Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis

Posted by dbos Rockefeller

Kavli Affiliate: Robert B. Darnell | Authors: Michael R. Mazzucco, Bella Mehta, Jenelys Ruiz-Ortiz, Caryn Hale, Fuadur Omi, Purva Singh, Ruoxi Yuan, Samantha Lessard, Eun Kyung Song, Mengrui Zhang, Shady Younis, William H. Robinson, Daniel Ramirez, Edward DiCarlo, Wei Wang, Thomas Carroll, Jose Rodriguez, Peter Sculco, Xiaoshun Li, YiYuan Wu, Robert B. Darnell, Martin Lotz, […]


Continue.. Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis

Lightning Pose 3D: an uncertainty-aware framework for data-efficient multi-view animal pose estimation

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: Lenny Aharon, Matthew R Whiteway, Karan Sikka, Keemin Lee, Yanchen Wang, Selmaan Chettih, Benjamin Midler, Ilana B Witten, Dmitriy Aronov, International Brain Laboratory and Liam Paninski | Summary: Multi-view pose estimation is essential for quantifying animal behavior in scientific research, yet current methods struggle to achieve accurate tracking with […]


Continue.. Lightning Pose 3D: an uncertainty-aware framework for data-efficient multi-view animal pose estimation

Inhibition of CKAMP44 attenuated seizure activity via protein phosphatase 3 regulatory subunit B-mediated GluA1 phosphorylation and synaptic transmission

Posted by dbos Hopkins

Kavli Affiliate: Xiaoqin Wang | Authors: Lihong Huang, Shiyu Chen, Haokun Guo, Hui Zhang, Liang Wang, Xiaoqin Wang, Yiming Guo, Shiyun Yuan, Jing Luo, Yang Lv and Weihua Yu | Summary: Abstract Temporal lobe epilepsy (TLE) is a complex neurological disorder characterized by spontaneous recurrent seizures and its underlying mechanism remains elusive. This study aimed […]


Continue.. Inhibition of CKAMP44 attenuated seizure activity via protein phosphatase 3 regulatory subunit B-mediated GluA1 phosphorylation and synaptic transmission

Meta-learning is expressed through altered prefrontal cortical dynamics

Posted by dbos UCSF

Kavli Affiliate: Joshua Berke, Loren Frank, and Razi Haque | Authors: Xulu Sun, Alison E. Comrie, Ari E. Kahn, Emily J. Monroe, Clayton B. Washington, Abhilasha Joshi, Jennifer A. Guidera, Eric L. Denovellis, Timothy A. Krausz, Jenny Zhou, Paige Thompson, Jose Hernandez, Allison Yorita, Razi Haque, Chethan Pandarinath, Joshua D. Berke, Nathaniel D. Daw and […]


Continue.. Meta-learning is expressed through altered prefrontal cortical dynamics

A Context-Aware Target Engagement and Pharmacodynamic Biomarker Resource to Accelerate Drug Discovery and Development

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Yuntao Yang, Li Zhao, Seyedmehdi Orouji, Ying Zhu, Rebecca L Johnson, David S Maxwell, Ioan Mica, Kaitlyn P Russell and Bissan Al-lazikani | Summary: Confirming target engagement in tumor experimental models remains a major challenge in oncology drug development. Pharmacodynamic biomarkers can help address this, but few systematic resources […]


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A recurrent neural network model of chronic pain development and recovery

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Katherine Huang, Guy Marmor, Tjitse van der Molen, Zongren Zhang, Paulina Gicqueau, Javier Reveles, Kareena Morrissey, Justin Tang, Lucy Lu, Kelly Ilmi, Jacob Lue, Gabriela Barba Zuniga, Michael B. Miller, Kenneth S. Kosik, Henry Yang, Tyler Santander, Francesco Bullo and Paul K. Hansma | Summary: Chronic pain presents a […]


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Representations converge as brain maps diverge along the cortical hierarchy

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Bogdan Petre, Martin A Lindquist and Tor Wager | Summary: Brain maps (e.g. topographies like retinotopy, somatotopy) vary across individuals. This is thought to reflect computational differences, motivating personalized functional localization. However, artificial neural networks (ANNs) show that similar performance and internal representations can coexist with diverse circuit layouts. […]


Continue.. Representations converge as brain maps diverge along the cortical hierarchy

A Unified Account of Lightness Illusions via Edge-Based Reconstruction of Natural Images

Posted by dbos Harvard

Kavli Affiliate: George A. Alvarez | Authors: Srijani Saha, Talia Konkle and George A. Alvarez | Summary: The human visual system transforms patterns of light into rich perceptual experiences, where what we see is a construction that goes beyond simple measurement. Lightness illusions—where identical parts of an image can appear dramatically different depending on context—provide […]


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Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Srujan Singh, Shishir Kumar Patel, Ryo Matsuura, Dee Velazquez, Zhaoli Sun, Sanjeev Noel, Hamid Rabb and Jean Fan | Summary: Kidney transplantation is the gold standard treatment strategy for end-stage renal disease. Deceased donor kidneys usually undergo cold storage until kidney transplantation, leading to cold ischemia injury that may […]


Continue.. Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Virtual multiplex staining of the pancreatic islets across type 1 diabetes progression using a Schroedinger bridge

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Yu Shen, Won June Cho, Saurabh Joshi, Benjamin Wen, Swarnagouri Naganathanhalli, Maria Beery, Casey R Grubel, Arrun Sivasubramanian, André Forjaz, Mia P Grahn, Lucie Dequiedt, Yichen Huang, Kyu Sang Han, Fan Wu, Brian A Pedro, Laura D Wood, Tiane Chen, Ralph H Hruban, Irina Kusmartseva, Mark A Atkinson, Denis […]


Continue.. Virtual multiplex staining of the pancreatic islets across type 1 diabetes progression using a Schroedinger bridge