Calcium-independent biosensors for multiplexed in vivo imaging of extracellular lactate dynamics

Kavli Affiliate: David Kleinfeld | Authors: Jia-Jin Liu, Hidenobu Mizuno, Emmanuel Than-Trong, Philipp Machler, Hideaki Kubotera, Tony Barbay, Ching-Yao Wang, Qin-Ling To, Yuki Kamijo, Taki Nishimura, Marc Boisvert, Marie-Eve Paquet, Mikhail Drobizhev, Stephanie J Cragg, Jun Nagai, David Kleinfeld, Serge Charpak and Yusuke NASU | Summary: Extracellular L-lactate reports cellular metabolism, but resolving its dynamics […]


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Sugarcane’s drought memory legacy: how past stress shapes future resilience

  Kavli Affiliate: Gabriel Silva | Authors: Maria Dolores Pissolato, Tamires Silva Martins, Marcela Trevenzoli Miranda, Gabriel Silva Pires, Rafael L. Almeida, Larissa Prado Cruz, Leonardo Perez Sousa, Adilson P. Domingues-Jr, Eduardo Caruso Machado, Alisdair R Fernie and Rafael Ribeiro | Summary: Plants frequently experience recurrent drought events separated by periods of rehydration. Although drought […]


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Axons organize into micro-tracts around the cortical vasculature

Kavli Affiliate: David Kleinfeld | Authors: Javier Josue How, Bethanny Danskin, Benjamin Pedigo, Elana Marie Memke, Stefan Stamenkovic, David Kleinfeld and Andy Shih | Summary: Neural activity is metabolically costly and supported by local increases in cerebral blood flow. The process by which neural activity drives blood flow increase, neurovascular coupling (NVC), remains poorly understood. […]


Continue.. Axons organize into micro-tracts around the cortical vasculature

Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Kavli Affiliate: John Serences | Authors: Rosanne L Rademaker and John Serences | Summary: People often remember visual information over brief delays while actively engaging with ongoing inputs from the surrounding visual environment. Depending on the situation, one might prioritize mnemonic contents (i.e., remembering details of a past event), or preferentially attend sensory inputs (i.e., […]


Continue.. Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Systematic evidence map of research on life-history traits in native and introduced earthworms

Kavli Affiliate: John Reynolds | Authors: Karina Vanadzina, Kaushalya Nagahawatte, Deshan Rupasinghe, George G. Brown, Erin K. Cameron, Sylvain Gérard, Céline Pelosi, John W. Reynolds, Alyssa Rice and Helen R.P. Phillips | Summary: Invasive species constitute one of the most significant threats to biodiversity worldwide, and are responsible for more than $400 billion in losses […]


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Physicochemical balancing facilitates fast cyclic immunolabeling in centimeter-scale FFPE tissues

Kavli Affiliate: Ann-Shyn Chiang | Authors: Ya-Hui Lin, Chao-Yin Huang, Yin-Hsu Chen, Yen-Hui Chen, Ping-Liang Ko, Heng-Hua Hsu, Yi-Chung Tung, Yu-Fang Chen, Hui-Chi Chen, Ann-Shyn Chiang, Chih-Ming Ho, Da-Jeng Yao, Kimberly L Fiock, Kuo-Chuan Wang, Chin-Hsien Lin, Shang-Hsiu Hu, Bi-Chang Chen and Li-An Chu | Summary: Archived formalin-fixed, paraffin-embedded (FFPE) tissues, including brain-bank specimens, are […]


Continue.. Physicochemical balancing facilitates fast cyclic immunolabeling in centimeter-scale FFPE tissues

RNA trans-splicing treatment for Duchenne muscular dystrophy

Kavli Affiliate: Samuel Pfaff | Authors: Ryan H. Hsu, Claire E. Williams, Geraldine Maier, Miriam Gullo, Karen Lettieri, Cindy J. Alvarez, Kip J. Hermann, Stella Kramer, Satchidananda Panda, Lukas C. Bachmann and Samuel L. Pfaff | Summary: Duchenne muscular dystrophy (DMD) is a fatal disorder caused by dystrophin mutations, leading to progressive muscle degeneration and cardiac failure. […]


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Parallel visual processing in the suprachiasmatic region of a diurnal mammal.

Kavli Affiliate: Timothy Brown | Authors: Patrycja Orlowska-Feuer, Jessica Rodgers, Rose Richardson, Asshen Dedigama Acharige, Martha Davey, Nina Milosavljevic, Annette E Allen, Timothy M Brown, Franck P Martial, Riccardo Storchi, Beatriz Bano Otalora and Robert J Lucas | Summary: Light shapes mammalian physiology and behaviour through hypothalamic pathways, yet how these pathways process visual information […]


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An intersectional expression platform for gene complementation using RNA-fragment end joining (REJ)

Kavli Affiliate: Samuel Pfaff | Authors: Lukas C. Bachmann, Ryan H. Hsu, Kip J. Hermann, Claire E. Williams, Richard L. Farman, Nicolas Criales, Craig Clark, Stella Kramer, Carolina Thorn Perez, Sawyer Randles, Karen Lettieri and Samuel L. Pfaff | Summary: Gene complementation is a powerful tool for genetic selection and protein functional studies but typically […]


Continue.. An intersectional expression platform for gene complementation using RNA-fragment end joining (REJ)

Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors

Kavli Affiliate: Kay Tye | Authors: Fergil Mills, Christopher R Lee, James R Howe, Hao Li, Maria N Keisler, Shan Shao, Felix H Taschbach, Mackenzie E Lemieux, Faith Aloboudi, Jesse White, May G Chan, Matilde R Borio, Laurel R Keyes, Hannah S Chen, Fabiha Bushra, Gates P Schneider, Dani P Lemon, Kyung J Lee, Alexa […]


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