SOL3D: Soft-lithography on 3D vat polymerised moulds for fast, versatile, and accessible high-resolution fabrication of customised multiscale cell culture devices with complex designs

Posted by klaurent NTNU

Kavli Affiliate: Valentina Di Maria | Authors: Cathleen Hagemann, Matthew C. D. Bailey, Eugenia Carraro, Valentina Maria Lionello, Noreen Khokhar, Pacharaporn Suklai, Carmen Moreno-Gonzalez, Kelly O’Toole, George Konstantinou, Sudeep Joshi, Eleonora Giagnorio, Mads Bergholt, Albane Imbert, Francesco Saverio Tedesco and Andrea Serio | Summary: Cell culture devices, such as microwells and microfluidic chips, are designed […]


Continue.. SOL3D: Soft-lithography on 3D vat polymerised moulds for fast, versatile, and accessible high-resolution fabrication of customised multiscale cell culture devices with complex designs

Direct Entorhinal Control of CA1 Temporal Coding

Posted by klaurent NTNU

Kavli Affiliate: Clifford Kentros | Authors: Matteo Guardamagna, Oscar M.T. Chadney, Federico Stella, Qiangwei Zhang, Clifford Kentros and Francesco P. Battaglia | Summary: Local computations of CA1 neurons are shaped by two direct input streams, from CA3 and EC LIII. By specifically silencing the direct input from the entorhinal cortex, we found that single-cell temporal […]


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Revealing abrupt transitions from goal-directed to habitual behavior

Posted by klaurent Hopkins

Kavli Affiliate: Kishore V. Kuchibhotla, Adam S. Charles | Authors: Sharlen Moore, Zyan Wang, Ziyi Zhu, Ruolan Sun, Angel Lee, Adam Charles and Kishore V Kuchibhotla | Summary: A fundamental tenet of animal behavior is that decision-making involves multiple ‘controllers.’ Initially, behavior is goal-directed, driven by desired outcomes, shifting later to habitual control, where cues […]


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Mapping general anesthesia states based on electro-encephalogram transition phases

Posted by klaurent UCSF

Kavli Affiliate: Jeanne Paz | Authors: Virginie Loison, Yuliya Voskobiynyk, Britta Lindquist, Deanna Necula, Dan Longrois, Jeanne T. Paz and David Holcman | Summary: Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate, or overdosed, with no transition […]


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Emergence of brain-like mirror-symmetric viewpoint tuning in convolutional neural networks

Posted by klaurent Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Amirhossein Farzmahdi, Wilbert Zarco, Winrich Freiwald, Nikolaus Kriegeskorte and Tal Golan | Summary: Primates can recognize objects despite 3D geometric variations such as in-depth rotations. The computational mechanisms that give rise to such invariances are yet to be fully understood. A curious case of partial invariance occurs in the […]


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Barley cultivars shape the abundance, phenotype, genotype and gene expression of their associated microbiota by differential root exudate secretion

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Alba Pacheco-Moreno, Anita Bollmann-Giolai, Govind Chandra, Paul Brett, Jack Davies, Owen Thornton, Philip Poole, Vinoy Ramachandran, James Brown, Paul Nicholson, Chris Ridout, Sarah DeVos and Jacob G. Malone | Summary: Plant associated microbes play vital roles in promoting plant growth and health, with plants secreting root exudates into […]


Continue.. Barley cultivars shape the abundance, phenotype, genotype and gene expression of their associated microbiota by differential root exudate secretion

Separating the control of moving and holding still in post-stroke arm paresis

Posted by klaurent Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]


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Mitochondria morphology governs ATP production rate

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Guadalupe C. Garcia, Kavya Gupta, Thomas M. Bartol, Jr., Terrence J. Sejnowski and Padmini Rangamani | Summary: Life is based on energy conversion. In particular, in the nervous system significant amounts of energy are needed to maintain synaptic transmission and homeostasis. To a large extent, neurons depend on oxidative […]


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A unified framework to identify demographic buffering in natural populations

Posted by klaurent UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Samuel J L Gascoigne, Andre Tavares Correia Dias, Maja Kajin and Rob Salguero-Gomez | Summary: The Demographic Buffering Hypothesis (DBH) predicts that natural selection reduces the temporal fluctuations in demographic processes (such as survival, development, and reproduction), due to their negative impacts on population dynamics. However, […]


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Cognitive rehabilitation can improve brain injury-induced deficits in behavioral flexibility and impulsivity linked to impaired reward-feedback activity.

Posted by klaurent UCSD / Salk

Kavli Affiliate: Dhakshin Ramanathan | Authors: Miranda Francoeur Koloski, Christopher M O’Hearn, Michelle Frankot, Lauren P Giesler, Dhakshin S Ramanathan and Cole Vonder Haar | Summary: Traumatic brain injury (TBI) affects a large population, resulting in severe cognitive impairments. Although cognitive rehabilitation is an accepted treatment for some deficits, studies in patients are limited in […]


Continue.. Cognitive rehabilitation can improve brain injury-induced deficits in behavioral flexibility and impulsivity linked to impaired reward-feedback activity.