Mapping the projectional architecture of the mouse midbrain dopaminergic system using cell type-specific barcoding

Posted by dbos Hopkins

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Cheng Xu, Craig Washington, Maggie Lowmann and Justus M Kebschull | Summary: Brain-wide neural circuits are formed by the diverse axonal branching patterns of many individual neurons. Here we introduce POINTseq (projections of interest by sequencing), a high-throughput and user-friendly barcoded connectomics method that uses cell […]


Continue.. Mapping the projectional architecture of the mouse midbrain dopaminergic system using cell type-specific barcoding

Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

Posted by dbos UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Simone D’Ambrogio, Jan Grohn, Nima Khalighinejad, Marcelo Mattar, Laurence T Hunt and Matthew F Rushworth | Summary: It has been suggested that humans and other animals are driven by a fundamental desire to acquire information about opportunities available in their environments. Not only might such a desire explain pathological […]


Continue.. Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Posted by dbos Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology (ephys) experiments, rendering traditional manual spike sorting […]


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Immunoinformatics Approach to Engineer a Multi-Epitope Vaccine Against SdrG in Skin Commensal Staphylococcus epidermidis

Posted by dbos UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Shahina Akter, Gabriel Vinícius Rolim Silva, Jonas Ivan Nobre Oliveira, Umberto Laino Fulco, Xianyang Xu and Yu Vincent Fu | Summary: The human skin serves as a dynamic ecosystem for beneficial commensal bacteria such as Staphylococcus epidermidis, which play a crucial role in maintaining skin barrier integrity and modulating […]


Continue.. Immunoinformatics Approach to Engineer a Multi-Epitope Vaccine Against SdrG in Skin Commensal Staphylococcus epidermidis

MAPseq2: a sensitive and cost-effective barcoded connectomics method

Posted by dbos Hopkins

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Huihui Qi, Craig Washington, Xiaoping Liang and Justus M Kebschull | Summary: The barcoded connectomics tool MAPseq enables highly multiplexed projection mapping of individual neurons by translating neuroanatomy into a DNA sequencing problem. Here we present MAPseq2, a user-friendly protocol with 3-4 fold increased barcode detection […]


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Single Cell Proteomics in the Developing Human Brain

Posted by dbos UCSF

Kavli Affiliate: Arnold R. Kriegstein | Authors: Tianzhi Wu, lihua jiang, Tanzila Mukhtar, Li Wang, ruiqi jian, Cheng Wang, Tiffany Trinh, Arnold Kriegstein, Michael Snyder and Jingjing Li | Summary: Proteins are the functional effectors of virtually all biological processes, and accurately measuring their abundance and dynamics is essential for understanding development and disease. Although […]


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Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: The global rise in human allergic and autoimmune diseases is linked to altered environmental microbiome exposures from increasing […]


Continue.. Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Posted by dbos NTNU

Kavli Affiliate: Valentina Di Maria | Authors: Daniel P. Moore, Heather B. Steele-Stallard, Luca Pinton, Valentina Maria Lionello, Lucia Rossi, Artadokht Aghaeipour, Salma Jalal, Cherry Tsz Yan Wong, Angela Clara-Hwang, Gisèle Bonne, Peter S. Zammit and Francesco Saverio Tedesco | Summary: LMNA-related congenital muscular dystrophy (L-CMD) is amongst the most severe forms of laminopathies, which […]


Continue.. Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]


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Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Yuan-Fei Pan, Yong He, Yu-Qi Liu, Yong-Tao Shan, Shu-Ning Liu, Xue Liu, Xiaoyun Pan, Yinqi Bai, Zan Xu, Zheng Wang, Jieping Ye, Edward C. Holmes, Bo Li, Yao-Qing Chen, Zhao-Rong Li and Mang Shi | Summary: Predicting the evolution and function of viruses is a fundamental biological challenge, largely […]


Continue.. Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus