Kavli Affiliate: Pietro De Camilli | Authors: Yumei Wu, Peng Xu, James Moran, C. Shan Xu, Kenneth J. Hayworth, Mian Cao, Lin Shao, D. James Surmeier, Harald F. Hess and Pietro De Camilli | Summary: Synaptojanin 1 is a brain enriched phosphoinositide phosphatase implicated in endocytosis at the synapse. A mutation (R258Q) that selectively impairs […]
Kavli Affiliate: Michael W. Young | Authors: Michael J Young, Fabricio Cotera, Clare C. C. Gill, Jacob A. Lewis, Frank G. Whitby, Alaa Abdellatif, Joana L. Rocha, Michael Singer, Mike A Nalls, Faraz Faghri, Peter H Sudmant, Owen Pornillos and Molly Ohainle | Summary: Of the two lineages of lentivirus that endemically infect chimpanzees, only […]
Kavli Affiliate: Vanessa Ruta and Priya Rajasethupathy | Authors: James Newton Brandt, Alessandra Bonito-Oliva, Navid Paknejad, Celine Chen, John J Fak, Andrew Luskin, Genelle Rankin, Miriam Kirylo, Leslie J Sibener, Amy Arnsten, Vanessa Ruta and Priya Rajasethupathy | Summary: Working memory capacity is poorly understood. The ability to control and extend working memory time-scales provides […]
Kavli Affiliate: Erich Jarvis | Authors: Chloé A van der Burg, Alexander A Goikoetxea, Simon Muncaster, Oscar Ortega-Recalde, Tim Hore, Kaj Kamstra, Olivier Fedrigo, Erich D Jarvis, Alan Tracey, Kerstin Howe, Erica V Todd and Neil Gemmell | Summary: Many fish undergo dramatic, socially cued female-to-male sex change, yet the events that initiate and then […]
Kavli Affiliate: Jeremy Nathans | Authors: Jeremy Nathans, Yanshu Wang, Ningyu Zhu, Amir Rattner and Philip M Smallwood | Summary: In CNS endothelial cells (ECs), VEGF signaling promotes vascular permeability, and Wnt/beta-catenin signaling reduces vascular permeability by controlling the gene expression program for the blood-brain barrier. Here we show, using genetic mosaics, that, in mouse […]
Kavli Affiliate: Kenneth Miller | Authors: Elenora Kelley, Emmet Thompson, Ahliya Harding, Katie Torrey, Kai Gurnoe Brantley, Chunyu Lin, Anders Bach, Kenneth A Miller and David J. Blake | Summary: Visceral leishmaniasis (VL) is a neglected tropical disease caused by the protozoan parasites Leishmania infantum (LI) and Leishmania donovani (LD). VL disproportionately affects populations that live in extreme poverty […]
Kavli Affiliate: David Linden | Authors: Vikram Joshi, Corey Seavey, Kaitlyn Knutson, Abhilash Sawant, Yasmeen MF Hamed, Mario D’Ambrosio, Emma Laible, Vladimir Dokic, Jason Paul Sinnwell, Yuanhang Liu, Franco F Jin, Colin Thomas, Gwyneth Garramone, Amelia Paul Mazzone, Ferdinando Bonfiglio, Mauro D’Amato, Recep Avci, Peng Du, Madhusudan Grover, Purna C Kashyap, Brooke R Druliner, David […]
Kavli Affiliate: Peter Walter | Authors: Asmita Pramanik, Siva Hariprasad Kurma, Zhiwei Wen, Hongyi Cai, Pierre-Christian Violet, Peter J. Walter, Tamar Demby, Oksana Gavrilova, Srinivas Pittala, Haressh Sajiir, Regina Umarova, Allison Wing, Yaron Rotman, Jurgen Wess and Kenneth A. Jacobson | Summary: Knockout of the UDP-glucose-activated P2Y14 receptor (P2Y14R) in adipocytes or whole-body has been reported […]
Kavli Affiliate: Anders Dale | Authors: Alison Rigby, Diliana Pecheva, Pravesh Parekh, Diana M. Smith, Ashley Becker, Janosch Linkersdoerfer, Richard Watts, Robert Loughnan, Donald J. Hagler, Kyung E. Rhee, Carolina Makowski, Anders M. Dale and Terry L. Jernigan | Summary: Abstract Importance Adolescent body mass index (BMI) is linked to brain microstructural alterations, but it is […]
Kavli Affiliate: Elaine Fuchs | Authors: Elizabeth A.N. Thompson, Clara Schimmer, Tatiana Omelchenko, Michele Paganini, Jesse S.S. Novak, Sienna T. Muller, Alain R. Bonny, Marina Schernthanner, Sairaj M. Sajjath, Charlotte J. Bell, Alp Gorgulu, S. Martina Parigi, Katherine S. Stewart, Priyam Banerjee, Elaine Fuchs and Stephanie J. Ellis | Summary: Stratified epithelia accumulate oncogenic mutations […]