Limitations of fluorescent timer protein maturation kinetics to isolate transcriptionally synchronized cortically differentiating human pluripotent stem cells

Posted by klaurent UCSF

Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman and Jeffrey D Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons […]


Continue.. Limitations of fluorescent timer protein maturation kinetics to isolate transcriptionally synchronized cortically differentiating human pluripotent stem cells

CaMKII autophosphorylation but not downstream kinase activity is required for synaptic memory

Posted by klaurent UCSF

Kavli Affiliate: Roger Nicoll | Authors: XIUMIN CHEN, Qixu Cai, jing zhou, Samuel J Pleasure, Howard Schulman, Mingjie Zhang and Roger A Nicoll | Summary: CaMKII plays a critical role in long-term potentiation (LTP), a well-established model for learning and memory through the enhancement of synaptic transmission. Biochemical studies indicate that CaMKII catalyzes a phosphotransferase […]


Continue.. CaMKII autophosphorylation but not downstream kinase activity is required for synaptic memory

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Cristiane dos Santos, Shristi Shrestha, Matthew A Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Melanie Cutler, Danielle Dean, Jean Philippe Cartailler, Patrick E MacDonald, Martin W Hetzer, Mark H Ellisman and Rafael Arrojo e Drigo | Summary: Caloric restriction (CR) extends organismal lifespan […]


Continue.. Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

Posted by klaurent Rockefeller

Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown and Timothy A Ryan | Summary: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular […]


Continue.. iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

Cell arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms

Posted by klaurent Columbia

Kavli Affiliate: Wei Min | Authors: Hannah Dayton, Julie Kiss, Mian Wei, Shradha Chauhan, Emily LaMarre, William Cole Cornell, Chase J. Morgan, Anuradha Janakiraman, Wei Min, Raju Tomer, Alexa Price-Whelan, Jasmine A Nirody and Lars E.P. Dietrich | Summary: Cells must access resources to survive, and the anatomy of multicellular structures influences this access. In […]


Continue.. Cell arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms

Ultra-high density electrodes improve detection, yield, and cell type specificity of brain recordings

Posted by klaurent Columbia

Kavli Affiliate: Nathaniel Sawtell, Liam Paninski | Authors: Zhiwen Ye, Andrew M. Shelton, Jordan R. Shaker, Julien Boussard, Jennifer Colonell, Sahar Manavi, Susu Chen, Charlie Windolf, Cole Hurwitz, Tomoyuki Namima, Federico Pedraja, Shahaf Weiss, Bogdan Raducanu, Torbjørn V. Ness, Gaute T. Einevoll, Gilles Laurent, Nathaniel B. Sawtell, Wyeth Bair, Anitha Pasupathy, Carolina Mora Lopez, Barun […]


Continue.. Ultra-high density electrodes improve detection, yield, and cell type specificity of brain recordings

Neuromuscular Basis of Drosophila larval escape behavior

Posted by klaurent Columbia

Kavli Affiliate: Elizabeth Hillman | Authors: Patricia C. Cooney, Yuhan Huang, Wenze Li, Dulanjana M. Perera, Richard Hormigo, Tanya Tabachnik, Isuru S. Godage, Elizabeth M.C. Hillman, Wesley B. Grueber and Aref A. Zarin | Summary: When threatened by dangerous or harmful stimuli, animals engage in diverse forms of rapid escape behaviors. In Drosophila larvae, one […]


Continue.. Neuromuscular Basis of Drosophila larval escape behavior

Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts

Posted by klaurent Columbia

Kavli Affiliate: Franck Polleux | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]


Continue.. Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts

Alignment of spatial transcriptomics data using diffeomorphic metric mapping

Posted by klaurent Hopkins

Kavli Affiliate: Justus M Kebschull, Michael Miller, Jean Fan | Authors: Kalen Clifton, Manjari Anant, Gohta Aihara, Lyla Atta, Osagie K Aimiuwu, Justus M Kebschull, Michael I Miller, Daniel Tward and Jean Fan | Summary: Spatial transcriptomics (ST) technologies enable high throughput gene expression characterization within thin tissue sections. However, comparing spatial observations across sections, […]


Continue.. Alignment of spatial transcriptomics data using diffeomorphic metric mapping

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Elleke Tissink, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Guy Hindley, Daniel Roelfs, Oleksandr Frei, Chun Chieh Fan, Mats Nagel, Terje Naerland, Magdalena Budisteanu, Srdjan Djurovic, Lars T. Westlye, Martijn van den Heuvel, Danielle Posthuma, Tobias Kaufmann, Anders M. Dale and Ole Andreassen | Summary: Genetic pleiotropy […]


Continue.. Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study