Kavli Affiliate: Mark Ellisman | Authors: Yaeram Jeong, chung-ha Davis, Aaron Muscarella, Viraj Deshpande, Keun-Young Kim, Mark Ellisman and Nicholas Marsh-Armstrong | Summary: We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of […]
Kavli Affiliate: Mark Ellisman | Authors: George A. Spirou, Matthew Kersting, Sean Carr, Bayan Razzaq, Carolyna Y. Alves-Pinto, Mariah Dawson, Mark H. Ellisman and Paul B. Manis | Summary: Globular bushy cells (GBCs) of the cochlear nucleus play central roles in the temporal processing of sound. Despite investigation over many decades, fundamental questions remain about […]
Kavli Affiliate: Liam Paninski | Authors: Marcus A Triplett, Marta Gajowa, Hillel Adesnik and Liam Paninski | Summary: Two-photon optogenetics has transformed our ability to probe the structure and function of neural circuits. However, achieving precise optogenetic control of neural ensemble activity has remained fundamentally constrained by the problem of off-target stimulation (OTS): the inadvertent […]
Kavli Affiliate: Hey-Kyoung Lee, Richard Huganir | Authors: Yoichi Araki, Elizabeth E. Gerber, Kacey E. Rajkovich, Ingie Hong, Richard C. Johnson, Hey-Kyoung Lee, Alfredo Kirkwood and Richard L. Huganir | Summary: SYNGAP1 is a Ras-GTPase activating protein highly enriched at excitatory synapses in the brain. De novo loss-of-function mutations in SYNGAP1 are a major cause […]
Kavli Affiliate: Roger Nicoll | Authors: Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N Chau, Julie C. Lauterborn, Salvatore Incontro, Kathy H. Li, Alma L. Burlingame, Katherine W. Roche, Christine M. Gall, Roger A. Nicoll and Javier Diaz-Alonso | Summary: Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing […]
Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip, Payton A Asch and John H Reynolds | Summary: Age-related cognitive impairment is not expressed uniformly across cognitive domains. Cognitive functions that rely on brain areas that undergo substantial neuroanatomical changes with age often show age-related impairment, while those that rely on brain areas […]
Kavli Affiliate: Li Zhao | Authors: Philipp Kaldis and Li Na Zhao | Summary: piRNAs are important in protecting germline integrity. 3’-terminal 2’-O-methylation is essential for piRNA maturation and to protect it from degradation. HENMT1 carries out the 2’-O-methylation, which is of key importance for piRNA stability and functionality. However, neither the structure nor the […]
Kavli Affiliate: Michael W. Young | Authors: Yi Sun, Tyler J. Florio, Sagar Gupta, Michael C. Young, Quinlen F. Marshall, Samuel E. Garfinkle, Georgia F. Papadaki, Hau V. Truong, Emily Mycek, Peiyao Li, Alvin Farrel, Nicole L. Church, Shereen Jabar, Matthew D. Beasley, Ben R. Kiefel, Mark Yarmarkovich, Leena Mallik, John M. Maris and Nikolaos […]
Kavli Affiliate: David Linden | Authors: Hanna Honcamp, Suvarnalata Xanthate Duggirala, Julio Rodino Climent, Aland Astudillo, Nelson J. Trujillo-Barreto, Michael Schwartze, David E.J. Linden, Therese Amelsvoort, Wael El-Deredy and Sonja A Kotz | Summary: Introduction Auditory verbal hallucinations (AVH) are a transdiagnostic phenomenon but also occur in the general population. The disposition to experience AVH […]
Kavli Affiliate: Robert Edwards | Authors: Swayam Fnu Prakash, Nisha R Dhanushkodi, Latifa Zayou, Izabela Coimbra Ibraim, Afshana Quadiri, Pierre Gregoire Coulon, Delia F Tifrea, Berfin Suzler, Mohamed Amin, Amruth Chilukuri, Robert A Edwards, Hawa Vahed, Anthony B. Nesburn, Baruch D Kuppermann, Jeffrey B Ulmer, Dan Gil, Trevor M Jones and Lbachir BenMohamed | Summary: […]