Neuromodulators generate multiple context-relevant behaviors in a recurrent neural network by shifting activity flows in hyperchannels

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye and Terrence Sejnowski | Authors: Ben Tsuda, Stefan C Pate, Kay M Tye, Hava T Siegelmann and Terrence J Sejnowski | Summary: Neuromodulators are critical controllers of neural states, with dysfunctions linked to various neuropsychiatric disorders. Although many biological aspects of neuromodulation have been studied, the computational principles underlying how neuromodulation […]


Continue.. Neuromodulators generate multiple context-relevant behaviors in a recurrent neural network by shifting activity flows in hyperchannels

Spontaneously regenerative corticospinal neurons in mice

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Benjamin W Fait, Bianca Cotto, Tatsuya C Murakami, Michael Hagemann-Jensen, Huiqing Zhan, Corinne Freivald, Isadora Turbek, Yuan Gao, Zizhen Yao, Sharon W Way, Hongkui Zeng, Bosiljka Tasic, Oswald Steward, Nathaniel Heintz and Eric F Schmidt | Summary: The spinal cord receives inputs from the cortex via corticospinal neurons (CSNs). […]


Continue.. Spontaneously regenerative corticospinal neurons in mice

Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors

Posted by dbos NTNU

Kavli Affiliate: Emre Yaksi | Authors: Anna Maria Ostenrath, Nicholas Faturos, Yagnur Isik Ciftci Cobanoglu, Bram Serneels, Inyoung Jeong, Anja Enz, Francisca Hinrichsen, Aytac Kadir Mutlu, Ricarda Bardenhewer, Suresh Kumar Jetti, Stephan C. F. Neuhauss, Nathalie Jurisch-Yaksi and Emre Yaksi | Summary: Inhibition contributes to various brain computations from sensory motor transformations to cognitive operations. […]


Continue.. Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors

A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

Posted by dbos Yale

Kavli Affiliate: Shawn Ferguson | Authors: Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage evoked by chemical and pathogenic stimuli. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood. […]


Continue.. A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

State of India’s Birds 2023: A framework to leverage semi-structured citizen science for bird conservation

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Ashwin Viswanathan, Karthik Thrikkadeeri, Pradeep Koulgi, Praveen J, Arpit Deomurari, Ashish Jha, Ashwin Warudkar, Kulbhushansingh Suryawanshi, MD Madhusudan, Monica Kaushik, Naman Goyal, Priti bangal, Rajah Jayapal, Suhel Quader, Sutirtha Dutta, Tarun Menon and Vivek Ramachandran | Summary: Birds and their habitats are threatened with extinction around the world. […]


Continue.. State of India’s Birds 2023: A framework to leverage semi-structured citizen science for bird conservation

Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Ye Li, Thomas van Kralingen, Megan Masi, Brandon Villaneuva Sanchez, Beyonca Mitchell, Joshua Johnson, Jorge Miranda-Barrientos, Jason J Rehg, Keri Martinowich and Gregory V Carr | Summary: Attention deficits, a hallmark of many neuropsychiatric disorders, significantly impair quality of life and functional outcome for patients. Continuous Performance Tests (CPTs) […]


Continue.. Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespan

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Yu Kang T Xu, Abigail Bush, Ephraim Musheyev, Anya A Kim, Sen Zhang, Jaime Eugenin von Bernhardi, Jeremias Sulam and Dwight E Bergles | Summary: Insulating sheaths of myelin accelerate neuronal signaling in complex networks of the mammalian brain. In the CNS, myelin sheaths are exclusively produced by oligodendrocytes, […]


Continue.. Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespan

Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Posted by dbos Hopkins

Kavli Affiliate: Kathleen Cullen | Authors: Kazuya Ono, Amandine Jarysta, Natasha C. Hughes, Alma Jukic, Hui Ho Vanessa Chang, Michael R Deans, Ruth Anne Eatock, Kathleen E Cullen, Katie S Kindt and Basile Tarchini | Summary: Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented […]


Continue.. Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Josselyn Vergara, Ana Pereira, Kenneth Pelkey, Thien Tran, Bram L. Gorissen, Anna Vlacho, Ariel Hairston, Shuhan Huang, Deepanjali Dwivedi, Sarah Du, Sara Wills, Justin McMahon, Anthony T. Lee, Edward F. Chang, Taha Razzaq, Ahmed Qazi, Geoffrey Vargish, Xiaoqing Yuan, Adam Caccavano, Steven […]


Continue.. An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

Brain-wide circuitry underlying altered auditory habituation in zebrafish models of autism.

Posted by dbos Yale

Kavli Affiliate: Ellen J. Hoffman | Authors: Maya Wilde, Anahita Ghanbari, Tessa Mancienne, Ailís Moran, Rebecca E. Poulsen, Lena Constantin, Conrad Lee, Leandro Aluisio Scholz, Joshua Arnold, Wei Qin, Timothy J. Karle, Steven Petrou, Itia A. Favre-Bulle, Ellen J. Hoffman and Ethan K. Scott | Summary: IAuditory processing is widely understood to occur differently in […]


Continue.. Brain-wide circuitry underlying altered auditory habituation in zebrafish models of autism.