Hypothalamic CRH Neurons Modulate Sevoflurane Anesthesia and The Post-anesthesia Stress Responses

Kavli Affiliate: Wei Min | Authors: Shan Jiang, Lu Chen, Wei-Min Qu, Zhi-Li Huang and Chang-Rui Chen | Summary: General anesthesia is a fundamental process required to undertake safely and humanely a high fraction of surgeries and invasive diagnostic procedures. However, the undesired stress response associated with general anesthesia (GA) causes delayed recovery and even […]


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Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

Kavli Affiliate: Denis Wirtz | Authors: Jeanette A.I. Johnson, Genevieve L Stein-O’Brien, Max Booth, Randy Heiland, Furkan Kurtoglu, Daniel Bergman, Elmar Bucher, Atul Deshpande, Andre Forjaz, Michael Getz, Ines Godet, Melissa Lyman, John Metzcar, Jacob Mitchell, Andrew Raddatz, Heber L. Rocha, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, Daniele M. Gilkes, Luciane T. Kagohara, Ashley L. […]


Continue.. Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Kavli Affiliate: Edward Chang | Authors: Sunada Khadka, Yu-Hsi Lin, Jeffrey J Ackroyd, Yi-An Chen, Yanghui Sheng, Wubin Qian, Sheng Guo, Yining Chen, Eliot Itzkow Behr, Yasaman Barekatin, Md. Nasir Uddin, Kenisha Arthur, Victoria C Yan, Edward Chang, Anton Poral, Theresa Tran, Wen-Hao Hsu, Surendra Chaurasiya, Dimitra K. Georgiou, John M. Asara, Floris P. Barthel, […]


Continue.. Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington’s Disease

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Matthew R Paul, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in Huntington’s disease (HD) cortex, the nature of somatic […]


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Cerebellar-driven cortical dynamics enable task acquisition, switching and consolidation

Kavli Affiliate: Costa, Rui | Authors: Joseph Pemberton, Paul Chadderton and Rui Ponte Costa | Summary: Abstract To drive behavior, the cortex must bridge sensory cues with future outcomes. However, the principles by which cortical networks learn such sensory-behavioural transformations remain largely elusive. Here, we posit that the cerebellum assumes a crucial role in driving […]


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Brain state and cortical layer-specific mechanisms underlying perception at threshold

Kavli Affiliate: Anirvan Nandy, John Reynolds | Authors: Mitchell P Morton, Sachira Denagamage, Isabel J Blume, John H Reynolds, Monika P Jadi and Anirvan S Nandy | Summary: Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in […]


Continue.. Brain state and cortical layer-specific mechanisms underlying perception at threshold

A model of marmoset monkey vocal turn-taking

Kavli Affiliate: Cory Miller | Authors: Dori Grijseels, Daniella Fairbank and Cory Miller | Summary: Vocal turn-taking has been described in a diversity of species. Yet a model that captures the various processes underlying this social behavior across species has not been developed. To this end, here we recorded a large and diverse dataset of […]


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Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

Kavli Affiliate: Laurent Younes & Donald Geman | Authors: Kun Yang, Koko Ishizuka, Andrew P Lane, Zui Narita, Arisa Hayashida, Yukiko Y Lema, Emma Heffron, Haydn Loudd, Maeve Schumacher, Shin-ichi Kano, Toshifumi Tomoda, Atsushi Kamiya, Minghong Ma, Donald Geman, Laurent Younes and Akira Sawa | Summary: Biopsy is crucial in clinical medicine to obtain tissues […]


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Cellular Calcium Activity at Depth Predicted from Surface Potential Recordings using Ultra-high Density Transparent Graphene Arrays

Kavli Affiliate: Takaki Komiyama | Authors: Mehrdad Ramezani, Jeong-Hoon Kim, Xin Liu, Chi Ren, Abdullah Alothman, Chawina De- Eknamkul, Madison Wilson, Ertugrul Cubukcu, Vikash Gilja, Takaki Komiyama and Duygu Kuzum | Summary: Recording brain activity with high spatial and high temporal resolution across deeper layers of cortex has been a long-sought methodology to study how […]


Continue.. Cellular Calcium Activity at Depth Predicted from Surface Potential Recordings using Ultra-high Density Transparent Graphene Arrays

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics technologies provide molecular profiling of cells while preserving their organization within tissues, allowing for the evaluation of cell-type […]


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