Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Yoshimichi Sato, Yuandong Li, Yuya Kato, Atsushi Kanoke, Yujiao Jennifer Sun, Yasuo Nishijima, Ruikang K Wang, Michael Stryker, Hidenori Endo and Jialing Liu | Summary: Type 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke […]


Continue.. Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke

Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration

Posted by dbos UCSF

Kavli Affiliate: Bjoern Schwer | Authors: Sarah Cohen, Laura Cheradame, Karishma Pratt, Sarah Collins, Ashlie Barillas, Annika Carlson, Vijay Ramani, Gaelle Legube, Saul Villeda, Dyche Mullins and Bjoern Schwer | Summary: Loss of genomic information due to the accumulation of somatic DNA damage has been implicated in aging and neurodegeneration. Somatic mutations in human neurons […]


Continue.. Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration

Dorsal-caudal and ventral hippocampus target different cell populations in the medial frontal cortex in rodents

Posted by dbos NTNU

Kavli Affiliate: Menno Witter | Authors: Paola Alemán-Andrade, Menno P. Witter, Ken-Ichiro Tsutsui and Shinya Ohara | Summary: Direct projections from the ventral hippocampus (vHPC) to the medial frontal cortex (MFC) play crucial roles in memory and emotional regulation. Using anterograde transsynaptic tracing and in vitro electrophysiology in mice, we document a previously unexplored pathway […]


Continue.. Dorsal-caudal and ventral hippocampus target different cell populations in the medial frontal cortex in rodents

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Michael S Totty, Rita Cervera-Juanes, Svitlana V Bach, Lamya Ben Ameur, Madeline R Valentine, Evan Simons, Mckenna D Romac, Hoa Trinh, Krystal Henderson, Ishbel Del Rosario, Madhavi Tippani, Ryan A Miller, Joel E Kleinman, Stephanie Cerceo Page, Arpiar Saunders, Thomas M Hyde, Keri Martinowich, Stephanie C Hicks and Vincent […]


Continue.. Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Caleb C. Reagor and A. J. Hudspeth | Summary: Like the sensory organs of the human inner ear, the lateral-line neuromasts (NMs) of fish such as the zebrafish (Danio rerio) contain mechanosensory hair cells (HCs) that are surrounded by progenitors called supporting cells. Damaged NMs can quickly regenerate […]


Continue.. ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts

Gut bacteria-derived succinate induces enteric nervous system regeneration

Posted by dbos Rockefeller

Kavli Affiliate: Daniel Mucida | Authors: Begüm Aydin, Izabela Mamede, Joana Cardoso, Julia Deere, Yelina Alvarez, Shanshan Qiao, Ved P. Sharma, Marissa A. Scavuzzo, Gregory P. Donaldson, Chun-Jun Guo and Daniel Mucida | Summary: Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion. Disruptions in microbial communities caused by antibiotics or enteric […]


Continue.. Gut bacteria-derived succinate induces enteric nervous system regeneration

Why do bats fly into cave doors? Inattentional blindness in echolocating animals

Posted by dbos Hopkins

Kavli Affiliate: Cynthia F. Moss | Authors: Nikita M Finger, Keegan E Eveland, Xiaoyan Yin and Cynthia F Moss | Summary: Echolocating bats can navigate complex 3D environments by integrating prior knowledge of spatial layouts and real-time sensory cues. This study demonstrates that inattentional blindness to sensory information undermines successful navigation in Egyptian fruit bats, […]


Continue.. Why do bats fly into cave doors? Inattentional blindness in echolocating animals

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease

Posted by dbos UCSF

Kavli Affiliate: Arnold R. Kriegstein | Authors: Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L. De Florencio, Lauren Chao, Yonatan Perez, Lea Tenenholz Grinberg, Salvatore Spina, Richard M Ransohoff, Arnold Kriegstein, William W Seeley, Tomasz J. Nowakowski and Xianhua Piao | Summary: Germline genetic architecture of Alzheimer’s disease (AD) indicates microglial […]


Continue.. Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease

Role of dopamine in reward expectation and predictability during execution of action sequences

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley Province, Nathalie Thiriet, Patricia H Janak and Youna Vandaele | Summary: Reward-associated cues serve different functions depending on whether they precede or terminate action sequences. Cues that precede action sequences and signal opportunity for reward could serve as GO signals to initiate […]


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HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Emmanuel C Ijezie, Michael J Miller, Celine Hardy, Ava R Jarvis, Timothy Czajka, Lianna D’Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy and David Butler | Summary: INTRODUCTION Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer’s Disease (AD) in neurons. One key marker of AD is the […]


Continue.. HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease