Loss of Adaptive Capacity Drives Climate Vulnerability Across Taxonomic Scales in an Alpine Specialist Species Complex

Kavli Affiliate: Timothy Brown | Authors: Kristen C Ruegg, Christen M Bossu, Reza Goljani Amirkhiz, Nikunj Goel, Erica CN Robertson, Timothy M Brown, Kathryn Bernier, Ben J Vernasco, Peri E Bolton, Erik R Funk, Scott A Taylor, Mevin B Hooten and Erika S Zavaleta | Summary: Accelerated warming at high elevations is having a disproportionate […]


Continue.. Loss of Adaptive Capacity Drives Climate Vulnerability Across Taxonomic Scales in an Alpine Specialist Species Complex

Vision shapes neural maps of space through an ancient midbrain pathway

Kavli Affiliate: Massimo Scanziani and Jeanne Paz | Authors: Joshua M. Brenner, Sarah Ruediger, Cameron Wilhite, Josue M. Regalado, Yuta Senzai, Yuliya Voskobiynyk, Jeanne T. Paz, Massimo Scanziani and Riccardo Beltramo | Summary: Mammals rely on their senses to establish their position in space. Neural activity in the hippocampus maps position, yet how sensory signals […]


Continue.. Vision shapes neural maps of space through an ancient midbrain pathway

Upregulated SEMA3C in astrocytes contributes to Rett Syndrome phenotypes

Kavli Affiliate: Nicola Allen | Authors: Krissy A Lyon, Adrien Paumier, Ananya Kandikonda, Andrea Melendez and Nicola J Allen | Summary: Astrocytes support neuronal function during development through secreted proteins, yet how astrocyte-secreted cues are altered in disease states and contribute to neurodevelopmental disorders remains poorly defined. Rett syndrome (RTT) is a regressive neurodevelopmental disorder […]


Continue.. Upregulated SEMA3C in astrocytes contributes to Rett Syndrome phenotypes

Loss of Adaptive Capacity Drives Climate Vulnerability Across Taxonomic Scales in an Alpine Specialist Species Complex

Kavli Affiliate: Timothy Brown | Authors: Kristen C Ruegg, Christen M Bossu, Reza Goljani Amirkhiz, Nikunj Goel, Erica Robertson, Timothy M Brown, Kathryn Bernier, Ben J Vernasco, Peri E Bolton, Erik R Funk, Scott A Taylor, Mevin B Hooten and Erica S Zavaleta | Summary: Accelerated warming at high elevations is having a disproportionate impact […]


Continue.. Loss of Adaptive Capacity Drives Climate Vulnerability Across Taxonomic Scales in an Alpine Specialist Species Complex

Compressed Cortical Input Separates Control from Dynamics in Striatum

Kavli Affiliate: Marcelo Mattar | Authors: Sreejan Kumar, Matthieu B Le Cauchois, Alexander Mathis, Lea Duncker, Jonathon R. Howlett and Marcelo G. Mattar | Summary: The dorsolateral striatum (DLS) supports diverse time-sensitive behaviors—action chunking, duration estimation, and motor timing—yet no single framework is able to explain all of these phenomena. Here, we propose that the […]


Continue.. Compressed Cortical Input Separates Control from Dynamics in Striatum

Novel visuomotor adaptation paradigm reveals a role of visual cortex in the plasticity of innate behaviors in mice

Kavli Affiliate: Massimo Scanziani | Authors: Ellery Jones and Massimo Scanziani | Summary: A long-standing hypothesis in sensory neuroscience suggests that the evolutionary expansion of cortex in mammals may contribute to sensory-dependent adaptation by acting on subcortical pathways that drive innate behavior. However, direct experimental evidence is lacking. Taking the visual system as a model, […]


Continue.. Novel visuomotor adaptation paradigm reveals a role of visual cortex in the plasticity of innate behaviors in mice

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

Kavli Affiliate: Mark Ellisman | Authors: Zhaoqi Yan, Andrew S Mendiola, Kelli Lauderdale, Keun-Young Kim, Yu Yong, Kun Leng, Eric A Bushong, Renaud Schuck, Anke Meyer-Franke, Ayushi Agrawal, Michela Traglia, Natalie Gill, Reuben Thomas, Jonah N Keller, Nikolaos Karvelas, Miguel F Vasquez, Daniel C Ballard, Matthew Madany, Jeffrey Simms, Brandon Guo, Reshmi Tognatta, Maria del […]


Continue.. Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer disease-related hyperexcitability and brain network dysfunction

Kavli Affiliate: Mark Ellisman | Authors: Kelli Lauderdale, Zhaoqi Yan, Andrew S. Mendiola, Yutong Zhang, Dakota Mallen, Pranav Nambiar, Erica Brady, Stephanie R. Miller, Rosa Meza Acevedo, Belinda Cabriga, Fred Jiang, Nick Kaliss, Kevin Shen, Jia Shin, Jessica Herbert, Keran Ma, Jae Kyu Ryu, Ayushi Agrawal, Renaud Schuck, Maria del Pilar S. Alzamora, Jorge Sanz-Ros, […]


Continue.. Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer disease-related hyperexcitability and brain network dysfunction

Multiscale Hyperbolic Embedding Reveals Hierarchical Structure in Complex Biological Systems

Kavli Affiliate: Tatyana Sharpee | Authors: Mingchen Yao, Anoop Praturu and Tatyana Sharpee | Summary: The rapid expansion of biological and computational datasets demands scalable methods that support both visualization and quantitative interpretation. Hyperbolic embeddings are well suited to represent hierarchical structure, but existing approaches are limited by fixed curvature assumptions or poor scalability to […]


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Balancing Stability and Flow in Hippocampal Networks via Inductive Bias and Learned Symmetry Breaking

Kavli Affiliate: Terrence Sejnowski | Authors: Margot Wagner, Yusi Chen, Arjun Karuvally, Mia Cameron and Terrence J Sejnowski | Summary: The hippocampus must balance stable memory representations with internally generated sequential dynamics underlying replay and prediction. How hippocampal circuitry achieves both remains unclear. Here, we show that recurrent neural networks trained on prediction tasks converge […]


Continue.. Balancing Stability and Flow in Hippocampal Networks via Inductive Bias and Learned Symmetry Breaking