Neuroscience – Page 14 – Kavli Institute Pre-Print Publications

Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

Posted by dbos February 23, 2024March 4, 2024UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is […]

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C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain

Posted by dbos February 22, 2024March 4, 2024UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Yishi Jin, Stephan M Blazie, Daniel Fortunati and Yan Zhao | Summary: Protein translation initiation is a complex and conserved process involving many proteins acting in concert. The eukaryotic initiation factor 3 (eIF3) complex is essential for the assembly of the pre-initiation complex that scans and positions mRNA at […]

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A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Posted by dbos February 22, 2024March 4, 2024Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Yaunlong Zhang, Lekang Yuan, Jiamin Wu, Tobias Noebauer, Rujin Zhang, Guihua Xiao, Mingrui Wang, Hao Xie, Qionghai Dai and Alipasha Vaziri | Summary: Understanding how neuronal dynamics gives rise to ethologically relevant behavior requires recording of neuronal population activity via technologies that are compatible with unconstrained animal behavior. However, […]

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Voice patches in the marmoset auditory cortex revealed by wide-field calcium imaging

Posted by dbos February 22, 2024March 4, 2024Hopkins

Kavli Affiliate: Xiaoqin Wang | Authors: Yang Zhang, Xindong Song, Yueqi Guo, Chenggang Chen, Michael S Osmanski and Xiaoqin Wang | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive […]

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Towards robust and generalizable representations of extracellular data using contrastive learning

Posted by dbos February 21, 2024March 4, 2024Columbia

Kavli Affiliate: Liam Paninski | Authors: Ankit Vishnubhotla, Charlotte Loh, Liam Paninski, Akash Srivastava and Cole Lincoln Hurwitz | Summary: Contrastive learning is quickly becoming an essential tool in neuroscience for extracting robust and meaningful representations of neural activity. Despite numerous applications to neuronal population data, there has been little exploration of how these methods […]

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Development of a Marmoset Apparatus for Automated Pulling (MarmoAAP) to Study Cooperative Behaviors

Posted by dbos February 21, 2024March 4, 2024Yale

Kavli Affiliate: Anirvan Nandy | Authors: Olivia C Meisner, Nicholas A Fagan, Joel Greenwood, Weikang Shi, Monika Jadi, Anirvan S. Nandy and Steve W. C. Chang | Summary: In recent years, the field of neuroscience has increasingly recognized the importance of studying animal behaviors in naturalistic environments to gain deeper insights into ethologically relevant behavioral […]

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Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection

Posted by dbos February 21, 2024March 4, 2024UCSD / Salk

Kavli Affiliate: Sreekanth Chalasani | Authors: Nadia B Haghani, Robert H Lampe, Buck Samuel, Sreekanth H Chalasani and Molly A Matty | Summary: In the wild, C. elegans are emersed in environments teeming with a veritable menagerie of microorganisms. The C. elegans cuticular surface serves as a barrier and first point of contact with this […]

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AIBP controls amyloid beta induced TLR4 inflammarafts and mitochondrial dysfunction in microglia

Posted by dbos February 21, 2024March 4, 2024UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Yi Sak Kim, SOO-HO CHOI, Keun-Young Kim, Juliana M Navia Pelaez, Guy A Perkins, Seunghwan Choi, Nicolaus Nazarenkov Miller, Jungsu Kim, Wonkyu Ju, Robert A Rissman, Mark H Ellisman and Yury I Miller | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia […]

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Multiple objects evoke fluctuating responses in several regions of the visual pathway

Posted by klaurent February 20, 2024March 4, 2024Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Meredith N Schmehl, Valeria C Caruso, Yunran Chen, Na Young Jun, Shawn M Willett, Jeff T Mohl, Douglas A Ruff, Marlene R Cohen, Akinori Ebihara, Winrich Freiwald, Surya T Tokdar and Jennifer M Groh | Summary: How neural representations preserve information about multiple stimuli is mysterious. Because tuning of […]

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A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

Posted by klaurent February 20, 2024March 4, 2024Rockefeller

Kavli Affiliate: Jean-Laurent Casanova, Charles M. Rice | Authors: Jeremie Le Pen, Gabrielle Paniccia, Michael Bauer, H.-Heinrich Hoffmann, Volker Kinast, Marcela Moncada-Velez, Ana Pinharanda, Inna Ricardo-Lax, Ansgar F Stenzel, Edwin A Rosado-Olivieri, Alison W Ashbrook, Kenneth H Dinnon, William Doyle, Catherine Freije, Seon-Hui Hong, Danyel Lee, Tyler Lewy, Joseph M Luna, Avery Peace, Carltin Schmidt, […]

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