The Central Nucleus of the Amygdala Encodes the Motivation to Pursue Ethanol

Kavli Affiliate: Patricia Janak | Authors: Matilde Castro, Jingren Gu, Teresa Dong, David J. Ottenheimer, Céline Drieu and Patricia H. Janak | Summary: Prior studies implicate the central nucleus of the amygdala (CeA) in reward motivation, yet how this region encodes motivation for ethanol (EtOH) seeking and consumption–and how this compares to encoding of natural […]


Continue.. The Central Nucleus of the Amygdala Encodes the Motivation to Pursue Ethanol

Loss of Adaptive Capacity Drives Climate Vulnerability Across Taxonomic Scales in an Alpine Specialist Species Complex

Kavli Affiliate: Timothy Brown | Authors: Kristen C Ruegg, Christen M Bossu, Reza Goljani Amirkhiz, Nikunj Goel, Erica Robertson, Timothy M Brown, Kathryn Bernier, Ben J Vernasco, Peri E Bolton, Erik R Funk, Scott A Taylor, Mevin B Hooten and Erica S Zavaleta | Summary: Accelerated warming at high elevations is having a disproportionate impact […]


Continue.. Loss of Adaptive Capacity Drives Climate Vulnerability Across Taxonomic Scales in an Alpine Specialist Species Complex

Explainable prediction and simulation of complex system dynamics through networks of manifolds

Kavli Affiliate: Loren Frank | Authors: Joseph Park, Cameron Smith, Shih Yi Tseng, Jennifer Guidera, Andrei V Semenov, Stanislav Smirnov, Loren M Frank and Gerald M Pao | Summary: Complex systems such as brains and other interacting biological and physical processes are difficult to represent because they evolve across many variables, scales, and nonlinear interactions. […]


Continue.. Explainable prediction and simulation of complex system dynamics through networks of manifolds

MM-ComBat and MM-CovBat: Multivariate Frameworks for Joint Harmonization of Multi-Metric Neuroimaging Data

Kavli Affiliate: Martin Lindquist | Authors: Zheng Ren, Patrick Sadil and Martin Lindquist | Summary: Aggregating neuroimaging data across sites and studies is increasingly common, yet site- and scanner-related batch effects can obscure meaningful biological variation and introduce spurious associations. Although ComBat and its extensions are widely used, they are primarily designed for single-metric harmonization. […]


Continue.. MM-ComBat and MM-CovBat: Multivariate Frameworks for Joint Harmonization of Multi-Metric Neuroimaging Data

Ecotypes, Wolbachia, and urbanization shape Culex pipiens population structure in a West Nile virus hotspot

Kavli Affiliate: Scott Small | Authors: Sonia Cebrián-Camisón, Ángel G. Rivera-Colón, Scott T. Small, Jordi Figuerola, Andrew D. Kern, Peter L. Ralph, Aureliano Bombarely and María José Ruiz-López | Summary: Culex pipiens is a major vector of West Nile Virus (WNV) in Europe and has a complex evolutionary history that has been linked to the […]


Continue.. Ecotypes, Wolbachia, and urbanization shape Culex pipiens population structure in a West Nile virus hotspot

Clustered Inputs Maximize Efficiency for Stable Place Field Encoding in Hippocampal Pyramidal Neurons

Kavli Affiliate: Attila Losonczy | Authors: Simone Tasciotti, Daniel Maxim Iascone, Spyridon Chavlis, Luke Hammond, Yardena Katz, Attila Losonczy, Franck Polleaux and Panayiota Poirazi | Summary: How spatial organization of synaptic inputs along the dendritic tree of neurons influence their feature selectivity is a central question in neuroscience. Here, we mapped the three-dimensional distribution of […]


Continue.. Clustered Inputs Maximize Efficiency for Stable Place Field Encoding in Hippocampal Pyramidal Neurons

Opioids modulate Curiosity-Driven Exploration in Music

Kavli Affiliate: Jacqueline Gottlieb | Authors: Claudia Alvarez-Martin, Raimund Buehler, Xim Cerda-Company, Gemma Cardona, Matthäus Willeit, Jacqueline Pallas Gottlieb, Giorgia Silani and Antoni Rodriguez-Fornells | Summary: Curiosity, a key driver of exploration and learning, is reinforced by reward-related neurochemical systems, yet the role of the opioidergic system in modulating this behavior remains unclear. Music, as […]


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Compressed Cortical Input Separates Control from Dynamics in Striatum

Kavli Affiliate: Marcelo Mattar | Authors: Sreejan Kumar, Matthieu B Le Cauchois, Alexander Mathis, Lea Duncker, Jonathon R. Howlett and Marcelo G. Mattar | Summary: The dorsolateral striatum (DLS) supports diverse time-sensitive behaviors—action chunking, duration estimation, and motor timing—yet no single framework is able to explain all of these phenomena. Here, we propose that the […]


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A family portrait of the genomic factors shaping tandem repeat mutagenesis

Kavli Affiliate: Michael Goldberg | Authors: Thomas A Sasani, Michael E Goldberg, Akshay K Avvaru, Thomas J Nicholas, Deborah W Neklason, Egor Dolzhenko, Tom Mokveld, Katherine M Munson, Kendra Hoekzema, Marcelo Ayllon, Eli J Kaufman, David Porubsky, Paul N Valdmanis, Evan E Eichler, Aaron R Quinlan and Harriet Dashnow | Summary: Tandem repeats (TRs) are […]


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A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]


Continue.. A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories