The representational geometry of emotional states in basolateral amygdala

Kavli Affiliate: Stefano Fusi, Daniel Salzman | Authors: Pia-Kelsey O’Neill, Lorenzo Posani, Jozsef Meszaros, Phebe Warren, Carl E. Schoonover, Andrew J.P. Fink, Stefano Fusi and C. Daniel Salzman | Summary: Sensory stimuli associated with aversive outcomes can cause multiple behavioral responses related to an animal’s evolving emotional state. We employed chemogenetic inactivation and two-photon imaging […]


Continue.. The representational geometry of emotional states in basolateral amygdala

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

Kavli Affiliate: Seth Blackshaw | Authors: Dong Won Kim, Soohyun Kim, Jeong Han, Karan Belday, Emily Li, Nicholas Mahoney, Seth Blackshaw and Fatemeh Rajaii | Summary: Despite recent advances in the treatment of thyroid eye disease (TED), significant gaps remain in our understanding of the underlying molecular mechanisms, particularly concerning the insulin-like growth factor-1 receptor […]


Continue.. Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings

Kavli Affiliate: Xiaoqin Wang | Authors: Liam Paninski and Nathaniel Sawtell | Summary: To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single neuron and single spike resolution. Extracellular electrophysiology delivers this, but it has biases in the neurons it detects and it imperfectly resolves their […]


Continue.. Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings

behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

Kavli Affiliate: Attila Losonczy | Authors: Kyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Bartholomew Starich, Jeremy Walston, Ashley L Kiemen, Sashank Reddy, Corrine Joshu, Joel Sunshine, Denis Wirtz and Pei-Hsun Wu | Summary: Investigators conducting behavioral experiments often need precise control over the timing of the delivery of stimuli […]


Continue.. behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

A mathematical theory of relational generalization in transitive inference

Kavli Affiliate: Vincent Ferrera | Authors: Samuel Lippl, Kenneth Kay, Greg Jensen, Vincent P. Ferrera and L.F. Abbott | Summary: Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items (“compositional generalization”). This allows them to respond appropriately to radically novel circumstances and is fundamental […]


Continue.. A mathematical theory of relational generalization in transitive inference

Learning enhances behaviorally relevant representations in apical dendrites

Kavli Affiliate: Elizabeth Hillman | Authors: Sam E. Benezra, Kripa B. Patel, Citlali Pérez Campos, Elizabeth M. C. Hillman and Randy M Bruno | Summary: Learning alters cortical representations and improves perception. Apical tuft dendrites in Layer 1, which are unique in their connectivity and biophysical properties, may be a key site of learning-induced plasticity. […]


Continue.. Learning enhances behaviorally relevant representations in apical dendrites

2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

Kavli Affiliate: Attila Losonczy | Authors: Jingcheng Shi, Boaz Nutkovich, Dahlia Kushinsky, Bovey Y Rao, Stephanie A Herrlinger, Tiberiu S Mihaila, Katayun Cohen-Kashi Malina, Cliodhna K OToole, Margaret E Conde Paredes, Hyun C Yong, Erdem Varol, Attila Losonczy and Ivo Spiegel | Summary: Neural circuits are characterized by genetically and functionally diverse cell types. A […]


Continue.. 2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

Cephalopod Sex Determination and its Ancient Evolutionary Origin Revealed by Chromosome-level Assembly of the California two-spot Octopus

Kavli Affiliate: Scott Small | Authors: Gabrielle C. Coffing, Silas Tittes, Scott T. Small, Jeremea O. Songco-Casey, Denise M. Piscopo, Judit R. Pungor, Adam C Miller, Cristopher Niell and Andrew D. Kern | Summary: Sex chromosomes are critical elements of sexual reproduction in many animal and plant taxa, however they show incredible diversity and rapid […]


Continue.. Cephalopod Sex Determination and its Ancient Evolutionary Origin Revealed by Chromosome-level Assembly of the California two-spot Octopus

Distal tuft dendrites shape and maintain new place fields

Kavli Affiliate: Franck Polleux Attila Losonczy | Authors: Justin K. O’Hare, Jamie Wang, Margjele D. Shala, Franck Polleux and Attila Losonczy | Summary: Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new ‘place fields’. Distal tuft dendrites are thought to initiate place field formation via plateau potentials. However, the hitherto experimental […]


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Towards robust and generalizable representations of extracellular data using contrastive learning

Kavli Affiliate: Liam Paninski | Authors: Ankit Vishnubhotla, Charlotte Loh, Liam Paninski, Akash Srivastava and Cole Lincoln Hurwitz | Summary: Contrastive learning is quickly becoming an essential tool in neuroscience for extracting robust and meaningful representations of neural activity. Despite numerous applications to neuronal population data, there has been little exploration of how these methods […]


Continue.. Towards robust and generalizable representations of extracellular data using contrastive learning