Predictive Sequence Learning in the Hippocampal Formation

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang, Mia Cameron and Terrence J Sejnowski | Summary: The hippocampus receives sequences of sensory inputs from the cortex during exploration and encodes the sequences with millisecond precision. We developed a predictive autoencoder model of the hippocampus including the trisynaptic and monosynaptic circuits from the entorhinal […]


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A spatial model of autophosphorylation of CaMKII in a glutamatergic spine suggests a network-driven kinetic mechanism for bistable changes in synaptic strength

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B. Kennedy | Summary: Activation of N-methyl-D-aspartate-type glutamate receptors (NMDARs) at synapses in the CNS triggers changes in synaptic strength that underlie memory formation in response to strong synaptic stimuli. The primary target of Ca2+ flowing through […]


Continue.. A spatial model of autophosphorylation of CaMKII in a glutamatergic spine suggests a network-driven kinetic mechanism for bistable changes in synaptic strength

Dynamic categorization rules alter representations in human visual cortex

Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Abstract Everyday perceptual tasks require sensory stimuli to be dynamically encoded and analyzed according to changing behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating […]


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CellBoost: A pipeline for machine assisted annotation in neuroanatomy

Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, Beth Friedman, Jun Takatoh, Fan Wang, David Kleinfeld and Yoav Freund | Summary: One of the important yet labor intensive tasks in neuroanatomy is the identification of select populations of cells. Current high-throughput techniques enable marking cells with histochemical fluorescent molecules as well as through the genetic […]


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Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis

Kavli Affiliate: Anders Dale | Authors: Atle Eskeland Rimehaug, Anders M. Dale, Anton Arkhipov and Gaute T. Einevoll | Summary: The local field potential (LFP), the low-frequency part of the extracellular potential, reflects transmembrane currents in the vicinity of the recording electrode. Thought mainly to stem from currents caused by synaptic input, it provides information […]


Continue.. Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis

Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus

Kavli Affiliate: Terrence Sejnowski | Authors: Dana E Cobb-Lewis, Anne George, Shannon Hu, Katherine Packard, Mingyuan Song, Oliver Nguyen-Lopez, Emily Ikematsu Tesone, Jhanay Rowden, Julie Wang and Maya Opendak | Summary: Long-term potentiation (LTP) has become a standard model for investigating synaptic mechanisms of learning and memory. Increasingly, it is of interest to understand how […]


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Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition

Kavli Affiliate: Elizabeth Hillman, Mark Ellisman and Darcy Peterka | Authors: Alexander R. Goldberg, Athanassios Dovas, Daniela Torres, Sohani Das Sharma, Angeliki Mela, Edward M. Merricks, Markel Olabarria, Leila Abrishami Shokoohm, Hanzhi T. Zhao, Corina Kotidis, Peter Calvaresi, Ashwin Viswanathan, Matei A. Banu, Aida Razavilar, Tejaswi D. Sudhakar, Ankita Saxena, Cole Chokran, Nelson Humala, Aayushi […]


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Long range projections of oxytocin neurons in the marmoset brain

Kavli Affiliate: Cory Miller | Arthur Lefevre, Jazlynn Meza and Cory Miller | Summary: The neurohormone oxytocin (OT) has become a major target for the development of novel therapeutic strategies to treat psychiatric disorders such as autism spectrum disorder because of its integral role in governing many facets of mammalian social behavior. Whereas extensive work […]


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Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry

Kavli Affiliate: Timothy Brown | Pratik Kumar, Alina Gutu, Amelia Waring, Timothy A Brown, Luke D Lavis and Alison G. Tebo | Summary: Chemigenetic tags are versatile labels for fluorescence microscopy that combine some of the advantages of genetically encoded tags with small molecule fluorophores. The Fluorescence Activating and absorbance Shifting Tags (FASTs) bind a […]


Continue.. Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry