Activity-induced weakening of hippocampal input to prefrontal VIP interneurons reshapes inhibitory microcircuit function: implications for spatial working memory task acquisition.

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Shana E Silverstein, Thomas T Clarity, Meena S Deshpande, Erik Vaughan, Shoshana Novik, Hector E Yarur, Shiliang Zhang, Valerie S Tsai, Rong Ye, Rachel M Mikofsky, Madeline Hsiang, Avery Bauman, Gabriel Loewinger, Francisco Pereira, Marisela Morales, Vikaas S Sohal, Hugo Tejeda, Joshua A Gordon and David A Kupferschmidt | […]


Continue.. Activity-induced weakening of hippocampal input to prefrontal VIP interneurons reshapes inhibitory microcircuit function: implications for spatial working memory task acquisition.

Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact

Posted by dbos Rockefeller

Kavli Affiliate: Yifan Cheng | Authors: Maureen A McGargill, Beiyun C Liu, Michael S Kuhns, Daniel Mucida, Isabella Rauch, Lauren B Rodda, Meghan A Koch, Hugo Gonzalez Velozo, Ken Cadwell, Tanya S Freedman, Tiffany C Scharschmidt, Richard Sever, Jose Ordovas-Montanes, Sara Suliman, Andrew Oberst, Brooke Runnette and Matthew F Krummel | Summary: Peer review serves […]


Continue.. Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact

ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Hao Wu, Upneet Kaur, Chengmin Li, Elise N. Munoz, Geeta J. Narlikar and Yifan Cheng | Summary: ATP-dependent chromatin remodeling enzymes play central roles in genome regulation by mobilizing nucleosomes. All remodelers except for one, position their core ATPase at an internal nucleosome location, superhelical location (SHL) 2, and […]


Continue.. ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

Posted by dbos Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most fMRI studies in rodents use anesthesia to […]


Continue.. Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

Posted by dbos UCSF

Kavli Affiliate: Arturo Alvarez-Buylla and Arnold R. Kriegstein | Authors: Arantxa Cebrian-Silla, Fiona R Dale-Huang, Stephanie A Redmond, Carmen Elena Aragon Ortiz, Juan Morianos, Marcos Assis Nascimento, Zhenmeiyu Li, Cristina Guinto, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Cathryn R Cadwell, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Arnold Kriegstein, Eric Huang and Arturo Alvarez-Buylla | Summary: Ependymal (E1) cells, […]


Continue.. Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

ATG2A interacts with RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Devin M Fuller, Yumei Wu, Florian Schueder, Burha Rasool, Shanta Nag, Justin L. Korfhage, Rolando Garcia-Milian, Katerina D Melnyk, Joerg Bewersdorf, Pietro De Camilli and Thomas Melia | Summary: Autophagosomes form from seed membranes that expand through bulk-lipid transport via the bridge-like lipid transporter ATG2. The origins of […]


Continue.. ATG2A interacts with RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis

Large population sizes shape genome evolution in barnacles

Posted by dbos Columbia

Kavli Affiliate: Scott Small | Authors: Angel G Rivera-Colón, Scott T Small, Erin Jezuit, John P Wares and Andrew D Kern | Summary: Population size is a key factor underlying the mode and tempo of evolution, particularly as it relates to the strength of selection and drift. While the mechanisms underlying the interactions between population […]


Continue.. Large population sizes shape genome evolution in barnacles

A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Antonis Athanasiadis, Georgios Dangas, Ansgar F. Stenzel, Paul Park, Anthi Maslarinou, Evgenia Moschogianni, Allan Henrique Depieri Cataneo, Catherine A Freije, Yichen Zhou, Kenneth C Levenson, Corrine Quirk, Chenhui Zou, William Matthew Schneider, Adriano Aguzzi, Charles M Rice, Ype P De Jong and Eleftherios Michailidis | Summary: More than […]


Continue.. A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors

scFair: Geometry-Aware Gene Budgets and Same-Rank Extension for Highly Variable Gene Selection

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Background Highly variable gene (HVG) selection begins almost every single-cell RNA-seq analysis. While ranking formulas have been compared extensively, the integer gene budget at which any ranking must be truncated is typically left to the user and habitually fixed near 2,000. […]


Continue.. scFair: Geometry-Aware Gene Budgets and Same-Rank Extension for Highly Variable Gene Selection

Chromosome-level genome assembly of the European leaf-toed gecko, Euleptes europaea

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Josephine R Paris, Linelle Abueg, Sarah Pelan, Ying Sims, Tatiana Tilley, Jacquelyn Mountcastle, Jennifer Balacco, Brian O’Toole, Olivier Fedrigo, Giulio Formenti, Erich D Jarvis, Daniele Canestrelli and Daniele Salvi | Summary: The European leaf-toed gecko (Euleptes europaea) is a small, nocturnal gecko endemic to the western Mediterranean. As a […]


Continue.. Chromosome-level genome assembly of the European leaf-toed gecko, Euleptes europaea