An emerging view of neural geometry in motor cortex supports high-performance decoding

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Mark Churchland | Authors: Sean M. Perkins, Elom A. Amematsro, John P. Cunningham, Qi Wang and Mark M. Churchland | Summary: Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen to reflect scientific beliefs while yielding tractable computations. Recent scientific advances suggest that the true constraints on neural activity, especially its […]


Continue.. An emerging view of neural geometry in motor cortex supports high-performance decoding

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Ann McDermott | Authors: Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Marko Jovanovic, Ann E McDermott, Daniel A Keedy and Neel H Shah | Summary: The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. […]


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Spectral-switching analysis reveals real-time neuronal network representations of concurrent spontaneous naturalistic behaviors in human brain

Posted by dbos Columbia

Kavli Affiliate: Elizabeth Hillman | Authors: Hongkun Zhu, Andrew J Michalak, Edward M Merricks, Alexander H. C. W. Agopyan-Miu, Joshua Jacobs, Marla J Hamberger, Sameer Sheth, Guy M McKhann, Neil Feldstein, Catherine Schevon and Elizabeth M. C. Hillman | Summary: Despite abundant evidence of functional networks in the human brain, their neuronal underpinnings, and relationships […]


Continue.. Spectral-switching analysis reveals real-time neuronal network representations of concurrent spontaneous naturalistic behaviors in human brain

Biomolecular condensates can function as inherent catalysts

Posted by dbos Columbia

Kavli Affiliate: Wei Min | Authors: Xiao Guo, Mina Farag, Naixin Qian, Xia Yu, Anton Ni, Yuefeng Ma, Wen Yu, Matthew King, Vicky Liu, Joonho Lee, Wei Min, Richard N Zare, Rohit V Pappu and Yifan Dai | Summary: TWe report the discovery that chemical reactions such as ATP hydrolysis can be catalyzed by condensates […]


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A lasting impact of serotonergic psychedelics on visual processing and behavior

Posted by dbos Columbia, Yale

Kavli Affiliate: Darcy Peterka | Authors: Chloe L West, Georgia Bastos, Annabel Duran, Samen Nadeem, David A Ricci, Anna M Rader, Joseph A Wargo, Darcy S Peterka, Neil Van Leeuwen and Jordan P Hamm | Summary: Serotonergic psychedelics (e.g., psilocybin) have shown potential for treating psychiatric disorders, with therapeutic effects lasting weeks after a single […]


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Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Posted by dbos Columbia

Kavli Affiliate: Franck Polleux | Authors: Carlos Diaz-Salazar, Marine A KRZISCH, Juyoun Yoo, Patricia Nano, Aparna Bhaduri, Rudolph Jaenisch and Franck Polleux | Summary: Microglia play key roles in shaping synaptic connectivity during neural circuits development. Whether microglia display human-specific features of structural and functional maturation is currently unknown. We show that the ancestral gene […]


Continue.. Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Reproducibility of in-vivo electrophysiological measurements in mice

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: The International Brain Laboratory, Kush Banga, Julius Benson, Niccolò Bonacchi, Sebastian A Bruijns, Rob Campbell, Gaëlle A Chapuis, Anne K Churchland, M Felicia Davatolhagh, Hyun Dong Lee, Mayo Faulkner, Fei Hu, Julia Hunterberg, Anup Khanal, Christopher Krasniak, Guido T Meijer, Nathaniel J Miska, Zeinab Mohammadi, Jean-Paul Noel, Liam Paninski, […]


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Variable recruitment of distal tuft dendrites shapes new hippocampal place fields

Posted by dbos Columbia

Kavli Affiliate: Attila Losonczy and Franck Polleux | Authors: Justin K. O’Hare, Jamie Wang, Margjele D. Shala, Franck Polleux and Attila Losonczy | Summary: Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new ‘place fields’. Distal tuft dendrites are widely thought to initiate place field formation by locally generating prolonged, globally-spreading […]


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Hypothalamic CRH Neurons Modulate Sevoflurane Anesthesia and The Post-anesthesia Stress Responses

Posted by klaurent Columbia

Kavli Affiliate: Wei Min | Authors: Shan Jiang, Lu Chen, Wei-Min Qu, Zhi-Li Huang and Chang-Rui Chen | Summary: General anesthesia is a fundamental process required to undertake safely and humanely a high fraction of surgeries and invasive diagnostic procedures. However, the undesired stress response associated with general anesthesia (GA) causes delayed recovery and even […]


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The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression

Posted by dbos Columbia

Kavli Affiliate: Steven Siegelbaum; | Authors: Lara M. Boyle, Wanhui Sheng, Felix Leroy, Rhea Sahai, Sarah Irfan, Heon-Jin Lee, Andres Villegas, W. Scott Young and Steven A Siegelbaum | Summary: Although it is well-known that the hippocampus mediates declarative memory (the repository of information of people, places, things and events) and influences behavior, the differential […]


Continue.. The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression