dbos – Page 4 – Kavli Institute Pre-Print Publications

Novel visuomotor adaptation paradigm reveals a role of visual cortex in the plasticity of innate behaviors in mice

Posted by dbos May 10, 2026May 20, 2026UCSD / Salk

Kavli Affiliate: Massimo Scanziani | Authors: Ellery Jones and Massimo Scanziani | Summary: A long-standing hypothesis in sensory neuroscience suggests that the evolutionary expansion of cortex in mammals may contribute to sensory-dependent adaptation by acting on subcortical pathways that drive innate behavior. However, direct experimental evidence is lacking. Taking the visual system as a model, […]

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D3 dopamine receptors implicate a striatal neuronal subtype in the aversive effects of the antipsychotic drug quetiapine

Posted by dbos May 10, 2026May 20, 2026UCSF

Kavli Affiliate: Kevin Bender | Authors: Elinor Lewis, Jessie Muir, Ling C Li, Madeline King, Kaden Adams, Julianna Glienke, Sarah Warren Gooding, Kevin Bender, Christina Kim and Jennifer Whistler | Summary: Second generation antipsychotics (SGAs) are widely used clinical tools; yet, they often cause negative side effects and take weeks to become effective, leading to […]

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Hippocampal representations of partner and novel individuals in monogamous California mice during pair bond formation

Posted by dbos May 9, 2026May 20, 2026Columbia

Kavli Affiliate: Steven Siegelbaum | Authors: Kimberly Hernandez Palacios, Oshmita Golam, Steven A Siegelbaum and Andres Bendesky | Summary: The hippocampal CA2 region is critical for social novelty recognition memory—the discrimination of whether a conspecific is novel or familiar. However, its role in forming a memory of a pair-bonded mate is unknown. To examine how […]

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Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Posted by dbos May 8, 2026May 20, 2026Yale

Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: α-Synuclein aggregates characterize α-synucleinopathies, including Parkinson’s disease and Dementia with Lewy bodies. A majority of people […]

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Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart

Posted by dbos May 8, 2026May 20, 2026Hopkins

Kavli Affiliate: Jean Fan | Authors: Yuening Liu, Annabelle M. Coles, Jonah Castiglione, Vijay Venu Thiyagarajan, Kalen Clifton, Deevanshu Goyal, Jerry Wu, Arlo Sheridan, Ana Vujic, Kristen M. Harris, Uri Manor, Talmo D. Pereira, Jean Fan, Richard T. Lee and Pallav Kosuri | Summary: Resilience to cardiac stress is essential for health, yet the relationship […]

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Spatial navigation through evolution: a single-cell atlas of the mammalian entorhinal cortex

Posted by dbos May 7, 2026May 20, 2026NTNU

Kavli Affiliate: Menno Witter | Authors: Dorottya M Ralbovszki, Jesse J Westfall, Yuki Mori, Stamatios A Tahas, Mads F Bertelsen, Irina Korshunova, Josefine Skov, Jan Gorodkin, Martin Hemberg, Ernst Stefan Seemann, Vanessa Hall, Menno Witter and Konstantin Khodosevich | Summary: Spatial navigation is a fundamental mammalian ability, supported by the entorhinal cortex (EC), a structurally […]

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Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

Posted by dbos May 7, 2026May 20, 2026UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Zhaoqi Yan, Andrew S Mendiola, Kelli Lauderdale, Keun-Young Kim, Yu Yong, Kun Leng, Eric A Bushong, Renaud Schuck, Anke Meyer-Franke, Ayushi Agrawal, Michela Traglia, Natalie Gill, Reuben Thomas, Jonah N Keller, Nikolaos Karvelas, Miguel F Vasquez, Daniel C Ballard, Matthew Madany, Jeffrey Simms, Brandon Guo, Reshmi Tognatta, Maria del […]

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Long-term maintenance of H3K27me3 in postmitotic neurons is dispensable for gene expression regulation

Posted by dbos May 7, 2026May 20, 2026Rockefeller

Kavli Affiliate: C. David Allis and Mary E. Hatten | Authors: Irma Laas, Matthew R Paul, Natarajan Bhanu, Lijuan Feng, Eve-Ellen Govek, Benjamin A Garcia, Thomas S Carroll, C David Allis, Mary E. Hatten and Kärt Mätlik | Summary: Neuronal maturation is associated with extensive changes in gene expression and chromatin organization. However, the molecular […]

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Real-time AI integration for MR to detect artifacts and guide pulse sequence adaptations

Posted by dbos May 7, 2026May 20, 2026Hopkins

Kavli Affiliate: Jeremias Sulam/p> | Authors: Aaron T. Gudmundson, Zahra Shams, Abdelrahman Gad, Shuyuan Wang, Dunja Simicic, Saipavitra Murali-Manohar, Gizeaddis Lamesgin Simegn, Ipek Özdemir, Christopher W. Davies-Jenkins, Vivek Yedavalli, Georg Oeltzschner, Omer Burak Demirel, Jeremias Sulam, Michael schär, Sandeep Ganji and Richard A. E. Edden | Summary: Purpose To present a first-of-its-kind artificial intelligence (AI-)integrated […]

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The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex

Posted by dbos May 6, 2026May 20, 2026Columbia

Kavli Affiliate: René Hen | Authors: Eva M Geoghegan, Megan Hastings Hagenauer, Erin Hernandez, Sophia Espinoza, Elizabeth I Flandreau, Phi T. Nguyen, Adrienne N. Santiago, Mubashshir Ra’eed Bhuiyan, Sophie Mensch, Stanley J. Watson, Jr., Huda Akil and René Hen | Summary: Depression can be treated with traditional pharmaceuticals targeting monoaminergic function, non-traditional drug classes and […]

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