Using phylogenetic summary statistics for epidemiological inference

Kavli Affiliate: Rafael Nunez | Authors: Rafael C Nunez, Gregory R Hart, Michael Famulare, Christopher Lorton and Joshua T Herbeck | Summary: Since the coining of the term phylodynamics, the use of phylogenies to understand infectious disease dynamics has steadily increased. As methods for phylodynamics and genomic epidemiology have proliferated and grown more computationally expensive, […]


Continue.. Using phylogenetic summary statistics for epidemiological inference

Synaptic Potentiation of Engram cells is Necessary and Sufficient for Context Fear Memory

Kavli Affiliate: Mark Mayford | Authors: Leonardo M Cardozo, Andre F Sousa, Blythe C Dillingham, Westley Dang, Nicholas Job, Eun J Yoo, Sural K Ranamukhaarachchi, Qi Yuan and Mark Mayford | Summary: The nature and distribution of the synaptic changes that underlie memory are not well understood. We examined the synaptic plasticity behind context fear […]


Continue.. Synaptic Potentiation of Engram cells is Necessary and Sufficient for Context Fear Memory

An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus

Kavli Affiliate: Charles M. Rice | Authors: Matthew A Cattle, Lauren C Aguado, Samantha Sze, Dylan Yueyang Wang, Thales Papagiannakopoulos, Susan Smith, Charles M Rice, William Matthew Schneider and John T Poirier | Summary: Retrons are a retroelement class found in diverse prokaryotes that can be adapted to augment CRISPR-Cas9 genome engineering technology to efficiently […]


Continue.. An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

Kavli Affiliate: Michael Miller | Authors: Hannah Mummey, Weston Elison, Katha Korgaonkar, Ruth Elgamel, Parul Kudtarkar, Emily Griffin, Paola Benaglio, Michael Miller, Alokkumar Jha, Jocelyn E Manning Fox, Mark Mccarthy, Sebastian Preissl, Anna L Gloyn, Patrick E Macdonald and Kyle J Gaulton | Summary: Physiological variability in pancreatic cell type gene regulation and the impact […]


Continue.. Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

Kavli Affiliate: Denis Wirtz | Authors: Ashley L Kiemen, Cristina Almagro Perez, Valentina Matos Romero, André Forjaz, Alicia M Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin, Jaanvi Mahesh Babu, Elizabeth D Thompson, Toby C Cornish, Won Jin Ho, Laura D Wood, PeiHsun Wu, Arrate Munoz-Barrutia, Ralph H Hruban and […]


Continue.. 3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

Kavli Affiliate: Xin Duan | Authors: Travis D Goode, Jason Bondoc Alipio, Antoine Besnard, Devesh Pathak, Michael Kritzer-Cheren, Ain Chung, Xin Duan and Amar Sahay | Summary: Adaptive regulation of feeding depends on linkage of internal states and food outcomes with contextual cues. Human brain imaging has identified dysregulation of a hippocampal-lateral hypothalamic area (LHA) […]


Continue.. A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

Conservation, alteration, and redistribution of mammalian striatal interneurons

Kavli Affiliate: Alex Pollen | Authors: Emily K Corrigan, Michael DeBerardine, Aunoy Poddar, Miguel Turrero Garcia, Matthew T Schmitz, Corey Harwell, Mercedes Paredes, Fenna M Krienen and Alex Aaron Pollen | Summary: Mammalian brains vary in size, structure, and function, but the extent to which evolutionarily novel cell types contribute to this variation remains unresolved1–4. […]


Continue.. Conservation, alteration, and redistribution of mammalian striatal interneurons

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree

Kavli Affiliate: Michael Goldberg | Authors: David Porubsky, Harriet Dashnow, Thomas A. Sasani, Glennis A. Logsdon, Pille Hallast, Michelle D. Noyes, Zev N. Kronenberg, Tom Mokveld, Nidhi Koundinya, Cillian Nolan, Cody J. Steely, Andrea Guarracino, Egor Dolzhenko, William T. Harvey, William J. Rowell, Kirill Grigorev, Thomas J. Nicholas, Keisuke K. Oshima, Jiadong Lin, Peter Ebert, […]


Continue.. A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]


Continue.. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Hierarchical gradients of multiple timescales in the mammalian forebrain

Kavli Affiliate: Daeyeol Lee | Authors: Min Song, Eun Ju Shin, Hyojung Seo, Alireza Soltani, Nicholas A Steinmetz, Daeyeol Lee, Min Whan Jung and Se-Bum Paik | Summary: Many anatomical and physiological features of cortical circuits, ranging from the biophysical properties of synapses to the connectivity patterns among different neuron types, exhibit consistent variation along […]


Continue.. Hierarchical gradients of multiple timescales in the mammalian forebrain