Multi-areal neural dynamics encode human decision making

Kavli Affiliate: Edward Chang | Authors: Jacqueline A Overton, Karen A Moxon, Matthew P Stickle, Logan M Peters, Jack J Lin, Edward F Chang, Robert T Knight, Ming Hsu and Ignacio Saez | Summary: Abstract Value-based decision-making involves multiple cortical and subcortical brain areas, but the exact nature of neural activity underlying choice behavior has […]


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Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

Kavli Affiliate: Hana El-Samad | Authors: Lindsey C Osimiri, Alain R Bonny, Seesha R Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann and Hana El-Samad | Summary: Abstract Many transcription factors (TFs) translocate to the nucleus with varied dynamic patterns in response to different inputs. A notable example of such behavior is RelA, a subunit of […]


Continue.. Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

Coordinated cadherin functions sculpt respiratory motor circuit connectivity

Kavli Affiliate: Xin Duan | Authors: Alicia N Vagnozzi, Matthew T Moore, Minshan Lin, Elyse M Brozost, Ritesh KC, Aambar Agarwal, Lindsay A Schwarz, Xin Duan, Niccolò Zampieri, Lynn T Landmesser and Polyxeni Philippidou | Summary: Abstract Breathing, and the motor circuits that control it, are essential for life. At the core of respiratory circuits […]


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Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex

Kavli Affiliate: Michael Stryker | Authors: Megumi Kaneko and Michael P Stryker | Summary: Abstract We have previously shown that recovery of visual responses to a deprived eye during the critical period in mouse primary visual cortex (V1) requires both export of mRNA encoding brain derived neurotrophic factor (BDNF) to the dendrites of cortical cells […]


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Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

Kavli Affiliate: Robert Edwards | Authors: Fei Li, Jacob Eriksen, Juan A Oses-Prieto, Yessica K Gomez, Hongfei Xu, Janet Finer-Moore, Phuong Nguyen, Alisa Bowen, Andrew Nelson, Alma Burlingame, Michael Grabe, Robert Stroud and Robert Edwards | Summary: Abstract Concentration of neurotransmitter inside synaptic vesicles (SVs) underlies the quantal nature of synaptic transmission. In contrast to […]


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Neuronal Activity Alters Neuron to OPC Synapses

Kavli Affiliate: Samuel Pleasure | Authors: Daniela S Moura, Alekhya Parvathaneni, Atehsa Sahagun, Hirofumi Noguchi, Iris Tilton, Emma Brennan, Robert M Brock, Lindsay R. Halladay, Samuel J Pleasure and Laura A. Cocas | Summary: Abstract The mechanisms that drive the timing and specificity of oligodendrocyte myelination during development, or remyelination after injury or immune attack […]


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Altered basal ganglia output during self-restraint

Kavli Affiliate: Joshua Berke | Authors: Bon-Mi Gu and Joshua D. Berke | Summary: Abstract Suppressing actions is essential for flexible behavior. Multiple neural circuits involved in behavioral inhibition converge upon a key basal ganglia output nucleus, the substantia nigra pars reticulata (SNr). To examine how changes in basal ganglia output contribute to self-restraint, we […]


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Cortical surface electrical potentials are composed of multiple bandlimited frequency components, including high-gamma

Kavli Affiliate: Kristofer Bouchard, Edward Chang | Authors: Jesse A Livezey, Ahyeon Hwang, Kseniya Usovich, Maximilian Dougherty, Edward F Chang and Kristofer E Bouchard | Summary: A common challenge in neuroscience is how to decompose noisy, multi-source signals measured in experiments into biophysically interpretable components. Analysis of cortical surface electrical potentials (CSEPs) measured using electrocorticography […]


Continue.. Cortical surface electrical potentials are composed of multiple bandlimited frequency components, including high-gamma

Oxytocin receptor is not required for social attachment in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Kristen M. Berendzen, Ruchira Sharma, Maricruz Alvarado, YiChao Wei, Forrest D. Rogers, Adele Seelke, Trenton C. Simmons, Jessica Bond, Rose D. Larios, Michael Sherman, Srinivas Parthasarathy, Isidero Espineda, Joseph R. Knoedler, Annaliese Beery, Karen L. Bales, Nirao M Shah and Devanand S. Manoli | Summary: Prairie voles are among […]


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Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors

Kavli Affiliate: Kira Poskanzer | Authors: Silvia Pittolo, Sae Yokoyama, Drew Willoughby, Charlotte Taylor, Michael Reitman, Vincent Tse, Zhaofa Wu, Roberto Etchenique, Yulong Li and Kira E Poskanzer | Summary: The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters and […]


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