FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Anders Dale and Wesley Thompson | Authors: Pravesh Parekh, Nadine Parker, Diliana Pecheva, Evgeniia Frei, Marc Vaudel, Diana M. Smith, Alison Rigby, Piotr Jahołkowski, Ida Elken Sønderby, Viktoria Birkenæs, Nora Refsum Bakken, Chun Chieh Fan, Carolina Makowski, Jakub Kopal, Robert John Loughnan, Donald J. Hagler, Jr., Dennis van der Meer, Stefan Johansson, Pål […]


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Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: Caroline Jia, Andrea Tran, Faith Aloboudi, Ella Say, Nick Thao, Christopher R. Lee, Kanha Batra, Amanda Nguyen, Aneesh Bal, Nathaniel N. Nono, Jeremy Delahanty, May G Chan, Laurel R. Keyes, Reesha R. Patel, Romy Wichmann, Felix Taschbach, Yulong Li, Marcus K. Benna, Talmo D Pereira, Hao Li and Kay […]


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A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Tatyana Sharpee and Sreekanth Chalasani | Authors: Iulia Rusu, Zachary T Cecere, Javier J How, Kathleen T Quach, Eviatar Yemini, Tatyana O Sharpee and Sreekanth H Chalasani | Summary: Neurons represent changes in external and internal environments by altering their activity patterns. While coherent brain-wide patterns of neural activity have been observed in […]


Continue.. A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Seizure-induced Transient Disruptive Changes in Brain Microstructure

Posted by dbos UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Akihiro Takamiya, Frank Riemer, Vera Jane Erchinger, Max Korbmacher, Hauke Bartsch, Olga Therese Ousdal, Ivan Maximov, Anders Dale, Louise Emsell, Ketil Joachim Oedegaard, Ute Kessler and Leif Oltedal | Summary: A leading hypothesis for the mechanisms of electroconvulsive therapy (ECT) posits an initial disruptive effect followed by enhanced neuroplasticity. […]


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Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Patrick Leavey, Lizhi Jiang, Nicole Pannullo, Clayton Santiago and Seth BlackshawLyndsey M Kirk, Guadalupe C Garcia, Dakota C Hanka, Kyle Zatyko, Thomas M Bartol, Terrence J Sejnowski and Kristen M. Harris | Summary: Long-term potentiation (LTP) induces presynaptic bouton enlargement and a reduction in the number of synaptic vesicles. […]


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Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pallé, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann and Kay […]


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Synaptic Spine Head Morphodynamics from Graph Grammar Rules for Actin Dynamics

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Matthew Hur, Thomas Bartol, Padmini Rangamani, Terrence Sejnowski and Eric Mjolsness | Summary: There is a morphodynamic component to synaptic learning by which changes in dendritic (postsynaptic) spine head size are associated with the strengthening or weakening of the synaptic connection between two neurons, in response to the temporal […]


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Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Posted by dbos UCSD / Salk, UCSF

Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]


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Glutamate indicators with increased sensitivity and tailored deactivation rates

Posted by klaurent UCSD / Salk

Kavli Affiliate: David Kleinfeld | Authors: Abhi Aggarwal, Adrian Negrean, Yang Chen, Rishyashring Iyer, Daniel Reep, Anyi Liu, Anirudh Palutla, Michael E Xie, Bryan MacLennan, Kenta M Hagihara, Lucas W Kinsey, Julianna L Sun, Pantong Yao, Jihong Zheng, Arthur Tsang, Getahun Tsegaye, Yonghai Zhang, Ronak H Patel, Benjamin J Arthur, Julien Hiblot, Philipp Leippe, Miroslaw […]


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Long-term editing of brain circuits in mice using an engineered electrical synapse

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: Elizabeth Ransey, Gwenaëlle Thomas, Elias Wisdom, Agustin Almoril-Porras, Ryan Bowman, Elise Adamson, Kathryn K Walder-Christensen, Jesse A White, Dalton N Hughes, Hannah Schwennesen, Caly Ferguson, Kay Tye, Stephen D Mague, Long-Gang Niu, Zhao-Wen Wang, Daniel Colón-Ramos, Rainbo Hultman, Nenad Bursac and Kafui Dzirasa | Summary: Electrical signaling across distinct […]


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