Cellular-resolution Three-photon Ultra-Deep Imaging (TrUDI) of neuronal population activity at 2 mm depth in the mammalian brain

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Alipasha Vaziri | Authors: Kalyan Santra, Francesca Logiacco, Agustina Frechou, Kevin Barber, Arash Bellafard, Jyun-you Liou and Alipasha Vaziri | Summary: Extending the depth reach of multi-photon microscopy for imaging neuronal population activity in the scattering mammalian brain is an exponentially hard problem. Three-photon (3p) microscopy has enabled imaging of neuroactivity at depths […]


Continue.. Cellular-resolution Three-photon Ultra-Deep Imaging (TrUDI) of neuronal population activity at 2 mm depth in the mammalian brain

The chemosensory system of the clonal raider ant larva

Posted by dbos Rockefeller

Kavli Affiliate: Daniel Kronauer | Authors: Daniel H. Pastor, Leonora Olivos-Cisneros, Alejandra Hurtado-Giraldo, Anurag Sharma, Patrick K. Piekarski, Giacomo L. Glotzer and Daniel Kronauer | Summary: Ant larvae are blind and immobile, depending heavily on the adults for care in the form of feeding, grooming, and transport. However, they are not inactive colony members but […]


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Genetic accessibility, not superior fitness, determines which anti-HBs antibody escape variants are selected in patients

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Yingpu Yu, Eleftherios Michailidis, Leon Louis Seifert, Mengyin Zhang, Chenhui Zou, Catherine Freije, Georgios Dangas, Antonis Athanasiadis, Andreas Puschnik, Audrey Hanson, Evelyn Rocha, Yi-Pei Chen, Xupeng Hong, Corrine Quirk, Yichen Zhou, Michael A Schmid, Florian A Lempp, Charles M Rice, William Schneider and Ype P De Jong | […]


Continue.. Genetic accessibility, not superior fitness, determines which anti-HBs antibody escape variants are selected in patients

AmbiDose: per-cell removal budgets for ambient RNA contamination

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Ambient RNA contamination confounds expression analysis in droplet-based single-cell and single-nucleus RNA sequencing. Here we present AmbiDose, which combines an ambient profile estimated from empty droplets with cell-specific nominal removal budgets and expression-based protection of lineage-enriched genes. Its ambient dose […]


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Chemical proteomics reveals post-translational remodeling of endosomal pathways during macrophage activation.

Posted by dbos Rockefeller

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Tiffany L. Zhang, Henry Sanford, Railia R. Gabbasova, Anne E. van Vlimmeren, Yannis Kalaidzidis, Hiroyuki Kojima, Charlotte R Wayne, Jeetayu Biswas, Priyam Banerjee, Beatrice Zhang, Omar Abdel-Wahab, Marino Zerial and Ekaterina V Vinogradova | Summary: Macrophages are central regulators of innate immunity, yet the post-translational mechanisms that enable […]


Continue.. Chemical proteomics reveals post-translational remodeling of endosomal pathways during macrophage activation.

Hypoxia Disrupts Multiple Processes Supporting Spatial Navigation

Posted by dbos Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Daniel J McKeown, Heiki M Bahnson-Wright, Trinity Caldwell, Madeliene Marks, Georgia R Marshall, Holly Newton, Dylan Stenholm, Michael Young, Douglas J Angus and Victor R Schinazi | Summary: Hypoxia impairs cognitive function, yet its effects on navigation and intrinsic brain activity remain poorly understood. This study investigated whether […]


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Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Martin Kampmann, Manoj T Duraisingh and Leslie B Vosshall | Summary: Amino acid composition within a proteome is conventionally viewed as a property of individual protein function. However, specific nutrient scarcity has been shown to reshape which amino acids are encoded in the genome of microbes. […]


Continue.. Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis and Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Philipp Brand, Irene Arnoldi, Alexandra E DeFoe, Jennifer R Balacco, Nadav Shai, Alex Makunin, Umberto Palatini, Takako Toma, Takao Okazawa, Christopher M Stone, Anita Schiller, Olivier Fedrigo, Erich D Jarvis, Mara KN Lawniczak, Ichiro Miyagi, Paolo Gabrieli and Leslie B Vosshall | Summary: […]


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The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Leon L Seifert, Georgios Dangas, Hoyin Chu, Yingpu Yu, Kosuke Ogata, Xupeng Hong, Mengyin Zhang, Yichen Zhou, Chenhui Zou, Alireza Ramandi, Corrine Quirk, Evgenia Moschogianni, Catherine A Freije, Antonis Athanasiadis, Leonardo Gonzales, Luis Chiriboga, Clifton Fulmer, Hong Hur, Manoj Kandpal, Anna S Lok, Caleb Lareau, William M Schneider, […]


Continue.. The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Rocking Without a Tune: Ex vivo and in vivo Responses to Sound in the Basilar Papilla of the Tokay Gecko

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Brian L. Frost, Yuriria Vázquez, Kazuhiro Horii, Brian A. Fabella and A. J. Hudspeth | Summary: Like mammals, some reptiles possess sensitive and frequency-selective hearing at mid- to high-kilohertz frequencies. Both groups employ a place-frequency map within the inner ear to encode sound stimuli, but the mechanisms by […]


Continue.. Rocking Without a Tune: Ex vivo and in vivo Responses to Sound in the Basilar Papilla of the Tokay Gecko