Biomolecular condensates can function as inherent catalysts

Kavli Affiliate: Wei Min | Authors: Xiao Guo, Mina Farag, Naixin Qian, Xia Yu, Anton Ni, Yuefeng Ma, Wen Yu, Matthew King, Vicky Liu, Joonho Lee, Wei Min, Richard N Zare, Rohit V Pappu and Yifan Dai | Summary: TWe report the discovery that chemical reactions such as ATP hydrolysis can be catalyzed by condensates […]


Continue.. Biomolecular condensates can function as inherent catalysts

Mobius Assembly for Plant Systems uncovers combinatorial interactions among promoters, coding sequences, and terminators in gene regulation

Kavli Affiliate: Andreas Andreou | Authors: Elif Gediz Kocaoglan, Andreas Andreou, Jessica Nirkko, Marisol Ochoa-Villarreal, Gary Loake and Naomi Nakayama | Summary: Plants are the primary biological platforms for producing food, energy, and materials in agriculture; however, they are largely untouched by synthetic biology-driven transformation in bioproduction technologies. Molecular tools for complex, multigene engineering are […]


Continue.. Mobius Assembly for Plant Systems uncovers combinatorial interactions among promoters, coding sequences, and terminators in gene regulation

Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

Kavli Affiliate: Li Zhao | Authors: Chuwen Zhang, Yong He, Jieni Wang, Tengkai Chen, Federico Baltar, Minjie Hu, Jing Liao, Xi Xiao, Zhao-Rong Li and Xiyang Dong | Summary: Phosphorus is essential for life and critically influences marine productivity. Despite geochemical evidence of active phosphorus cycling in deep-sea cold seep ecosystems, the microbial processes involved […]


Continue.. Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

Kavli Affiliate: Adam S. Charles | Authors: Kyle A. Johnsen, Nathanael A. Cruzado, Zachary C. Menard, Adam A. Willats, Adam S. Charles, Jeffrey E. Markowitz and Christopher J. Rozell | Summary: Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments such as all-optical or closed-loop […]


Continue.. Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

High Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene Editors

Kavli Affiliate: Seth Shipman | Authors: Kate D. Crawford, Asim G. Khan, Santiago C. Lopez, Hani Goodarzi and Seth Shipman | Summary: The bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applications. In these technologies, a natural retron non-coding RNA (ncRNA) is modified to encode a […]


Continue.. High Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene Editors

Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Arantxa Cebrian-Silla, Marcos Assis Nascimento, Walter Mancia Leon, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Kirsten Obernier, David M Steffen, Daniel A Lim, Jose Manuel Garcia-Verdugo and Arturo Alvarez-Buylla | Summary: Neurogenesis and gliogenesis continue in the Ventricular-Subventricular Zone (V-SVZ) of the adult rodent brain. B1 cells are astroglial cells derived from […]


Continue.. Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone

qMAP Enabled Microanatomical Mapping of Human Skin Aging

Kavli Affiliate: Denis Wirtz | Authors: CKyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Yebin Im, Guoqing Cheng, Bartholomew Starich, Ashley L Kiemen, Jude M Phillip, Sashank Reddy, Corrine Joshu, Joel Sunshine, Jeremy Walston, Denis Wirtz and Pei-Hsun Wu | Summary: Aging is a major driver of diseases in humans. […]


Continue.. qMAP Enabled Microanatomical Mapping of Human Skin Aging

A lasting impact of serotonergic psychedelics on visual processing and behavior

Kavli Affiliate: Darcy Peterka | Authors: Chloe L West, Georgia Bastos, Annabel Duran, Samen Nadeem, David A Ricci, Anna M Rader, Joseph A Wargo, Darcy S Peterka, Neil Van Leeuwen and Jordan P Hamm | Summary: Serotonergic psychedelics (e.g., psilocybin) have shown potential for treating psychiatric disorders, with therapeutic effects lasting weeks after a single […]


Continue.. A lasting impact of serotonergic psychedelics on visual processing and behavior

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Kavli Affiliate: Kathleen Cullen | Authors: Arnaud P. J. Giese, Wei-Hsiang Weng, Katie S Kindt, Vanessa H. H. Chang, Jonathan S Montgomery, Evan M. Ratzan, Alisha J. Beirl, Roberto Aponte Rivera, Jeffrey M. Lotthammer, Sanket Walujkar, Mark P. Foster, Omid A. Zobeiri, Jeffrey R. Holt, Saima Riazuddin, Kathleen E. Cullen, Marcos Sotomayor and Zubair M […]


Continue.. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

Kavli Affiliate: Denis Wirtz | Authors: Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng-Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nico Macaluso, Joon Eoh, Kyu Sang Han, Luo Gu, Jeremey Walston, Sean Sun, Pei-Hsun Wu, Denis Wirtz and Jude M. Phillip | Summary: Cellular senescence is a major driver of aging and disease. Here […]


Continue.. Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts