Oxytocin receptor is not required for social attachment in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Kristen M. Berendzen, Ruchira Sharma, Maricruz Alvarado, YiChao Wei, Forrest D. Rogers, Adele Seelke, Trenton C. Simmons, Jessica Bond, Rose D. Larios, Michael Sherman, Srinivas Parthasarathy, Isidero Espineda, Joseph R. Knoedler, Annaliese Beery, Karen L. Bales, Nirao M Shah and Devanand S. Manoli | Summary: Prairie voles are among […]


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Suboptimal phenotypic reliability impedes reproducible human neuroscience

Kavli Affiliate: Joshua Vogelstein | Authors: Aki Nikolaidis, Andrew An Chen, Xiaoning He, Russell Shinohara, Joshua Vogelstein, Michael Milham and Haochang Shou | Summary: Biomarkers of behavior and psychiatric illness for cognitive and clinical neuroscience remain out of reach. Suboptimal reliability of biological measurements, such as functional magnetic resonance imaging (fMRI), is increasingly cited as […]


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Versatile Multiple Object Tracking in Sparse 2D/3D Videos Via Diffeomorphic Image Registration

Kavli Affiliate: Liam Paninski | Authors: James Yu, Amin Nejatbakhsh, Mahdi Torkashvand, Sahana Gangadharan, Maedeh Seyedolmohadesin, Jinmahn Kim, Liam Paninski and Vivek Venkatachalam | Summary: Tracking body parts in behaving animals, extracting fluorescence signals from cells embedded in deforming tissue, and analyzing cell migration patterns during development all require tracking objects with partially correlated motion. […]


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Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors

Kavli Affiliate: Kira Poskanzer | Authors: Silvia Pittolo, Sae Yokoyama, Drew Willoughby, Charlotte Taylor, Michael Reitman, Vincent Tse, Zhaofa Wu, Roberto Etchenique, Yulong Li and Kira E Poskanzer | Summary: The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters and […]


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The Precision nEDM Measurement with UltraCold Neutrons at TRIUMF

Kavli Affiliate: Eric Miller | First 5 Authors: Ryohei Matsumiya, Hiroaki Akatsuka, Chris P. Bidinosti, Charles A. Davis, Beatrice Franke | Summary: The TRIUMF Ultra-Cold Advanced Neutron (TUCAN) collaboration aims at a precision neutron electric dipole moment (nEDM) measurement with an uncertainty of $10^{-27},ecdotmathrm{cm}$, which is an order-of-magnitude better than the current nEDM upper limit […]


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The energetics of rapid cellular mechanotransduction

Kavli Affiliate: Michael Young | Authors: Michael N Young, Michael J Sindoni, Amanda H Lewis, Stefan Zauscher and Jorg Grandl | Summary: Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as […]


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Thalamus sends information about arousal but not valence to the amygdala

Kavli Affiliate: Kay Tye | Authors: Chris A Leppla, Laurel Keyes, Gordon Glober, Gillian A Matthews, Kanha Batra, Maya Jay, Yu Feng, Hannah S Chen, Fergil Mills, Jeremy Delahanty, Jake Olsen, Edward H Nieh, Praneeth Namburi, Craig Wildes, Romy Wichmann, Anna Beyelar, Eyal Y Kimchi and Kay M. Tye | Summary: Rationale The basolateral amygdala […]


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Engineered Adhesion Molecules Drive Synapse Organization

Kavli Affiliate: Richard Huganir | Authors: William Dylan Hale, Thomas C. Sudhof and Richard L. Huganir | Summary: In multicellular organisms, cell-adhesion molecules connect cells into tissues and mediate intercellular signaling between these cells. In vertebrate brains, synaptic cell-adhesion molecules (SAMs) guide the formation, specification, and plasticity of synapses. Some SAMs, when overexpressed in cultured […]


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Benchmarking verified logic operations for fault tolerance

Kavli Affiliate: Irfan Siddiqi | First 5 Authors: Akel Hashim, Stefan Seritan, Timothy Proctor, Kenneth Rudinger, Noah Goss | Summary: The promise of quantum computing depends upon the eventual achievement of fault-tolerant quantum error correction, which requires that the total rate of errors falls below some threshold. However, most contemporary methods for benchmarking noisy quantum […]


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