Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Martin Kampmann, Manoj T Duraisingh and Leslie B Vosshall | Summary: Amino acid composition within a proteome is conventionally viewed as a property of individual protein function. However, specific nutrient scarcity has been shown to reshape which amino acids are encoded in the genome of microbes. […]


Continue.. Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes

Kavli Affiliate: Erich Jarvis and Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Philipp Brand, Irene Arnoldi, Alexandra E DeFoe, Jennifer R Balacco, Nadav Shai, Alex Makunin, Umberto Palatini, Takako Toma, Takao Okazawa, Christopher M Stone, Anita Schiller, Olivier Fedrigo, Erich D Jarvis, Mara KN Lawniczak, Ichiro Miyagi, Paolo Gabrieli and Leslie B Vosshall | Summary: […]


Continue.. Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes

The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Kavli Affiliate: Charles M. Rice | Authors: Leon L Seifert, Georgios Dangas, Hoyin Chu, Yingpu Yu, Kosuke Ogata, Xupeng Hong, Mengyin Zhang, Yichen Zhou, Chenhui Zou, Alireza Ramandi, Corrine Quirk, Evgenia Moschogianni, Catherine A Freije, Antonis Athanasiadis, Leonardo Gonzales, Luis Chiriboga, Clifton Fulmer, Hong Hur, Manoj Kandpal, Anna S Lok, Caleb Lareau, William M Schneider, […]


Continue.. The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Rocking Without a Tune: Ex vivo and in vivo Responses to Sound in the Basilar Papilla of the Tokay Gecko

Kavli Affiliate: A. James Hudspeth | Authors: Brian L. Frost, Yuriria Vázquez, Kazuhiro Horii, Brian A. Fabella and A. J. Hudspeth | Summary: Like mammals, some reptiles possess sensitive and frequency-selective hearing at mid- to high-kilohertz frequencies. Both groups employ a place-frequency map within the inner ear to encode sound stimuli, but the mechanisms by […]


Continue.. Rocking Without a Tune: Ex vivo and in vivo Responses to Sound in the Basilar Papilla of the Tokay Gecko

Local translation couples synaptic activity to mitochondrial adaptation in dendrites

Kavli Affiliate: Robert B. Darnell | Authors: Madison T Jones, Natalie Noble, Robert B Darnell and Ezgi Hacisuleyman | Summary: Neurons rely on localized protein synthesis to rapidly adapt synaptic function to activity, yet how dendritic translation regulates mitochondrial remodeling during synaptic plasticity remains poorly understood. Here, we show that neuronal activity engages a spatially […]


Continue.. Local translation couples synaptic activity to mitochondrial adaptation in dendrites

The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell intrinsic control of endosomal dynamics

Kavli Affiliate: Charles M. Rice | Authors: Boris Bonaventure, Kyna Reyes, Marie-France Martin, Heng Pan, R. Blake Richardson, Eva Bednarski, Alison W. Ashbrook, Allison Sowa, William Janssen, Oded Danziger, Anastasija Cupic, Lisa Miorin, Charles M Rice, Jean K Lim, Brad R Rosenberg, Matthew J Evans and Jeffrey R Johnson | Summary: Neurodevelopmental disorders are increasingly […]


Continue.. The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell intrinsic control of endosomal dynamics

CypA is a molecular barrier to HIV emergence from Eastern chimpanzees

Kavli Affiliate: Michael W. Young | Authors: Michael J Young, Fabricio Cotera, Clare C. C. Gill, Jacob A. Lewis, Frank G. Whitby, Alaa Abdellatif, Joana L. Rocha, Michael Singer, Mike A Nalls, Faraz Faghri, Peter H Sudmant, Owen Pornillos and Molly Ohainle | Summary: Of the two lineages of lentivirus that endemically infect chimpanzees, only […]


Continue.. CypA is a molecular barrier to HIV emergence from Eastern chimpanzees

Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales

Kavli Affiliate: Vanessa Ruta and Priya Rajasethupathy | Authors: James Newton Brandt, Alessandra Bonito-Oliva, Navid Paknejad, Celine Chen, John J Fak, Andrew Luskin, Genelle Rankin, Miriam Kirylo, Leslie J Sibener, Amy Arnsten, Vanessa Ruta and Priya Rajasethupathy | Summary: Working memory capacity is poorly understood. The ability to control and extend working memory time-scales provides […]


Continue.. Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales

Gonadal remodelling in socially driven sex change is associated with novel and known sex genes, epigenetic reprogramming, and inflammation-mediated apoptosis.

Kavli Affiliate: Erich Jarvis | Authors: Chloé A van der Burg, Alexander A Goikoetxea, Simon Muncaster, Oscar Ortega-Recalde, Tim Hore, Kaj Kamstra, Olivier Fedrigo, Erich D Jarvis, Alan Tracey, Kerstin Howe, Erica V Todd and Neil Gemmell | Summary: Many fish undergo dramatic, socially cued female-to-male sex change, yet the events that initiate and then […]


Continue.. Gonadal remodelling in socially driven sex change is associated with novel and known sex genes, epigenetic reprogramming, and inflammation-mediated apoptosis.

E-cadherin-mediated neighborhood surveillance dictates pre-malignant outcomes

Kavli Affiliate: Elaine Fuchs | Authors: Elizabeth A.N. Thompson, Clara Schimmer, Tatiana Omelchenko, Michele Paganini, Jesse S.S. Novak, Sienna T. Muller, Alain R. Bonny, Marina Schernthanner, Sairaj M. Sajjath, Charlotte J. Bell, Alp Gorgulu, S. Martina Parigi, Katherine S. Stewart, Priyam Banerjee, Elaine Fuchs and Stephanie J. Ellis | Summary: Stratified epithelia accumulate oncogenic mutations […]


Continue.. E-cadherin-mediated neighborhood surveillance dictates pre-malignant outcomes