Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Leslie Hassanein, Bernard Mulvey, Harris Blankenship, Margaret M Tish, Anu Korukonda, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Rosa Villalba, Xiangchuan Chen, Khan Hekmatyar, Jenny Yang, Daniel Huddleston, Seong Su Kang, Arielle Segal, Steven A Sloan, Keri Martinowich, Keqiang Ye, Joseph D Dougherty, Katharine E McCann, Yoland Smith, […]


Continue.. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Behavioral Signatures of Post-Decisional Attention in Preferential Choice

Posted by dbos Columbia

Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg, Ian Krajbich and Michael N Shadlen | Summary: Attention plays a key role in decision-making by directing limited cognitive resources to relevant information. It has been proposed that attention also biases the decision process, due to a multiplicative interaction between attention and subjective value (e.g., Krajbich et […]


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Type 1 lymphocytes accumulate in the thalamus and produce interferon-γ to restrict seizure susceptibility after brain injury

Posted by dbos UCSF

Kavli Affiliate: Anna Molofsky and Jeanne Paz | Authors: Nicholas M Mroz, Agnieszka Ciesielska, Nathan A Ewing-Crystal, Leah C Dorman, Rafael T Han, Jerika J Barron, Nicholas J Silva, Audrey Magsig, Anna V Molofsky, Ari B Molofsky and Jeanne T Paz | Summary: Chronic neural circuit hyperexcitability frequently emerges after brain injury, but endogenous mechanisms […]


Continue.. Type 1 lymphocytes accumulate in the thalamus and produce interferon-γ to restrict seizure susceptibility after brain injury

Calsyntenin-1 and calsyntenin-3 coordinate TGN exit of axonal cargoes

Posted by dbos Yale

Kavli Affiliate: Shawn Ferguson | Authors: Derk Draper, Noortje Kersten, Shietela Sewnarain Sukul, Rebecca Jark, Inge Rothuis, Poorvi Ravindra, Aniruddha Mitra, Lukas C. Kapitein, Shawn Ferguson, Judith Klumperman and Ginny G. Farías | Summary: Neurons rely on precise biosynthetic protein transport from the soma to the axon and dendrites. Brain-enriched calsyntenins (CSTN1–3) are unique transmembrane […]


Continue.. Calsyntenin-1 and calsyntenin-3 coordinate TGN exit of axonal cargoes

Continuous partitioning of neuronal variability

Posted by dbos Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Anuththara Rupasinghe, Adam S Charles and Jonathan W Pillow | Summary: Neurons exhibit substantial trial-to-trial variability in response to repeated stimuli, posing a major challenge for understanding the information content of neural spike trains. In the visual cortex, responses show greater-than-Poisson variability, whose origins and structure remain unclear. […]


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Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits

Posted by dbos Columbia

Kavli Affiliate: Darcy Peterka | Authors: Chloe L West, Fumiyasu Imai, Georgia Bastos, Molly Hornick, Lital Rachmany, Annabel Duran, Samen Nadeem, David A Ricci, Anna M Rader Groves, Joseph A Wargo, Neil Van Leeuwen, Henry Sershen, Vinod Yaragudri, Darcy S Peterka and Jordan P Hamm | Summary: Serotonergic psychedelics (e.g., psilocybin, LSD) have potential to […]


Continue.. Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Nandini Ramesh, Mingyun Bae, Ann Caplin, Diane D Shao, Bezawit Sahile, Kow Essuman, Eitan Goodman, Michael B Miller, August Yue Huang, William J. Nathan, Andre Nussenzweig, Peter J Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee and Christopher […]


Continue.. Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders

The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy

Posted by dbos UCSF

Kavli Affiliate: Xin Duan and Massimo Scanziani | Authors: Xinxin Ge, Xing Wei, Baixi Ruan, Qin Ying Wu, Siyuan Chang, Nicole Tsai, Shaobo Zhang, Xin Duan and Massimo Scanziani | Summary: The hierarchical organization of sensory cortices and the rich molecular taxonomy of their cell types are defining features of the mammalian cortex. Cortical areas […]


Continue.. The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy

Coordination of spike timing among the neurons of the cerebellum

Posted by dbos Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Mohammad Amin Fakharian, Elijah A Taeckens, Alexander N Vasserman, Alden Shoup and Reza Shadmehr | Summary: We tend to think of neurons as either excitatory or inhibitory, but certain neurons chemically inhibit their downstream targets while electrically exciting their neighbors. For example, in the cerebellum, molecular layer interneurons (MLIs) […]


Continue.. Coordination of spike timing among the neurons of the cerebellum

Rust fungi secretomes contain structurally diverse effector families including cysteine-rich metal-binding proteins

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Megan Outram, Zhao Li, Michael Kuiper, Simon J Williams, Melania Figueroa, Peter Dodds and Jana Sperschneider | Summary: Rust fungi are significant threats to global food security, causing substantial damage to crops through their ability to adapt and evolve new strains that overcome resistance. These obligate biotrophs infect host […]


Continue.. Rust fungi secretomes contain structurally diverse effector families including cysteine-rich metal-binding proteins