Learning Interpretable Switching Dynamics in Shared Neural-Behavioral Latent Space

Posted by dbos This Week: Neuroscience, Yale

Kavli Affiliate: Michael J Higley | Authors: Yongxu Zhang, Josue Ortega Caro, Rachel Oren, Michael James Higley, Jessica Cardin, Anne Churchland and Shreya Saxena | Summary: Modern recording technologies enable simultaneous measurement of high-dimensional neural activity and rich behavioral variables, creating both an opportunity and a modeling challenge: identifying the shared latent structure that mediates […]


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Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes

Posted by dbos Yale

Kavli Affiliate: Ellen J. Hoffman | Authors: April Pruitt, Liang Yang, Seoyeon Lee, Novin Balafkan, Shilin Gao, Carina Seah, Yi Dai, Elizabeth Davidson, Suha Khan, Annabel Sen, Jenny Liu, Isabel Wood, Gang Xu, Xiayuan Huang, Marina Carlson, Dejian Zhao, Priyanka Jamadagni, Grace Dossou, Kayla Retallick-Townsley, Xinyun Liu, Xenophon Papademetris, P.J. Michael Deans, Meilin Fernandez Garcia, […]


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Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms

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Kavli Affiliate: Pietro De Camilli | Authors: Yumei Wu, Peng Xu, James Moran, C. Shan Xu, Kenneth J. Hayworth, Mian Cao, Lin Shao, D. James Surmeier, Harald F. Hess and Pietro De Camilli | Summary: Synaptojanin 1 is a brain enriched phosphoinositide phosphatase implicated in endocytosis at the synapse. A mutation (R258Q) that selectively impairs […]


Continue.. Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms

ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes

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Kavli Affiliate: Shawn Ferguson | Authors: Devin Clegg, Amanda Bentley-DeSousa, Agnes Roczniak-Ferguson and Shawn M Ferguson | Summary: Increased activity of leucine-rich repeat kinase 2 (LRRK2) confers Parkinson’ s disease risk. LRRK2 dynamically localizes to lysosomal membranes in response to various stresses, yet the mechanisms by which distinct lysosomal perturbations are communicated to LRRK2 remain […]


Continue.. ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes

Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

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Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most fMRI studies in rodents use anesthesia to […]


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ATG2A interacts with RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis

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Kavli Affiliate: Pietro De Camilli | Authors: Devin M Fuller, Yumei Wu, Florian Schueder, Burha Rasool, Shanta Nag, Justin L. Korfhage, Rolando Garcia-Milian, Katerina D Melnyk, Joerg Bewersdorf, Pietro De Camilli and Thomas Melia | Summary: Autophagosomes form from seed membranes that expand through bulk-lipid transport via the bridge-like lipid transporter ATG2. The origins of […]


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Calsyntenin-1 and calsyntenin-3 coordinate TGN exit of axonal cargoes

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Kavli Affiliate: Shawn Ferguson | Authors: Derk Draper, Noortje Kersten, Shietela Sewnarain Sukul, Rebecca Jark, Inge Rothuis, Poorvi Ravindra, Aniruddha Mitra, Lukas C. Kapitein, Shawn Ferguson, Judith Klumperman and Ginny G. Farías | Summary: Neurons rely on precise biosynthetic protein transport from the soma to the axon and dendrites. Brain-enriched calsyntenins (CSTN1–3) are unique transmembrane […]


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Dynamic trajectory cues drive sequenced integration in approach detectors

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Kavli Affiliate: Damon Clark | Authors: Harsh Vashistha, Natalia CB Matos, Heng Wu and Damon A Clark | Summary: Detecting approaching objects is essential for survival, and studies across animals have identified neurons and circuits selective for objects that grow in size over time, a hallmark of visual approach. However, approach as a physical process […]


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Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in a Shank3-/- Autism Model

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Kavli Affiliate: Marina Picciotto | Authors: Oakleigh M Folkes, Meaghan Donahue, Rafael E Perez, Angélica Minier-Toribio, Paola N. Negrón-Moreno, Marina R. Picciotto and Yong-Hui Jiang | Summary: Social behavior deficits are a common symptom of neuropsychiatric disorders, including autism spectrum disorder (ASD), but there are limited pharmacological treatments for these symptoms. Understanding how neurons encode […]


Continue.. Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in a Shank3-/- Autism Model

Experience-Dependent Gain Modulation Drives Thermosensory Responses in Behavior

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Kavli Affiliate: Damon Clark | Authors: Malcom Díaz García, Jonathan Beagan, Ernesto Cabezas-Bou, Matthew J. Thomas, Sandeep Kumar, Lin Shao, Xingyang Fu, Andrea Cuentas-Condori, Jacqueline R. McVay, Josh D. Hawk, Andrew Lauziere, William Mohler, Hari Shroff, Damon Clark and Daniel A. Colón-Ramos | Summary: Sensory neurons must extract behaviorally relevant features from dynamic environments while […]


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