The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Kavli Affiliate: Vikram Chib | Authors: Grace E Steward and Vikram S Chib | Summary: Feelings of cognitive fatigue emerge through repeated mental exertion and are ubiquitous in our daily lives. However, there is a limited understanding of the neurobiological mechanisms underlying the influence of cognitive fatigue on decisions to exert. We use functional magnetic […]


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Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, AndrĂ© Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, AndrĂ© Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Sst- and Vip-Cre mouse lines without age-related hearing loss

Kavli Affiliate: Andrea Hasenstaub | Authors: Calvin T Foss, Timothy Olsen, James Bigelow and Andrea R Hasenstaub | Summary: GABAergic interneurons, including somatostatin (SST) and vasoactive intestinal peptide (VIP) positive cells, play a crucial role in cortical circuit processing. Cre recombinase-mediated manipulation of these interneurons is facilitated by commercially available knock-in mouse strains such as […]


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Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits

Kavli Affiliate: Edward Callaway | Authors: Rachel M. Cassidy, Angel V. Macias, Willian N. Lagos, Chiamaka Ugorji and Edward M. Callaway | Summary: Corticocortical (CC) projections in the visual system facilitate the hierarchical processing of sensory information. In addition to direct CC connections, indirect cortico-thalamo-cortical (CTC) pathways through the pulvinar nucleus of the thalamus can […]


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An emerging view of neural geometry in motor cortex supports high-performance decoding

Kavli Affiliate: Mark Churchland | Authors: Sean M. Perkins, Elom A. Amematsro, John P. Cunningham, Qi Wang and Mark M. Churchland | Summary: Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen to reflect scientific beliefs while yielding tractable computations. Recent scientific advances suggest that the true constraints on neural activity, especially its […]


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Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

Kavli Affiliate: Ann McDermott | Authors: Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Marko Jovanovic, Ann E McDermott, Daniel A Keedy and Neel H Shah | Summary: The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. […]


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Distinct pathway for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses

Kavli Affiliate: Charles M. Rice | Authors: Alexandra L. Tse, Cory M. Acreman, Inna Ricardo-Lax, Jacob Berrigan, Gorka Lasso, Toheeb Balogun, Fiona L. Kearns, Lorenzo Casalino, Georgia L. McClain, Amartya Mudry Chandran, Charlotte Lemeunier, Rommie E. Amaro, Charles M. Rice, Rohit K. Jangra, Jason S. McLellan, Kartik Chandran and Emily Happy Miller | Summary: Understanding […]


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Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Kavli Affiliate: Yishi Jin | Authors: Erin M Ritchie, Siming Zhong, Qianyi Pu, Yunbo Li, Binhai Zheng and Yishi Jin | Summary: The conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in neuronal development, axon injury and stress responses, and neurodegeneration, depending on cell-type and cellular contexts. Emerging evidence implicates abnormal DLK signaling in […]


Continue.. Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Spectral-switching analysis reveals real-time neuronal network representations of concurrent spontaneous naturalistic behaviors in human brain

Kavli Affiliate: Elizabeth Hillman | Authors: Hongkun Zhu, Andrew J Michalak, Edward M Merricks, Alexander H. C. W. Agopyan-Miu, Joshua Jacobs, Marla J Hamberger, Sameer Sheth, Guy M McKhann, Neil Feldstein, Catherine Schevon and Elizabeth M. C. Hillman | Summary: Despite abundant evidence of functional networks in the human brain, their neuronal underpinnings, and relationships […]


Continue.. Spectral-switching analysis reveals real-time neuronal network representations of concurrent spontaneous naturalistic behaviors in human brain