Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Pin Lyu, Isabella Palazzo, yang jin, Leah Campbell, Clayton Santiago, Rogger Carmen-Orzoco, Thanh Hoang, Jared Tangeman, Alexander Park, Shawn Yang, Jianming Shao, Rui Chen, David Hyde, Jiang Qian and Seth Blackshaw | Summary: Biological age is a major risk factor in the development of common degenerative retinal diseases such […]


Continue.. Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

Adrenomedullin restores human cortical interneurons migration defects induced by hypoxia

Posted by dbos UCSF

Kavli Affiliate: Jeremy Willsey | Authors: Alyssa Puno, Wojciech M Michno, Li Li, Amanda Everitt, Kate McCluskey, Saw Htun, Dhriti Nagar, Jong Bin Choi, Yuqin Dai, Seyeon Park, Emily Gurwitz, Jeremy Willsey, Fikri Birey and Anca M Pasca | Summary: Extremely preterm birth (at < 28 postconceptional weeks) leads to brain injury and represents the […]


Continue.. Adrenomedullin restores human cortical interneurons migration defects induced by hypoxia

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer knock-in mouse phenotypes

Posted by dbos Yale

Kavli Affiliate: Stephen Strittmatter | Authors: LaShae Nicholson, Si Jie Tang, Tejaswini Karra, Habiba Abouletta and Stephen M. Strittmatter | Summary: Metabolic dysfunction contributes to the risk and progression of Alzheimer”s disease (AD) through insulin signaling, but the cellular mechanisms are not fully understood. In this study, we examined the effects of streptozotocin-induced insulin deficiency […]


Continue.. Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer knock-in mouse phenotypes

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Jorge Alberto Miranda-Barrientos, Suhaas Adiraju, Jason J Rehg, Michael S Totty, Henry Hallock, Ye Li, Greggory Carr and Keri Martinowich | Summary: Sustained attention, the ability to focus on a stimulus or task over extended periods, is crucial for higher level cognition, and is impaired across multiple neuropsychiatric and […]


Continue.. Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Prashanthi Ravichandran, Svitlana V. Bach, Robert A. Phillips III, Madeline R. Valentine, Nicholas J. Eagles, Yufeng Du, Ishbel Del Rosario, Ryan A. Miller, Heena R. Divecha, Madhavi Tippani, Kelsey D. Montgomery, Joel E. Kleinman, Shizhong Han, Stephanie Cerceo Page III, Thomas M. Hyde, Leonardo Collado Torres, Alexis Battle, Keri […]


Continue.. Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Progress toward a demonstration of high contrast imaging at ultraviolet wavelengths

Posted by klaurent Stanford

Kavli Affiliate: Bruce Macintosh | First 5 Authors: Kyle Van Gorkom, Kyle Van Gorkom, , , | Summary: NASA’s Habitable Worlds Observatory (HWO) aims to achieve starlight suppression to the $10^-10$ level for the detection and spectral characterization of Earth-like exoplanets. Broadband ozone absorption features are key biosignatures that appear in the 200-400nm near-ultraviolet (UV) […]


Continue.. Progress toward a demonstration of high contrast imaging at ultraviolet wavelengths

Environmental vs. intrinsic quenching at cosmic noon: Predictions from cosmological hydrodynamical simulations for VLT-MOONRISE

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | First 5 Authors: Paul H. Goubert, Paul H. Goubert, , , | Summary: We present an investigation into the quenching of simulated galaxies across cosmic time, honing in on the role played by both intrinsic and environmental mechanisms at different epochs. In anticipation of VLT-MOONRISE, the first wide-field spectroscopic galaxy […]


Continue.. Environmental vs. intrinsic quenching at cosmic noon: Predictions from cosmological hydrodynamical simulations for VLT-MOONRISE

Harnessing Uncertainty: Entropy-Modulated Policy Gradients for Long-Horizon LLM Agents

Posted by klaurent Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Jiawei Wang, Jiawei Wang, , , | Summary: In long-horizon tasks, recent agents based on Large Language Models (LLMs) face a significant challenge that sparse, outcome-based rewards make it difficult to assign credit to intermediate steps. Previous methods mainly focus on creating dense reward signals to guide […]


Continue.. Harnessing Uncertainty: Entropy-Modulated Policy Gradients for Long-Horizon LLM Agents

Bilateral Hydrogenation Realizes High-Temperature Quantum Anomalous Hall Insulator in 2D Cr$_text2$Ge$_text2$Te$_text6$

Posted by klaurent UCAS

Kavli Affiliate: Gang Su | First 5 Authors: Xiang Li, Xiang Li, , , | Summary: The pursuit of high-temperature quantum anomalous Hall (QAH) insulators faces fundamental challenges, including narrow topological gaps and low Curie temperatures ($T_textC$) in existing materials. Here, we propose a transformative strategy using bilateral hydrogenation to engineer a robust QAH state […]


Continue.. Bilateral Hydrogenation Realizes High-Temperature Quantum Anomalous Hall Insulator in 2D Cr$_text2$Ge$_text2$Te$_text6$

R-parity violation and 8 TeV four-jet events at the LHC: a falsification opportunity for Wagner’s Rule

Posted by klaurent Chicago

Kavli Affiliate: Carlos E. M. Wagner | First 5 Authors: Pedro Bittar, Pedro Bittar, , , | Summary: The CMS Collaboration at the Large Hadron Collider (LHC) has observed two four-jet events with a total invariant mass of about 8 TeV; within each event, the jets can be paired into two dijets with invariant masses […]


Continue.. R-parity violation and 8 TeV four-jet events at the LHC: a falsification opportunity for Wagner’s Rule