HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Daniel Ranti, Haocheng Yu, Yuanshuo Wang, Christine Bieber, Trine Strandgaard, Berengere Salome, Sean Houghton, Junbum Kim, Hiranmayi Ravichandran, Iyinyeoluwa Okulate, Elliot Merritt, Sunjoo Bang, Alexandros Demetriou, Zhao Li, Sia Viborg Lindskrog, Dan Fu Ruan, Jorge Daza, Richa Rai, Everardo Hegewisch-Solloa, Emily Mace, Ruben Fernandez-Rodriguez, Sudeh Izadmehr, Glenn Doherty, Adam […]


Continue.. HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer

Evolution of lateralized gustation in nematodes

Posted by dbos UCSD / Salk

Kavli Affiliate: Sreekanth Chalasani | Authors: Marisa Mackie, Vivian Vy Le, Heather R Carstensen, Nicole R Kushnir, Dylan L Castro, Ivan M Dimov, Kathleen T Quach, Steve J Cook, Oliver Hobert, Sreekanth H Chalasani and Ray L Hong | Summary: Animals with small nervous systems have a limited number of sensory neurons that must encode […]


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Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

Posted by dbos Hopkins

Kavli Affiliate: Michael Beer | Authors: Bess P. Rosen, Qing V. Li, Hyein S. Cho, Dingyu Liu, Dapeng Yang, Sarah Graff, Jielin Yan, Renhe Luo, Nipun Verma, Jeyaram R. Damodaran, Hanuman T. Kale, Samuel J. Kaplan, Michael A. Beer, Simone Sidoli and Danwei Huangfu | Summary: Pluripotent stem cells are defined by their self-renewal capacity, […]


Continue.. Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

Estrus-Tracking Cortical Neurons Integrate Social cues and Reproductive states to Adaptively Control Sexually Dimorphic Sociosexual Behaviors

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Yuping Wang, Xinli Song, Xiangmao Chen, Ying Zhou, Jihao Ma, Fang Zhang, Liqiang Wei, Guoxu Qi, Nakul Yadav, Benjie Miao, Yiming Yan, Guohua Yuan, Da Mi, Priyamvada Rajasethupathy, Ines Ibanez-Tallon, Xiaoxuan Jia, Nathaniel Heintz and Kun Li | Summary: Female sociosexual behaviors, essential for survival and reproduction, are adaptively […]


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Brain Charts for the Rhesus Macaque Lifespan

Posted by dbos Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Samuel Alldritt, Julian S.B. Ramirez, Reinder Vos de Wael, Richard Bethlehem, Jakob Seidlitz, Zexi Wang, Karl-Heinz Nenning, Nathalia B. Esper, Jonathan Smallwood, Alexandre R. Franco, Kyoungseob Byeon, Aaron Alexander-Bloch, Adam Messinger, Aihua Chen, Alexander Thiele, Alison R. Weiss, Amir Shmuel, Andrew Fox, Anita Tusche, Ansgar M. Brambrink, Arnaud Falchier, […]


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A Hybrid Type I and II Polyketide Synthases Yields Distinct Aromatic Polyketides

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Li Ya Zhao, Jing Shi, Zhao Yang Xu, Jia Lin Sun, Zhang Yuan Yan, Zhi Wu Tong, Ren Xiang Tan, Rui Hua Jiao and Hui Ming Ge | Summary: Bacterial aromatic polyketides are compounds with multiple aromatic rings synthesized by bacterial type II polyketide synthases (PKSs), some of which […]


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De novo-designed minibinders expand the synthetic biology sensing repertoire

Posted by dbos UCSF

Kavli Affiliate: Hana El-Samad | Authors: Zara Y. Weinberg, Sarah S. Soliman, Matthew S. Kim, Irene P. Chen, Melanie Ott and Hana El-Samad | Summary: Synthetic and chimeric receptors capable of recognizing and responding to user-defined antigens have enabled “smart” therapeutics based on engineered cells. These cell engineering tools depend on antigen sensors which are […]


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Polyunsaturated fatty acid-derived lipid mediator networks characterize COVID-19 severity and risk for critical illness

Posted by dbos Rockefeller

Kavli Affiliate: Martin Lindquist | Authors: Maria Papadaki, Eleftherios Pavlos, Marc Dubourdeau, Vincent Bailif, Kamal Badirou, Ioanna-Evdokia Galani, Dimitris Papelis, Natalia Kamperi, Vasiliki Triantafyllia, Lena Siouti, Maria Salagianni, Maria Manioudaki, Nikolaos Paschalidis, Giannis Vatsellas, Evangelia Koukaki, Vasiliki Rapti, Dimitris Thanos, Nikoletta Rovina, Garyfallia Poulakou, Aurelie Cobat, Jean-Laurent Casanova, Constantin Tamvakopoulos and Evangelos Andreakos | Summary: […]


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Effects of connectivity hyperalignment (CHA) on estimated brain network properties: from coarse-scale to fine-scale

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Farzad V. Farahani, Mary Beth Nebel, Tor Wager and Martin A. Lindquist | Summary: Recent gains in functional magnetic resonance imaging (fMRI) studies have been driven by increasingly sophisticated statistical and computational techniques and the ability to capture brain data at finer spatial and temporal resolution. These advances allow […]


Continue.. Effects of connectivity hyperalignment (CHA) on estimated brain network properties: from coarse-scale to fine-scale

Using artificial intelligence to document the hidden RNA virosphere

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]


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