Age-related reorganization of locus coeruleus–cortical functional connectivity gradients

Posted by dbos NTNU

Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Xiaqing Lan, Alireza Salami, Heidi Jacobs and Maryam Ziaei | Summary: The locus coeruleus (LC) regulates attention, arousal, and adaptive behavior via widespread noradrenergic projections to cortex, yet its large-scale cortical organization and age-related vulnerability remain poorly understood. Using 7T MRI during naturalistic movie-viewing with […]


Continue.. Age-related reorganization of locus coeruleus–cortical functional connectivity gradients

Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Martin Kampmann, Manoj T Duraisingh and Leslie B Vosshall | Summary: Amino acid composition within a proteome is conventionally viewed as a property of individual protein function. However, specific nutrient scarcity has been shown to reshape which amino acids are encoded in the genome of microbes. […]


Continue.. Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis and Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Philipp Brand, Irene Arnoldi, Alexandra E DeFoe, Jennifer R Balacco, Nadav Shai, Alex Makunin, Umberto Palatini, Takako Toma, Takao Okazawa, Christopher M Stone, Anita Schiller, Olivier Fedrigo, Erich D Jarvis, Mara KN Lawniczak, Ichiro Miyagi, Paolo Gabrieli and Leslie B Vosshall | Summary: […]


Continue.. Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes

Hunger reconfigures a reward learning circuit into a memory competent mode

Posted by dbos Columbia

Kavli Affiliate: Rui Costa | Authors: Annie Park, Bhagyashree Senapati, Nino Mancini, Youchong Zhang, Juliana Choi, Ian Cone, Christoph D Treiber, Rui Ponte Costa, Lisa M Fenk, Salil Sanjay Bidaye and Scott Waddell | Summary: Internal states such as hunger dynamically reshape activity across circuits to support resource seeking. Neuromodulation provides a means of controlling […]


Continue.. Hunger reconfigures a reward learning circuit into a memory competent mode

Protein hunger-driven nitrogen flow from phospholipids to amino acids in Drosophila

Posted by dbos UCSF

Kavli Affiliate: Qili Liu | Authors: Qili Liu, Tianji Ma, Guangyan Wu, Lauren Tham, Madison Palarca-Wong, Sharon Vaz, Nick Allen, Carrie Shao, Ashley Tsai, Richard W. Song and Pamela M. England | Summary: Protein is unique among macronutrients due to its nitrogen content and that its building blocks, essential amino acids, cannot be synthesized by […]


Continue.. Protein hunger-driven nitrogen flow from phospholipids to amino acids in Drosophila

Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning

Posted by dbos Hopkins

Kavli Affiliate: Vikram Chib | Authors: Naser Al-Fawakhiri, Vikram S. Chib and Samuel D. McDougle | Summary: Motor learning depends on the integration of several, often competing signals, including reward and punishment (which guide learning the value of actions via reinforcement learning) and sensorimotor errors (which refine the execution of actions via motor adaptation). If […]


Continue.. Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning

Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Emre Caglayan, Ishaan Lamba, Monica Devi Manam, Benjamin Finander, Lovelace J. Luquette, David Exposito-Alonso, Sijing Zhao, Bowen Jin, Michael B Miller, Peter J Park, Chet C. Sherwood and Christopher A Walsh | Summary: Human brain aging is frequently studied in model mammals that rarely show the natural age-related neurodegenerative […]


Continue.. Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging

An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Paolo Piovani, Carole Belliardo, Rahul Makam, Boglarka Zambo, Annabelle Mantilleri, Amandine Chassot, Gergo Gogl, Christian P. Schaaf, Seth Blackshaw, Patrick Yu-Wai-Man, Michele Bertacchi and Michele Studer | Summary: The molecular programs that establish specialized retinal regions during development are essential for high-acuity vision, yet how their disruption contributes to […]


Continue.. An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS

The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Leon L Seifert, Georgios Dangas, Hoyin Chu, Yingpu Yu, Kosuke Ogata, Xupeng Hong, Mengyin Zhang, Yichen Zhou, Chenhui Zou, Alireza Ramandi, Corrine Quirk, Evgenia Moschogianni, Catherine A Freije, Antonis Athanasiadis, Leonardo Gonzales, Luis Chiriboga, Clifton Fulmer, Hong Hur, Manoj Kandpal, Anna S Lok, Caleb Lareau, William M Schneider, […]


Continue.. The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Novelty-seeking and directed exploration scale with dissociable social network outcomes and brain systems in older adults

Posted by dbos UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Christian Valtierra, Jeremy Hogeveen, Gabriella Mace, Samantha Moreno, Avery Ostrand, Sydney Griffith, Maria Jose Auil, Patrick McConnell, Joseph C.C. Chen, Jennifer Mitchell, Gary R. Turner, Nathan Spreng, Adam Gazzaley and Lorenzo Pasquini | Summary: Social isolation and loneliness are major determinants of well-being in older adults. Shrinking social networks […]


Continue.. Novelty-seeking and directed exploration scale with dissociable social network outcomes and brain systems in older adults