Kavli Affiliate: Michael Miller
| Authors: MoTrPAC Study Group, Anna R Brandt, Jerome Fleg, Bret H Goodpaster, Byron Jaeger, Christopher A Jin, Neil M Johannsen, Dan Katz, Hasmik Keshishian, Wendy M Kohrt, William E Kraus, Bridget Lester, Edward L Melanson, Michael E Miller, Samuel Montalvo, W Jack Rejeski, Samiya M Shimly, Gregory R Smith, Cynthia L Stowe, Scott Trappe, Hiba AbouAssi, Nicole Adams, David Amar, Euan Ashley, Arianne Aslamy, Marcas M Bamman, Alicia Belangee, Will Bennett, Bryan C Bergman, Daniel H Bessesen, Sue C Bodine, Gerard Boyd, Thomas W Buford, Charles F Burant, Elvis A Carnero, Steven Carr, Toby L Chambers, Clarisa Chavez, Haiying Chen, Shyh-Huei Chen, Jeffrey W Christle, Alex Claiborne, Natalie Clark, Zachary S Clayton, Paul M Coen, Samuel Cohen, Katherine A Collins-Bennett, Dan M Cooper, Tif fany Cortes, Brian Coyne, Gary R Cutter, Matthew Douglass, Shannon S Emilson, Sara Espinoza, Jason Fanning, Will Fountain, Robert E Gerszten, Catherine Gervais, Laurie J Goodyear, Aaron Gouw, Bruce Graham, Kevin Gries, Fadia Haddad, Melissa Harris, Patrick Hart, Andrew Hepler, Joseph A Houmard, Fang-Chi Hsu, Kim M Huffman, Ryan P Hughes, John M Jakicic, Catherine M Jankowski, David Jimenez-Morales, Johanna L Johnson, Raymond Jones, Andrew Jones, Dillon Kuszmaul, Malene E Lindholm, Adam Lowe, Colleen Lynch, Kiril Minchev, Cristhian Montenegro, Kerrie L Moreau, Michael Muehlbauer, Nicolas Musi, Jonathan Myers, Masatoshi Naruse, Christopher B Newgard, Shlomit Radom-Aizik, Tuomo Rankinen, Blake B Rasmussen, Ulrika Raue, Eric Ravussin, Eric W Reynolds, Joseph Rigdon, Ethan Robbins, Jeremy M Robbins, Renee Rogers, Kaitlyn Rogers, Jessica L Rooney, Leanna M Ross, Irene E Schauer, Robert S Schwartz, Stuart C Sealfon, Courtney Simmons, Chad Skiles, Michael P Snyder, Lauren M Sparks, Andrew Stroh, Yifei Sun, Kristen Sutton, Jennifer W Talton, Taylor Taylor, Anna Thalacker-Mercer, Russell Tracy, Todd A Trappe, Caroline S Vincenty, Elena Volpi, Michael P Walkup, Martin J Walsh, Gary Weaver, Matthew T Wheeler, Zhen Yan and Gilhyeon Yoon
| Summary:
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to examine the physiological and molecular basis for health benefits in response to acute and chronic exercise. Prior to COVID-19 suspension, healthy, sedentary participants (N=206, 18-74y) were randomized to endurance exercise (N=80), resistance exercise (N=81), or non-exercise control (N=45) interventions. The prescribed vigorous acute endurance and resistance exercise bouts induced physiological and metabolic perturbations relative to resting homeostasis. The supervised chronic (3d/wk, 12wk) endurance or resistance training programs robustly improved several physiological parameters (i.e., VO2peak, muscular strength). Temporal biospecimen (blood, muscle, and adipose) collections and processing coupled to the acute exercise bouts were highly successful. In most cases, over 90% success was achieved for blood, muscle, and adipose samples. Endurance and resistance exercise induced distinct acute and chronic physiological responses, which provide a framework to interrogate the molecular basis for health adaptations to these two popular exercise modalities.