The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Leon L Seifert, Georgios Dangas, Hoyin Chu, Yingpu Yu, Kosuke Ogata, Xupeng Hong, Mengyin Zhang, Yichen Zhou, Chenhui Zou, Alireza Ramandi, Corrine Quirk, Evgenia Moschogianni, Catherine A Freije, Antonis Athanasiadis, Leonardo Gonzales, Luis Chiriboga, Clifton Fulmer, Hong Hur, Manoj Kandpal, Anna S Lok, Caleb Lareau, William M Schneider, […]


Continue.. The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Novelty-seeking and directed exploration scale with dissociable social network outcomes and brain systems in older adults

Posted by dbos UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Christian Valtierra, Jeremy Hogeveen, Gabriella Mace, Samantha Moreno, Avery Ostrand, Sydney Griffith, Maria Jose Auil, Patrick McConnell, Joseph C.C. Chen, Jennifer Mitchell, Gary R. Turner, Nathan Spreng, Adam Gazzaley and Lorenzo Pasquini | Summary: Social isolation and loneliness are major determinants of well-being in older adults. Shrinking social networks […]


Continue.. Novelty-seeking and directed exploration scale with dissociable social network outcomes and brain systems in older adults

Structural Adaptability in HIV-2 Vif Drives Broad Antagonism of APOBEC3G

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Estelle K Ronayne, Michelle Lilly, Xiaoxuan Lin, Yange Niu, Nicholas M Chesarino, Michael Emerman, Yifan Cheng and John D Gross | Summary: APOBEC3G (A3G), a restriction factor, is a barrier for zoonosis and targeted for degradation by the lentiviral protein Vif. Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 […]


Continue.. Structural Adaptability in HIV-2 Vif Drives Broad Antagonism of APOBEC3G

Depolarization block in substantia nigra pars reticulata neurons drives dystonia in a mouse model

Posted by dbos UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Olivia K Barnhill, Kasandra M Romo and Alexandra B Nelson | Summary: Dystonia is a common movement disorder characterized by involuntary co-contraction of antagonist muscles, resulting in abnormal postures. The brain often appears grossly normal, suggesting dysfunctional neural activity as a cause. The basal ganglia are implicated in dystonia, […]


Continue.. Depolarization block in substantia nigra pars reticulata neurons drives dystonia in a mouse model

Dual-targeted nanoparticles enable the ex vivo generation of cytotoxic and phagocytic CAR effector cells

Posted by dbos Hopkins

Kavli Affiliate: Jin Kang | Authors: Jisu Hong, Jinwoong Lim, Minho Park, Jimin Song, Byung Joon Lee, Miyoung Park, Min-Kyoo Shin, Hyungseok Seo, Hyoung Jin Kang, Byung-Soo Kim and Chang-Han Lee | Summary: Chimeric antigen receptor (CAR)-T cells and CAR-macrophages (or CAR-monocytes) offer complementary antitumor functions. CAR-T cells exert potent cytotoxicity against cancer cells, whereas […]


Continue.. Dual-targeted nanoparticles enable the ex vivo generation of cytotoxic and phagocytic CAR effector cells

Lasting aversive consequences of a single dose of 4-hydroxytamoxifen

Posted by dbos Columbia

Kavli Affiliate: Daniel Salzman | Authors: Evan J. Kyzar, Ruby Setara, Maya Eisengart, Sophia Virkar, Lydia Rogerson, Alejandro Ramirez and C. Daniel Salzman | Summary: 4-hydroxytamoxifen (4-OHT) is commonly used to facilitate activity-dependent recombination in neurons. Here we show that one dose of 4-OHT devalues alcohol, contexts, and tastants, indicating that experimental designs using 4-OHT […]


Continue.. Lasting aversive consequences of a single dose of 4-hydroxytamoxifen

Rocking Without a Tune: Ex vivo and in vivo Responses to Sound in the Basilar Papilla of the Tokay Gecko

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Brian L. Frost, Yuriria Vázquez, Kazuhiro Horii, Brian A. Fabella and A. J. Hudspeth | Summary: Like mammals, some reptiles possess sensitive and frequency-selective hearing at mid- to high-kilohertz frequencies. Both groups employ a place-frequency map within the inner ear to encode sound stimuli, but the mechanisms by […]


Continue.. Rocking Without a Tune: Ex vivo and in vivo Responses to Sound in the Basilar Papilla of the Tokay Gecko

Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: John Serences | Authors: Rosanne L Rademaker and John Serences | Summary: People often remember visual information over brief delays while actively engaging with ongoing inputs from the surrounding visual environment. Depending on the situation, one might prioritize mnemonic contents (i.e., remembering details of a past event), or preferentially attend sensory inputs (i.e., […]


Continue.. Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

The impact of alpha synuclein overexpression on nigrostriatal transmission

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Nikolas Bergum, Andrew Yee, Robert Edwards and Christopher P. Ford | Summary: Accumulation of wild-type α-synuclein in dopamine neurons of the Substantia Nigra pars compacta (SNc) is a pathological hallmark of Parkinson’s disease (PD), which commonly precedes neurodegeneration. Yet how α-synuclein accumulation affects nigrostriatal neurotransmission early in the progression of PD […]


Continue.. The impact of alpha synuclein overexpression on nigrostriatal transmission

The functional diversification of somatosensory neuron repertoires across Mammalia

Posted by dbos Hopkins

Kavli Affiliate: Cynthia F. Moss and Elena Gracheva | Authors: S. Andrew Shuster, Jia Yin Xiao, Bruno Gegenhuber, Shamsuddin A. Bhuiyan, Min Dai, Yongting Chen, Michelle M. DeLisle, Preston Sheng, Elizabeth Howell, Michael Brecht, Elena O. Gracheva, Cynthia F. Moss, David L. Paul, Ishmail Abdus-Saboor, Gord Fishell, William Renthal, Michael E. Greenberg and David D. […]


Continue.. The functional diversification of somatosensory neuron repertoires across Mammalia