Dysregulation of the fluid homeostasis system by aging

Kavli Affiliate: Zachary Knight | Authors: Heeun Jang, Alexis Behne Sharma, Usan Dan, Jasmine H. Wong, Zachary A. Knight and Jennifer L. Garrison | Summary: Chronic dehydration is a leading cause of morbidity for the elderly, but how aging alters the fluid homeostasis system is not well understood. Here, we used a combination of physiologic, […]


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Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

Kavli Affiliate: Graeme Davis | Authors: Jacob Ellegood, Antoine Beauchamp, Yohan Yee, Gabe Devenyi, Justine Ziolkowski, Lily Qiu, Rand Askalan, Muhammad Ayub, Philipp Suetterlin, Alex Donovan, M. Albert Basson, Katherine M Quesnel, Nathalie G Berube, Taeseon Woo, David Beversdorf, Hans Bjornsson, Randy Blakely, Froylan Calderon de Anda, Jacqueline Crawley, Jennifer Crosbie, Brian O Orr, Graeme […]


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Central carbon metabolism switching in lytic versus temperate coral reef viral communities

Kavli Affiliate: Robert Edwards | Authors: Jacob Kelman, Meena Khan, Chibundu Umunna, Russell Brainard, Grace Donohue, Robert A Edwards, Natalie A Falta, Emma E. George, Eleanor Gorham, Juris Grasis, Kevin Green, Andreas F Haas, Kimberly Halsey, Eric Hester, Summer Jacob, Aydin Loid Karatas, Yan Wei Lim, Mark Little, Stuart Sandin, Jessie Segnitz, Maya Serota, Natalia […]


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Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

Kavli Affiliate: Yuh Nung Jan and Lily Jan | Authors: Adeline J.H. Yong, Yayu Wang, Juan A. Oses-Prieto, Tong Cheng, Chao Chen, Lane Domke, Mario V. Zubia, Angelina Koroknay, Jeffrey Simms, Alma L. Burlingame, Lily Y. Jan, Nicholas T. Ingolia, J. Wren Kim and Yuh Nung Jan | Summary: Activity-dependent remodeling of the synaptic proteome […]


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Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands

Kavli Affiliate: Joshua Berke and Loren Frank | Authors: Alison E. Comrie, Emily J. Monroe, Ari E. Kahn, Eric L. Denovellis, Abhilasha Joshi, Jennifer A. Guidera, Timothy A. Krausz, Joshua D. Berke, Nathaniel D. Daw and Loren M. Frank | Summary: The cognitive ability to go beyond the present to consider alternative possibilities, including potential […]


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Activity-induced weakening of hippocampal input to prefrontal VIP interneurons reshapes inhibitory microcircuit function: implications for spatial working memory task acquisition.

Kavli Affiliate: Vikaas Sohal | Authors: Shana E Silverstein, Thomas T Clarity, Meena S Deshpande, Erik Vaughan, Shoshana Novik, Hector E Yarur, Shiliang Zhang, Valerie S Tsai, Rong Ye, Rachel M Mikofsky, Madeline Hsiang, Avery Bauman, Gabriel Loewinger, Francisco Pereira, Marisela Morales, Vikaas S Sohal, Hugo Tejeda, Joshua A Gordon and David A Kupferschmidt | […]


Continue.. Activity-induced weakening of hippocampal input to prefrontal VIP interneurons reshapes inhibitory microcircuit function: implications for spatial working memory task acquisition.

ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Kavli Affiliate: Yifan Cheng | Authors: Hao Wu, Upneet Kaur, Chengmin Li, Elise N. Munoz, Geeta J. Narlikar and Yifan Cheng | Summary: ATP-dependent chromatin remodeling enzymes play central roles in genome regulation by mobilizing nucleosomes. All remodelers except for one, position their core ATPase at an internal nucleosome location, superhelical location (SHL) 2, and […]


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Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

Kavli Affiliate: Arturo Alvarez-Buylla and Arnold R. Kriegstein | Authors: Arantxa Cebrian-Silla, Fiona R Dale-Huang, Stephanie A Redmond, Carmen Elena Aragon Ortiz, Juan Morianos, Marcos Assis Nascimento, Zhenmeiyu Li, Cristina Guinto, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Cathryn R Cadwell, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Arnold Kriegstein, Eric Huang and Arturo Alvarez-Buylla | Summary: Ependymal (E1) cells, […]


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Coordination of turn-related activity in the superior colliculus with locomotor dynamics and hippocampal representations of possible futures

Kavli Affiliate: Massimo Scanziani and Loren Frank | Authors: Cameron Wilhite, Loren M. Frank and Massimo Scanziani | Summary: Turning left or right is a core element of animal navigation. Such turns occur in precise coordination with the ongoing stepping rhythm and require internal planning for the animal’s future path. The superior colliculus (SC) is […]


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Smells like γ-synchrony: Insula-prefrontal communication depends on γ-synchrony and supports modality-specific changes in behavioral strategies

Kavli Affiliate: Vikaas Sohal | Authors: Lara L. Hagopian, Aarron J. Phensy, Austin J. Gallagher and Vikaas S. Sohal | Summary: The prefrontal cortex is critical for many aspects of flexible behavior, but how it interacts with other brain regions to perform this function remains largely unknown. The insula is bidirectionally coupled with prefrontal cortex […]


Continue.. Smells like γ-synchrony: Insula-prefrontal communication depends on γ-synchrony and supports modality-specific changes in behavioral strategies