scATrans: annotating single-cell differential expression as transcription- or stabilization-weighted using unspliced RNA

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Single-cell differential expression (DE) reports changes in mature mRNA abundance, but the same fold-change can reflect faster synthesis or slower decay. Metabolic labeling resolves this ambiguity but is costly and cannot be applied retrospectively to the vast majority of published […]


Continue.. scATrans: annotating single-cell differential expression as transcription- or stabilization-weighted using unspliced RNA

Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Posted by dbos NTNU

Kavli Affiliate: Menno Witter | Authors: Yassir El-Amri, Nelson David Villalba-Moreno, Julia Urban, Maider Alzueta-Torrecillas, Cesar A Valdez-Gaxiola, Juliana Gonzalez-Perez, Zhiyuan Song, Rui Tang, Duvan Cardona-Madrigal, Andres Villegas, Susanne Krasemann, Markus Glatzel, David Aguillon, Asgeir Kobro-Flatmoen, Menno Witter, Victoria Fernandez, Haiqing Zhao, Agustin Ruiz, Claudia Marino and Diego Sepulveda-Falla | Summary: Two PSEN1 E280A carriers have presented […]


Continue.. Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Identifying adaptive variation in spatially structured populations using low-coverage whole-genome sequencing data

Posted by dbos UCSD / Salk

Kavli Affiliate: Timothy Brown | Authors: Nikunj Goel, Christen M. Bossu, Seorim Yi, Erica C. N. Robertson, Timothy M. Brown, Peri E. Bolton, Ben J. Vernasco, Erika Zavaleta, Kristen C. Ruegg and Mevin B. Hooten | Summary: Successful implementation of evolutionary programs to rescue climatically threatened species requires identification of adaptive variation. Although many genotype-environment […]


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SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Posted by dbos Hopkins

  Kavli Affiliate: Adam S. Charles and Kathleen Cullen | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Kathleen E Cullen, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology […]


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Behavioural and neural mechanisms for stochastic choices in mixed strategy games

Posted by dbos Hopkins

  Kavli Affiliate: Daeyeol Lee | Authors: Joanna Aloor, Timothy PH Sit, Oliver M Gauld, Joseph Warren, Matthew Mower, Daeyeol Lee and Chunyu A. Duan | Summary: Adaptive behaviour usually requires exploiting regularities in the environment, but in competitive settings the opposite can be true: predictable choice patterns can be exploited by others, making unpredictability […]


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Real-time AI integration for MR to detect artifacts and guide pulse sequence adaptations

Posted by dbos Hopkins

  Kavli Affiliate: Jeremias Sulam | Authors: Aaron T. Gudmundson, Zahra Shams, Abdelrahman Gad, Shuyuan Wang, Dunja Simicic, Saipavitra Murali-Manohar, Gizeaddis Lamesgin Simegn, Ipek Özdemir, Christopher W. Davies-Jenkins, Yulu Song, Vivek Yedavalli, Georg Oeltzschner, Omer Burak Demirel, Jeremias Sulam, Michael schär, Sandeep Ganji and Richard A. E. Edden | Summary: This work presents a first-of-its-kind […]


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Microglia extract neuronal proteolytic organelles via skoupocytosis

Posted by dbos Hopkins

  Kavli Affiliate: Dwight Bergles | Authors: Renee Pepper, Jacqueline M. Griswold, Frances Middleton-Davis, Sarah Syed, Yuuta Imoto, Lani Tran, Eunbin Park, Yu Kang T. Xu, Dwight Bergles, JoAnn Buchanan and Shigeki Watanabe | Summary: Neurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically […]


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HPRC2: A human pangenome reference with near-complete coverage of common genetic variation

Posted by dbos Rockefeller

  Kavli Affiliate: Erich Jarvis | Authors: Julian K. Lucas, Prajna Hebbar, Wen-Wei Liao, Juan F. Macias-Velasco, Adam M. Novak, Mobin Asri, Jennifer R. Balacco, Andrew P. Blair, Davide Bolognini, Jana Ebler, Joshua M.V. Gardner, Margarita Geleta, Cristian Groza, Andrea Guarracino, Peter Heringer, Glenn Hickey, Sergey Koren, Shuangjia Lu, Maximillian G. Marin, Christopher Markovic, Mira […]


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The Live Concert of Brains: Performer-Audience Neural Coupling Links Ensemble Coordination to Shared Audience Integration

Posted by dbos Hopkins

  Kavli Affiliate: Xiaoqin Wang | Authors: Yue Ding, Jiameng Liu, Yifan Xu, Li Ji, Yubo Gao, Zheng Liang, Yingying Tang, Juan Huang, Xiaoqin Wang and Dan Zhang | Summary: Collective social events often require coordinated action by one group to become shared experience in another, yet how this transformation is organized across multiple brains […]


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Older adults do not have a higher metabolic cost than younger adults in outdoor overground walking.

Posted by dbos Hopkins

  Kavli Affiliate: Michael Miller | Authors: Eline van der Kruk, Koen Jongbloed, Monica Orlandi, Michael Miller and Anne Silverman | Summary: The metabolic cost of walking is widely used to evaluate human performance and effectiveness of clinical interventions. Decades of laboratory research, largely based on treadmill experiments, have established a canonical relationship between walking […]


Continue.. Older adults do not have a higher metabolic cost than younger adults in outdoor overground walking.