Kavli Affiliate: Lily Jan | Authors: Kunal Shroff, Molly C O’Brien, Tyler J Smith, Jialing Fang, Kelly S Yu, Sonia I Lombroso, Shengjie Feng, Chao Chen, Gregory A Mohl, Indigo V L Rose, Nidhi R Lokesh, Mark E Pownall, Lily Y Jan and Martin Kampmann | Summary: Neuronal synapses are eliminated during brain development and […]
Kavli Affiliate: Erich Jarvis | Authors: Jonathan Fenn, Jessica C Edge, Vladimir Ovchinnikov, Olga Amelkina, Melea Sinclair, Tiago H C De Bem, Alessandra Bridi, Irene Malo-Estepa, Angela Gonella-Diaza, Felipe Perecin, Juliano C da Silveira, Guilherme Pugliesi, Flavio Vieira Meirelles, Zenab Butt, Haidee Tinning, Giulio Formenti, Erich Jarvis, Bastian Fromm, James O McInerney, Niamh Forde and […]
Kavli Affiliate: Bjoern Schwer | Authors: Joseph A Stewart, Jeanmarie Mishler, Samreen Ahmed, Bjoern Schwer, Thomas W. Glover and Thomas E Wilson | Summary: High-fidelity detection of rare structural variants (SVs) remains challenging because library preparation and sequencing techniques generate artifactual junctions that obscure true single-molecule events. Here, we present HiFiRe3, an error-minimized sequencing framework […]
Kavli Affiliate: Vikram Chib | Authors: Naser Al-Fawakhiri, Vikram S. Chib and Samuel D. McDougle | Summary: Multiple learning signals can shape motor output, including reward and punishment (via value-based reinforcement learning) and sensorimotor error (via motor adaptation). However, it is unclear if action values, learned via reinforcement learning, interact with error-based motor learning. Here, […]
Kavli Affiliate: Pietro De Camilli | Authors: Yumei Wu, Peng Xu, James Moran, C. Shan Xu, Kenneth J. Hayworth, Mian Cao, Lin Shao, D. James Surmeier, Harald F. Hess and Pietro De Camilli | Summary: Synaptojanin 1 is a brain enriched phosphoinositide phosphatase implicated in endocytosis at the synapse. A mutation (R258Q) that selectively impairs […]
Kavli Affiliate: Wei Min | Authors: Alexander-Hoi Nguyen, Vicky Li, Wei-Min Chen, Jacob Kimberg, Anthony J. Davis, David G. McFadden and Juan Manuel Povedano | Summary: DNA mismatch repair (MMR) deficiency has been widely utilized in forward genetic screens to identify drug resistance mutations and elucidate the mechanisms of action of cytotoxic small molecules. However, […]
Kavli Affiliate: Vincent Ferrera | Authors: Vincent P. Ferrera, Samuel Lippl, Kenneth Kay, Fabian Munoz, Yuhao Jin, Greg Jensen and Herbert S. Terrace | Summary: Transitive inference (TI) is the ability to reason about transitive relationships in an ordered set of items (e.g., if A>B and B>C, then A>C). TI is widely held to depend […]
Kavli Affiliate: Alexandra Nelson | Authors: Emily L Twedell, Chloe J Bair-Marshall, Allison E Girasole, Lara K Scaria, Sadhana Sridhar and Alexandra B Nelson | Summary: Striatal medium spiny neurons (MSNs) integrate convergent cortical, thalamic, and dopaminergic inputs to shape motor output. In addition, MSNs form local inhibitory synaptic connections with one another. The function […]
Kavli Affiliate: Mark Ellisman | Authors: Zhaoqi Yan, Andrew S Mendiola, Kelli Lauderdale, Keun-Young Kim, Yu Yong, Kun Leng, Eric A Bushong, Renaud Schuck, Anke Meyer-Franke, Ayushi Agrawal, Michela Traglia, Natalie Gill, Reuben Thomas, Jonah N Keller, Nikolaos Karvelas, Miguel F Vasquez, Daniel C Ballard, Matthew Madany, Jeffrey Simms, Brandon Guo, Reshmi Tognatta, Maria del […]
Kavli Affiliate: Gabriel Silva | Authors: Pedro Rocha Tenorio, Gabriel Smolak Sobieski e Silva, Isadora Chagas Vercellone, Débora Hipólito Quadreli, Juliany Carolina Duma de Castro, Glaura Scantamburlo Alves Fernandes and Fábio Goulart de Andrade | Summary: While obesity is widely recognized as a global epidemic, the specific roles of food processing and macronutrient composition in […]