Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD

Posted by dbos Hopkins

Kavli Affiliate: Richard Huganir | Authors: Kevin Chen, Junhua Yang, Bian Liu, Chaohua Jiang, Nicholas Koylass, Zhe Zhang, Shuying Sun, Richard L. Huganir and Zhaozhu Qiu | Summary: Endosomal homeostasis is critical for neuronal function, including the post-synaptic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Dynamic AMPAR trafficking is a major component of synaptic plasticity, such […]


Continue.. Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD

Latent-TGF-β has a domain swapped architecture

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Mingliang Jin, Robert Seed, Tiffany Shing, Yifan Cheng and Stephen Nishimura | Summary: The multifunctional cytokine TGF-β is produced in a latent form (L-TGF-β) where a RGD containing homodimeric prodomain forms a “ring” encircling mature TGF-β shielding it from its receptors. Thus L-TGF-β must be activated to function, a […]


Continue.. Latent-TGF-β has a domain swapped architecture

Dysregulation of the fluid homeostasis system by aging

Posted by dbos UCSF

Kavli Affiliate: Zachary Knight | Authors: Heeun Jang, Alexis Behne Sharma, Usan Dan, Jasmine H. Wong, Zachary A. Knight and Jennifer L. Garrison | Summary: Chronic dehydration is a leading cause of morbidity for the elderly, but how aging alters the fluid homeostasis system is not well understood. Here, we used a combination of physiologic, […]


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Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Vysakh Ramachandran, William Brown and Davit A Potoyan | Summary: Liquid-liquid phase separation of proteins and nucleic acids into condensate phases is a versatile mechanism for ensuring compartmentalization of cellular biochemistry. RNA molecules play critical roles in these condensates, particularly in transcriptional regulation and stress responses, exhibiting a […]


Continue.. Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Posted by dbos UCSF

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Matthew Kinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]


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Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Sina Ghandian, Liane Albarghouthi, Kiana Nava, Shivam R. Rai Sharma, Lise Minaud, Laurel Beckett, Naomi Saito, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger and Michael J. Keiser | Summary: Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of […]


Continue.. Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Disparate demographic impacts of the Roman Colonization and the Migration Period in the Iberian Peninsula

Posted by dbos UCSD / Salk

Kavli Affiliate: Jose Ricardo Suarez | Authors: Pablo Carrion, Inigo Olalde, Juan Manuel Jimenez-Arenas, Neus Coromina, David Vivo, Josep Maria Verges, Ana Costa, Daniel Botella, Macarena Bustamante-Alvarez, Javier Heras-Mora, Ricardo Ortega-Ruiz, Celia Chaves, Maite Iris Garcia-Collado, Juan Quiros-Castillo, Jordi Roig, Jose Suarez-Padilla, Ildelfonso Navarro-Luengo, Miguel Angel Cuadrado, Isidro Aguilera, Jordi Morera, Raul Catalan, Maria Luisa […]


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A feedforward mechanism for human-like contour integration

Posted by dbos Harvard

Kavli Affiliate: George A. Alvarez | Authors: Fenil R. Doshi, Talia Konkle and George A. Alvarez | Summary: Summary: Deep neural network models provide a powerful experimental platform for exploring core mechanisms underlying human visual perception, such as perceptual grouping and contour integration — the process of linking local edge elements to arrive at a […]


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Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Juthi Biswas, Dilruba Akter, Michael J Miller, Dennis J Thiele, Eain A. Murphy, Christine O’Connor, Jennifer F Moffat and Gary Chan | Summary: Summary: FDA-approved antivirals against HCMV have several limitations, including only targeting the later stages of the viral replication cycle, adverse side effects, and the emergence of […]


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Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands

Posted by dbos UCSF

Kavli Affiliate: Joshua Berke and Loren Frank | Authors: Alison E. Comrie, Emily J. Monroe, Ari E. Kahn, Eric L. Denovellis, Abhilasha Joshi, Jennifer A. Guidera, Timothy A. Krausz, Joshua D. Berke, Nathaniel D. Daw and Loren M. Frank | Summary: Summary: The cognitive ability to go beyond the present to consider alternative possibilities, including […]


Continue.. Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands