Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

Kavli Affiliate: Denis Wirtz | Authors: Kanako Iwasaki, Hui Pan, Jonathan M. Dreyfuss, Maya Jackson, Sergii Domanskyi, Dylan Baker, Priscila Carapeto, Christopher Cahill, Sandra Le, Francesko Hela, Juliana Alcoforado Diniz, Giray Naim Eryilmaz, Fan Wu, Pei-Hsun Wu, Bofei Yu, Denis Wirtz, Sara Espinoza, Alejandro Pena, Francisco G. Cigarroa, Gregory Abrahamian, Jillian L Woodworth, Peter D. […]


Continue.. Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

Naturalistic behavior and self-generated neural activity predictive of self-correction.

Kavli Affiliate: Loren Frank | Authors: Shijie Gu, Chenyan Liu, Anna K. Gillespie, Rhino Nevers, Eric L. Denovellis, Michael E. Coulter, Kenneth Kay and Loren M. Frank | Summary: Changing one’s mind –– revising a past decision independently of external cues –– can lead to better outcomes, but its neural basis remains poorly understood. We […]


Continue.. Naturalistic behavior and self-generated neural activity predictive of self-correction.

Generation and validation of an Acan-Cre mouse line to selectively label Class-B excitatory neurons of the cerebellar nuclei

Kavli Affiliate: Justus M Kebschull | Authors: Julian Cheron, Maggie Lowman, Manjari Anant, Max Siauw and Justus M Kebschull | Summary: The cerebellar nuclei form the main output structures of the cerebellum and are composed of a deeply conserved set of cell types. Two excitatory cell classes, Class-A and -B, are present in each cerebellar […]


Continue.. Generation and validation of an Acan-Cre mouse line to selectively label Class-B excitatory neurons of the cerebellar nuclei

Computational prediction resolves thousands of homooligomeric phage protein structures

Kavli Affiliate: Robert Edwards | Authors: Susanna R Grigson, Natia Geliashvili, Torsten Schubert, George Bouras, Vijini Mallawaarachchi, Marta Bogacz, Ute Hellmich, Robert A Edwards and Bas E. Dutilh | Summary: Bacteriophages (phages) play essential roles in microbial systems, yet most phage proteins remain poorly characterised. Protein tertiary and quaternary structure information contributes valuable information about […]


Continue.. Computational prediction resolves thousands of homooligomeric phage protein structures

Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments

Kavli Affiliate: Patrick Kanold | Authors: Marina Cardoso de Oliveira and Patrick O Kanold | Summary: Listening in complex environments requires the enhancement of relevant sounds and suppression of irrelevant ones. Corticothalamic neurons (CTNs) in auditory cortex layer (L) 6 provide modulatory feedback to thalamic nuclei and to upper cortical layers and are thought to […]


Continue.. Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments

Photon-Resolved Excitation-Denoised (PRED) Three-Photon Imaging Improves Detection of Neuronal Activity in Awake and Behaving Mice

Kavli Affiliate: Attila Losonczy and Darcy Peterka | Authors: Attila Losonczy, Tiberiu S Mihaila, Eunji Kong, Adrian Negrean, Tristan Geiller and Darcy S Peterka | Summary: Three-photon microscopy (3PM) has enabled the optical access of neurons ∼500-1500µm below the brain surface but has been limited to slow imaging frame rates or small imaged area due […]


Continue.. Photon-Resolved Excitation-Denoised (PRED) Three-Photon Imaging Improves Detection of Neuronal Activity in Awake and Behaving Mice

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Boyi Guo, Cindy Fang, Madhavi Tippani, Svitlana V Bach, Ryan A Miller, Sarah E Maguire, Artemis Iatrou, Geo Pertea, Nicholas J Eagles, Madeline R Valentine, Seyun Oh, Aarti Jajoo, Vijetha Balakundi, Yufeng Du, Annie B Nguyen, Ruth Zhang, Uma M Kaipa, Heena R Divecha, Jashandeep S. […]


Continue.. Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

Kavli Affiliate: Denis Wirtz | Authors: Tushar D Nichakawade, Brian Mog, Alexander D Pearlman, Taha S. Ahmedna, Nikita Marcou, Ricardo Mora-Cartin, Evangeline Watson, Bum Seok Lee, Sarah R. DiNapoli, Nickolas Papadopoulos, Chetan Bettegowda, Marco Dal Molin, Denis Wirtz, Drew M. Pardoll, Suman Paul, Surojit Sur, Kathleen L. Gabrielson, Shibin Zhou, Bert Vogelstein and Kenneth W. […]


Continue.. Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors

Kavli Affiliate: Richard Huganir | Authors: Sohum Mehta, Nidhi A. Thaker, Kengo Adachi, Christopher Y. Ko, Bian Liu, Sai S. Divkaruni, Oguz C. Koc, Anne C. Lyons, Samantha A. Sanchez, Pauline Löffler, Yoshihisa Nakahata, Jody L. Martin, Jared L. Johnson, Tomer M. Yaron-Barir, Lewis C. Cantley, Martin J. Lohse, Andreas Bock, Donald M. Bers, Ryohei […]


Continue.. Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors

Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Jing Hui Adeline J. H. Yong, Yuh Nung Jan, Yayu Wang, Juan A Oses-Prieto, Tong Cheng, Chao Chen, Mario V Zubia, Alma Burlingame, Lily Y Jan, Nicholas T Ingolia and J. Wren Kim | Summary: Synapses are dynamic structures whose protein composition remodels in response […]


Continue.. Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses