Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Kavli Affiliate: Flora Vaccarino | Authors: Soraya Scuderi, Tae-Yun Kang, Alexandre Jourdon, Liang Yang, Feinan Wu, Alex Nelson, George M. Anderson, Jessica Mariani, VIVEKANANDA SARANGI, Alexej Abyzov, Andre Levchenko and Flora M. Vaccarino | Summary: The repertory of neurons generated by progenitor cells depends on their location along antero-posterior and dorso-ventral axes of the neural […]


Continue.. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Kavli Affiliate: Flora Vaccarino | Authors: Yifan Wang, Liana Fasching, Feinan Wu, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F. Leckman, Alexej Abyzov and Flora M. Vaccarino | Summary: Tourette syndrome (TS) is a disorder of high-order integration of sensory, motor, and cognitive functions afflicting as many as 1 in 150 children and characterized by […]


Continue.. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Widespread Receptive Field Remapping in Early Visual Cortex

Kavli Affiliate: Anirvan Nandy | Authors: Sachira Denagamage, Mitchell P Morton and Anirvan Nandy | Summary: Our eyes are in constant motion, yet we perceive the visual world as being stable. Predictive remapping of receptive fields is thought to be one of the critical mechanisms for enforcing perceptual stability during eye movements. While receptive field […]


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Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Kavli Affiliate: Pietro De Camilli | Authors: Hanieh Falahati, Yumei Wu and Pietro De Camill | Summary: Abstract The endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites, and the cisternal organelle of axonal initial segments. Both organelles […]


Continue.. Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Adaptation to visual sparsity enhances responses to infrequent stimuli

Kavli Affiliate: Damon Clark | Authors: Tong Gou, Catherine A Matulis and Damon A Clark | Summary: Sensory systems adapt their response properties to the statistics of their inputs. For instance, visual systems adapt to low-order statistics like mean and variance to encode the stimulus efficiently or to facilitate specific downstream computations. However, it remains […]


Continue.. Adaptation to visual sparsity enhances responses to infrequent stimuli

Non-uniform contextual interactions in the visual cortex place fundamental limits on spatial vision

Kavli Affiliate: Anirvan Nandy | Authors: Mitchell P Morton, Sachira Denagamage, Nyomi V Hudson and Anirvan S Nandy | Summary: A prevailing assumption in our understanding of how neurons in the primary visual cortex (V1) integrate contextual information is that such processes are spatially uniform. Conversely, perceptual phenomena such as visual crowding, the impaired ability […]


Continue.. Non-uniform contextual interactions in the visual cortex place fundamental limits on spatial vision

Hypothalamic hormone deficiency enables physiological anorexia

Kavli Affiliate: Elena Gracheva | Authors: Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev and Elena O Gracheva | Summary: Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal […]


Continue.. Hypothalamic hormone deficiency enables physiological anorexia

Developmental trajectory of cortical somatostatin interneuron function

Kavli Affiliate: Michael J Higley | Authors: Alex Wang, Katie A. Ferguson, Jyoti Gupta, Michael J. Higley and Jessica A. Cardin | Summary: GABAergic inhibition is critical to the proper development of neocortical circuits. However, GABAergic interneurons are highly diverse and the developmental roles of distinct inhibitory subpopulations remain largely unclear. Dendrite-targeting, somatostatin-expressing interneurons (SST-INs) […]


Continue.. Developmental trajectory of cortical somatostatin interneuron function

Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Kavli Affiliate: Flora Vaccarino | Authors: Yifan Wang, Liana Fasching, Feinan Wu, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F. Leckman, Alexej Abyzov and Flora M. Vaccarino | Summary: Tourette syndrome (TS) is a disorder of high-order integration of sensory, motor, and cognitive functions afflicting as many as 1 in 150 children and characterized by […]


Continue.. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

Kavli Affiliate: Anirvan Nandy | Authors: Xize Xu, Mitchell P Morton, Nyomi Hudson, Anirvan Nandy and Monika P. Jadi | Summary: Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet how the spatial organization of objects influences neural activity in this hierarchy remains poorly understood. We […]


Continue.. Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex