Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons

Kavli Affiliate: Timothy A. Ryan; | Authors: Kirsten Bredvik, Charmaine Liu and Timothy A. Ryan | Summary: The ketogenic diet is an effective treatment for drug-resistant epilepsy, but the therapeutic mechanisms are poorly understood. Although ketones are able to fuel the brain, it is not known whether ketones are directly metabolized by neurons on a […]


Continue.. Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

Kavli Affiliate: Li Zhao; | Authors: Mingxin Xu, Neelima Thottappillil, Masnsen Cherief, Zhao Li, Manyu Zhu, Xin Xing, Mario Gomez-Salazar, Juliet Mukiri Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Chi Zhang, Xue-Wei Wang, Mary Archer, Yun Guan, Robert J. Tower, Patrick Cahan, Theodore J. Price, Thomas L. Clemens and Aaron W. James | Summary: The profound pain […]


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Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers

Kavli Affiliate: Franck Polleux; | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]


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Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli; | Authors: Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, Pietro De Camilli, Timothy A. Ryan and […]


Continue.. Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Differential Control of Inhibitory and Excitatory Nerve Terminal Function by Mitochondria

Kavli Affiliate: Timothy A. Ryan | Authors: Kirsten Bredvik and Timothy A Ryan | Summary: Inhibitory neurons shape the brain’s computational landscape and rely on different cellular architectures and intrinsic properties than excitatory neurons. Maintenance of the overall balance of excitatory (E) versus inhibitory (I) drive is essential, as disruptions can lead to neuropathological conditions, […]


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Structure of the Flotillin Complex in a Native Membrane Environment

Kavli Affiliate: Roderick MacKinnon | Authors: Ziao Fu and Roderick MacKinnon; | Summary: In this study we used cryo-electron microscopy to determine the structures of the Flotillin protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily, from cell-derived vesicles without detergents. It forms a right-handed helical barrel consisting of 22 pairs of […]


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Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

Kavli Affiliate: Jeffrey M. Friedman | Authors: Santiago R Unda, Roberta Marongiu, Lisa E Pomeranz, Jonathan P Dyke, Edward K Fung, Logan Grosenick, Rick Zirkel, Aldana M Antoniazzi, Sofya Norman, Conor M Liston, Chris B Schaffer, Nozomi Nishimura, Sarah A Stanley, Jeffrey M Friedman and Michael G Kaplitt | Summary: Regulating the activity of discrete […]


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Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Cong Li, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single-cell RNA-sequencing (scRNA-Seq) studies. […]


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Sampling Techniques and Genomic Analysis of Biological Material from Artworks

Kavli Affiliate: Thomas P. Sakmar | Authors: Rhonda K Roby, Rosana A Wiscovitch-Russo, Rebecca Hart, Amanda E Appel, Manija A Kazmi, Thomas Huber, Karina C Åberg, Thomas P Sakmar, José A Lorente and Norberto Gonzalez-Juarbe | Summary: The genomic analysis of biological material obtained from artwork or cultural heritage artifacts can be used to guide […]


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Magnetogenetic cell activation using endogenous ferritin

Kavli Affiliate: Jeffrey M. Friedman | Authors: Lisa E Pomeranz, Rosemary Li, Xiaofei A Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, Daniel Gross, Matthew I Brier, George Vaisey, Putianqi Wang, Maria Jimenez-Gonzalez, Adolfo Garcia-Ocana, Jonathan Dordick, Jeffrey M. Friedman and Sarah A Stanley | Summary: The ability to precisely control the activity of defined cell […]


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