Dissipative Optomechanics in High-Frequency Nanomechanical Resonators

Kavli Affiliate: Simon Groblacher | First 5 Authors: André G. Primo, Pedro V. Pinho, Rodrigo Benevides, Simon Gröblacher, Gustavo S. Wiederhecker | Summary: The coherent transduction of information between microwave and optical domains is a fundamental building block for future quantum networks. A promising way to bridge these widely different frequencies is using high-frequency nanomechanical […]


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Towards Hodge Theoretic Characterizations of 2d Rational SCFTs: II

Kavli Affiliate: Taizan Watari | First 5 Authors: Masaki Okada, Taizan Watari, , , | Summary: A characterization of rational superconformal field theories (SCFTs) on 1+1 dimensions with Ricci-flat Kahler targets was proposed by S. Gukov and C. Vafa in terms of the Hodge structure of the target space. The article [arXiv:2205.10299] refined this idea […]


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Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie and Stephen M. Strittmatter | Summary: Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that […]


Continue.. Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]


Continue.. Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Multi-center integrated analysis of non-coding CRISPR screens

Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]


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Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

First Flight Performance of the Micro-X Microcalorimeter X-Ray Sounding Rocket

Kavli Affiliate: Sarah N. T. Heine | First 5 Authors: Joseph S. Adams, Robert Baker, Simon R. Bandler, Noemie Bastidon, Daniel Castro | Summary: The flight of the Micro-X sounding rocket on July 22, 2018 marked the first operation of Transition-Edge Sensors and their SQUID readouts in space. The instrument combines the microcalorimeter array with […]


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