Kavli Affiliate: Rafael Yuste | Authors: Justin Lines and Rafael Yuste | Summary: During sleep onset (i.e. hypnagogia), visual hallucinations can occur in healthy human subjects following prolonged sensory experience. These percepts at sleep onset also occur in amnesiac patients and have signatures in human scalp electroencephalography recordings, suggesting a cortical origin. At the cellular […]
Kavli Affiliate: Richard Axel and Stavros Lomvardas | Authors: Tessa G. Montague, Connor J. Gibbons, G. Thomas Barlow, Elizaveta V. Bashkirova, Yilan Xu, Eva C. Castagna, Thomas J. Mungioli, Kelly A. Patrick, Adriana Nemes, Aalok Varma, Loren L. Looger, Caroline B. Albertin, Stavros Lomvardas and Richard Axel | Summary: Coleoid cephalopods (cuttlefish, octopus, and […]
Kavli Affiliate: Rui Costa | Authors: Annie Park, Bhagyashree Senapati, Nino Mancini, Youchong Zhang, Juliana Choi, Ian Cone, Christoph D Treiber, Rui Ponte Costa, Lisa M Fenk, Salil Sanjay Bidaye and Scott Waddell | Summary: Internal states such as hunger dynamically reshape activity across circuits to support resource seeking. Neuromodulation provides a means of controlling […]
Kavli Affiliate: Daniel Salzman | Authors: Evan J. Kyzar, Ruby Setara, Maya Eisengart, Sophia Virkar, Lydia Rogerson, Alejandro Ramirez and C. Daniel Salzman | Summary: 4-hydroxytamoxifen (4-OHT) is commonly used to facilitate activity-dependent recombination in neurons. Here we show that one dose of 4-OHT devalues alcohol, contexts, and tastants, indicating that experimental designs using 4-OHT […]
Kavli Affiliate: Michael Shadlen | Authors: NaYoung So, Ariel Zylberberg and Michael N Shadlen | Summary: Perceptual decisions are widely modeled as the accumulation of evidence to a bound. In the lateral intraparietal area (LIP), this computation is thought to be implemented in a low-dimensional population representation organized around the single action used to report […]
Kavli Affiliate: Attila Losonczy | Authors: Andor Domonkos, Daniel Schlingloff, Balint Kiraly, Litsa Ledri, Marta Jelitai, Gergely Turi, Rita M Karlocai, Edit Papp, Panna Hegedus, Gabor Nyiri, Attila I Gulyas, Tamas F Freund, Karl Deisseroth, Attila Losonczy, Balazs Hangya and Viktor Varga | Summary: Encoding novel experiences and retrieving stored information rely on the hippocampal […]
Kavli Affiliate: Kenneth Miller | Authors: Yue Kris Wu and Kenneth D Miller | Summary: Paradoxical responses, in which excitatory perturbations of inhibitory neurons reduce their firing rates, are widely regarded as a hallmark of inhibition-stabilized networks (ISNs) and have been observed in multiple brain regions. However, because brain regions are interconnected by long-range projections, […]
Kavli Affiliate: Kenneth Miller | Authors: Elenora Kelley, Emmet Thompson, Ahliya Harding, Katie Torrey, Kai Gurnoe Brantley, Chunyu Lin, Anders Bach, Kenneth A Miller and David J. Blake | Summary: Visceral leishmaniasis (VL) is a neglected tropical disease caused by the protozoan parasites Leishmania infantum (LI) and Leishmania donovani (LD). VL disproportionately affects populations that live in extreme poverty […]
Kavli Affiliate: Loren Frank, Massimo Scanziani, and Razi Haque | Authors: Kyu Hyun Lee, Philip Adenekan, Fan Gao, Jenny Zhou, Jose Hernandez, Allison Yorita, Razi Haque, Kenneth Kay, Massimo Scanziani and Loren Frank | Summary: Primary visual cortex (V1) is a critical substrate for mammalian vision. Traditionally, visual inputs are thought to be the main […]
Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Ian Anton Oldenburg, Kenneth D Miller and Agostina Palmigiano | Summary: Optogenetics enables causal manipulation of cortical activity. Perturbation responses can be counterintuitive due to network interactions, making theory essential for predicting them. Existing approaches often rely on linear approximations, which fail for many biologically relevant […]