Protocol for genotyping cephalopod sex using a skin swab and quantitative PCR

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Scott Small | Authors: Tessa G Montague, Frederick A Rubino, Connor J Gibbons, Thomas J Mungioli, Scott T Small, Gabrielle C Coffing and Andrew D. Kern | Summary: The coleoid cephalopods (octopus, cuttlefish, and squid) are emerging model organisms for […]


Continue.. Protocol for genotyping cephalopod sex using a skin swab and quantitative PCR

Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Michael Miller | Authors: Mei-Lin Okino, Han Zhu, Sierra Corban, Paola Benaglio, Jovina Djulamsah, Bailey OMahony, Kennedy Vanderstel, Ruth Elgamal, Michael Miller, Allen Wang, Maike Sander and Kyle J Gaulton | Summary: Endoplasmic reticulum (ER) stress in pancreatic beta cells […]


Continue.. Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk

Eye-head coordination during goal-directed orienting in mice

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kathleen Cullen | Authors: Brandie Morris Verdone, Hui Ho Vanessa Chang, Dale C Roberts and Kathleen E Cullen | Summary: In afoveate species such as mice, it is accepted that gaze is typically redirected by head movements with a saccade-and-fixate […]


Continue.. Eye-head coordination during goal-directed orienting in mice

Baktfold: Sensitive protein functional annotation across the microbial tree of life using structural information

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Robert Edwards | Authors: George Bouras, Sung.won Lim, Lindsay Durr, Sarah Vreugde, Alexander Goesmann, Robert A Edwards and Oliver Schwengers | Summary: The functional annotation of protein sequences has undergone tremendous progress over recent years, but still too-many protein sequences […]


Continue.. Baktfold: Sensitive protein functional annotation across the microbial tree of life using structural information

PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gαq

Kavli Affiliate: Roderick MacKinnon | Authors: Maria Falzone, Priyam Banerjee and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 from the plasma membrane, producing IP3 and DAG, which regulate intracellular Ca2+ levels and protein kinase C activity, respectively. They are regulated by GPCR signaling through the G proteins Gβγ and Gαq and have been shown […]


Continue.. PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gαq

A Three-dimensional Analytical Framework for Retinal Microvasculature Reveals Layer-associated Vulnerability in Development and Neovascular Remodeling

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Xin Duan | Authors: Wenhao Shang, Guiying Hong, William E Keller, Ryan A Morton, Pierre Zeboulon, Toma Kenichi, Xin Duan, Douglas B Gould and Tyson N Kim | Summary: The neurosensory retina is one of the most metabolically active tissues […]


Continue.. A Three-dimensional Analytical Framework for Retinal Microvasculature Reveals Layer-associated Vulnerability in Development and Neovascular Remodeling

eSIG-Net: Accurate prediction of single-mutation induced perturbations on protein interactions using a language model

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Li Zhao | Authors: Xingxin Pan, Aditya Shrawat, Sidharth Raghavan, Chuanpeng Dong, Yuntao Yang, Zhao Li, W. Jim Zheng, S. Gail Eckhardt, Erxi Wu, Juan I Fuxman Bass, Daniel F Jarosz, Sidi Chen, Daniel J McGrail, Gloria M Sheynkman, Jason […]


Continue.. eSIG-Net: Accurate prediction of single-mutation induced perturbations on protein interactions using a language model

Inhibitory-modulatory coupling generates persistent activity during working memory

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Dhruv Grover | Authors: Marissa L Heintschel, Jingyue Xu and Dhruv Grover | Summary: Working memory requires the stable maintenance of neural representations across temporal gaps, yet the circuit mechanisms that generate and stabilize persistent activity remain unsolved. Prevailing models […]


Continue.. Inhibitory-modulatory coupling generates persistent activity during working memory

Epigenomic methylome landscape of promoters in vertebrate genomes

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Young Ho Lee, Chul Lee, Erich Jarvis and Heebal Kim | Summary: Genomic promoters are crucial gene regulatory elements1,2. Yet, comparative analyses of promoter architecture have been constrained by the limited resolution of GC-rich regions in […]


Continue.. Epigenomic methylome landscape of promoters in vertebrate genomes

The diploid reference genome of a human embryonic stem cell line

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Ivana Pacar, Matteo Tommaso Ungaro, Ying Chen, Hamza Dallali, Jack A. Medico, Prajna Hebbar, Mark Diekhaus, Elena Di Tommaso, Margarita Geleta, Patricia P. Chan, Todd M. Lowe, Jennifer Balacco, Nivesh Jain, Francine Ackerman, Michela Mochi, Alexander […]


Continue.. The diploid reference genome of a human embryonic stem cell line