Condenzymes: Biomolecular condensates with inherent catalytic activities

Kavli Affiliate: Wei Min | Authors: Michael W Chen, Xiao Guo, Mina Farag, Naixin Qian, Xiaowei Song, Anton Ni, Vicky Liu, Xia Yu, Yuefeng Ma, Leshan Yang, Wen Yu, Matthew King, Joonho Lee, Richard N Zare, Wei Min, Rohit V Pappu and Yifan Dai | Summary: We report the discovery that chemical reactions can be […]


Continue.. Condenzymes: Biomolecular condensates with inherent catalytic activities

Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Alexis M Black, Natsumi Komatsu, Jiaxuan Zhao, Scarlet R Taskey, Nicole S Serrano, Ruchira Sharma, Devanand S. Manoli, Markita P Landry and Annaliese Beery | Summary: Friendships, or selective peer relationships, are a vital component of healthy social functioning in humans, while deficits in these relationships are associated with […]


Continue.. Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Kavli Affiliate: Anders Dale and Wesley Thompson | Authors: Pravesh Parekh, Nadine Parker, Diliana Pecheva, Evgeniia Frei, Marc Vaudel, Diana M. Smith, Alison Rigby, Piotr Jahołkowski, Ida Elken Sønderby, Viktoria Birkenæs, Nora Refsum Bakken, Chun Chieh Fan, Carolina Makowski, Jakub Kopal, Robert John Loughnan, Donald J. Hagler, Jr., Dennis van der Meer, Stefan Johansson, Pål […]


Continue.. FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

Kavli Affiliate: Maryam Ziaei | Authors: Shuer Ye, Arjun Dave, Alireza Salami and Maryam Ziaei | Summary: Functional dedifferentiation, a hallmark of brain aging particularly evident within the frontoparietal network (FPN), has been extensively investigated in the context of cognitive decline, yet its implications for late-life mental health remain poorly understood. Leveraging naturalistic fMRI combined […]


Continue.. Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Kavli Affiliate: David Rowitch | Authors: Grant de Jong, Fani Memi, Tannia Gracia, Olga Lazareva, Oliver Gould, Alexander Aivazidis, Manas Dave, Qianqian Zhang, Melanie Jensen, Ahmet Sureyya Rifaioglu, Joao D. Barros-Silva, Sabine Eckert, Di Zhou, Yvette Wood, Elizabeth Tuck, Sezgin Er, Henry Marshall, Kenny Roberts, Andrew L. Trinh, Shreya Rai, Tyler Shaw, Agnes Oszlanczi, Hayden […]


Continue.. A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

Kavli Affiliate: Kay Tye | Authors: Caroline Jia, Andrea Tran, Faith Aloboudi, Ella Say, Nick Thao, Christopher R. Lee, Kanha Batra, Amanda Nguyen, Aneesh Bal, Nathaniel N. Nono, Jeremy Delahanty, May G Chan, Laurel R. Keyes, Reesha R. Patel, Romy Wichmann, Felix Taschbach, Yulong Li, Marcus K. Benna, Talmo D Pereira, Hao Li and Kay […]


Continue.. Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Kavli Affiliate: Tatyana Sharpee and Sreekanth Chalasani | Authors: Iulia Rusu, Zachary T Cecere, Javier J How, Kathleen T Quach, Eviatar Yemini, Tatyana O Sharpee and Sreekanth H Chalasani | Summary: Neurons represent changes in external and internal environments by altering their activity patterns. While coherent brain-wide patterns of neural activity have been observed in […]


Continue.. A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Kavli Affiliate: Philip Starr | Authors: Jin-Xiao Zhang, Clay Smyth, Md Fahim Anjum, Yue Leng, Andrew D. Krystal, Philip A. Starr and Simon Little | Summary: Sleep disturbance is involved in the progression of neurodegenerative diseases, but the neurophysiological mechanisms remain unclear in humans. We recorded sleep at home using portable polysomnography for multiple nights […]


Continue.. A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Working memory by distributed neural oscillators in a simple nervous system

Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: Working memory allows an animal to gather sensory evidence over time, integrate it with evolving internal needs, and make informed decisions about […]


Continue.. Working memory by distributed neural oscillators in a simple nervous system

Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice

Kavli Affiliate: Pietro De Camilli | Authors: Peng Xu, Rubia Isler Mancuso, Marianna Leonzino, Caroline J Zeiss, Diane S Krause and Pietro De Camilli | Summary: VPS13 is the founding member of a family of proteins that mediate lipid transfer at intracellular membrane contact sites by a bridge-like mechanism. Mammalian genomes comprise 4 VPS13 genes […]


Continue.. Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice