A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B Kennedy | Summary: Long-term potentiation (LTP) is a biochemical process in excitatory glutamatergic synapses in the Central Nervous System (CNS). It is initiated by a bout of synaptic activation that is strong enough to contribute to […]


Continue.. A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Edward Callaway | Authors: Rachel M. Cassidy, Angel V. Macias, Willian N. Lagos, Chiamaka Ugorji and Edward M. Callaway | Summary: Corticocortical (CC) projections in the visual system facilitate the hierarchical processing of sensory information. In addition to direct CC connections, indirect cortico-thalamo-cortical (CTC) pathways through the pulvinar nucleus of the thalamus can […]


Continue.. Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Posted by dbos UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Erin M Ritchie, Siming Zhong, Qianyi Pu, Yunbo Li, Binhai Zheng and Yishi Jin | Summary: The conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in neuronal development, axon injury and stress responses, and neurodegeneration, depending on cell-type and cellular contexts. Emerging evidence implicates abnormal DLK signaling in […]


Continue.. Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Control of innate olfactory valence by segregated cortical amygdala circuits

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: James R Howe, Chung-Lung Chan, Donghyung Lee, Marlon Blanquart, Haylie Romero, Abigail N Zadina, Mackenzie E Lemieux, Paula A Desplats, Kay M Tye and Cory M Root | Summary: Animals perform innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or […]


Continue.. Control of innate olfactory valence by segregated cortical amygdala circuits

Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Posted by dbos UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: James Deng, Lara Labarta-Bajo, Ashley N Brandebura, Samuel B Kahn, Antonio F M Pinto, Jolene K Diedrich and Nicola J Allen | Summary: Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder with manifestations spanning molecular, neuroanatomical, and behavioral changes. Astrocytes contribute to FXS pathogenesis and show hundreds of […]


Continue.. Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Brain state and cortical layer-specific mechanisms underlying perception at threshold

Posted by klaurent UCSD / Salk, Yale

Kavli Affiliate: Anirvan Nandy, John Reynolds | Authors: Mitchell P Morton, Sachira Denagamage, Isabel J Blume, John H Reynolds, Monika P Jadi and Anirvan S Nandy | Summary: Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in […]


Continue.. Brain state and cortical layer-specific mechanisms underlying perception at threshold

Low-dimensional olfactory signatures of fruit ripening and fermentation

Posted by dbos UCSD / Salk

Kavli Affiliate: Tatyana Sharpee | Authors: Yuansheng Zhou, Thomas F O’Connell, Majid Ghaninia, Brian Smith, Elizabeth J Hong and Tatyana O Sharpee | Summary: Odors provide an important communication channel between plants and animals. Fruits, vital nutrient sources for animals, emit a complex array of monomolecular volatiles. Animals can use the structure of these mixtures […]


Continue.. Low-dimensional olfactory signatures of fruit ripening and fermentation

Posterior parietal cortex maps progress along routes sharing the same meta-structure

Posted by dbos UCSD / Salk

Kavli Affiliate: Douglas Nitz | Authors: Alexander B Johnson and Douglas A Nitz | Summary: Neurons of posterior parietal cortex were recorded as rats performed a working memory task within a network of intersecting paths. The specific routes utilized in task performance provided opportunity to contrast responses of posterior parietal cortex sub-populations to linear and […]


Continue.. Posterior parietal cortex maps progress along routes sharing the same meta-structure

Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study

Posted by dbos UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Lin Li, Mohammadreza Bayat, Timothy Hayes, Wesley K. Thompson, Arianna Morgan Sandmark Gard and Anthony Steven Dick | Summary: This paper addresses the challenges of managing missing values within expansive longitudinal neuroimaging datasets, using the specific example of data derived from the Adolescent Brain and Cognitive Development ABCD study. […]


Continue.. Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study

Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark H. Tuszynski; | Authors: Pabitra K Sahoo, Nick Hanovice, Patricia Ward, Manasi A Agrawal, Terika P Smith, HaoMin SiMa, Jennifer N Dulin, Lauren S Vaughn, Mark Tuszynski, Kristy Welshhans, Larry Benowitz, Arthur English, John D Houle and Jeffery L Twiss | Summary: Depletion or inhibition of core stress granule proteins, G3BP1 in […]


Continue.. Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration