Kavli Affiliate: Liedewij Laan | Summary:Multidomain proteins with flexible unstructured sequence regions are abundant in cellular signaling. This protein architecture enables self-assembly into supramolecular structures, but how structured interaction domains and overall protein architecture jointly regulate the assembly size, structure and kinetics remains unclear. Here we use the budding yeast protein Bem1 as a model […]
Continue.. Tunable supramolecular polymerization from protein charge heterogeneity and architecture