Kavli Affiliate: Scott Small | Authors: Graham Gower, Nathaniel S. Pope, Murillo F. Rodrigues, Silas Tittes, Linh N. Tran, Ornob Alam, Maria Izabel Alves Cavassim, Peter D. Fields, Benjamin C. Haller, Xin Huang, Ben Jeffrey, Kevin Korfmann, Christopher C. Kyriazis, Jiseon Min, Ines Rebollo, Clara T Rehmann, Scott T. Small, Christopher C. R. Smith, Georgia […]
Kavli Affiliate: Alex Pollen | Authors: Nathan K Schaefer, Bryan J Pavlovic and Alex Aaron Pollen | Summary: Pooled processing, in which cells from multiple sources are cultured or captured together, is an increasingly popular strategy for droplet-based single cell sequencing studies. This design allows efficient scaling of experiments, isolation of cell-intrinsic differences, and mitigation […]
Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Jina Lee, Kathryn Rozen-Gagnon, Wei Wang, Thomas S Carroll and Daniel J C Kronauer | Summary: Sex determination is a developmental switch that triggers sex-specific developmental programs. This switch is flipped by the expression of genes that promote male- or female-specific development. Many lineages have evolved […]
Kavli Affiliate: Robert Edwards | Authors: Laura K Inglis, Michael J Roach, Susanna R Grigson and Robert A. Edwards | Summary: Prophages—viruses that integrate into bacterial genomes—are ubiquitous in the microbial realm. Prophages contribute significantly to horizontal gene transfer, including the potential spread of antimicrobial resistance (AMR) genes, because they can collect host genes. Understanding […]
Kavli Affiliate: Kevin Bender | Authors: Mitchell J. Vaughn, Kevin J. Bender and Julie S. Haas | Summary: Electrical synapses are present widely across the mammalian brain and are crucial components of active neural circuitry and connectomes. Identification of electrically coupled networks in living tissue has been limited by technical demands of multiplexed recordings, and […]
Kavli Affiliate: Stefano Fusi and René Hen | Authors: Jack E Berry, Jessica C Jimenez, Wei-Li Chang, Kenechukwu Michael Ogbu, Nicholas Manfred, Karly Tegang, Stefano Fusi, René Hen and Clay Lacefield | Summary: In addition to its role in episodic memory and spatial navigation, the hippocampus has also been found to influence mood-related disorders such […]
Kavli Affiliate: Douglas Nitz | Authors: Hin Wai Lui, Elizabeth R. Chrastil, Douglas A. Nitz and Jeffrey L. Krichmar | Summary: Humans and many animals possess the remarkable ability to navigate environments by seamlessly switching between first-person perspectives (FPP) and global map perspectives (GMP). However, the neural mechanisms that underlie this transformation remain poorly understood. […]
Kavli Affiliate: Xingde Li | Authors: Cheng-Yu Lee and Xingde Li | Summary: We present an effective approach to compensate for multiple scattering effects in Quantitative Optical Coherence Tomography (qOCT) imaging, with the goal of accurately extracting tissue attenuation coefficients, which is crucial for precise clinical diagnosis. In clinical practice, especially for intra-operative imaging, an […]
Kavli Affiliate: Emre Yaksi | Authors: Aytac Kadir Mutlu, Bram Serneels, Christoph Wiest, Anh-Tuan Trinh, Ricarda Bardenhewer, Fabrizio Palumbo, Oda Bjornevik Frisvold, Inger Kristine Fjeldskaar Aukrus, Anna Maria Ostenrath and Emre Yaksi | Summary: The dorsal raphe nucleus (DRN) plays an important role in shaping a wide range of behaviors, including mood, motivation, appetite, sleep, […]
Kavli Affiliate: Michael Miller | Authors: Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Mingyun Bae, Diane D Shao, Bezawit Sahile, Michael B Miller, August Yue Huang, Peter J Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee and Christopher A Walsh | Summary: Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s […]