Distinct cortical networks associated with subregions of the hippocampal-entorhinal system in the first two years of human life

Kavli Affiliate: Menno Witter | Authors: Daniel Reznik, Cheslie C. Klein, Shir Filo, Menno P. Witter and Charlotte Grosse Wiesmann | Summary: Episodic memory critically depends on the hippocampus and the entorhinal cortex. Despite a rapid developmental change in human episodic memory during the first two years of life, little is known about the developmental […]


Continue.. Distinct cortical networks associated with subregions of the hippocampal-entorhinal system in the first two years of human life

Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis

  Kavli Affiliate: Emre Yaksi | Authors: Hilal Piril Saracoglu, Marwan Nashabat, Duygu Naz Kutlu, Burak Saribas, Elanur Yilmaz, Seymanur Tur, Hulya Kayserili, Emre Yaksi, Nasrin Nabavizadeh and Nathalie Escande-Beillard | Summary: Loss-of-function variants in SNUPN, encoding the nuclear import factor Snurportin-1 (SPN1) required for spliceosomal small nuclear ribonucleoprotein (snRNP) transport, cause a recently described […]


Continue.. Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis

Age-related reorganization of locus coeruleus–cortical functional connectivity gradients

Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Xiaqing Lan, Alireza Salami, Heidi Jacobs and Maryam Ziaei | Summary: The locus coeruleus (LC) regulates attention, arousal, and adaptive behavior via widespread noradrenergic projections to cortex, yet its large-scale cortical organization and age-related vulnerability remain poorly understood. Using 7T MRI during naturalistic movie-viewing with […]


Continue.. Age-related reorganization of locus coeruleus–cortical functional connectivity gradients

Transcriptomic characteristics along the longitudinal axis of the hippocampus and medial entorhinal cortex across species

Kavli Affiliate: Menno Witter | Authors: Sihui Cheng, Qirun Wang, Ye Feng, Cong Chen, Guge Suri, Yilan Liang, Yikai Yang, Kai Gao, Menno Witter, Huixia Yang, Jie Lin and Chenglin Miao | Summary: The hippocampus (HPC) and medial entorhinal cortex (MEC) are essential for learning, memory, and spatial cognition, and both exhibit dorsoventral (longitudinal) organization […]


Continue.. Transcriptomic characteristics along the longitudinal axis of the hippocampus and medial entorhinal cortex across species

Phylogeny of cortical-hippocampal projections reveals selective elimination of input from sensory regions

Kavli Affiliate: Menno Witter | Authors: Daniel Reznik, Piotr Majka, Marcello GP Rosa, Menno P Witter and Christian F Doeller | Summary: The study of cross-species differences in the organization of the cerebral cortex received significant attention during the past century. However, the evolutionary principles governing changes in brain connectivity and their impact on cognition […]


Continue.. Phylogeny of cortical-hippocampal projections reveals selective elimination of input from sensory regions

Heterogeneous single-cell dynamics support stable population codes for objects in the mouse anterior cingulate cortex

Kavli Affiliate: Clifford Kentros | Authors: Lucie A.L. Descamps, Wesley P. Clawson, Miguel M. Carvalho, Thomas Rogerson, Omer Hazon, Oscar M.T. Chadney, Mark J. Schnitzer and Clifford Kentrosa | Summary: Remembering object locations is crucial for survival, yet how the anterior cingulate cortex (ACC) encodes spatial features across repeated experiences has not been fully characterized. […]


Continue.. Heterogeneous single-cell dynamics support stable population codes for objects in the mouse anterior cingulate cortex

Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Kavli Affiliate: Menno Witter | Authors: Yassir El-Amri, Nelson David Villalba-Moreno, Julia Urban, Maider Alzueta-Torrecillas, Cesar A Valdez-Gaxiola, Juliana Gonzalez-Perez, Zhiyuan Song, Rui Tang, Duvan Cardona-Madrigal, Andres Villegas, Susanne Krasemann, Markus Glatzel, David Aguillon, Asgeir Kobro-Flatmoen, Menno Witter, Victoria Fernandez, Haiqing Zhao, Agustin Ruiz, Claudia Marino and Diego Sepulveda-Falla | Summary: Two PSEN1 E280A carriers have presented […]


Continue.. Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampal formation

  Kavli Affiliate: Menno Witter | Authors: Eirik S. Nilssen, Bente Jacobsen, Thanh P. Doan, Paulo J.B. Girao and Menno P. Witter | Summary: The functionally different lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC) are strongly interconnected. The role of this interconnectivity in view of their functional differences is not known. Here we […]


Continue.. Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampal formation

The emergence of a novel CA1 spatial map requires direct entorhinal input

Kavli Affiliate: Clifford Kentros | Authors: Oscar M. T. Chadney, Matteo Guardamagna, Felix Dorr, Lucie A. L. Descamps, Federico Stella, Francesco Battaglia and Clifford G. Kentros | Summary: The hippocampus and its main input, the entorhinal cortex, are essential for memory formation, yet how they interact to do so remains unresolved. Hippocampal CA1 pyramidal neurons […]


Continue.. The emergence of a novel CA1 spatial map requires direct entorhinal input

Spatial navigation through evolution: a single-cell atlas of the mammalian entorhinal cortex

Kavli Affiliate: Menno Witter | Authors: Dorottya M Ralbovszki, Jesse J Westfall, Yuki Mori, Stamatios A Tahas, Mads F Bertelsen, Irina Korshunova, Josefine Skov, Jan Gorodkin, Martin Hemberg, Ernst Stefan Seemann, Vanessa Hall, Menno Witter and Konstantin Khodosevich | Summary: Spatial navigation is a fundamental mammalian ability, supported by the entorhinal cortex (EC), a structurally […]


Continue.. Spatial navigation through evolution: a single-cell atlas of the mammalian entorhinal cortex