The combination of feedforward and feedback processing accounts for contextual effects in visual cortex

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Serena Di Santo, Mario Dipoppa, Andreas Keller, Morgane Roth, Massimo Scanziani and Kenneth D Miller | Summary: Abstract Sensory systems must combine local features with context to infer meaning. Accordingly, context profoundly influences neural responses. We developed a unified circuit model demonstrating how feedforward and feedback inputs are integrated […]


Continue.. The combination of feedforward and feedback processing accounts for contextual effects in visual cortex

CellBoost: A pipeline for machine assisted annotation in neuroanatomy

Posted by dbos UCSD / Salk

Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, Beth Friedman, Jun Takatoh, Fan Wang, David Kleinfeld and Yoav Freund | Summary: One of the important yet labor intensive tasks in neuroanatomy is the identification of select populations of cells. Current high-throughput techniques enable marking cells with histochemical fluorescent molecules as well as through the genetic […]


Continue.. CellBoost: A pipeline for machine assisted annotation in neuroanatomy

Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture

Posted by dbos Rockefeller

Kavli Affiliate: Sidney Strickland | Authors: Pradeep K Singh, Elisa Nicoloso Simoes-Pires, Zu-Lin Chen, Daniel Torrente, Marissa Calvano, Anurag Sharma, Sidney Strickland and Erin H Norris | Summary: Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer’s disease (AD). Vascular deficits include a compromised blood-brain barrier, which can lead to extravasation of […]


Continue.. Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture

Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis

Posted by dbos UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Atle Eskeland Rimehaug, Anders M. Dale, Anton Arkhipov and Gaute T. Einevoll | Summary: The local field potential (LFP), the low-frequency part of the extracellular potential, reflects transmembrane currents in the vicinity of the recording electrode. Thought mainly to stem from currents caused by synaptic input, it provides information […]


Continue.. Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Posted by dbos UCSF

Kavli Affiliate: Xin Duan, Arnold R. Kriegstein, and Xin Duan | Authors: Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Arantxa Cebrian-Silla, Qiuli Bi, Jonathan J. Augustin, Lilian G. de Oliveira, Mengyi Song, Xinxin Ge, Guolong Zuo, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing […]


Continue.. Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number

Posted by dbos Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley, Jefferey Demas, Hyewon Kim, Francisca Martinez Traub and Alipasha Vaziri | Summary: The brain’s remarkable properties arise from collective activity of millions of neurons. Widespread application of dimensionality reduction to multi-neuron recordings implies that neural dynamics can be approximated by low-dimensional “latent” signals reflecting neural computations. However, […]


Continue.. Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number

Value construction through sequential sampling explains serial dependencies in decision making

Posted by dbos Columbia

Kavli Affiliate: Daphna Shohamy and Michael Shadlen | Authors: Ariel Zylberberg, Akram Bakkour, Daphna Shohamy and Michael N Shadlen | Summary: Many decisions are expressed as a preference for one item over another. When these items are familiar, it is often assumed that the decision maker assigns a value to each of the items and […]


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De novo-designed minibinders expand the synthetic biology sensing repertoire

Posted by dbos UCSF

Kavli Affiliate: Hana El-Samad | Authors: Zara Y. Weinberg, Sarah S. Soliman, Matthew S. Kim, Irene P. Chen, Melanie Ott and Hana El-Samad | Summary: Synthetic and chimeric receptors capable of recognizing and responding to user-defined antigens have enabled “smart” therapeutics based on engineered cells. These cell engineering tools depend on antigen sensors which are […]


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Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Dana E Cobb-Lewis, Anne George, Shannon Hu, Katherine Packard, Mingyuan Song, Oliver Nguyen-Lopez, Emily Ikematsu Tesone, Jhanay Rowden, Julie Wang and Maya Opendak | Summary: Long-term potentiation (LTP) has become a standard model for investigating synaptic mechanisms of learning and memory. Increasingly, it is of interest to understand how […]


Continue.. Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus