Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Kavli Affiliate: Peter Walter | Authors: Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason E. Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John Le Quesne, Tuomas Tammela and Antonis E. Koromilas | Summary: The link between the “stress phenotype”-a well-established hallmark of cancer-and its role in tumor […]


Continue.. Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Kavli Affiliate: Stefano Fusi | Authors: Lorenzo Posani, Shuqi Wang, Samuel Muscinelli, Liam Paninski and Stefano Fusi | Summary: A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently (“categorical” representations [1–3]) and the implications for neural computation. Here, we systematically analyzed how cortical neurons encode […]


Continue.. Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

Kavli Affiliate: Pietro De Camilli | Authors: Michael G Hanna, Hely O Rodriguez Cruz, Kenshiro Fujise, Yumei Wu, C Shan Xu, Song Pang, Li Zhuoning, Mara Monetti and Pietro De Camilli | Summary: Recent studies have identified a family of rod-shaped proteins thought to mediate lipid transfer at intracellular membrane contacts by a bridge-like mechanism. […]


Continue.. BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

A vector calculus for neural computation in the cerebellum

Kavli Affiliate: Reza Shadmehr | Authors: Mohammad Amin Fakharian, Alden Shoup, Paul Hage, Hisham Elseweifi and Reza Shadmehr | Summary: Null space theory predicts that a neuron will often generate spikes not to produce behavior, but to prevent another neuron’s impact on behavior. Here, we present a direct test of this theory in the brain. […]


Continue.. A vector calculus for neural computation in the cerebellum

Striatal and cerebellar interactions during reward-based motor performance

Kavli Affiliate: Kathleen Cullen and Vikram Chib | Authors: Joonhee Leo Lee, Agostina Casamento-Moran, Amy J Bastian, Kathleen E Cullen and Vikram S. Chib | Summary: Goal-directed motor performance relies on the brain’s ability to distinguish between actions that lead to successful and unsuccessful outcomes. The basal ganglia (BG) and cerebellum (CBL) are integral to […]


Continue.. Striatal and cerebellar interactions during reward-based motor performance

A lateralized pathway for associating nutrients with flavors

Kavli Affiliate: Zachary Knight | Authors: James C.R. Grove, Queenie Li, Heiko Backes, Bojana Kuzmanovic, Jaewon Choi, Violeta Ubadiah, Longhui Qiu, Jingkun Zhang, Zhengya Liu, Dana M. Small, Marc Tittgemeyer and Zachary A Knight | Summary: Animals learn about the external world, in part, via interoceptive signals1,2. For example, the nutrient content of food is […]


Continue.. A lateralized pathway for associating nutrients with flavors

Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae

Kavli Affiliate: Scott Small | Authors: Clara T Rehmann, Scott T Small, Peter L Ralph and Andrew D. Kern | Summary: As organisms adapt to environmental changes, natural selection modifies the frequency of non-neutral alleles. For beneficial mutations, the outcome of this process may be a selective sweep, in which an allele rapidly increases in […]


Continue.. Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae

Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics

Kavli Affiliate: Pietro De Camilli | Authors: Anbang Dai, Peng Xu, Chase Amos, Kenshiro Fujise, Yumei Wu, Han Yang, Julia N. Eisen, Andrés Guillén-Samander and Pietro De Camilli | Summary: BLTP2/KIAA0100, a bridge-like lipid transfer protein, was reported to localize at contacts of the endoplasmic reticulum (ER) with either the plasma membrane (PM) or recycling […]


Continue.. Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics

Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice

Kavli Affiliate: Takaki Komiyama | Authors: Sonja Blumenstock, David Arakelyan, Nicholas del Grosso, Sonja Schneider, Yufeng Shao, Enida Gjoni, Ruediger Klein, Irina Dudanova and Takaki Komiyama | Summary: Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral […]


Continue.. Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice

Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study

Kavli Affiliate: Anders Dale | Authors: Xueying Chen, Hao Wang, Iris Broce, Anders M Dale, Bing Yu, Laura Y Zhou, Xihao Li, Maria Argos, Martha L Daviglus, Jianwen Cai, Nora Franceschini and Tamar Sofer | Summary: Hispanic/Latino populations are admixed, with genetic contributions from multiple ancestral populations. Studies of genetic association in these admixed populations […]


Continue.. Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study