Development of a Marmoset Apparatus for Automated Pulling (MarmoAAP) to Study Cooperative Behaviors

Kavli Affiliate: Anirvan Nandy | Authors: Olivia C Meisner, Nicholas A Fagan, Joel Greenwood, Weikang Shi, Monika Jadi, Anirvan S. Nandy and Steve W. C. Chang | Summary: In recent years, the field of neuroscience has increasingly recognized the importance of studying animal behaviors in naturalistic environments to gain deeper insights into ethologically relevant behavioral […]


Continue.. Development of a Marmoset Apparatus for Automated Pulling (MarmoAAP) to Study Cooperative Behaviors

Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection

Kavli Affiliate: Sreekanth Chalasani | Authors: Nadia B Haghani, Robert H Lampe, Buck Samuel, Sreekanth H Chalasani and Molly A Matty | Summary: In the wild, C. elegans are emersed in environments teeming with a veritable menagerie of microorganisms. The C. elegans cuticular surface serves as a barrier and first point of contact with this […]


Continue.. Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection

AIBP controls amyloid beta induced TLR4 inflammarafts and mitochondrial dysfunction in microglia

Kavli Affiliate: Mark Ellisman | Authors: Yi Sak Kim, SOO-HO CHOI, Keun-Young Kim, Juliana M Navia Pelaez, Guy A Perkins, Seunghwan Choi, Nicolaus Nazarenkov Miller, Jungsu Kim, Wonkyu Ju, Robert A Rissman, Mark H Ellisman and Yury I Miller | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia […]


Continue.. AIBP controls amyloid beta induced TLR4 inflammarafts and mitochondrial dysfunction in microglia

Multiple objects evoke fluctuating responses in several regions of the visual pathway

Kavli Affiliate: Winrich Freiwald | Authors: Meredith N Schmehl, Valeria C Caruso, Yunran Chen, Na Young Jun, Shawn M Willett, Jeff T Mohl, Douglas A Ruff, Marlene R Cohen, Akinori Ebihara, Winrich Freiwald, Surya T Tokdar and Jennifer M Groh | Summary: How neural representations preserve information about multiple stimuli is mysterious. Because tuning of […]


Continue.. Multiple objects evoke fluctuating responses in several regions of the visual pathway

A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

Kavli Affiliate: Jean-Laurent Casanova, Charles M. Rice | Authors: Jeremie Le Pen, Gabrielle Paniccia, Michael Bauer, H.-Heinrich Hoffmann, Volker Kinast, Marcela Moncada-Velez, Ana Pinharanda, Inna Ricardo-Lax, Ansgar F Stenzel, Edwin A Rosado-Olivieri, Alison W Ashbrook, Kenneth H Dinnon, William Doyle, Catherine Freije, Seon-Hui Hong, Danyel Lee, Tyler Lewy, Joseph M Luna, Avery Peace, Carltin Schmidt, […]


Continue.. A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

The olivary input to the cerebellum dissociates sensory events from movement plans

Kavli Affiliate: Reza Shadmehr | Authors: Jay S Pi, Mohammad Amin Fakharian, Paul Hage, Ehsan Sedaghat-Nejad, Salomon Z Muller and Reza Shadmehr | Summary: Neurons in the inferior olive are thought to anatomically organize the Purkinje cells (P-cells) of the cerebellum into computational modules. To better understand what is computed by these modules, we designed […]


Continue.. The olivary input to the cerebellum dissociates sensory events from movement plans

Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction

Kavli Affiliate: Menno Witter | Authors: Katrine Sjaastad Hanssen, Nicolai Winter-Hjelm, Salome Nora Niethammer, Asgeir Kobro-Flatmoen, Menno P. Witter, Axel Sandvig and Ioanna Sandvig | Summary: Engineered biological neural networks are indispensable models for investigation of neural function and dysfunction from the subcellular to the network level. Notably, advanced neuro-engineering approaches are of significant interest […]


Continue.. Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction

Automated 3D analysis of social head-gaze behaviors in freely moving marmosets

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Alec Graham Sheffield, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Social communication relies on the ability to perceive and interpret the direction of others’ attention, which is commonly conveyed through head orientation and gaze direction in both humans and non-human primates. […]


Continue.. Automated 3D analysis of social head-gaze behaviors in freely moving marmosets

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Kavli Affiliate: Mary E. Hatten | Authors: Michalina Hanzel, Kayla Fernando, Susan E Maloney, Shioaching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty, Court Hull and Mary E Hatten | Summary: Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and […]


Continue.. Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions

Kavli Affiliate: Marina Picciotto | Authors: Paul Jongseo Lee, Alexa R Soares, Yu Sun, Caroline Fai, Marina Picciotto and Junjie U Guo | Summary: While previous studies suggest that many mRNAs contain more than one translation initiation site (TIS), the biological significance of most alternative TISs and their corresponding protein isoforms (proteoforms) remains undetermined. Here […]


Continue.. Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions