Kavli Affiliate: Rafael Yuste | Authors: Netanel Ofer, Victor Hugo Cornejo and Rafael Yuste | Summary: Abstract The propagation of action potentials along axons is traditionally considered to be reliable, as a consequence of the high safety factor of action potential propagation. However, numerical simulations have suggested that, at high frequencies, spikes could fail to […]
Kavli Affiliate: Rafael Yuste | Authors: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O’Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel and Tony Kelly | Summary: Abstract Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using […]
Kavli Affiliate: Adam S. Charles | Authors: Augustine Xiaoran Yuan, Jennifer I Colonell, Anna Lebedeva, Michael Okun, Adam Charles and Timothy D Harris | Summary: Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. New advances in high density extracellular electrophysiology recording probes, […]
Kavli Affiliate: Roderick MacKinnon | Authors: Gonzalo Pérez-Mitta, Yeliz Sezgin, Weiwei Wang and Roderick MacKinnon | Summary: Abstract Integral membrane proteins (IMPs) constitute a large fraction of organismal proteomes, playing fundamental roles in physiology and disease. Despite their importance, the mechanisms underlying dynamic features of IMPs, such as anomalous diffusion, protein-protein interactions, and protein clustering, […]
Kavli Affiliate: Seth Shipman | Authors: Asim G. Khan, Matías Rojas-Montero, Alejandro González-Delgado, Santiago C. Lopez, Rebecca F. Fang and Seth L. Shipman | Summary: Abstract Retrons are bacterial immune systems that use reverse transcribed DNA as a detector of phage infection. They are also increasingly deployed as a component of biotechnology. For genome editing, […]
Kavli Affiliate: Razi Haque Christoph Kirst Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Sam Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Andrew Tritt, Oliver Oliver Ruebel, Thinh Nguyen, […]
Kavli Affiliate: Anirvan Nandy | Authors: Mitchell P. Morton, Sachira Denagamage, Nyomi V. Hudson and Anirvan S. Nandy | Summary: Crowding, the impaired ability to accurately recognize a target stimulus among distractors, is a major bottleneck in visual perception. The spatial configuration of distractors in relation to the target profoundly influences perceptual fidelity. Notably, when […]
Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Abstract Everyday perceptual tasks require sensory stimuli to be dynamically encoded and analyzed according to changing behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating […]
Kavli Affiliate: Joshua Vogelstein | Authors: Xinhui Li, Nathalia Bianchini Esper, Lei Ai, Steve Giavasis, Hecheng Jin, Eric Feczko, Ting Xu, Jon Clucas, Alexandre Franco, Anibal Solon Heinsfeld, Azeez Adebimpe, Joshua T. Vogelstein, Chao-Gan Yan, Oscar Esteban, Russell A. Poldrack, Cameron Craddock, Damien Fair, Theodore Satterthwaite, Gregory Kiar and Michael P. Milham | Summary: Abstract […]
Kavli Affiliate: Darcy Peterka | Authors: Robert M. Lees, Isaac H. Bianco, Robert A. A. Campbell, Natalia Orlova, Darcy S. Peterka, Bruno Pichler, Spencer LaVere Smith, Dimitri Yatsenko, Che-Hang Yu and Adam M. Packer | Summary: Abstract The goal of this protocol is to enable better characterisation of multiphoton microscopy hardware across a large user […]