Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Posted by dbos Rockefeller, Yale

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Acute Neuropixels recordings in the marmoset monkey

Posted by dbos UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Nicholas M Dotson, Zachary W Davis, Patrick Jendritza and John H Reynolds | Summary: High-density linear probes, like Neuropixels, provide an unprecedented opportunity to understand how neural populations within specific laminar compartments contribute to behavior. Marmoset monkeys, unlike macaque monkeys, have a lissencephalic (smooth) cortex that enables recording perpendicular […]


Continue.. Acute Neuropixels recordings in the marmoset monkey

A software tool for at-home measurement of sensorimotor adaptation

Posted by dbos Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Jihoon Jang, Reza Shadmehr and Scott T Albert | Summary: Sensorimotor adaptation is traditionally studied in well-controlled laboratory settings with specialized equipment. However, recent public health concerns such as the COVID-19 pandemic, as well as a desire to recruit a more diverse study population, have led the motor control […]


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Resilience-driven neural synchrony during naturalistic movie watching: an ultra-high field fMRI study

Posted by dbos NTNU

Kavli Affiliate: Maryam Ziaei | Authors: Shuer Ye, Leona Rahel Batz, Jain Jain, Alireza Salami and Maryam Ziaei | Summary: Sharing others’ emotional states may facilitate the understanding of their well-being characteristics, such as resilience. Despite increasing attention given to resilience for its role in maintaining mental health, the intricacies of its underlying neural correlates […]


Continue.. Resilience-driven neural synchrony during naturalistic movie watching: an ultra-high field fMRI study

Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making

Posted by dbos UCSF

Kavli Affiliate: Philip Starr | Authors: Colin W Hoy, Coralie de Hemptinne, Sarah S Wang, Catherine J Harmer, Matthew A J Apps, Masud Husain, Philip A Starr and Simon Little | Summary: Choosing whether to exert effort to obtain rewards is fundamental to human motivated behavior. However, the neural dynamics underlying the evaluation of reward […]


Continue.. Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making

Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for partially resolved cellular profiling has enabled in-depth quantitative tissue mapping […]


Continue.. Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues

A reference genome for the Andean cavefish Trichomycterus rosablanca (Siluriformes, Trichomycteridae): building genomic resources to study evolution in cave environments

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Daniel Cadena, Laura Pabon, Carlos DoNascimiento, Linelle Abueg, Tatiana Tiley, Brian O-Toole, Dominic Absolon, Ying Sims, Giulio Formenti, Olivier Fedrigo, Erich Jarvis and Mauricio Torres | Summary: Animals living in caves are of broad relevance to evolutionary biologists interested in understanding the mechanisms underpinning convergent evolution. In the Eastern […]


Continue.. A reference genome for the Andean cavefish Trichomycterus rosablanca (Siluriformes, Trichomycteridae): building genomic resources to study evolution in cave environments

Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans

Posted by dbos Rockefeller

Kavli Affiliate: Shai Shaham | Authors: Colin W Hoy, Coralie de Hemptinne, Sarah S Wang, Catherine J Harmer, Matthew A J Apps, Masud Husain, Philip A Starr and Simon Little | Summary: Neurons have elaborate structures that determine their connectivity and functions. Changes in neuronal structure accompany learning and memory formation and are hallmarks of […]


Continue.. Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans

A Photoactivatable Norepinephrine for Probing Adrenergic Neural Circuits

Posted by dbos UCSF

Kavli Affiliate: Kira Poskanzer | Authors: Michelle K. Cahill, Yeraldith Rojas Perez, Amara Larpthaveesarp, Roberto Etchenique and Kira E Poskanzer | Summary: Norepinephrine (NE) is a critical neuromodulator that mediates a wide range of behavior and neurophysiology, including attention, arousal, plasticity, and memory consolidation. A major source of NE is the brainstem nucleus the locus […]


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Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Sonya Kumar Bharathkar, Michael J. Miller and Beth M. Stadtmueller | Summary: Secretory (S) Immunoglobin (Ig) A is the predominant mucosal antibody, which mediates host interactions with commensal and pathogenic microbes, including Clostridioides difficile. SIgA adopts a polymeric IgA structure that is bound by secretory component (SC). Despite significance, […]


Continue.. Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile