Population Representation of the Confidence in a Decision in the Parietal Cortex

Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg and Michael N Shadlen | Summary: Confidence in a decision is the belief, prior to feedback, that one’s choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information […]


Continue.. Population Representation of the Confidence in a Decision in the Parietal Cortex

The geometry of the neural state space of decisions

Kavli Affiliate: Kenneth Miller | Authors: Mauro M. Monsalve-Mercado and Kenneth D Miller | Summary: How do populations of neurons collectively encode and process information during cognitive tasks? We analyze high-yield population recordings from the macaque lateral intraparietal area (LIP) during a reaction-time random-dot-motion direction-discrimination task. We find that the trajectories of neural population activity […]


Continue.. The geometry of the neural state space of decisions

Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]


Continue.. Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment

Kavli Affiliate: Stefano Fusi and Kenneth Miller | Authors: Mario Dipoppa, Ramon Nogueira, Stéphane Bugeon, Yoni Friedman, Charu B. Reddy, Kenneth D. Harris, Dario L. Ringach, Kenneth D. Miller, Matteo Carandini and Stefano Fusi | Summary: Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic Sensory adaptation dynamically changes neural responses as a […]


Continue.. Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment

The effects of task similarity during representation learning in brains and neural networks

Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, William Jeffrey Johnston, Simone Vigano’, Max Andreas Bosse Hinrichs, Burkhard Maess, Stefano Fusi and Christian F Doeller | Summary: The complexity of our environment poses significant challenges for adaptive behavior. Recognizing shared structures across tasks can theoretically improve learning through generalization. However, how such shared representations emerge […]


Continue.. The effects of task similarity during representation learning in brains and neural networks

Experience-dependent reorganization of inhibitory neuron synaptic connectivity

Kavli Affiliate: Richard Axel | Authors: Andrew Jacob Pixley Fink, Samuel Muscinelli, Shuqi Wang, Marcus I Hogan, Daniel Fine English, Richard Axel, Ashok Litwin-Kumar and Carl E. Schoonover | Summary: Organisms continually tune their perceptual systems to the features they encounter in their environment1–3. We have studied how ongoing experience reorganizes the synaptic connectivity of […]


Continue.. Experience-dependent reorganization of inhibitory neuron synaptic connectivity

Distinct roles of cortical layer 5 subtypes in associative learning

Kavli Affiliate: Rui Costa | Authors: Sara Moberg, Michele Garibbo, Camille Mazo, Ariel Gilad, Dietmar Schmitz, Rui Ponte Costa, Matthew E Larkum and Naoya Takahashi | Summary: Adaptive behavior is critically dependent on associative learning, where environmental cues are linked with subsequent positive or negative outcomes. In mammals, primary neocortical sensory areas serve as pivotal […]


Continue.. Distinct roles of cortical layer 5 subtypes in associative learning

A Brain-Wide Map of Neural Activity during Complex Behaviour

Kavli Affiliate: Liam Paninski | Authors: International Brain Lab, Brandon Benson, Julius Benson, Daniel Birman, Niccolo Bonacchi, Matteo Carandini, Joana A Catarino, Gaelle A Chapuis, Anne K Churchland, Yang Dan, Peter Dayan, Eric EJ DeWitt, Tatiana A Engel, Michele Fabbri, Mayo Faulkner, Ila Rani Fiete, Charles Findling, Laura Freitas-Silva, Berk Gercek, Kenneth D Harris, Michael […]


Continue.. A Brain-Wide Map of Neural Activity during Complex Behaviour

Proactive and reactive construction of memory-based preferences

Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Nathaniel D. Daw and Daphna Shohamy | Summary: We are often faced with decisions we have never encountered before, requiring us to infer possible outcomes before making a choice. Computational theories suggest that one way to make these types of decisions is by accessing and linking related […]


Continue.. Proactive and reactive construction of memory-based preferences

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Kavli Affiliate: Liam Paninski | Authors: Stefano Fusi and Liam Paninski | Summary: The brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations (categorical […]


Continue.. Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy