RNA trans-splicing treatment for Duchenne muscular dystrophy

Kavli Affiliate: Samuel Pfaff | Authors: Ryan H. Hsu, Claire E. Williams, Geraldine Maier, Miriam Gullo, Karen Lettieri, Cindy J. Alvarez, Kip J. Hermann, Stella Kramer, Satchidananda Panda, Lukas C. Bachmann and Samuel L. Pfaff | Summary: Duchenne muscular dystrophy (DMD) is a fatal disorder caused by dystrophin mutations, leading to progressive muscle degeneration and cardiac failure. […]


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Hippocampo-septal inhibitory feedback controls the medial septal circuit as a function of brain state, pyramidal cell activity and movement speed.

Kavli Affiliate: Attila Losonczy | Authors: Andor Domonkos, Daniel Schlingloff, Balint Kiraly, Litsa Ledri, Marta Jelitai, Gergely Turi, Rita M Karlocai, Edit Papp, Panna Hegedus, Gabor Nyiri, Attila I Gulyas, Tamas F Freund, Karl Deisseroth, Attila Losonczy, Balazs Hangya and Viktor Varga | Summary: Encoding novel experiences and retrieving stored information rely on the hippocampal […]


Continue.. Hippocampo-septal inhibitory feedback controls the medial septal circuit as a function of brain state, pyramidal cell activity and movement speed.

Inter-regional interactions uncouple within-region inhibition stabilization and paradoxical responses

Kavli Affiliate: Kenneth Miller | Authors: Yue Kris Wu and Kenneth D Miller | Summary: Paradoxical responses, in which excitatory perturbations of inhibitory neurons reduce their firing rates, are widely regarded as a hallmark of inhibition-stabilized networks (ISNs) and have been observed in multiple brain regions. However, because brain regions are interconnected by long-range projections, […]


Continue.. Inter-regional interactions uncouple within-region inhibition stabilization and paradoxical responses

Peptide inhibitors recognize prefusion viral fusion proteins with heterogeneous stoichiometry and rapid kinetics

Kavli Affiliate: Robert Edwards | Authors: Revan H Katte, Junyu Liu, Yufan He, Bhishem Thakur, Xiao Huang, Jared Lindenberger, Wang Xu, Narendra Kumar Gonepudi, Yang Han, Katarzyna Janowska, Robert J. Edwards, Priyamvada Acharya and Maolin Lu | Summary: Peptide fusion inhibitors, an important class of antivirals, block viral entry by targeting fusion proteins required for […]


Continue.. Peptide inhibitors recognize prefusion viral fusion proteins with heterogeneous stoichiometry and rapid kinetics

Parallel visual processing in the suprachiasmatic region of a diurnal mammal.

Kavli Affiliate: Timothy Brown | Authors: Patrycja Orlowska-Feuer, Jessica Rodgers, Rose Richardson, Asshen Dedigama Acharige, Martha Davey, Nina Milosavljevic, Annette E Allen, Timothy M Brown, Franck P Martial, Riccardo Storchi, Beatriz Bano Otalora and Robert J Lucas | Summary: Light shapes mammalian physiology and behaviour through hypothalamic pathways, yet how these pathways process visual information […]


Continue.. Parallel visual processing in the suprachiasmatic region of a diurnal mammal.

An intersectional expression platform for gene complementation using RNA-fragment end joining (REJ)

Kavli Affiliate: Samuel Pfaff | Authors: Lukas C. Bachmann, Ryan H. Hsu, Kip J. Hermann, Claire E. Williams, Richard L. Farman, Nicolas Criales, Craig Clark, Stella Kramer, Carolina Thorn Perez, Sawyer Randles, Karen Lettieri and Samuel L. Pfaff | Summary: Gene complementation is a powerful tool for genetic selection and protein functional studies but typically […]


Continue.. An intersectional expression platform for gene complementation using RNA-fragment end joining (REJ)

Discovery of a molecular glue inhibitor that stabilises a non-productive Kalirin-Rac1 complex

Kavli Affiliate: Michael Miller | Authors: Janine L. Gray, Mia C. Callens, Amelia Henley, Daniel Zaidman, Carmen Jimenez Antunez, Andrew P. Thompson, Zhihe Lei, Rachael Skyner, Michael Miller, Eleanor P. Williams, Anya Robinson, Raina Seupal, Matt T. Fry, Mihajlo Filep, Frank von Delft, Michael P. Willis, Annette R. von Delft, Nir London and Paul E. […]


Continue.. Discovery of a molecular glue inhibitor that stabilises a non-productive Kalirin-Rac1 complex

The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell intrinsic control of endosomal dynamics

Kavli Affiliate: Charles M. Rice | Authors: Boris Bonaventure, Kyna Reyes, Marie-France Martin, Heng Pan, R. Blake Richardson, Eva Bednarski, Alison W. Ashbrook, Allison Sowa, William Janssen, Oded Danziger, Anastasija Cupic, Lisa Miorin, Charles M Rice, Jean K Lim, Brad R Rosenberg, Matthew J Evans and Jeffrey R Johnson | Summary: Neurodevelopmental disorders are increasingly […]


Continue.. The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell intrinsic control of endosomal dynamics

Parvalbumin interneurons gate and shape striatal sequences

Kavli Affiliate: Joshua Berke | Authors: Mariana Duhne, Isabelle Gonzalez Montalvo, Chelsea S Zheng, Lilian Pelattini and Joshua D Berke | Summary: Impulsive and uncontrolled behaviors are associated with loss of parvalbumin-expressing striatal interneurons (PV+). To understand this microcircuit mechanism we compared spiking of five classes of identified neurons in sensorimotor striatum, as rats waited […]


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Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors

Kavli Affiliate: Kay Tye | Authors: Fergil Mills, Christopher R Lee, James R Howe, Hao Li, Maria N Keisler, Shan Shao, Felix H Taschbach, Mackenzie E Lemieux, Faith Aloboudi, Jesse White, May G Chan, Matilde R Borio, Laurel R Keyes, Hannah S Chen, Fabiha Bushra, Gates P Schneider, Dani P Lemon, Kyung J Lee, Alexa […]


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