The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Anjali Sandhu, Xiaohui Lyu, Xinghaoyun Wan, Xuefeng Meng, Ngang Heok Tang, Gilberto Gonzalez, Ishana N Syed, Lizhen Chen, Yishi Jin and Andrew D Chisholm | Summary: Microtubules (MTs) are dynamic components of the cytoskeleton and play essential roles in morphogenesis and maintenance of tissue and cell integrity. Despite recent […]


Continue.. The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Multiple and subject-specific roles of uncertainty in reward-guided decision-making

Posted by dbos UCSD / Salk

Kavli Affiliate: Angela Yu | Authors: Alexander Paunov, Maëva L’Hôtellier, Zoe He, Dalin Guo, Angela Yu and Florent Meyniel | Summary: Decision-making in noisy, changing, and partially observable environments entails a basic tradeoff between immediate reward and longer-term information gain, known as the exploration-exploitation dilemma. Computationally, an effective way to balance this tradeoff is by […]


Continue.. Multiple and subject-specific roles of uncertainty in reward-guided decision-making

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform […]


Continue.. AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

Representing the dynamics of natural marmoset vocal behaviors in frontal cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: Cory Miller | Authors: Jingwen Li, Mikio Christian Aoi and Cory Miller | Summary: Here we tested the respective contributions of primate premotor and prefrontal cortex to support vocal behavior. We applied a model-based GLM analysis that better accounts for the inherent variance in natural, continuous behaviors to characterize the activity of neurons […]


Continue.. Representing the dynamics of natural marmoset vocal behaviors in frontal cortex

Neurexin drives C. elegans avoidance behavior independently of its post-synaptic binding partner Neuroligin

Posted by dbos UCSD / Salk

Kavli Affiliate: Sreekanth Chalasani | Authors: Caroline S Muirhead, Kirthi C Reddy, Sophia Guerra, Michael Rieger, Michael P Hart, Jagan Srinivasan and Sreekanth H Chalasani | Summary: Neurexins and their canonical binding partners, neuroligins, are localized to neuronal pre-, and post-synapses, respectively, but less is known about their role in driving behaviors. Here, we use […]


Continue.. Neurexin drives C. elegans avoidance behavior independently of its post-synaptic binding partner Neuroligin

Astrocyte CCN1 stabilizes neural circuits in the adult brain

Posted by dbos UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: Laura Sancho, Matthew M Boisvert, Trinity Dawoodtabar, Jillybeth Burgado, Ellen Wang and Nicola J Allen | Summary: Neural circuits in many brain regions are refined by experience. Sensory circuits support higher plasticity at younger ages during critical periods – times of circuit refinement and maturation – and limit plasticity […]


Continue.. Astrocyte CCN1 stabilizes neural circuits in the adult brain

A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: John Serences | Authors: Anna Shafer-Skelton, Timothy F Brady and John T Serences | Summary: Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information from co-occurring features and cues (e.g., the 3D shape […]


Continue.. A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

A series of spontaneously blinking dyes for super-resolution microscopy

Posted by dbos UCSD / Salk

Kavli Affiliate: Timothy Brown | Authors: Katie L. Holland, Sarah E. Plutkis, Timothy A. Daugird, Abhishek Sau, Jonathan B. Grimm, Brian P. English, Qinsi Zheng, Sandeep Dave, Fariha Rahman, Liangqi Xie, Peng Dong, Ariana N. Tkachuk, Timothy A. Brown, Robert H. Singer, Zhe J. Liu, Catherine G. Galbraith, Siegfried M. Musser, Wesley R. Legant and […]


Continue.. A series of spontaneously blinking dyes for super-resolution microscopy

The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

Posted by dbos UCSD / Salk

Kavli Affiliate: Li Zhao | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sayal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


Continue.. The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain

Posted by dbos UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Yishi Jin, Stephan M Blazie, Daniel Fortunati and Yan Zhao | Summary: Protein translation initiation is a complex and conserved process involving many proteins acting in concert. The eukaryotic initiation factor 3 (eIF3) complex is essential for the assembly of the pre-initiation complex that scans and positions mRNA at […]


Continue.. C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain