A predicted structural interactome reveals binding interference from intrinsically disordered regions

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Junhui Peng and Li Zhao | Summary: Proteins function through dynamic interactions with other proteins in cells, forming complex networks fundamental to cellular processes. While high-resolution and high-throughput methods have significantly advanced our understanding of how proteins interact with each other, the molecular details of many important protein-protein interactions are […]


Continue.. A predicted structural interactome reveals binding interference from intrinsically disordered regions

An Anterior Cingulate Cortex Neuronal Ensemble Controls Contextual Opioid Analgesic Tolerance

Posted by dbos Yale

Kavli Affiliate: Marina Picciotto | Rafael E Perez, Yann S Mineur, Cheryl Chen, Wenliang Zhou, Julian Lee Thompsom, Saagar S Motupally, Angelica Minier-Toribio and Marina R Picciotto | Summary: Despite well-established cellular and molecular adaptations, opioid analgesic tolerance can be rapidly reversed in settings where these drugs are not expected. The specific neuronal populations that […]


Continue.. An Anterior Cingulate Cortex Neuronal Ensemble Controls Contextual Opioid Analgesic Tolerance

Neuromodulator control of energy reserves in dopaminergic neurons

Posted by dbos Rockefeller

Kavli Affiliate: Timothy A. Ryan | Camila Pulido, Matthew S. Gentry and Timothy A. Ryan | Summary: The brain is a metabolically vulnerable organ as neurons have both high resting metabolic rates and the need for local rapid conversion of carbon sources to ATP during activity. Midbrain dopamine neurons are thought to be particularly vulnerable […]


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Dynamic representation of sound locations during task engagement in marmoset auditory cortex

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: In auditory cortex, neural responses to stimuli inside receptive fields (RFs) can be further facilitated by behavioral demands, such as attending to a spatial location. It is less clear how off-RF stimuli modulate neural responses and contribute to […]


Continue.. Dynamic representation of sound locations during task engagement in marmoset auditory cortex

Uncertainty and reward histories have distinct effects on decisions after wins and losses

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: Intelligent behavior necessitates an adaptive integration of feedback. It is well-known that animals asymmetrically learn from positive and negative feedback. While asymmetrical learning is a robust behavioral effect, the latent computations behind how animals represent their environments and […]


Continue.. Uncertainty and reward histories have distinct effects on decisions after wins and losses

Neuroanatomical Basis of Coma in Acute Ischemic Stroke

Posted by dbos Rockefeller

Kavli Affiliate: Michael W. Young | Zheng Zhang, Milo White, Jennifer A Kim, Victor M Torres-Lopez, Aya Khalaf, David Jin, Aaron D Boes, Brian L Edlow, Stephen W English, David Fischer, Joel Geerling, Saleem M Halablab, Maarten G Lansberg, Margy McCullough-Hicks, James F Meschia, Patrik L Michel, Paola Palazzo, Benjamin D Reasoner, Robert W Regenhardt, […]


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Genomic resources for comparative analyses of obligate avian brood parasitism

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Rachel A Carroll, Edward Stallknecht Ricemeyer, LaDeana W Hillier, Jeffrey M DaCosta, Ekaterina Osipova, Sara Smith, Gabriel Jamie, Juan Gabriel Martinez, Mercedes Molina-Morales, Tomas Marques-Bonet, Joseph D Manthey, Diana Haddad, Matthew J Fuxjager, Kathleen S Lynch, Jonathan M.D. Wood, Erich Jarvis, Patrick Masterson, Francoise Thibaud-Nissen, Mark Hauber, Claire N […]


Continue.. Genomic resources for comparative analyses of obligate avian brood parasitism

Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Posted by dbos Hopkins

Kavli Affiliate: Alexander Szalay | Authors: Tricia R Cottrell, Jeffrey S Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel C Sunshine, Daniel Jimenez-Sanchez, Zhen Zheng, Justina X Caushi, Jiajia Zhang, Nina D’Amiano, Julie Stein-Deutsch, Sonali Uttam, Katie Pirie, Darah Vlaminck, Michelle Mataj, Alexa Fiorante, Nicole Espinosa, Teodora Popa, […]


Continue.. Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Spatial Transcriptomics Reveal Developmental Dynamics of the Human Cerebral Cortex and Striatum

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Yunjia Zhang, Youning Lin, Xunan Shen, Xue Xiao, Cai Song, Xiaobo Shi, Tao Zhou, Yanxin Li, Zihan Wu, Zhenkun Zhuang, Chunqiong Li, Meng Li, Feng Wen, Jianlin Liu, Lei Cao, Qiangqiang Zhang, Zhao-Lu Li, Songbo Zhang, Susu Qu, Yaqi Li, Jianhua Yao, Fubaoqian Huang, Xin Liu, Ziqing Deng, Longqi […]


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Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Posted by dbos UCSF

Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]


Continue.. Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making