Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

Kavli Affiliate: Michael Miller | Authors: P Monroe Butler, Anna Francis, Angela L Meunier, Amirah K Anderson, Elizabeth L Hennessey, Michael B Miller, Cynthia A Lemere, Dennis J Selkoe and Andrew M Stern | Summary: Importance Anti-amyloid immunotherapy is used to treat Alzheimer disease (AD) with moderate benefits and potentially serious side effects due to […]


Continue.. Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

Gaplessness from disorder and quantum geometry in gapped superconductors

Kavli Affiliate: Debanjan Chowdhury | First 5 Authors: Omri Lesser, Sagnik Banerjee, Xuepeng Wang, Jaewon Kim, Ehud Altman | Summary: It is well known that disorder can induce low-energy Andreev bound states in a sign-changing, but fully gapped, superconductor at $pi-$junctions. Generically, these excitations are localized. Starting from a superconductor with a sign-changing and nodeless […]


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On the creation of narrow AI: hierarchy and nonlocality of neural network skills

Kavli Affiliate: Max Tegmark | First 5 Authors: Eric J. Michaud, Asher Parker-Sartori, Max Tegmark, , | Summary: We study the problem of creating strong, yet narrow, AI systems. While recent AI progress has been driven by the training of large general-purpose foundation models, the creation of smaller models specialized for narrow domains could be […]


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Shared and distinct cortical mechanisms for working memory and decision-making.

Kavli Affiliate: Daeyeol Lee | Authors: Hyojung Seo, Daeyeol Lee and Shanna K Murray | Summary: The dorsolateral prefrontal cortex (DLPFC) and lateral intraparietal cortex (LIP) in the primate brain are critically involved in working memory during tasks that require the retention of information over a delay. These same regions have also been implicated in […]


Continue.. Shared and distinct cortical mechanisms for working memory and decision-making.

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Kavli Affiliate: Alexandra Nelson | Authors: Rodrigo M Paz, Michael B Ryan, Pamela F Marcott, Allison E Girasole, Joseph Faryean, Vincent Duong, Sadhana Sridhar and Alexandra B Nelson | Summary: The use of levodopa to manage Parkinson’s disease (PD) symptoms leads to levodopa-induced dyskinesia (LID) and other motor fluctuations, which worsen with disease progression and […]


Continue.. Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

A Novel Benchmark and Dataset for Efficient 3D Gaussian Splatting with Gaussian Point Cloud Compression

Kavli Affiliate: Wei Gao | First 5 Authors: Kangli Wang, Shihao Li, Qianxi Yi, Wei Gao, | Summary: Recently, immersive media and autonomous driving applications have significantly advanced through 3D Gaussian Splatting (3DGS), which offers high-fidelity rendering and computational efficiency. Despite these advantages, 3DGS as a display-oriented representation requires substantial storage due to its numerous […]


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AsynFusion: Towards Asynchronous Latent Consistency Models for Decoupled Whole-Body Audio-Driven Avatars

Kavli Affiliate: Zheng Zhu | First 5 Authors: Tianbao Zhang, Jian Zhao, Yuer Li, Zheng Zhu, Ping Hu | Summary: Whole-body audio-driven avatar pose and expression generation is a critical task for creating lifelike digital humans and enhancing the capabilities of interactive virtual agents, with wide-ranging applications in virtual reality, digital entertainment, and remote communication. […]


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Superconducting vacancy-ordered rock-salt NbO films

Kavli Affiliate: Joseph Falson | First 5 Authors: Jeong Rae Kim, Sandra Glotzer, Evan Krysko, Matthew R. Barone, Jinkwon Kim | Summary: We report molecular beam epitaxy synthesis of vacancy-ordered rocksalt NbO thin films which display superconductivity. A comparative study of substrates identifies Al$_2$O$_3$ (0001) as the optimal platform for realizing high-quality, single-phase films when […]


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Sequential Interval Passing for Compressed Sensing

Kavli Affiliate: Salman Habib | First 5 Authors: Salman Habib, Remi Chou, Taejoon Kim, , | Summary: The reconstruction of sparse signals from a limited set of measurements poses a significant challenge as it necessitates a solution to an underdetermined system of linear equations. Compressed sensing (CS) deals with sparse signal reconstruction using techniques such […]


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Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Kavli Affiliate: Michael Miller | Authors: Maria Luisa Amaral, Sainath Mamde, Michael Miller, Xiaomeng Hou, Jessica Arzavala, Julia Osteen, Elizabeth Walker Smoot, Qian Yang, Emily Eisner, Qiurui Zeng, Cindy Tatiana Baez-Becerra, Jacqueline Olness, Joseph Colin Kern, Jonathan Rink, Nicholas Johnson, Ariana Barcoma, Silvia Cho, Stella Cao, Nora Emerson, Jasper Lee, Jackson Willier, Timothy Loe, Henry […]


Continue.. Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging