Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]


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WITHDRAWN: CEBPB as a potential biomarker for prognosis and immuneinfiltration in clear cell renal cell carcinoma

Kavli Affiliate: Wei Min | Authors: Yaoqiang Ren, Baoping Qiao, Min Wei, Quanfa Tian and Wenke Guo | Summary: The authors have withdrawn this manuscript because [an error in the figures or improper use of them]. Therefore, the authors do not wish this work to be cited as reference for the project. If you have […]


Continue.. WITHDRAWN: CEBPB as a potential biomarker for prognosis and immuneinfiltration in clear cell renal cell carcinoma

Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons

Kavli Affiliate: Darcy Peterka | Authors: Eddy Albarran, Akira Fushiki, Anders Nelson, David Ng, Corryn Chaimowitz, Laudan Nikoobakht, Tanya Sippy, Darcy S Peterka and Rui M Costa | Summary: The basal ganglia and midbrain dopaminergic systems are critical for motor control, reward processing, and reinforcement learning, with dysfunction in these systems implicated in numerous neurodegenerative […]


Continue.. Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons

Credit Assignment via Behavioral Timescale Synaptic Plasticity: Theoretical Frameworks

Kavli Affiliate: Rui Costa | Authors: Ian Cone, Claudia Clopath and Rui Ponte Costa | Summary: Behavioral Timescale Synaptic Plasticity (BTSP) is a form of synaptic plasticity in which dendritic Ca2+ plateau potentials in hippocampal pyramidal neurons drive rapid place field formation. Unlike traditional learning rules, BTSP learns correlations on the timescales of seconds and […]


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The selective dynamics of interruptions at short tandem repeats

Kavli Affiliate: Michael Goldberg | Authors: Michael E Goldberg, Harriet Dashnow, Kelley Harris and Aaron R Quinlan | Summary: Short tandem repeats (STRs) are hotspots of genomic instability that mutate at rates orders of magnitude greater than non-repetitive loci due to frequent replication slippage. Expansions at some STR loci cause Mendelian diseases, while variation at […]


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From Morphology to Computation: How Synaptic Organization Shapes Place Fields in CA1 Pyramidal Neurons

Kavli Affiliate: Attila Losonczy | Authors: Simone Tasciotti, Daniel Maxim Iascone, Spyridon Chavlis, Luke Hammond, Yardena Katz, Attila Losonczy, Franck Polleaux and Panayiota Poirazi | Summary: The synaptic mechanisms driving feature selectivity in specific neuron types remains a fundamental and unresolved challenge in neuroscience. In hippocampal CA1 pyramidal neurons (PNs), the development of place selectivity, […]


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Condenzymes: Biomolecular condensates with inherent catalytic activities

Kavli Affiliate: Wei Min | Authors: Michael W Chen, Xiao Guo, Mina Farag, Naixin Qian, Xiaowei Song, Anton Ni, Vicky Liu, Xia Yu, Yuefeng Ma, Leshan Yang, Wen Yu, Matthew King, Joonho Lee, Richard N Zare, Wei Min, Rohit V Pappu and Yifan Dai | Summary: We report the discovery that chemical reactions can be […]


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Theory of interaction between untuned modulatory inputs and tuned sensory inputs

Kavli Affiliate: Kenneth Miller | Authors: Tuan Nguyen, Agostina Palmigiano and Kenneth D Miller | Summary: How does the brain integrate sensory inputs with non-feature-tuned signals, such as those arising from behavioral state changes or neuromodulation? Here, we show that the dynamics of disordered E/I networks with structured, feature-dependent connectivity can be well characterized by […]


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Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae

Kavli Affiliate: Scott Small | Authors: Clara T Rehmann, Scott T Small, Peter L Ralph and Andrew D. Kern | Summary: As organisms adapt to environmental changes, natural selection modifies the frequency of non-neutral alleles. For beneficial mutations, the outcome of this process may be a selective sweep, in which an allele rapidly increases in […]


Continue.. Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae

A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Kavli Affiliate: Rafael Yuste | Authors: Kengo Takahashi, Gerhardus Jan Huis in ‘t Veld, Davide Benedetti, Jun-Ying Wang, Samuel Pontes Quero, Rafael Yuste, Cyriel M.A. Pennartz and Umberto Olcese | Summary: Many techniques to record and manipulate neuronal activity across large portions of the vertebrate brain, such as widefield and two-photon calcium imaging, electrophysiology, and […]


Continue.. A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics