LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Cells maintain optimal levels of lysosome degradative activity to protect against pathogens, clear waste and generate nutrients. Here we show that LRRK2, a protein that is tightly linked to Parkinson’s disease, negatively regulates lysosome degradative activity in macrophages and microglia via […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

Reports of the death of brain-behavior associations have been greatly exaggerated

Posted by klaurent UCSD / Salk

Kavli Affiliate: Timothy Brown, Anders Dale | Authors: Carolina Makowski, Timothy T Brown, Weiqi Zhao, Donald J Hagler, Pravesh Parekh, Hugh Garavan, Thomas E Nichols, Terry L Jernigan and Anders M Dale | Summary: Magnetic resonance imaging (MRI) has been a popular and useful non-invasive method to map patterns of brain structure and function to […]


Continue.. Reports of the death of brain-behavior associations have been greatly exaggerated

Spatially clustered neurons encode vocalization categories in the bat midbrain

Posted by klaurent Hopkins

Kavli Affiliate: Kishore V. Kuchibhotla, Cynthia F. Moss | Authors: Jennifer Lawlor, Melville Wohlgemuth, Cynthia F Moss and Kishore V Kuchibhotla | Summary: Rapid categorization of vocalizations enables adaptive behavior across species. While categorical perception is thought to arise in the neocortex, humans and other animals could benefit from functional organization of ethologically-relevant sounds at […]


Continue.. Spatially clustered neurons encode vocalization categories in the bat midbrain

Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Michael J. Lynch, Maithili Deshpande, Kurni Kyrniyati, Kai Zhang, Milinda James, Michael Miller, Sheng Zhang, Felipe J. Passalia, Elsio A. Wunder, Jr., Nyles W. Charon, Chunhao Li and Brian R Crane | Summary: Spirochete bacteria cause Lyme disease, leptospirosis, syphilis and several other human illnesses. Unlike other bacteria, spirochete […]


Continue.. Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook

Brain-wide measurement of protein turnover with high spatial and temporal resolution

Posted by klaurent UCSD / Salk

Kavli Affiliate: Timothy Brown | Authors: Boaz Mohar, Jonathan B. Grimm, Ronak Patel, Timothy A. Brown, Paul Tillberg, Luke D. Lavis, Nelson Spruston and Karel Svoboda | Summary: Cellular functions are regulated by synthesizing and degrading proteins on time scales ranging from minutes to weeks. Protein turnover varies across proteins, cellular compartments, cell types, and […]


Continue.. Brain-wide measurement of protein turnover with high spatial and temporal resolution

Generative models inferred using statistical tests reveal context-dependent syllable transitions in Bengalese finch songs

Posted by klaurent UCSF

Kavli Affiliate: Kristofer Bouchard | Authors: Jiali Lu, Sumithra Surendralal, Kristofer E Bouchard and Dezhe Z. Jin | Summary: Generative models are widely used in modeling sequences from language to birdsong. Here we show that a statistical test designed to guard against overgeneralization of a model in generating sequences can be used to infer minimal […]


Continue.. Generative models inferred using statistical tests reveal context-dependent syllable transitions in Bengalese finch songs

Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, Amit Laxmikant Deshmukh, David A Davis, Matthew R Paul, Thomas S Carroll, Marie-Christine Caron, Jean-Yves Masson, Christopher E Pearson and Nathaniel Heintz | Summary: Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT) CAG tract are key features of Huntington’s disease […]


Continue.. Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum

Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Nisha Dhanushkodi, Swayam Prakash, Afshana Quadiri, Latifa Zayou, Ruchi Srivastava, Amin Mohammed Shaik, Berfin Suzer, Izabela Coimbra Ibraim, Gary Landucci, Delia F Tifrea, Mahmoud Singer, Leila Jamal, Robert A Edwards, Hawa Vahed, Lawrence Brown and LBACHIR BENMOHAMED | Summary: Significance SARS-CoV-2 Variants of Concern (VOCs) continue to evolve and […]


Continue.. Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: JAEKWANG JEONG, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Juhyeon Hong, Kwangmin Yoo, David Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann Haberman, Lark Kyun Kim, Shawn Ferguson, Jungmin Choi and John Wysolmerski | Summary: Read More


Continue.. Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

Precision-engineered biomimetics: the human fallopian tube

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J Crawford, André Forjaz, Isha Bhorkar, Triya Roy, David Schell, Vasco Queiroga, Kehan Ren, Donald Kramer, Joanna Bons, Wilson Huang, Gabriella C Russo, Meng-Horng Lee, Birgit Schilling, Pei-Hsun Wu, Ie-Ming Shih, Tian-Li Wang, Ashley Kiemen and Denis Wirtz | Summary: The fallopian tube has an essential role in […]


Continue.. Precision-engineered biomimetics: the human fallopian tube