Kavli Affiliate: Shawn Ferguson | Authors: Devin Clegg, Amanda Bentley-DeSousa, Agnes Roczniak-Ferguson and Shawn M Ferguson | Summary: Increased activity of leucine-rich repeat kinase 2 (LRRK2) confers Parkinson’ s disease risk. LRRK2 dynamically localizes to lysosomal membranes in response to various stresses, yet the mechanisms by which distinct lysosomal perturbations are communicated to LRRK2 remain […]
Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most fMRI studies in rodents use anesthesia to […]
Kavli Affiliate: Pietro De Camilli | Authors: Devin M Fuller, Yumei Wu, Florian Schueder, Burha Rasool, Shanta Nag, Justin L. Korfhage, Rolando Garcia-Milian, Katerina D Melnyk, Joerg Bewersdorf, Pietro De Camilli and Thomas Melia | Summary: Autophagosomes form from seed membranes that expand through bulk-lipid transport via the bridge-like lipid transporter ATG2. The origins of […]
Kavli Affiliate: Pietro De Camilli | Authors: Yumei Wu, Peng Xu, James Moran, C. Shan Xu, Kenneth J. Hayworth, Mian Cao, Lin Shao, D. James Surmeier, Harald F. Hess and Pietro De Camilli | Summary: Synaptojanin 1 is a brain enriched phosphoinositide phosphatase implicated in endocytosis at the synapse. A mutation (R258Q) that selectively impairs […]
Kavli Affiliate: Shawn Ferguson | Authors: Derk Draper, Noortje Kersten, Shietela Sewnarain Sukul, Rebecca Jark, Inge Rothuis, Poorvi Ravindra, Aniruddha Mitra, Lukas C. Kapitein, Shawn Ferguson, Judith Klumperman and Ginny G. Farías | Summary: Neurons rely on precise biosynthetic protein transport from the soma to the axon and dendrites. Brain-enriched calsyntenins (CSTN1–3) are unique transmembrane […]
Kavli Affiliate: Damon Clark | Authors: Harsh Vashistha, Natalia CB Matos, Heng Wu and Damon A Clark | Summary: Detecting approaching objects is essential for survival, and studies across animals have identified neurons and circuits selective for objects that grow in size over time, a hallmark of visual approach. However, approach as a physical process […]
Kavli Affiliate: Marina Picciotto | Authors: Oakleigh M Folkes, Meaghan Donahue, Rafael E Perez, Angélica Minier-Toribio, Paola N. Negrón-Moreno, Marina R. Picciotto and Yong-Hui Jiang | Summary: Social behavior deficits are a common symptom of neuropsychiatric disorders, including autism spectrum disorder (ASD), but there are limited pharmacological treatments for these symptoms. Understanding how neurons encode […]
Kavli Affiliate: Damon Clark | Authors: Malcom Díaz García, Jonathan Beagan, Ernesto Cabezas-Bou, Matthew J. Thomas, Sandeep Kumar, Lin Shao, Xingyang Fu, Andrea Cuentas-Condori, Jacqueline R. McVay, Josh D. Hawk, Andrew Lauziere, William Mohler, Hari Shroff, Damon Clark and Daniel A. Colón-Ramos | Summary: Sensory neurons must extract behaviorally relevant features from dynamic environments while […]
Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: α-Synuclein aggregates characterize α-synucleinopathies, including Parkinson’s disease and Dementia with Lewy bodies. A majority of people […]
Kavli Affiliate: Flora Vaccarino | Authors: Taejeong Bae, Livia Tomasini, Leszek J. Klimczak, Merit Kayastha, Milovan Suvakov, Yeongjun Jang, Alexandre Jourdon, Dmitry A. Gordenin, Flora M. Vaccarino and Alexej Abyzov | Summary: Somatic mutations that arise post-zygotically create genetic diversity among normal human cells and provide key insights into human development and aging. Fibroblast-derived induced […]