Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Jin Kang | Authors: Sang-Hun Lee, Young-Jin Kang and Bret N Smith | Summary: Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits. Most dentate PV+ interneurons survive status epilepticus, but surviving PV+ interneuron […]


Continue.. Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy

behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

Posted by dbos Columbia

Kavli Affiliate: Attila Losonczy | Authors: Kyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Bartholomew Starich, Jeremy Walston, Ashley L Kiemen, Sashank Reddy, Corrine Joshu, Joel Sunshine, Denis Wirtz and Pei-Hsun Wu | Summary: Investigators conducting behavioral experiments often need precise control over the timing of the delivery of stimuli […]


Continue.. behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Lucie Dequiedt, Andre Forjaz, Jamie O. Lo, Owen J McCarty, Pei-Hsun Wu, Avi Rosenberg, Denis Wirtz and Ashley L. Kiemen | Summary: Kidneys are among the most structurally complex organs in the body. Their architecture is critical to ensure proper function and is often impacted by diseases such as […]


Continue.. Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

Posted by dbos UCSF

Kavli Affiliate: Stanley Prusiner | Authors: Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth and Carlo Condello | Summary: Down Syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, […]


Continue.. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

Posted by dbos UCSF

Kavli Affiliate: Xin Duan | Authors: Dong Liu, Hannah C. Webber, Fuyun Bian, Yangfan Xu, Manjari Prakash, Xue Feng, Ming Yang, Hang Yang, In-Jee You, Liang Li, Liping Liu, Pingting Liu, Haoliang Huang, Chien-Yi Chang, Liang Liu, Sahil H. Shah, Anna La Torre, Derek S. Welsbie, Yang Sun, Xin Duan, Jeffrey L Goldberg, Marcus Braun, […]


Continue.. Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

Structure and function of an intermediate GPCR-G protein complex

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Maxine Bi, Xudong Wang, Jinan Wang, JUN xu, Wenkai Sun, Victtor Ayo Adediwrua, Yinglong Miao, Yifan Cheng and Libin Ye | Summary: Despite hundreds of GPCR-Gαβγ complex structures, these snapshots uniquely capture the fully activated complex. Consequently, a comprehensive understanding of the conformational transitions during GPCR activation and the […]


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Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Katy Boerner, Philip D Blood, Jonathan C Silverstein, Matthew Ruffalo, Sarah A Teichmann, Gloria Pryhuber, Ravi S Misra, Jeffrey M Purkerson, Jean Fan, John W Hickey, Gesmira Molla, Chuan Xu, Yun Zhang, Griffin M Weber, Yashvardhan Jain, Danial Qaurooni, Yongxin Kong, Andreas Bueckle and Bruce W Herr II | […]


Continue.. Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

A mathematical theory of relational generalization in transitive inference

Posted by klaurent Columbia

Kavli Affiliate: Vincent Ferrera | Authors: Samuel Lippl, Kenneth Kay, Greg Jensen, Vincent P. Ferrera and L.F. Abbott | Summary: Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items (“compositional generalization”). This allows them to respond appropriately to radically novel circumstances and is fundamental […]


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Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations

Posted by dbos Hopkins

Kavli Affiliate: Daeyeol Lee | Authors: James Webb, Paul Steffan, Benjamin Y Hayden, Daeyeol Lee, Caleb Kemere and Matthew McGinley | Summary: Foraging theory has been a remarkably successful approach to understanding the behavior of animals in many contexts. In patch-based foraging contexts, the marginal value theorem (MVT) shows that the optimal strategy is to […]


Continue.. Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations