A genetic driver of epileptic encephalopathy impairs gating of synaptic glycolysis

Kavli Affiliate: Timothy A. Ryan | Authors: Zhanat Koshenov, Alexandros C. Kokotos, Lorena Benedetti, Jennifer Lippincott Schwartz and Timothy A. Ryan | Summary: The brain is a disproportionately large consumer of fuel, estimated to expend ∼20% of the whole-body energy budget, and therefore it is critical to adequately control brain fuel expenditures while satisfying its […]


Continue.. A genetic driver of epileptic encephalopathy impairs gating of synaptic glycolysis

Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Kavli Affiliate: Marcelo Mattar | Authors: Hua-Dong Xiong, Li Ji-An, Marcelo G Mattar and Robert C Wilson | Summary: Cognitive modeling in psychology and neuroscience provides a formal approach to formulate and test hypotheses of cognitive processes. Such models rely on cognitive parameters that are intended to represent interpretable and identifiable psychological constructs. However, accurately […]


Continue.. Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Kavli Affiliate: Marcelo Mattar | Authors: Hua-Dong Xiong, Li Ji-An, Marcelo G Mattar and Robert C Wilson | Summary: Cognitive modeling in psychology and neuroscience provides a formal approach to formulate and test hypotheses of cognitive processes. Such models rely on cognitive parameters that are intended to represent interpretable and identifiable psychological constructs. However, accurately […]


Continue.. Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Spectral disruption of inter-hemispheric resting-state BOLD coherence at vasomotor frequency (~0.1 Hz) links vascular dysfunction to functional connectivity loss in carotid artery stenosis

Kavli Affiliate: David Kleinfeld | Authors: Sangcheon Choi, Gabriel Hoffmann, Sebastian Schneider, Stephan Kaczmarz, David Kleinfeld, Xin Yu, Christian Sorg and Christine Preibisch | Summary: Vasomotor dynamics at the infra-slow frequencies (~0.1 Hz), driven by synchronized oscillation of smooth muscle cells in vessel walls, play an important role in regulating cerebral perfusion and constitute a […]


Continue.. Spectral disruption of inter-hemispheric resting-state BOLD coherence at vasomotor frequency (~0.1 Hz) links vascular dysfunction to functional connectivity loss in carotid artery stenosis

Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Kavli Affiliate: Sreekanth Chalasani | Authors: Jessica A Haley, Tianyi Chen, Mikio Aoi and Sreekanth H Chalasani | Summary: Decision-making is a ubiquitous component of animal behavior that is often studied in the context of foraging. Foragers make a series of decisions while locating food (food search), choosing between food types (diet or patch choice), […]


Continue.. Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

WITHDRAWN: CEBPB as a potential biomarker for prognosis and immuneinfiltration in clear cell renal cell carcinoma

Kavli Affiliate: Wei Min | Authors: Yaoqiang Ren, Baoping Qiao, Min Wei, Quanfa Tian and Wenke Guo | Summary: The authors have withdrawn this manuscript because [an error in the figures or improper use of them]. Therefore, the authors do not wish this work to be cited as reference for the project. If you have […]


Continue.. WITHDRAWN: CEBPB as a potential biomarker for prognosis and immuneinfiltration in clear cell renal cell carcinoma

Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor

Kavli Affiliate: Richard Huganir | Authors: William Dylan Hale, Richard L. Huganir and Edward C Twomey | Summary: AMPA-subtype glutamate receptors (AMPARs), composed of subunits GluA1-4, mediate fast, excitatory synaptic transmission in the brain. After glutamate binding, AMPAR ion channels exhibit multiple subconductance states that tune neuronal responses to glutamate. GluA4 is the rarest subunit […]


Continue.. Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor

Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons

Kavli Affiliate: Darcy Peterka | Authors: Eddy Albarran, Akira Fushiki, Anders Nelson, David Ng, Corryn Chaimowitz, Laudan Nikoobakht, Tanya Sippy, Darcy S Peterka and Rui M Costa | Summary: The basal ganglia and midbrain dopaminergic systems are critical for motor control, reward processing, and reinforcement learning, with dysfunction in these systems implicated in numerous neurodegenerative […]


Continue.. Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons

Clover-like object vector representations support human spatial cognition

Kavli Affiliate: Jonathan Whitlock | Authors: Marcia Becu, Ivan Markel Krasovec, Pearl Saldanha, Jonathan Whitlock and Christian F Doeller | Summary: Vector-based spatial coding has been demonstrated in rodents, yet its neural basis in humans and its contribution to navigation remain poorly understood. Using a novel spatial updating task, we show that egocentric directional signals […]


Continue.. Clover-like object vector representations support human spatial cognition

xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales

Kavli Affiliate: Laurent Younes and Michael Miller | Authors: Kaitlin Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouve and Michael I Miller | Summary: Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose […]


Continue.. xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales