Kavli Affiliate: Martin Lindquist | Authors: Heejung Jung, Maryam Amini, Bethany J Hunt, Eilis I Murphy, Patrick Sadil, Yaroslav O Halchenko, Bogdan Petre, Zizhuang Miao, Philip A Kragel, Xiaochun Han, Mickela O Heilicher, Michael Sun, Owen G Collins, Martin A Lindquist and Tor D Wager | Summary: Cognitive neuroscience has advanced significantly due to the […]
Kavli Affiliate: Li Zhao | Authors: Aaron W. James, Qizhi Qin, Sowmya Ramesh, Zhao Li, Lingke Zhong, Masnsen Cherief, Mary Archer, Xin Xing, Neelima Thottappillil, Mario Gomez-Salazar, Manyu Zhu, Leslie Chang, Ankit Uniyal, Khadijah Mazhar, Monisha Mittal, Edward F. McCarthy, Carol D. Morris, Benjamin Levi, Yun Guan, Thomas L. Clemens and Theodore J. Price | […]
Kavli Affiliate: Nicola Allen | Authors: James Deng, Lara Labarta-Bajo, Ashley N Brandebura, Samuel B Kahn, Antonio F M Pinto, Jolene K Diedrich and Nicola J Allen | Summary: Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder with manifestations spanning molecular, neuroanatomical, and behavioral changes. Astrocytes contribute to FXS pathogenesis and show hundreds of […]
Kavli Affiliate: Yifan Cheng | Authors: Xi Liu, Yang Li, Lennice Castro, Zanlin Yu, Yifan Cheng, Matthew D Daugherty and John D Gross | Summary: ZYG11B is a substrate specificity factor for Cullin-RING ubiquitin ligase (CRL2) involved in many biological processes, including Gly/N-degron pathways. Yet how the binding of ZYG11B with CRL2 is coupled to […]
Kavli Affiliate: Yuh Nung and Jan Yifan Cheng and Yuh Nung Jan | Authors: Yukun Wang, Peng Jin, Avinash Kumar, Lily Jan, Yifan Cheng, Yuh-Nung Jan and Yongli Zhang | Summary: TCytoskeleton-tethered mechanosensitive channels (MSCs) utilize compliant proteins or protein domains called gating springs to convert mechanical stimuli into electric signals, enabling sound and touch […]
Kavli Affiliate: Devanand Manoli | Authors: Kimberly Lorraine Page Long, Nerissa Emmy Graetz Hoglen, Alex J. Keip, Robert M. Klinkel, Déjenaé L. See, Joseph Maa, Jenna C. Wong, Michael Sherman and Devanand Manoli | Summary: The formation of enduring relationships dramatically influences future behavior, promoting affiliation between familiar individuals. How such attachments are encoded to […]
Kavli Affiliate: Flora Vaccarino | Authors: Yeongjun Jang, Livia Tomasini, Taejeong Bae, Anna Szekely, Flora M. Vaccarino and Alexej Abyzov | Summary: Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing […]
Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: Cognitive impairment is a frequent non-motor symptom in Parkinson’s disease, and cortical Lewy pathology is strongly […]
Kavli Affiliate: Liam Paninski | Authors: The International Brain Laboratory, Kush Banga, Julius Benson, Niccolò Bonacchi, Sebastian A Bruijns, Rob Campbell, Gaëlle A Chapuis, Anne K Churchland, M Felicia Davatolhagh, Hyun Dong Lee, Mayo Faulkner, Fei Hu, Julia Hunterberg, Anup Khanal, Christopher Krasniak, Guido T Meijer, Nathaniel J Miska, Zeinab Mohammadi, Jean-Paul Noel, Liam Paninski, […]
Kavli Affiliate: Shreesh P. Mysore | Authors: Ninad B Kothari, Wen-Kai You, Arunima Banerjee, Qingcheng Zhang and Shreesh P Mysore | Summary: Animal behavior at any instant is guided by information from only a subset of the plethora of stimuli in their sensory environments. The neural circuit mechanisms that select a behaviorally relevant ‘target’ from […]