Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Posted by dbos This Week: Neuroscience, Yale

Kavli Affiliate: Pietro De Camilli | Authors: Hanieh Falahati, Yumei Wu and Pietro De Camill | Summary: Abstract The endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites, and the cisternal organelle of axonal initial segments. Both organelles […]


Continue.. Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Adaptation to visual sparsity enhances responses to infrequent stimuli

Posted by dbos Yale

Kavli Affiliate: Damon Clark | Authors: Tong Gou, Catherine A Matulis and Damon A Clark | Summary: Sensory systems adapt their response properties to the statistics of their inputs. For instance, visual systems adapt to low-order statistics like mean and variance to encode the stimulus efficiently or to facilitate specific downstream computations. However, it remains […]


Continue.. Adaptation to visual sparsity enhances responses to infrequent stimuli

Non-uniform contextual interactions in the visual cortex place fundamental limits on spatial vision

Posted by dbos Yale

Kavli Affiliate: Anirvan Nandy | Authors: Mitchell P Morton, Sachira Denagamage, Nyomi V Hudson and Anirvan S Nandy | Summary: A prevailing assumption in our understanding of how neurons in the primary visual cortex (V1) integrate contextual information is that such processes are spatially uniform. Conversely, perceptual phenomena such as visual crowding, the impaired ability […]


Continue.. Non-uniform contextual interactions in the visual cortex place fundamental limits on spatial vision

Hypothalamic hormone deficiency enables physiological anorexia

Posted by dbos Yale

Kavli Affiliate: Elena Gracheva | Authors: Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev and Elena O Gracheva | Summary: Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal […]


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Developmental trajectory of cortical somatostatin interneuron function

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Kavli Affiliate: Michael J Higley | Authors: Alex Wang, Katie A. Ferguson, Jyoti Gupta, Michael J. Higley and Jessica A. Cardin | Summary: GABAergic inhibition is critical to the proper development of neocortical circuits. However, GABAergic interneurons are highly diverse and the developmental roles of distinct inhibitory subpopulations remain largely unclear. Dendrite-targeting, somatostatin-expressing interneurons (SST-INs) […]


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Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Posted by dbos Yale

Kavli Affiliate: Flora Vaccarino | Authors: Yifan Wang, Liana Fasching, Feinan Wu, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F. Leckman, Alexej Abyzov and Flora M. Vaccarino | Summary: Tourette syndrome (TS) is a disorder of high-order integration of sensory, motor, and cognitive functions afflicting as many as 1 in 150 children and characterized by […]


Continue.. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

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Kavli Affiliate: Anirvan Nandy | Authors: Xize Xu, Mitchell P Morton, Nyomi Hudson, Anirvan Nandy and Monika P. Jadi | Summary: Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet how the spatial organization of objects influences neural activity in this hierarchy remains poorly understood. We […]


Continue.. Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

Development of a Marmoset Apparatus for Automated Pulling (MarmoAAP) to Study Cooperative Behaviors

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Kavli Affiliate: Anirvan Nandy | Authors: Olivia C Meisner, Nicholas A Fagan, Joel Greenwood, Weikang Shi, Monika Jadi, Anirvan S. Nandy and Steve W. C. Chang | Summary: In recent years, the field of neuroscience has increasingly recognized the importance of studying animal behaviors in naturalistic environments to gain deeper insights into ethologically relevant behavioral […]


Continue.. Development of a Marmoset Apparatus for Automated Pulling (MarmoAAP) to Study Cooperative Behaviors

Automated 3D analysis of social head-gaze behaviors in freely moving marmosets

Posted by klaurent Yale

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Alec Graham Sheffield, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Social communication relies on the ability to perceive and interpret the direction of others’ attention, which is commonly conveyed through head orientation and gaze direction in both humans and non-human primates. […]


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Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions

Posted by klaurent Yale

Kavli Affiliate: Marina Picciotto | Authors: Paul Jongseo Lee, Alexa R Soares, Yu Sun, Caroline Fai, Marina Picciotto and Junjie U Guo | Summary: While previous studies suggest that many mRNAs contain more than one translation initiation site (TIS), the biological significance of most alternative TISs and their corresponding protein isoforms (proteoforms) remains undetermined. Here […]


Continue.. Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions