Pervasive Somatic Mutations in NF1 Drive Cell Type and Spatially Specific Clonal Selection in Neurofibromatosis

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Daniel A Snellings, Kow Essuman, Benjamin Finander, Eitan Goodman, Christie Cambridge, Jannis Buecking, Brian Chhouk, Chunhui Cai, Liang Sun, Urmi Ghosh, Michael B. Miller and Christopher A. Walsh | Summary: Tumorigenesis is a multi-step process shaped by the accumulation of somatic driver mutations, but identifying the earliest steps and […]


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Sugarcane’s drought memory legacy: how past stress shapes future resilience

Posted by dbos UCSD / Salk

  Kavli Affiliate: Gabriel Silva | Authors: Maria Dolores Pissolato, Tamires Silva Martins, Marcela Trevenzoli Miranda, Gabriel Silva Pires, Rafael L. Almeida, Larissa Prado Cruz, Leonardo Perez Sousa, Adilson P. Domingues-Jr, Eduardo Caruso Machado, Alisdair R Fernie and Rafael Ribeiro | Summary: Plants frequently experience recurrent drought events separated by periods of rehydration. Although drought […]


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Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis

Posted by dbos NTNU

  Kavli Affiliate: Emre Yaksi | Authors: Hilal Piril Saracoglu, Marwan Nashabat, Duygu Naz Kutlu, Burak Saribas, Elanur Yilmaz, Seymanur Tur, Hulya Kayserili, Emre Yaksi, Nasrin Nabavizadeh and Nathalie Escande-Beillard | Summary: Loss-of-function variants in SNUPN, encoding the nuclear import factor Snurportin-1 (SPN1) required for spliceosomal small nuclear ribonucleoprotein (snRNP) transport, cause a recently described […]


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Divergent Dopamine Dynamics within the Accumbens Core

Posted by dbos UCSF

  Kavli Affiliate: Joshua Berke | Authors: Seongtak Kang, Dennis A Burke, Caroline Kornbrek, Farah Farouq, Huijeong Jeong, Vijay Mohan K Namboodiri and Joshua Berke | Summary: Dopamine in the nucleus accumbens Core powerfully influences motivation and learning, yet the information encoded by Core dopamine remains unresolved. Competing theories typically assume a spatially uniform signal, […]


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Real-time AI integration for MR to detect artifacts and guide pulse sequence adaptations

Posted by dbos Hopkins

  Kavli Affiliate: Jeremias Sulam | Authors: Aaron T. Gudmundson, Zahra Shams, Abdelrahman Gad, Shuyuan Wang, Dunja Simicic, Saipavitra Murali-Manohar, Gizeaddis Lamesgin Simegn, Ipek Özdemir, Christopher W. Davies-Jenkins, Yulu Song, Vivek Yedavalli, Georg Oeltzschner, Omer Burak Demirel, Jeremias Sulam, Michael schär, Sandeep Ganji and Richard A. E. Edden | Summary: This work presents a first-of-its-kind […]


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Generation of a transgenic cephalopod

Posted by dbos Columbia

  Kavli Affiliate: Richard Axel and Stavros Lomvardas | Authors: Tessa G. Montague, Connor J. Gibbons, G. Thomas Barlow, Elizaveta V. Bashkirova, Yilan Xu, Eva C. Castagna, Thomas J. Mungioli, Kelly A. Patrick, Adriana Nemes, Aalok Varma, Loren L. Looger, Caroline B. Albertin, Stavros Lomvardas and Richard Axel | Summary: Coleoid cephalopods (cuttlefish, octopus, and […]


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SpiraMed: A Stereotactic Helix-based Therapy Delivery system for the Human Brain

Posted by dbos UCSF

Kavli Affiliate: David Rowitch | Authors: Harry JCJ Bulstrode, Adam Young, Ifenya Huysman, Dushanth Seevaratnam, King Ki Man, Ho Lim Pak, Grace Wilson, AthenaStamper, Xinyi Wang, Yujun Wang, Xin Tang, An Truong, Saeed Kayhanian, Francisca Ferreira, Mark Plummer, Adam O’Connell, Dominika Bogusiewicz, Daniel Brown, Danny Godfrey, Ronan Daly, George G Malliaras, David H Rowitch, Peter […]


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Axons organize into micro-tracts around the cortical vasculature

Posted by dbos UCSD / Salk

Kavli Affiliate: David Kleinfeld | Authors: Javier Josue How, Bethanny Danskin, Benjamin Pedigo, Elana Marie Memke, Stefan Stamenkovic, David Kleinfeld and Andy Shih | Summary: Neural activity is metabolically costly and supported by local increases in cerebral blood flow. The process by which neural activity drives blood flow increase, neurovascular coupling (NVC), remains poorly understood. […]


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Three dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Jianing Yao, Svitlana V Bach, Ishbel Del Rosario Alvia, Yufeng Du, Sarah E Maguire, Ruth Zhang, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Keri Martinowich, Kristen R Maynard and Stephanie C Hicks | Summary: Spatial transcriptomics has transformed molecular characterization of the human […]


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SCREWx: A Screwless, Chronic, Recoverable, and Lightweight Neuropixels fixture for freely-moving rodents

Posted by dbos Hopkins

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: James Knierim and Kathleen Cullen | Authors: Alexandra Cheng, Tate DeWeese, Yueqing Zhou, Yotaro Sueoka, Sai Koukuntla, Merrill Green, Kathleen Cullen, James Knierim, Austin Graves and Timothy Harris | Summary: High-density Neuropixels probes enable the study of large neural populations […]


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