Early development of direction selectivity in higher visual cortex

Kavli Affiliate: Kristina Nielsen | Authors: Dallas C Khamiss, Augusto A Lempel, Brandon R Nanfito and Kristina Juliane Nielsen | Summary: A fundamental aspect of visual motion processing is the computation of motion direction. In ferrets, as in primates, selectivity for motion direction is found both in early cortical stages like the primary visual cortex […]


Continue.. Early development of direction selectivity in higher visual cortex

A ventral tegmental area GABAergic projection to the ventral pallidum regulates value-based decision making in mice

Kavli Affiliate: Marina Picciotto | Authors: WenLiang Zhou, Hanna Yousuf, Yann S Mineur and Marina Picciotto | Summary: Activity of the mesolimbic system is essential for adaptive performance of reward-related behaviors. Within this system, dopaminergic (DAergic) neurons play a critical role in driving motivation to obtain rewards and encoding predictions and error signals during reinforcement […]


Continue.. A ventral tegmental area GABAergic projection to the ventral pallidum regulates value-based decision making in mice

Impact of Data Quality on Deep Learning Prediction of Spatial Transcriptomics from Histology Images

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Calixto-Hope G Lucas, Jr. and Jean Fan | Summary: Abstract Spatial transcriptomics technologies enable high-throughput quantification of gene expression at specific locations across tissue sections, facilitating insights into the spatial organization of biological processes. However, high costs associated with these technologies have motivated the development of deep […]


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Estradiol modulates neuronal network hyperexcitability in select NDD risk genes

Kavli Affiliate: Ellen J. Hoffman | Authors: April Pruitt, Liang Yang, Seoyeon Lee, Novin Balafkan, Carina Seah, Yi Dai, Elizabeth Davidson, Suha Khan, Annabel Sen, Jenny Liu, Isabel Wood, Gang Xu, Xiayuan Huang, Marina Carlson, Dejian Zhao, Priyanka Jamadagni, Grace Dossou, Kayla Retallick-Townsley, Xinyun Liu, P.J. Michael Deans, Meilin Fernandez Garcia, Huanyao Gao, Zuoheng Wang […]


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3D, multi-omic imaging reveals molecular biomarkers of the pre-metastatic niche in lung cancer

Kavli Affiliate: Denis Wirtz | Authors: John Michel, Andre Forjaz, Vasco Queiroga, Kelly Casella, Kaitlin Stivers, Helen Nguyen, Maria Browne, Feiyu Chen, Ada Tam, Omkar Dhaygude, Hongni Fan, Hitoaki Maehira, Cheng Ting Lin, Elise Gray-Gaillard, Talia Benducci, Suguru Yamauchi, Ife Shoyombo, Ziying Xu, Eugene Shenderov, Peng Huang, Denis Wirtz, Jennifer Elisseeff, Yun Chen, Malcolm V […]


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Active pursuit gates egocentric coding in Retrosplenial Cortex

Kavli Affiliate: Jonathan Whitlock | Authors: Pearl Saldanha, Martin Bjerke, Benjamin Adric Dunn and Jonathan Robert Whitlock | Summary: Spatial navigation is commonly studied in static environments, but adaptive behavior frequently hinges on tracking moving goals in real time. Active pursuit exemplifies this challenge, since it is an inherently egocentric spatial behavior requiring continual localization […]


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Age-related reconfiguration of locus coeruleus-cortical functional organization

Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Xiaqing Lan, Alireza Salami, Heidi Jacobs and Maryam Ziaei | Summary: The locus coeruleus (LC) regulates attention, arousal and adaptive behavior via widespread noradrenergic projections to cortex, yet its large-scale cortical organization and vulnerability to aging remain poorly understood. Using ultra-high-field 7T–MRI during naturalistic viewing […]


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Functional connectivity profile of the amygdala subfields associates with emotional well-being in aging

Kavli Affiliate: Maryam Ziaei and Menno Witter | Authors: Shuer Ye, Arjun Dave, Xiaqing Lan, Menno P. Witter, Alireza Salami and Maryam Ziaei | Summary: Amygdala-related functional connectivity plays a crucial role in human emotion, cognition, and mental well-being. The amygdala is a highly heterogeneous structure, with subregions that have both distinct and overlapping functions. […]


Continue.. Functional connectivity profile of the amygdala subfields associates with emotional well-being in aging

A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease

Kavli Affiliate: Rui Costa | Authors: Akira Fushiki, David Ng, Zachary R. Lewis, Archana Yadav, Tatiana Saraiva, Luke A. Hammand, Christoph Wirblich, Bosiljka Tasic, Vilas Menon, Joaquim Alves da Silva and Rui M. Costa | Summary: In Parkinson′s disease (PD), dopaminergic neurons (DANs) in the midbrain gradually degenerate, with ventral substantia nigra pars compacta (SNc) […]


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Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Boyi Guo, Cindy Fang, Madhavi Tippani, Svitlana V Bach, Ryan A Miller, Sarah E Maguire, Artemis Iatrou, Geo Pertea, Nicholas J Eagles, Madeline R Valentine, Seyun Oh, Aarti Jajoo, Vijetha Balakundi, Yufeng Du, Annie B Nguyen, Ruth Zhang, Uma M Kaipa, Heena R Divecha, Jashandeep S. […]


Continue.. Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex