Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Pietro De Camilli | Authors: Dazhi Li, Xinbo Wang, Bodan Hu, Hongyan Hao, Stephanie Hamill, Yuting Li, Guochao Chen, Pietro De Camilli and Karin M. Reinisch | Summary: Bridge-like lipid transfer proteins (BLTPs) play central roles in redistributing lipids from […]


Continue.. Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C

Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics.

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Michael J Higley | Authors: Andrew Moberly, Jessica A Cardin and Michael Higley | Summary: Neuromodulation by acetylcholine (ACh) plays a critical role in reshaping neural dynamics in the neocortex as a function of development, behavioral state, and learning 1–6. […]


Continue.. Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics.

Drosophila melanogaster model of RVCL-S demonstrates age dependent disease progression

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Elena Gracheva | Authors: Elena Gracheva, Abigail Matt, Fei Wang, Raymond Hsin, Hongwu Liang, Xiangping Ouyang, Jimin Ding, Jonathan J Miner and Chao Zhou | Summary: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a disease that causes […]


Continue.. Drosophila melanogaster model of RVCL-S demonstrates age dependent disease progression

A comprehensive view of somatic mosaicism by single-cell DNA analysis

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Flora Vaccarino | Authors: Lovelace J Luquette, Tim H.H. Coorens, Abhiram Natu, Milovan Suvakov, Ann Caplin, Mee Sook Jun, Alisa Mo, Joe Pelt, Lisa Anderson, Michele Berselli, Sravya Bhamidipati, Thomas Blanchard, Joseph Brew, Hye-Jung E. Chun, Hyunbin Chun, Mrunal K. […]


Continue.. A comprehensive view of somatic mosaicism by single-cell DNA analysis

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

Kavli Affiliate: Richard Huganir | Authors: Laura Sichlinger, Molly Reilly, Sakshi Arora, Shuo Zhang, Nicolas Marotta, Kiara L. Rodriguez-Acevedo, Marisol Hooks, Kyle S. Czarnecki, Julia J. Winter, Elisa A. Waxman, Lea V. Dungan, Ingie Hong, Yoichi Araki, Richard Johnson, Richard L. Huganir, Giulia Pavani, Deborah L. French, Beverly L. Davidson, Benjamin L. Prosser and Elizabeth […]


Continue.. CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry

Kavli Affiliate: Flora Vaccarino | Authors: Abhiram Natu, Mrunal K. Dehankar, Reenal Pattni, Milovan Suvakov, Dmitrii Olisov, Livia Tomasini, Yeongjun Jang, Yiling Huang, Eva Benito-Garragori, Patrick Hasenfeld, Jan Korbel, Alexander E. Urban, Alexej Abyzov and Flora M. Vaccarino | Summary: The role of somatic mutations in human development and disease is obscured by difficulties in […]


Continue.. Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry

Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most neuroimaging studies in rodents use anesthesia to […]


Continue.. Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice

Canonical decision computations underlie behavioral and neural signatures of cooperation in primates

Kavli Affiliate: Anirvan Nandy | Authors: Weikang Shi, Olivia C. Meisner, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Successful cooperation requires dynamic integration of social cues. However, the neural mechanisms supporting this complex process remain unknown. Here, we reveal that the primate dorsomedial prefrontal cortex (dmPFC) implements a gaze-dependent […]


Continue.. Canonical decision computations underlie behavioral and neural signatures of cooperation in primates

Distinct Filament Conformation for Receptor-Bound Amyloid-β from Alzheimers Disease Brain

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Stephen Strittmatter | Authors: Mikhail A Kostylev, Carmen Butan, Graham P Carmen, Yangyi Liu, Pallavi Gopal and Stephen M Strittmatter | Summary: Alzheimer’s disease is triggered by amyloid-ß, with symptoms linked to synapse loss. Oligomeric amyloid-ß, rather than monomeric or […]


Continue.. Distinct Filament Conformation for Receptor-Bound Amyloid-β from Alzheimers Disease Brain

Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Stephen Strittmatter | Authors: Ramakrishnan Kannan, Xingxing Wang, LaShae Nicholson, Nancy Z. Lin, Elisa M. Howard, Atrayee Basu, Ines Ingabire, Yuichi Sekine and Stephen M. Strittmatter | Summary: Adult CNS trauma frequently causes neuronal disconnection and persistent deficits due to […]


Continue.. Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8