beta modulation is linked to pathological bradykinesia. However, the functional differences […]


Continue.. Separable global and local beta burst dynamics in motor cortex of primates

Synaptic vesicles that store monoamines and glutamate differ in protein composition.

Kavli Affiliate: Robert Edwards | Authors: Hrach Asmerian, Alexia J. Diaz, Hongfei Xu, Juan A Oses-Prieto, Jacob Alberts, Anna M. Sanetra, Barathan Gnanabharathi, Noah Carr, Alma L. Burlingame, Robert H. Edwards and Katlin Silm | Summary: Neuromodulators such as the monoamines are known to differ from classical neurotransmitters like glutamate in the time scale of […]


Continue.. Synaptic vesicles that store monoamines and glutamate differ in protein composition.

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Kavli Affiliate: Robert Edwards | Authors: Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frederic Bibollet-Ruche, Younghoon Park, Colby J. Agostino, Ajay Singh, Christian L. Martella, Emily Lewis, Jinery Lora, […]


Continue.. Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Dynamics of auditory word form encoding in human speech cortex

Kavli Affiliate: Edward Chang | Authors: Yizhen Zhang, Matthew K Leonard, Laura Gwilliams, Ilina Bhaya-Grossman and Edward F Chang | Summary: When we hear continuous speech, we perceive it as a series of discrete words, despite the lack of clear boundaries in the acoustic signal. The superior temporal gyrus (STG) encodes phonetic elements like consonants […]


Continue.. Dynamics of auditory word form encoding in human speech cortex