Rockefeller – Kavli Institute Pre-Print Publications

scATrans: annotating single-cell differential expression as transcription- or stabilization-weighted using unspliced RNA

Posted by dbos August 7, 2026August 10, 2026Rockefeller, This Week: Neuroscience

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Single-cell differential expression (DE) reports changes in mature mRNA abundance, but the same fold-change can reflect faster synthesis or slower decay. Metabolic labeling resolves this ambiguity but is costly and cannot be applied retrospectively to the vast majority of published […]

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HPRC2: A human pangenome reference with near-complete coverage of common genetic variation

Posted by dbos August 5, 2026August 10, 2026Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Julian K. Lucas, Prajna Hebbar, Wen-Wei Liao, Juan F. Macias-Velasco, Adam M. Novak, Mobin Asri, Jennifer R. Balacco, Andrew P. Blair, Davide Bolognini, Jana Ebler, Joshua M.V. Gardner, Margarita Geleta, Cristian Groza, Andrea Guarracino, Peter Heringer, Glenn Hickey, Sergey Koren, Shuangjia Lu, Maximillian G. Marin, Christopher Markovic, Mira […]

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A guanosine nucleotide metabolism-bioenergetics intersection drives Parkinson’s disease

Posted by dbos August 4, 2026August 10, 2026Rockefeller, This Week: Neuroscience

Kavli Affiliate: Timothy A. Ryan | Authors: Alexandros C. Kokotos, Santiago R. Unda, Paula R Reyes-Perez, Mariam Isayan, Maria Teresa Perinan, Michael G Kaplitt and Timothy A Ryan | Summary: Several Parkinson’s Disease (PD) linked mutations are known to drive deficits in a pathway that relies on an adequate supply of guanosine nucleotide triphosphate […]

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Iterative co-creation of harmonized human and non-human primate cellular and structural ontologies and 3D common coordinate frameworks for the basal ganglia

Posted by dbos August 4, 2026August 10, 2026Rockefeller, This Week: Neuroscience

Kavli Affiliate: Winrich Freiwald | Authors: Song-Lin Ding, Ashwin Bhandiwad, Burke Rosen, Stephanie C. Seeman, Brian Long, Nelson J. Johansen, Ugur Bayindir, Benjamin Facer, Yuanyuan Fu, Yoel Halimi, Yujie Hou, Dingzi Hu, Mike Huang, Takuro Ikeda, Brian Kalmbach, Lauren Kruse, Phil Lesnar, Xiao-Ping Liu, Zhaoke Luo, Patrick Ray, Joshua J Royall, Matthew T Schmitz, […]

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PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gαq

Posted by dbos July 26, 2026August 10, 2026Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Maria Falzone, Priyam Banerjee and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 from the plasma membrane, producing IP3 and DAG, which regulate intracellular Ca2+ levels and protein kinase C activity, respectively. They are regulated by GPCR signaling through the G proteins Gβγ and Gαq and have been shown […]

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Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

Posted by dbos July 24, 2026August 10, 2026Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Catherine A Freije, Georgios Dangas, Antonis Athanasiadis, Evgenia Moschogianni, Madeleine K Sanders, Allan Henrique Depieri Cataneo, Chloe K Boehm, Maria Bousali, Dar-Yin Li, Sooyoung Lee, Guillaume Cornelis, Gary Lo, Leah B Soriaga, Amalio Telenti, Julia di Iulio, Ana L P Mosimann, Juliano Bordignon, Kirin Karver, Lukas Fu, […]

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Spatial deconstruction of the plasma membrane

Posted by dbos July 23, 2026August 10, 2026Rockefeller

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Roderick MacKinnon | Authors: Venkata Shiva Mandala, Chen Zhao, Qiuying Chen, Steven Gross, Jacob B Geri and Roderick MacKinnon | Summary: The plasma membrane of cells is known to be heterogeneous with regards to the spatial distribution of proteins and […]

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Isolation and Lipidomic Profiling of Neuronal Lipid Droplets to Unveil the Lipid Landscape of Neurodegenerative Disorders

Posted by dbos July 23, 2026August 10, 2026Rockefeller

Kavli Affiliate: Timothy A. Ryan | Authors: Mukesh Kumar, Rachel McAllister, Souvik Roy, Justin A Knapp, Kallol Gupta and Timothy A. Ryan | Summary: Recent advances have expanded the role of lipid droplets (LDs) beyond passive lipid storage, implicating their involvement in various metabolic processes across mammalian tissues. Neuronal LDs, whose existence has long […]

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IL-32 is a stress-responsive node locked in a noncanonical NF-κB inflammatory loop during MASLD to HCC transition

Posted by dbos July 22, 2026August 10, 2026Rockefeller

Kavli Affiliate: Li Zhao | Authors: Li Na Zhao, Philipp Kaldis and Jesper B. Andersen | Summary: Background Interleukin-32 (IL-32) presents a long-standing paradox in liver disease, with markedly elevated expression in hepatocellular carcinoma (HCC) yet a protective role against hepatic steatosis. The absence of a canonical receptor or defined secretory pathway has obscured its […]

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Rare sex punctuates strict asexual reproduction in the clonal raider ant, Ooceraea biroi

Posted by dbos July 8, 2026July 13, 2026Rockefeller

Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Nicolas Châline and Daniel J.C. Kronauer | Summary: While asexual species can often outcompete their sexual counterparts over ecological timescales, their long-term evolutionary success is hindered by a diminished ability to purge deleterious mutations and to adapt to changing environments. However, some asexual species persist for […]

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