Circuit-motivated generalized affine models characterize stimulus-dependent visual cortical shared variability

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Ji Xia, Anna Jasper, Adam Kohn and Kenneth D Miller | Summary: Correlated variability in the visual cortex is modulated by stimulus properties. The stimulus dependence of correlated variability impacts stimulus coding and is indicative of circuit structure. An affine model combining a factor proportional to mean stimulus response […]


Continue.. Circuit-motivated generalized affine models characterize stimulus-dependent visual cortical shared variability

CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Isabel E Wassing, Atsuya Nishiyama, Moeri Hiruta, Qingyuan Jia, Reia Shikimachi, Amika Kikuchi, Keita Sugimura, Xin Hong, Yoshie Chiba, Junhui Peng, Christopher Jenness, Makoto Nakanishi, Li Zhao, Kyohei Arita and Hironori Funabiki | Summary: Mutations of the SNF2 family ATPase HELLS and its activator CDCA7 cause immunodeficiency-centromeric instability-facial anomalies […]


Continue.. CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Posted by dbos Rockefeller

Kavli Affiliate: Robert Edwards | Authors: R. Dilshan Malewana, Victoria Stalls, Aaron May, Xiaozhi Lu, David R Martinez, Alexandra Schafer, Dapeng Li, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Whitney Edwards Beck, Amanda Newman, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, C. Todd DeMarco, Thomas N Denny, Thomas H Oguin III, Wes […]


Continue.. Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Predicting stop codon reassignment improves functional annotation of bacteriophages

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Ryan Cook, Andrea Telatin, George Bouras, Antonio Pedro Camargo, Martin Larralde, Robert A Edwards and Evelien M Adriaenssens | Summary: The majority of bacteriophage diversity remains uncharacterised, and new intriguing mechanisms of their biology are being continually described. Members of some phage lineages, such as the Crassvirales, repurpose stop […]


Continue.. Predicting stop codon reassignment improves functional annotation of bacteriophages

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

Posted by dbos Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli | Authors: Mukesh Kumar, Yumei Wu, Justin Knapp, Daehun Park, Kallol Gupta, Pietro De Camilli and Timothy A. Ryan | Summary: HSP54, a hereditary spastic paraplegia associated with cognitive impairment, is caused by mutations in the neuron-specific triglyceride (TG) lipase DDHD2. Loss of DDHD2 function results […]


Continue.. DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Berrak Ugur, Florian Schueder, Jimann Shin, Michael G Hanna, Yumei Wu, Marianna Leonzino, Maohan Su, Anthony R. McAdow, Catherine A. Wilson, John Postlethwait, Lilianna Solnica-Krezel, Joerg Bewersdorf and Pietro De Camilli | Summary: Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between […]


Continue.. VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1

Covalent Targeting of Splicing in T Cells.

Posted by dbos Rockefeller

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab and Ekaterina V Vinogradova | Summary: Despite significant interest in therapeutic targeting of splicing, few chemical probes […]


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Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

Posted by dbos Yale

Kavli Affiliate: Shawn Ferguson | Authors: Gabriel Talaia, Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Lysosomes play a pivotal role in coordinating macromolecule degradation and regulating cell growth and metabolism. Despite substantial progress in identifying lysosomal signaling proteins, understanding the pathways that synchronize lysosome functions with changing cellular demands remains incomplete. This study uncovers a […]


Continue.. Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Posted by dbos Rockefeller, Yale

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Acute Neuropixels recordings in the marmoset monkey

Posted by dbos UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Nicholas M Dotson, Zachary W Davis, Patrick Jendritza and John H Reynolds | Summary: High-density linear probes, like Neuropixels, provide an unprecedented opportunity to understand how neural populations within specific laminar compartments contribute to behavior. Marmoset monkeys, unlike macaque monkeys, have a lissencephalic (smooth) cortex that enables recording perpendicular […]


Continue.. Acute Neuropixels recordings in the marmoset monkey