Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

Posted by dbos Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Kyle A. Johnsen, Nathanael A. Cruzado, Zachary C. Menard, Adam A. Willats, Adam S. Charles, Jeffrey E. Markowitz and Christopher J. Rozell | Summary: Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments such as all-optical or closed-loop […]


Continue.. Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

High Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene Editors

Posted by dbos UCSF

Kavli Affiliate: Seth Shipman | Authors: Kate D. Crawford, Asim G. Khan, Santiago C. Lopez, Hani Goodarzi and Seth Shipman | Summary: The bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applications. In these technologies, a natural retron non-coding RNA (ncRNA) is modified to encode a […]


Continue.. High Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene Editors

Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone

Posted by dbos UCSF

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Arantxa Cebrian-Silla, Marcos Assis Nascimento, Walter Mancia Leon, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Kirsten Obernier, David M Steffen, Daniel A Lim, Jose Manuel Garcia-Verdugo and Arturo Alvarez-Buylla | Summary: Neurogenesis and gliogenesis continue in the Ventricular-Subventricular Zone (V-SVZ) of the adult rodent brain. B1 cells are astroglial cells derived from […]


Continue.. Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone

qMAP Enabled Microanatomical Mapping of Human Skin Aging

Posted by dbos Hopkins, Yale

Kavli Affiliate: Denis Wirtz | Authors: CKyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Yebin Im, Guoqing Cheng, Bartholomew Starich, Ashley L Kiemen, Jude M Phillip, Sashank Reddy, Corrine Joshu, Joel Sunshine, Jeremy Walston, Denis Wirtz and Pei-Hsun Wu | Summary: Aging is a major driver of diseases in humans. […]


Continue.. qMAP Enabled Microanatomical Mapping of Human Skin Aging

A lasting impact of serotonergic psychedelics on visual processing and behavior

Posted by dbos Columbia, Yale

Kavli Affiliate: Darcy Peterka | Authors: Chloe L West, Georgia Bastos, Annabel Duran, Samen Nadeem, David A Ricci, Anna M Rader, Joseph A Wargo, Darcy S Peterka, Neil Van Leeuwen and Jordan P Hamm | Summary: Serotonergic psychedelics (e.g., psilocybin) have shown potential for treating psychiatric disorders, with therapeutic effects lasting weeks after a single […]


Continue.. A lasting impact of serotonergic psychedelics on visual processing and behavior

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Posted by dbos Hopkins, Yale

Kavli Affiliate: Kathleen Cullen | Authors: Arnaud P. J. Giese, Wei-Hsiang Weng, Katie S Kindt, Vanessa H. H. Chang, Jonathan S Montgomery, Evan M. Ratzan, Alisha J. Beirl, Roberto Aponte Rivera, Jeffrey M. Lotthammer, Sanket Walujkar, Mark P. Foster, Omid A. Zobeiri, Jeffrey R. Holt, Saima Riazuddin, Kathleen E. Cullen, Marcos Sotomayor and Zubair M […]


Continue.. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

Posted by dbos Hopkins, Yale

Kavli Affiliate: Denis Wirtz | Authors: Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng-Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nico Macaluso, Joon Eoh, Kyu Sang Han, Luo Gu, Jeremey Walston, Sean Sun, Pei-Hsun Wu, Denis Wirtz and Jude M. Phillip | Summary: Cellular senescence is a major driver of aging and disease. Here […]


Continue.. Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

Dopamine D1 receptor expression in dlPFC inhibitory parvalbumin neurons may contribute to higher visuospatial distractibility in marmosets versus macaques

Posted by dbos Yale

Kavli Affiliate: Anirvan Nandy | Authors: Mary Kate P Joyce, Tsvetoslav G Ivanov, Fenna Krienen, Jude Mitchell, Shaojie Ma, Wataru Inoue, Anirvan P Nandy, Dibyadeep Datta, Alvaro Duque, Jon I Arellano, Rahul Gupta, Guillermo Gonzalez-Burgos, David A Lewis, Nenad Sestan, Steven A McCarroll, Julio C Martinez-Trujillo, Seán Froudist-Walsh and Amy FT Arnsten | Summary: Marmosets […]


Continue.. Dopamine D1 receptor expression in dlPFC inhibitory parvalbumin neurons may contribute to higher visuospatial distractibility in marmosets versus macaques

Control of innate olfactory valence by segregated cortical amygdala circuits

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: James R Howe, Chung-Lung Chan, Donghyung Lee, Marlon Blanquart, Haylie Romero, Abigail N Zadina, Mackenzie E Lemieux, Paula A Desplats, Kay M Tye and Cory M Root | Summary: Animals perform innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or […]


Continue.. Control of innate olfactory valence by segregated cortical amygdala circuits

Multi-sample non-negative spatial factorization

Posted by dbos Hopkins

Kavli Affiliate: Loyal Goff | Authors: Multi-sample non-negative spatial factorization | Summary: It is important to model biological variation when analyzing spatial transcriptomics data from multiple samples. One approach to multi-sample analysis is to spatially align samples, but this is a challenging problem. Here, we provide an alignment-free framework for generalizing a one-sample spatial factorization […]


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