A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

Kavli Affiliate: Shawn Ferguson | Authors: Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage evoked by chemical and pathogenic stimuli. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood. […]


Continue.. A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons

Kavli Affiliate: Pietro De Camilli | Authors: Nisha Mohd Rafiq, Kenshiro Fujise, Martin Rosenfeld, Peng Xu, Yumei Wu and Pietro De Camilli | Summary: Synaptojanin-1 (SJ1) is a major neuronal-enriched PI(4,5)P2 4- and 5-phosphatase implicated in the shedding of endocytic factors during endocytosis. A mutation (R258Q) that impairs selectively its 4-phosphatase activity causes Parkinsonism in […]


Continue.. Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons

Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Kavli Affiliate: Timothy A. Ryan & Pietro De Camilli | Authors: Talex Kokotos, Aldana Antoniazzi, Santiago Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael Kaplitt, Pietro De Camilli and Timothy Ryan | Summary: Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since […]


Continue.. Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Brain state and cortical layer-specific mechanisms underlying perception at threshold

Kavli Affiliate: Anirvan Nandy, John Reynolds | Authors: Mitchell P Morton, Sachira Denagamage, Isabel J Blume, John H Reynolds, Monika P Jadi and Anirvan S Nandy | Summary: Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in […]


Continue.. Brain state and cortical layer-specific mechanisms underlying perception at threshold

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]


Continue.. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Kavli Affiliate: Michael J Higley | Authors: Olivier Dubanet and Michael J. Higley | Summary: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely […]


Continue.. Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

Kavli Affiliate: Sreeganga Chandra | Authors: Na Wang, Biqing Zhu, Mary Alice Allnutt, Rosalie M Grijalva, Hongyu Zhao and Sreeganga S Chandra | Summary: Synapse maintenance is essential for generating functional circuitry and decrement in this process is a hallmark of neurodegenerative disease. While we are beginning to understand the basis of synapse formation, much […]


Continue.. Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

Acetylcholine signaling in the medial prefrontal cortex mediates the ability to learn an active avoidance response following learned helplessness training

Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Yann S Mineur, Richard B Crouse, Ian M Etherington, Hanna Yousuf, Jessica J Na and Marina R Picciotto | Summary: Increased brain levels of acetylcholine (ACh) are observed in subsets of patients with depression and increasing ACh levels chronically can precipitate stress-related behaviors in humans and […]


Continue.. Acetylcholine signaling in the medial prefrontal cortex mediates the ability to learn an active avoidance response following learned helplessness training

Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]


Continue.. Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Enhancer-driven regulatory network of forebrain human development provides insights into autism

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]


Continue.. Enhancer-driven regulatory network of forebrain human development provides insights into autism