Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: Cognitive impairment is a frequent non-motor symptom in Parkinson’s disease, and cortical Lewy pathology is strongly […]


Continue.. Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Bowen Jin, Katherine S.-M. Brown, Denis S. Smirnov, Samuel M. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey, Guanlan Dong, Shulin Mao, Samadhi P. Wijethunga, Theresa Connors Stewart, Dennis J. Selkoe, Matthew P. Frosh, Derek H. Oakley, Bradley T. Hyman, August Yue Huang and Michael Miller | Summary: Tau deposition […]


Continue.. Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frederic Bibollet-Ruche, Younghoon Park, Colby J. Agostino, Ajay Singh, Christian L. Martella, Emily Lewis, Jinery Lora, […]


Continue.. Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Development of a Charge-Resistant Embedding Media for High-Performance Serial Block Face Imaging of Cells and Tissues

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Thomas Deerinck, Steven Peltier and Mark Ellisman | Summary: Serial block-face scanning electron microscopy (SBEM) enables high-resolution 3D imaging of biological specimens but is often limited by specimen charging due to the use of non-conductive epoxy resins. While heavy metal staining and variable-pressure SEM can reduce charging, these methods […]


Continue.. Development of a Charge-Resistant Embedding Media for High-Performance Serial Block Face Imaging of Cells and Tissues

The shape of attention: How cognitive goals sculpt cortical representation of speech.

Posted by dbos Hopkins

Kavli Affiliate: Mounya Elhilali | Authors: Moïra-Phoebé Huet and Mounya Elhilali | Summary: Perception requires more than passive sensing—it involves prioritizing the features most relevant to ongoing cognitive goals, a process guided by selective attention. A central question is whether attention operates by enhancing all features of a selected target, or by optimizing neural encoding […]


Continue.. The shape of attention: How cognitive goals sculpt cortical representation of speech.

Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Jonathan Choy, Shadi Charara, Kalyani Cauwenberghs, Quintyn McKaughan, Keun-Young Kim, Mark Ellisman and Chih-Ying Su | Summary: Dendritic morphology is a defining characteristic of neuronal subtypes. In Drosophila, heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies, but whether such diversity exists among homotypic ORNs remains […]


Continue.. Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Srujan Singh, Shishir Kumar Patel, Ryo Matsuura, Dee Velazquez, Zhaoli Sun, Sanjeev Noel, Hamid Rabb and Jean Fan | Summary: Kidney transplantation is the gold standard treatment strategy for end-stage renal disease. Deceased donor kidneys usually undergo cold storage until kidney transplantation, leading to cold ischemia injury that may […]


Continue.. Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Optimized Theta Burst Stimulation with Extended Intervals Enhances Excitatory-Inhibitory Balance

Posted by dbos UCSD / Salk

Kavli Affiliate: Dhakshin Ramanathan and Jyoti Mishra | Authors: Morteza Salimi, Milad Nazari, Jonathan Mishler, Jennifer Rodger, Sahar Jomehpour, Jyoti Mishra and Dhakshin Ramanathan | Summary: Varying inter-train intervals (ITIs) during theta burst stimulation (TBS) differentially modulates neuronal activity in the medial prefrontal cortex. Short ITIs (e.g., ITI 4 s) induce strong glutamatergic excitation but […]


Continue.. Optimized Theta Burst Stimulation with Extended Intervals Enhances Excitatory-Inhibitory Balance

Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Posted by dbos Rockefeller

Kavli Affiliate: Priya Rajasethupathy | Authors: Andrea Terceros, Celine Chen, Yujin Harada, Tim Eilers, Millennium Gebremedhin, Richard P Koche, Pierre-Jacques Hamard, Roshan Sharma and Priya Rajasethupathy | Summary: The molecular mechanisms that enable memories to persist over long time-scales from days to weeks and months are still poorly understood. To develop insights we created a […]


Continue.. Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Neuroticism Heterogeneity Through Item-Level Associations in Resting-State Functional Connectivity

Posted by dbos UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Masaya Misaki, Chun Chieh Fan, Wesley K Thompson, Heekyeong Park, Bohan Xu and Martin M Paulus | Summary: Neuroticism is characterized by emotional instability and increased susceptibility to stress-related disorders. While traditionally treated as a unitary construct, growing evidence suggests that neuroticism is heterogeneous in both its genetic basis […]


Continue.. Neuroticism Heterogeneity Through Item-Level Associations in Resting-State Functional Connectivity