Large-scale simulations reveal evolutionary constraints on intrinsically disordered regions imposed by full-length protein architecture

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Li Zhao | Authors: Yang Jiang, Xiaoyang Liu, Li Zhao and Zhong-Yuan Lu | Summary: Intrinsically disordered regions (IDRs) are pervasive in eukaryotic proteomes and play central roles in regulatory complexity and evolutionary innovation. While their conformational ensembles have been extensively characterized in isolation, most long IDRs function within multidomain proteins, where domain […]


Continue.. Large-scale simulations reveal evolutionary constraints on intrinsically disordered regions imposed by full-length protein architecture

Notch-driven fate asymmetry dictates hair cell behavior via a fate-specific kinase

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: A. James Hudspeth | Authors: Emily Atlas, Caleb C. Reagor, Brian Frost, Sapna Krishnakumar, A. J. Hudspeth and Adrian Jacobo | Summary: Cell-cell signaling and cell-fate decisions are essential for organ assembly, but how these molecular events translate into the physical properties and cell behaviors that drive development remains poorly understood. In the […]


Continue.. Notch-driven fate asymmetry dictates hair cell behavior via a fate-specific kinase

Assessing climate adaptation among Canada lynx (Lynx canadensis) populations at the trailing edge

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Tanya M Lama, Blair P Bentley, Warren E Johnson, Lisa M Komoroske, Stephen DeStefano, Jennifer Vashon, Kaela Beauclerc, Jason M Kamilar, Giulio Formenti, Andrea Batista, Andrew G Spencer, Olivier Federigo, Erich D Jarvis, Jeff S Bowman, Paul Wilson and John F Organ | Summary: Species must acclimate, shift their […]


Continue.. Assessing climate adaptation among Canada lynx (Lynx canadensis) populations at the trailing edge

Global Trends and Hotspots in Grassland Root Functional Traits Research (2000–2025)

Posted by dbos Rockefeller

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kivanc Birsoy, Shanshan Liu, Mark Gad, Caifan Li, Kevin Cho, Yuyang Liu, khando Wangdu, Victor Belay, Alon Millet, Hiroyuki Kojima, Henry Sanford, Michele Wolk, Linas Urnavicius, Maria Fedorova, Gary J. J. Patti, Ekaterina V Vinogradova and Richard K Hite | Summary: Grasslands, as one of the most important […]


Continue.. Global Trends and Hotspots in Grassland Root Functional Traits Research (2000–2025)

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Posted by dbos Rockefeller

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kivanc Birsoy, Shanshan Liu, Mark Gad, Caifan Li, Kevin Cho, Yuyang Liu, khando Wangdu, Victor Belay, Alon Millet, Hiroyuki Kojima, Henry Sanford, Michele Wolk, Linas Urnavicius, Maria Fedorova, Gary J. J. Patti, Ekaterina V Vinogradova and Richard K Hite | Summary: The endoplasmic reticulum (ER) requires an oxidative […]


Continue.. SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Divergent mitochondrial and metabolic adaptations shape selective vulnerability in ALS

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Bianca A Cotto, Lizi Zhang, Benjamin W Fait, Christopher Peralta, Ece Kilic, Henrik Molina, Nathaniel Heintz and Eric F Schmidt | Summary: Neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) exhibit striking cell-type selectivity, yet the basis for this vulnerability remains elusive. Here, we uncover that even closely related neurons […]


Continue.. Divergent mitochondrial and metabolic adaptations shape selective vulnerability in ALS

PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gαq

Posted by dbos Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Maria Falzone, Priyam Banerjee and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 from the plasma membrane, producing IP3 and DAG, which regulate intracellular Ca2+ levels and protein kinase C activity, respectively. They are regulated by GPCR signaling through the G proteins Gβγ and Gαq and have been shown […]


Continue.. PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gαq

Immune cells adapt to distinct stem cell niches to govern tissue homeostasis

Posted by dbos Rockefeller

Kavli Affiliate: Daniel Mucida and Elaine Fuchs | Authors: Sara Martina Parigi, Sairaj Munavar Sajjath, Charlotte Jeanne Bell, Shaopeng Yuan, Vitoria Murakami Olyntho, Alain Robert Bonny, Sandra Nakandakari-Higa, Sergio Lira, Daniel Mucida, Gabriel D Victora and Elaine Fuchs | Summary: In adult tissues, epithelial stem cells exist within distinct residences, each endowing them with exclusive […]


Continue.. Immune cells adapt to distinct stem cell niches to govern tissue homeostasis

C. elegans CED-3 caspase promotes non-apoptotic linker cell dismantling but not death onset

Posted by dbos Rockefeller

Kavli Affiliate: Shai Shaham | Authors: Olya Yarychkivska, Lena M Kutscher, Betty Ortiz Bido, Juliana Kagan, Yoon A Kim, Dana Mamriev, Yun Lu, Elli Puscher, Wolfgang Keil, Sarit Larisch and Shai Shaham | Summary: dismantling of the C. elegans linker cell, which undergoes non-apoptotic morphologically-conserved cell death characterized by nuclear envelope crenellations and cell splitting. […]


Continue.. C. elegans CED-3 caspase promotes non-apoptotic linker cell dismantling but not death onset

Neural representation of action grammar structure in primate frontal cortex

Posted by dbos Rockefeller

Kavli Affiliate: Stefano Fusi | Authors: Ramon Nogueira, Saleh Esteki, Stefano Fusi and Roozbeh Kiani | Summary: Humans and other animals can solve new problems, even on the first attempt. This capacity to generate novel problem-solving behavior has been hypothesized to depend on brain mechanisms for recombining units of knowledge using systems of procedural rules, […]


Continue.. Neural representation of action grammar structure in primate frontal cortex