Kavli Affiliate: Michael Beer | Authors: Kijin Jang, Kevin Ostacolo, Valdimar Sveinsson, Michael A Beer, Kimberley Jade Anderson and Hans Tomas Bjornsson | Summary: Abstract The mild hypothermia response (MHR) is a conserved mammalian cytoprotective program activated upon exposure to mild hypothermia (32 °C) that contributes to the neuroprotective effects of therapeutic hypothermia following hypoxic […]
Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]
Kavli Affiliate: Loren Frank, Massimo Scanziani, and Razi Haque | Authors: Kyu Hyun Lee, Philip Adenekan, Fan Gao, Jenny Zhou, Jose Hernandez, Allison Yorita, Razi Haque, Kenneth Kay, Massimo Scanziani and Loren Frank | Summary: Primary visual cortex (V1) is a critical substrate for mammalian vision. Traditionally, visual inputs are thought to be the main […]
Kavli Affiliate: Li Zhao | Authors: Cong Li, Bing-Jun Wang, Junhui Peng, Nicolas Svetec and Li Zhao | Summary: Innate immunity has been dissected in exquisite detail in Drosophila melanogaster, yet how immune systems diversify between species remains largely unknown. Here we compare responses to bacterial infection across five drosophilid species spanning 60 million years of […]
Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Ian Anton Oldenburg, Kenneth D Miller and Agostina Palmigiano | Summary: Optogenetics enables causal manipulation of cortical activity. Perturbation responses can be counterintuitive due to network interactions, making theory essential for predicting them. Existing approaches often rely on linear approximations, which fail for many biologically relevant […]
Kavli Affiliate: Denis Wirtz | Authors: Pei-Hsun Wu, Chongguang Jin, Tiffany Chu, Qiming Zhang and Denis Wirtz | Summary: Preclinical drug evaluation relies heavily on two-dimensional (2D) monolayer assays, which fail to recapitulate the structural and functional complexity of the tumor microenvironment and may therefore misrepresent therapeutic efficacy. Here, we present VITAL (Volumetric Imaging-based Toxicity […]
Kavli Affiliate: Massimo Scanziani and Loren Frank | Authors: Cameron Wilhite, Loren M. Frank and Massimo Scanziani | Summary: Fluid behavior requires temporal coordination across brain systems that orchestrate movement. A clear example is locomotion, in which left and right turns are not only precisely coordinated with the ongoing stepping rhythm but occur at opposite […]
Kavli Affiliate: Massimo Scanziani and Loren Frank | Authors: Cameron Wilhite, Loren M. Frank and Massimo Scanziani | Summary: Motivation Imaging-based spatially resolved transcriptomics (imSRT) technologies provide high-throughput molecular-resolution spatial characterization of genes within cells. Conventional analysis methods to identify cell-types and states in imSRT data rely on gene count matrices derived from tallying the […]
Kavli Affiliate: Jean Fan | Authors: Dee Velazquez, Caleb Hallinan, Roujin An, Kalen Clifton and Jean Fan | Summary: Motivation Imaging-based spatially resolved transcriptomics (imSRT) technologies provide high-throughput molecular-resolution spatial characterization of genes within cells. Conventional analysis methods to identify cell-types and states in imSRT data rely on gene count matrices derived from tallying the […]
Kavli Affiliate: Michael Beer | Authors: Michael Beer, Jim Spencer and Adrian J Mulholland | Summary: Carbapenems are the most potent β-lactams, key antibiotics for healthcare-associated infections by Gram-negative bacteria and evade hydrolysis by most β-lactamases; but are increasingly threatened by emergence of enzymes exhibiting hydrolytic activity towards them. Of the four recognised β-lactamase subclasses, […]