Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Posted by dbos Columbia, UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Song-Yi Lee, Heegwang Roh, David Gonzalez-Perez, Mason R Mackey, Keun-Young Kim, Daniel Hoces, Colleen McLaughlin, Stephen R Adams, Khanh Nguyen, David J Luginbuhl, Liqun Luo, Namrata Udeshi, Steven A Carr, Rogelio A Hernandez-Lopez, Mark Ellisman, Miguel Alcalde and Alice Y Ting | Summary: Enzymes that oxidize aromatic substrates have […]


Continue.. Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Separating the control of moving and holding still in post-stroke arm paresis

Posted by klaurent Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]


Continue.. Separating the control of moving and holding still in post-stroke arm paresis

Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Matthew Davenport, Ha Na Choe, Hiroaki Matsunami and Erich D Jarvis | Summary: Zebra finches are sexually dimorphic vocal learners. Males learn to sing by imitating mature conspecifics, but females do not. Absence of song in females is associated with atrophy and apparent repression of several vocal learning brain […]


Continue.. Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

A circuit model for transsaccadic space updating and mislocalization

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Xiao Wang, Sophia Tsien, Michael E. Goldberg, Mingsha Zhang and Ning Qian | Summary: We perceive a stable, continuous world despite drastic changes of retinal images across saccades. However, while persistent objects in daily life appear stable across saccades, stimuli flashed around saccades can be grossly mislocalized. We address […]


Continue.. A circuit model for transsaccadic space updating and mislocalization

Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles and Loyal Goff | Authors: Dongeun Heo, Anya A. Kim, Björn Neumann, Valerie N. Doze, Yu Kang T Xu, Yevgeniya A. Mironova, Jared Slosberg, Loyal A. Goff, Robin J. M. Franklin and Dwight E Bergles | Summary: Oligodendrocyte progenitor cells (OPCs) are highly dynamic, widely distributed glial cells of the central […]


Continue.. Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan

Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Posted by dbos UCSF

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Matthew Kinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]


Continue.. Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Saeko Takada, Bonnie J. Bolkan, MaryJane O’Connor, Michael Goldberg and Michael B. O’Connor | Summary: Toys are us (Trus) is the Drosophila ortholog of mammalian Programmed Cell Death 2-Like (PDCD2L), a protein that has been implicated in ribosome biogenesis, cell cycle regulation, and oncogenesis. In this study, we examined […]


Continue.. Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Encoding manifolds constructed from grating responses organize responses to natural scenes in cortical visual areas

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: We have created “encoding manifolds” to reveal the overall responses of a brain area to a variety of stimuli. Encoding manifolds organize response properties globally: each point on an encoding manifold is a neuron, and […]


Continue.. Encoding manifolds constructed from grating responses organize responses to natural scenes in cortical visual areas

Closed-loop modulation of remote hippocampal representations with neurofeedback

Posted by dbos UCSF

Kavli Affiliate: Loren Frank | Authors: Michael E. Coulter, Anna K. Gillespie, Joshua P Chu, Eric L. Denovellis, Trevor T.K. Nguyen, Daniel Liu, Katherine Wadhwani, Biabhav Sharma, Kevin Wang, Xinyi Deng, Uri Eden, Caleb Kemere and Loren M. Frank | Summary: Humans can remember specific events without acting on them and can influence which memories […]


Continue.. Closed-loop modulation of remote hippocampal representations with neurofeedback

Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson′s disease and Dementia with Lewy bodies

Posted by dbos Yale

Kavli Affiliate: Sreeganga Chandra | Authors: D J Vidyadhara, David Backstrom, Risha Chakraborty, Jiapeng Ruan, Jae-Min Park, Pramod K. Mistry and Sreeganga S. Chandra | Summary: GBA mutations are major risk factors for Parkinson′s disease (PD) and Dementia with Lewy Bodies (DLB), two common α-synucleinopathies associated with cognitive impairment. Here, we investigated the role of […]


Continue.. Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson′s disease and Dementia with Lewy bodies