Distinct patterns of genetic variation at low-recombining genomic regions represent haplotype structure

Posted by klaurent Rockefeller, This Week: Neuroscience

Kavli Affiliate: Erich Jarvis | Authors: Jun Ishigohoka, Karen Bascón-Cardozo, Andrea Bours, Janina Fuß, Arang Rhie, Jacquelyn Mountcastle, Bettina Haase, William Chow, Joanna Collins, Kerstin Howe, Marcela Uliano-Silva, Olivier Fedrigo, Erich D. Jarvis, Javier Pérez-Tris, Juan Carlos Illera and Miriam Liedvogel | Summary: Genetic variation of the entire genome represents population structure, yet individual loci […]


Continue.. Distinct patterns of genetic variation at low-recombining genomic regions represent haplotype structure

Magnetogenetic cell activation using endogenous ferritin

Posted by klaurent Rockefeller, This Week: Neuroscience

Kavli Affiliate: Jeffrey M. Friedman | Authors: Lisa E Pomeranz, Rosemary Li, Xiaofei A Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, Daniel Gross, Matthew I Brier, George Vaisey, Putianqi Wang, Maria Jimenez-Gonzalez, Adolfo Garcia-Ocana, Jonathan Dordick, Jeffrey M. Friedman and Sarah A Stanley | Summary: The ability to precisely control the activity of defined cell […]


Continue.. Magnetogenetic cell activation using endogenous ferritin

A modular circuit architecture coordinates the diversification of courtship strategies in Drosophila

Posted by klaurent Rockefeller

Kavli Affiliate: Vanessa Ruta | Authors: Rory T Coleman, Ianessa Morantte, Gabriel T Koreman, Megan L Cheng, Yun Ding and Vanessa Ruta | Summary: Identifying a mate is a central imperative for males of most species but poses the challenge of distinguishing a suitable partner from an array of potential male competitors or females of […]


Continue.. A modular circuit architecture coordinates the diversification of courtship strategies in Drosophila

Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Posted by klaurent Rockefeller

Kavli Affiliate: Alipasha Vaziri, Jeffrey M. Friedman | Authors: Bowen Tan, Caleb J Browne, Tobias Nobauer, Alipasha Vaziri, Jeffrey M. Friedman and Eric J. Nestler | Summary: Addiction prioritizes drug use over innate needs by hijacking brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron […]


Continue.. Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Sensory neurons couple arousal and foraging decisions in C. elegans

Posted by klaurent Rockefeller

Kavli Affiliate: Cori Bargmann | Authors: Elias Scheer and Cori Bargmann | Summary: Foraging animals optimize feeding decisions by adjusting both common and rare behavioral patterns. Here, we characterize the relationship between an animal’s arousal state and a rare decision to leave a patch of bacterial food. Using long-term tracking and behavioral state classification, we […]


Continue.. Sensory neurons couple arousal and foraging decisions in C. elegans

The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis.

Posted by klaurent Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Maria Elizabeth Falzone and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 producing IP3 and DAG. PIP2 modulates the function of many ion channels, while IP3 and DAG regulate intracellular Ca2+ levels and protein phosphorylation by protein kinase C, respectively. PLCb enzymes are under the control of GPCR signaling […]


Continue.. The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis.

Cellular and Molecular Basis of Leptin Resistance

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Ji-Dung Luo, Joshua D. Rabinowitz and Jeffrey M. Friedman | Summary: Diet-induced obese (DIO) mice and obese humans have high circulating levels of leptin and do not respond to the exogenous hormone suggesting that they develop leptin resistance. However, the […]


Continue.. Cellular and Molecular Basis of Leptin Resistance

iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

Posted by klaurent Rockefeller

Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown and Timothy A Ryan | Summary: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular […]


Continue.. iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

Multiple objects evoke fluctuating responses in several regions of the visual pathway

Posted by klaurent Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Meredith N Schmehl, Valeria C Caruso, Yunran Chen, Na Young Jun, Shawn M Willett, Jeff T Mohl, Douglas A Ruff, Marlene R Cohen, Akinori Ebihara, Winrich Freiwald, Surya T Tokdar and Jennifer M Groh | Summary: How neural representations preserve information about multiple stimuli is mysterious. Because tuning of […]


Continue.. Multiple objects evoke fluctuating responses in several regions of the visual pathway

The Cousa objective: a long working distance air objective for multiphoton imaging in vivo

Posted by klaurent Hopkins, Rockefeller, Yale

Kavli Affiliate: Michael Higley, Alipasha Vaziri, Kristina Nielsen | Authors: Che-Hang Yu, Yiyi Yu, Liam M. Adsit, Jeremy T. Chang, Jad Barchini, Andrew H. Moberly, Hadas Benisty, Jinkyung Kim, Brent K Young, Kathleen Heng, Deano M. Farinella, Austin Leikvoll, Rishaab Pavan, Rachel Vistein, Brandon R. Nanfito, David G. C. Hildebrand, Santiago Otero-Coronel, Alipasha Vaziri, Jeffery […]


Continue.. The Cousa objective: a long working distance air objective for multiphoton imaging in vivo