Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD

Posted by klaurent UCSF

Kavli Affiliate: Kevin Bender | Authors: Chenyu Wang, Kimberly D Derderian, Elizabeth Hamada, Xujia Zhou, Andrew D Nelson, Henry Kyoung, Nadav Ahituv, Guy Bouvier and Kevin Bender | Summary: Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity, or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be overwhelming, causing high […]


Continue.. Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD

Conjunctive vector coding and place coding in hippocampus share a common directional signal

Posted by klaurent Hopkins

Kavli Affiliate: James Knierim | Authors: Yue-Qing Zhou, Vyash Puliyadi, Xiaojing Chen, Joonhee Leo Lee, Lan-Yuan Zhang and James J Knierim | Summary: Vector coding is becoming increasingly understood as a major mechanism by which neural systems represent an animal’s location in both a global reference frame and a local, item-based reference frame. Landmark vector […]


Continue.. Conjunctive vector coding and place coding in hippocampus share a common directional signal

Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Posted by klaurent UCSF

Kavli Affiliate: John Rubenstein | Authors: Siavash Fazel Darbandi, Joon Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, Athena Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S Nord, Stephan J. Sanders and John L.R. Rubenstein | Summary: SUMMARY Many autism spectrum disorder (ASD)-associated genes act as transcriptional regulators (TRs). ChIP-seq was used to identify […]


Continue.. Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Judging the difficulty of perceptual decisions

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Anne Löffler, Ariel Zylberberg, Michael N. Shadlen and Daniel M Wolpert | Summary: Deciding how difficult it is going to be to perform a task allows us to choose between tasks, allocate appropriate resources, and predict future performance. To be useful for planning, difficulty judgments should not require completion […]


Continue.. Judging the difficulty of perceptual decisions

Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Nuttida Rungratsameetaweemana, Robert Kim, Thiparat Chotibut and Terrence Sejnowski | Summary: Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neurons perform cognitive tasks. Training such networks to perform tasks that require information maintenance over a brief […]


Continue.. Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation

The HLA-II immunopeptidome of SARS-CoV-2

Posted by klaurent Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B Taylor, Matteo Gentili, Leah R Pearlman, Matthew R Bauer, Charles M Rice, Karl R Clauser, Nir Hacohen, Steven A Carr, Jennifer G Abelin, Mohsan Saeed and Pardis C Sabeti | Summary: Targeted synthetic vaccines have the potential to transform our […]


Continue.. The HLA-II immunopeptidome of SARS-CoV-2

Cross-Modal Representation of Identity in Primate Hippocampus

Posted by klaurent UCSD / Salk

Kavli Affiliate: Cory Miller | Authors: Timothy Tyree, Michael Metke and Cory Miller | Summary: Faces and voices are the dominant social signals used to recognize individuals amongst human and nonhuman primates (1–4). Yet it is not known how these critical signals are integrated into a cross-modal representation of individual identity in the primate brain. […]


Continue.. Cross-Modal Representation of Identity in Primate Hippocampus

An Open-Source Tool for Automated Human-Level Circling Behavior Detection

Posted by klaurent Hopkins

Kavli Affiliate: Kathleen Cullen | Authors: Oliver R Stanley, Ananya Swaminathan, Elias Wojahn, Zubair M Ahmed and Kathleen E Cullen | Summary: Quantifying behavior and relating it to underlying biological states is of paramount importance in many life science fields. Although barriers to recording postural data have been reduced by progress in deep-learning-based computer vision […]


Continue.. An Open-Source Tool for Automated Human-Level Circling Behavior Detection

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Posted by klaurent Hopkins

Kavli Affiliate: Kathleen Cullen | Authors: Arnaud P. J. Giese, Wei-Hsiang Weng, Katie S Kindt, Vanessa H. H. Chang, Jonathan S Montgomery, Evan M. Ratzan, Alisha J. Beirl, Roberto Aponte Rivera, Jeffrey M. Lotthammer, Sanket Walujkar, Mark P. Foster, Omid A. Zobeiri, Jeffrey R. Holt, Saima Riazuddin, Kathleen E. Cullen, Marcos Sotomayor and Zubair M […]


Continue.. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Yaeram Jeong, chung-ha Davis, Aaron Muscarella, Viraj Deshpande, Keun-Young Kim, Mark Ellisman and Nicholas Marsh-Armstrong | Summary: We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of […]


Continue.. Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve