Hyper-migratory CAR T cells alleviate ovarian cancer metastatic burden and improve prognosis

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Eban Hanna, Saurabh Joshi, Victoria Duarte Alvarado, Challice Bonifant and Denis Wirtz | Summary: Cellular immunotherapy has shown remarkable efficacy in hematological malignancies but remains limited by infiltration issues in solid tumors, leading to poor treatment efficacy. We have recently shown that mesothelin-targeting CAR T cells […]


Continue.. Hyper-migratory CAR T cells alleviate ovarian cancer metastatic burden and improve prognosis

Effects of Primordial Black Holes on IGM History

Posted by klaurent Chicago

Kavli Affiliate: Nickolay Gnedin | Summary:Currently the asteroid mass window (mass $sim 10^17- 10^21$ grams) remains unconstrained for Primordial Black Holes (PBHs) to make up all of the dark matter content of the universe. Given these PBHs have very small masses, their Hawking temperature can be up to hundreds of keV. This study investigates the […]


Continue.. Effects of Primordial Black Holes on IGM History

Effects of Primordial Black Holes on IGM History

Posted by klaurent Chicago

Kavli Affiliate: Nickolay Y. Gnedin | First 5 Authors: Emily Koivu, Emily Koivu, , , | Summary: Currently the asteroid mass window (mass $sim 10^17- 10^21$ grams) remains unconstrained for Primordial Black Holes (PBHs) to make up all of the dark matter content of the universe. Given these PBHs have very small masses, their Hawking […]


Continue.. Effects of Primordial Black Holes on IGM History

A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih-Che Weng, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti, Adriana Rosas-Villegas, Yael N. Tsitohay, Madison M. Walker, Ben R. Hopkins, Mosquito Cell Atlas Consortium, Omar S. Akbari, Laura B. Duvall, Helen White-Cooper, Trevor R. Sorrells, Roshan Sharma, […]


Continue.. A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Single-Neuron Encoding of Learnability in the Dorsal Anterior Cingulate Cortex

Posted by dbos Columbia

Kavli Affiliate: Vincent Ferrera and Jacqueline Gottlieb | Authors: Yuhao Jin, Greg Jensen, Vincent Ferrera and Jacqueline Gottlieb | Summary: In natural environments, associations that indicate true learnable regularities are intermixed with those that arise from random and ultimately unlearnable relationships between events. To efficiently allocate cognitive resources and avoid inferring spurious patterns, organisms must […]


Continue.. Single-Neuron Encoding of Learnability in the Dorsal Anterior Cingulate Cortex

Approximate Quantum State Preparation with Tree-Based Bayesian Optimization Surrogates

Posted by klaurent Stanford

Kavli Affiliate: Hsiao-Mei (Sherry) Cho| First 5 Authors: [#item_custom_name[1, [#item_custom_name[2, [#item_custom_name[3, [#item_custom_name[4, [#item_custom_name[5| Summary:We study the problem of approximate state preparation on near-term quantum computers, where the goal is to construct a parameterized circuit that reproduces the output distribution of a target quantum state while minimizing resource overhead. This task is especially relevant for near-term […]


Continue.. Approximate Quantum State Preparation with Tree-Based Bayesian Optimization Surrogates

JADES: An Abundance of Ultra-Distant T- and Y-Dwarfs in Deep Extragalactic Data

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | Summary:Ultra-cool T- (T$_mathrmeff approx$ 500 – 1200 K) and Y-dwarfs (T$_mathrmeff$ $lessapprox 500$ K) have historically been found only a few hundred parsecs from the Sun. The sensitivity and wavelength coverage of the NIRCam instrument on board the James Webb Space Telescope offer a unique method for finding low-temperature brown […]


Continue.. JADES: An Abundance of Ultra-Distant T- and Y-Dwarfs in Deep Extragalactic Data

Constraints on the Thompson optical depth to the CMB from the Lyman-$α$ forest

Posted by klaurent Cambridge

Kavli Affiliate: Martin Haehnelt | Summary:We present the first constraints on the electron optical depth to reionization, $τ_mathrme$, from the Lyman-$α$ forest alone for physically motivated reionization models that match the reionization’s end-point, $z_rmend$, required by the same astrophysical probe, and for symmetric reionization models with fixed duration, $Δz$, commonly adopted in CMB reionization analyses. […]


Continue.. Constraints on the Thompson optical depth to the CMB from the Lyman-$α$ forest

The warm outer layer of a Little Red Dot as the source of [Fe II] and collisional Balmer lines with scattering wings

Posted by klaurent MIT

Kavli Affiliate: Robert Simcoe | Summary:The population of the Little Red Dots (LRDs) may represent a key phase of supermassive black hole (SMBH) growth. A cocoon of dense excited gas is emerging as key component to explain the most striking properties of LRDs, such as strong Balmer breaks and Balmer absorption, as well as the […]


Continue.. The warm outer layer of a Little Red Dot as the source of [Fe II] and collisional Balmer lines with scattering wings