The mechanotransduction channel Piezo2 refines axonal projections to the accessory optic system and regulates the optokinetic reflex

Posted by dbos Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Natalie R Hamilton, Victoria N Neckles, Timour Al-Khindi, Nitya Donthi, Shun Mizutori, Renata Fu, James K Kiraly, Bea C Winship, Alex L Kolodkin and Karina Chaudhari | Summary: The optokinetic reflex (OKR) is an evolutionarily conserved reflexive behavior that ensures image stabilization on the retina during global motion. It […]


Continue.. The mechanotransduction channel Piezo2 refines axonal projections to the accessory optic system and regulates the optokinetic reflex

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses

Posted by dbos Rockefeller

Kavli Affiliate: Daniel Mucida | Authors: Marwa Saad, Alexandra Thoms, Yue S. Yin, Izabela Mamede, Afsana Rahman, Ruonan Chen, Sebastian E. Carrasco, Patrick W. Darcy, Norihiro Goto, Sohail F. Tavazoie, Angelina M. Bilate and Daniel Mucida | Summary: Colorectal cancer (CRC) remains a leading cause of cancer mortality, with most cases refractory to immunotherapy. Distinguishing […]


Continue.. Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses

CryoROLE: describing large inter-domain rotation in single particle cryo-EM

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Chengmin Li, Wooyoung Choi, Hao Wu and Yifan Cheng | Summary: In single particle cryo-EM, analysis of continuous conformational heterogeneity has always been challenging. Both linear and deep learning-based methods treat conformational heterogeneity as perturbations to the consensus average conformation, limiting their capability in analyzing large protein motions. While […]


Continue.. CryoROLE: describing large inter-domain rotation in single particle cryo-EM

Clinical Relevant Immunosuppressive Drugs Differentially Modulate Axonal Outgrowth from Human Stem Cell Derived Neurons

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark H. Tuszynski | Authors: Gunnar H.D. Poplawski, Chase Weinholtz, Grace Woodruff, Ruhel Ahmad, Wyatt Bunner, Rodrigo Gonzales and Mark H. Tuszynski | Summary: Neural stem cell (NSC) transplantation is a promising strategy for repairing the injured spinal cord, but transplanted cells typically require immunosuppressive therapy to prevent rejection—even for induced pluripotent stem […]


Continue.. Clinical Relevant Immunosuppressive Drugs Differentially Modulate Axonal Outgrowth from Human Stem Cell Derived Neurons

Uncovering internal states with a robust shared-state multi-neuron GLM-HMM framework

Posted by dbos Hopkins

Kavli Affiliate: Adam S. Charles and Patricia Janak | Authors: Aamna Lawrence, Eva Yezerets, Patricia H Janak and Adam Charles | Summary: Neural systems exhibit multiple firing states that reflect an organism’s internal state and modulate the relationship between external environmental stimuli and behavior. Several studies have inferred these latent states by supplementing the traditional […]


Continue.. Uncovering internal states with a robust shared-state multi-neuron GLM-HMM framework

A 3D Brain Geometry Toolkit for Multisite Neuroimaging Analysis

Posted by dbos UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Yanghee Im, Melody J.Y. Kang, Boris A. Gutman, Pravesh Parekh, Diliana Pecheva, Anders M. Dale, Ole A. Andreassen, Paul M. Thompson, Christopher R.K. Ching and for the ENIGMA Bipolar Disorder Working Groupz | Summary: Compared to traditional gross volumetrics, surface-based models provide greater spatial precision for understanding brain alterations […]


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Host species background, defence systems, and phage tail gene architecture shape phage infectivity in cystic fibrosis-associated Achromobacter

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Anita Tarasenko, Bhavya Papudeshi, Van Nguyen, Susanna Rose Grigson, George Bouras, Vijini Mallawaarachchi, Abbey Louise, Kelly Hutton, Renee Green, Jack Ramsay, Hamza Hajama, Ana Georgina Cobian-Guemes, Anca Mara Segall, Morgyn Warner, Sarah Giles, Clarice Harker and Robert A Edwards | Summary: Achromobacter species are emerging multidrug-resistant (MDR) pathogens in people […]


Continue.. Host species background, defence systems, and phage tail gene architecture shape phage infectivity in cystic fibrosis-associated Achromobacter

Synaptic activity controls local exposure of an ‘eat-me’ signal via ANO3-ITPR1 signaling

Posted by dbos UCSF

Kavli Affiliate: Lily Jan | Authors: Kunal Shroff, Molly C O’Brien, Tyler J Smith, Jialing Fang, Kelly S Yu, Sonia I Lombroso, Shengjie Feng, Chao Chen, Gregory A Mohl, Indigo V L Rose, Nidhi R Lokesh, Mark E Pownall, Lily Y Jan and Martin Kampmann | Summary: Neuronal synapses are eliminated during brain development and […]


Continue.. Synaptic activity controls local exposure of an ‘eat-me’ signal via ANO3-ITPR1 signaling

Mammal placental phenotypes are predictable from microRNA repertoires.

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Jonathan Fenn, Jessica C Edge, Vladimir Ovchinnikov, Olga Amelkina, Melea Sinclair, Tiago H C De Bem, Alessandra Bridi, Irene Malo-Estepa, Angela Gonella-Diaza, Felipe Perecin, Juliano C da Silveira, Guilherme Pugliesi, Flavio Vieira Meirelles, Zenab Butt, Haidee Tinning, Giulio Formenti, Erich Jarvis, Bastian Fromm, James O McInerney, Niamh Forde and […]


Continue.. Mammal placental phenotypes are predictable from microRNA repertoires.

High-fidelity rare structural variant detection with HiFiRE3 reduced representation via restriction enzyme ends

Posted by dbos UCSF

Kavli Affiliate: Bjoern Schwer | Authors: Joseph A Stewart, Jeanmarie Mishler, Samreen Ahmed, Bjoern Schwer, Thomas W. Glover and Thomas E Wilson | Summary: High-fidelity detection of rare structural variants (SVs) remains challenging because library preparation and sequencing techniques generate artifactual junctions that obscure true single-molecule events. Here, we present HiFiRe3, an error-minimized sequencing framework […]


Continue.. High-fidelity rare structural variant detection with HiFiRE3 reduced representation via restriction enzyme ends