Spatial navigation through evolution: a single-cell atlas of the mammalian entorhinal cortex

Kavli Affiliate: Menno Witter | Authors: Dorottya M Ralbovszki, Jesse J Westfall, Yuki Mori, Stamatios A Tahas, Mads F Bertelsen, Irina Korshunova, Josefine Skov, Jan Gorodkin, Martin Hemberg, Ernst Stefan Seemann, Vanessa Hall, Menno Witter and Konstantin Khodosevich | Summary: Spatial navigation is a fundamental mammalian ability, supported by the entorhinal cortex (EC), a structurally […]


Continue.. Spatial navigation through evolution: a single-cell atlas of the mammalian entorhinal cortex

Organization of functional brain networks architecture during negative movie watching in late adulthood

Kavli Affiliate: Maryam Ziaei | Authors: Sara Sarebannejad, Shuer Ye and Maryam Ziaei | Summary: Most evidence on age-related network topology derives from resting-state paradigms, leaving unclear how aging alters brain organization during naturalistic processing and whether graph-theoretical metrics relate to emotional and cognitive functioning in ecologically valid contexts. We analyzed movie-fMRI and behavioral data […]


Continue.. Organization of functional brain networks architecture during negative movie watching in late adulthood

Spatial representation in CA1 superficial pyramidal cells is impaired after postnatal ablation of hippocampal Cajal Retzius cells

Kavli Affiliate: Giulia Quattrocolo | Authors: Sachuriga, Kristian Moan, Keagan Dunville, Nina Seiffert, Ingvild Lynneberg Glaerum, Giulia Fiori and Giulia Quattrocolo | Summary: Cajal-Retzius neurons (CRs) are a transient cell type that populates the postnatal hippocampus. To test how the persistence of CRs shapes the maturation of hippocampal function, we used a CRs-specific transgenic mouse […]


Continue.. Spatial representation in CA1 superficial pyramidal cells is impaired after postnatal ablation of hippocampal Cajal Retzius cells

Toroidal topology of grid-cell activity precedes spatial navigation during development

Kavli Affiliate: Edvard Moser and May-Britt Moser | Authors: Matteo Guardamagna, Erik Hermansen, Jordan Carpenter, Christine Marie Lykken, Benjamin Adric Dunn, Edvard Ingjald Moser and May-Britt Moser | Summary: The medial entorhinal cortex (MEC) is a central component of the mammalian navigation system1–5, in which spatially and directionally tuned neurons, including grid cells and head-direction […]


Continue.. Toroidal topology of grid-cell activity precedes spatial navigation during development

Active pursuit gates egocentric coding in Retrosplenial Cortex

Kavli Affiliate: Jonathan Whitlock | Authors: Pearl Saldanha, Martin Bjerke, Benjamin Adric Dunn and Jonathan Robert Whitlock | Summary: Spatial navigation is commonly studied in static environments, but adaptive behavior frequently hinges on tracking moving goals in real time. Active pursuit exemplifies this challenge, since it is an inherently egocentric spatial behavior requiring continual localization […]


Continue.. Active pursuit gates egocentric coding in Retrosplenial Cortex

Age-related reconfiguration of locus coeruleus-cortical functional organization

Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Xiaqing Lan, Alireza Salami, Heidi Jacobs and Maryam Ziaei | Summary: The locus coeruleus (LC) regulates attention, arousal and adaptive behavior via widespread noradrenergic projections to cortex, yet its large-scale cortical organization and vulnerability to aging remain poorly understood. Using ultra-high-field 7T–MRI during naturalistic viewing […]


Continue.. Age-related reconfiguration of locus coeruleus-cortical functional organization

Functional connectivity profile of the amygdala subfields associates with emotional well-being in aging

Kavli Affiliate: Maryam Ziaei and Menno Witter | Authors: Shuer Ye, Arjun Dave, Xiaqing Lan, Menno P. Witter, Alireza Salami and Maryam Ziaei | Summary: Amygdala-related functional connectivity plays a crucial role in human emotion, cognition, and mental well-being. The amygdala is a highly heterogeneous structure, with subregions that have both distinct and overlapping functions. […]


Continue.. Functional connectivity profile of the amygdala subfields associates with emotional well-being in aging

Functional connectivity profile of the amygdala subfields associates with emotional well-being in aging

Kavli Affiliate: Maryam Ziaei and Menno Witter | Authors: Shuer Ye, Arjun Dave, Xiaqing Lan, Menno P. Witter, Alireza Salami and Maryam Ziaei | Summary: Amygdala-related functional connectivity plays a crucial role in human emotion, cognition, and mental well-being. The amygdala is a highly heterogeneous structure, with subregions that have both distinct and overlapping functions. […]


Continue.. Functional connectivity profile of the amygdala subfields associates with emotional well-being in aging

Heterogeneous single-cell dynamics support stable population codes for objects in the mouse anterior cingulate cortex

Kavli Affiliate: Clifford Kentros | Authors: Lucie A.L. Descamps, Wesley P. Clawson, Miguel M. Carvalho, Thomas Rogerson, Omer Hazon, Oscar M.T. Chadney, Mark J. Schnitzer and Clifford Kentros | Summary: Remembering our environment and its principal features is essential to our survival. The anterior cingulate cortex (ACC) has been implicated as a key region in […]


Continue.. Heterogeneous single-cell dynamics support stable population codes for objects in the mouse anterior cingulate cortex

Preferential generation of pathological tau species in specific subtypes of entorhinal neurons: implications for Alzheimer’s Disease.

Kavli Affiliate: Clifford Kentros, Valentina Di Maria and Menno Witter | Authors: Isak Martinsson, Valentina di Maria, Miguel Carvalho, Asgeir Kobro-Flatmoen, Maria-Letizia Potenza, Menno Witter and Clifford Kentros | Summary: Alzheimer’s Disease (AD) is distinguished by the presence of two key pathological features: amyloid plaques, accumulations of proteolytic products of Amyloid Precursor Protein, and neurofibrillary […]


Continue.. Preferential generation of pathological tau species in specific subtypes of entorhinal neurons: implications for Alzheimer’s Disease.