Kavli Affiliate: Seth Shipman | Authors: Kazuo Nakamura, Karen Zhang, Mario R Mestre, Matias Rojas-Montero and Seth Shipman | Summary: Retrons are bacterial immune systems that protect a bacterial population against phages by killing infected hosts. Retrons typically comprise a reverse transcriptase, a template noncoding RNA that is partially reverse transcribed into RT-DNA, and a […]
Kavli Affiliate: Seth Blackshaw | Authors: Krishna Singh, yang jin, Mingwen Hu, Isabella Pallazo, Marisol Cano,, Thanh Hoang, Imran Bhutto, Shusheng Wang, Debasish Sinha, Seth Blackshaw, Jiang Qian and James T. Handa | Summary: Environmental exposure such as cigarette smoke induces epigenetic changes that can induce degenerative heterogeneity and accelerate aging. In early age-related macular […]
Kavli Affiliate: Kathleen Cullen | Authors: Hannah R Martin, Brandie Morris Verdone, Omar Lopez-Ramirez, Merrill Green, Dana Silvian, Emily Scott, Kathleen E Cullen and Ruth Anne Eatock | Summary: Vestibular hair cells (HCs) faithfully and rapidly detect head motions and gravity, driving motor reflexes that stabilize balance and gaze during locomotion. With the transition from […]
Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]
Kavli Affiliate: David Kleinfeld | Authors: Heet Kaku, Liu D Liu, Runbo Gao, Steven West, Song-Mao Liao, Arseny Finkelstein, David Kleinfeld, Alyse Thomas, Sri Laasya Tipparaju, Karel Svoboda and Nuo Li | Summary: Rhythmic orofacial movements, such as eating, drinking, or vocalization, are controlled by distinct premotor oscillator networks in the brainstem. Orofacial movements must […]
Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Jina Lee, Kathryn Rozen-Gagnon, Wei Wang, Thomas S Carroll and Daniel J C Kronauer | Summary: Sex determination is a developmental switch that triggers sex-specific developmental programs. This switch is “flipped” by the expression of genes that promote male- or female-specific development. Many lineages have evolved […]
Kavli Affiliate: Kenneth Miller | Authors: Mauro M. Monsalve-Mercado and Kenneth D Miller | Summary: How do populations of neurons collectively encode and process information during cognitive tasks? We analyze high-yield population recordings from the macaque lateral intraparietal area (LIP) during a reaction-time random-dot-motion direction-discrimination task. We find that the trajectories of neural population activity […]
Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]
Kavli Affiliate: Stefano Fusi and Kenneth Miller | Authors: Mario Dipoppa, Ramon Nogueira, Stéphane Bugeon, Yoni Friedman, Charu B. Reddy, Kenneth D. Harris, Dario L. Ringach, Kenneth D. Miller, Matteo Carandini and Stefano Fusi | Summary: Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic Sensory adaptation dynamically changes neural responses as a […]
Kavli Affiliate: Li Zhao | Authors: Haven R Garber, Danwei Wang, Celine Kerros, Hannah C Beird, Xizeng Mao, Nina G Howard, Jianhua Zhang, Jason Roszik, John P Miller, Paul Leonard, Yu Cao, Li Zhao, Xingzhi Song, Sahil Seth, Pei Lin, Huandong Sun, Lisa S St John, Sijie Lu, William Wierda, Issa F Khouri, Karen Clise-Dwyer, […]