High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

Kavli Affiliate: Edward Callaway | Authors: Li Alex Zhang, Peichao Li and Edward M. Callaway | Summary: Summary: Laminar electrode arrays allow simultaneous recording of activity of many cortical neurons and assignment to layers using current source density (CSD) analyses. Electrode arrays with 100-micron contact spacing have been used to estimate borders between layer 4 […]


Continue.. High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

The HIV-1 Nuclear Export Complex Reveals the Role of RNA in Crm1 Cargo Recognition

Kavli Affiliate: Keri Martinowich | Authors: Amber M Smith, Yang Li, Arianna Velarde, Yifan Cheng and Alan D. Frankel | Summary: Summary: Crm1 is a highly conserved nuclear exportin that transports >1000 human proteins including ribonucleoprotein (RNP) complexes. The interface between Crm1 and RNP cargos is unknown. The HIV regulatory protein, Rev, was one of […]


Continue.. The HIV-1 Nuclear Export Complex Reveals the Role of RNA in Crm1 Cargo Recognition

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species

Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Seyun Oh, Svitlana V Bach, Yufeng Du, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Stephanie C Hicks, Stephanie Cerceo Page and Keri Martinowich | Summary: The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in […]


Continue.. Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species

Mobius Assembly for Plant Systems highlights promoter-coding sequence terminator interaction in gene regulation

Kavli Affiliate: Andreas Andreou | Authors: Elif Gediz Kocaoglan, Andreas Andreou, Jessica Nirkko, Marisol Ochoa-Villarreal, Gary Loake and Naomi Nakayama | Summary: Plants are the primary biological platforms for producing food, energy, and materials in agriculture; however, they remain a minor player in the recent synthetic biology-driven transformation in bioproduction. Molecular tools and technologies for […]


Continue.. Mobius Assembly for Plant Systems highlights promoter-coding sequence terminator interaction in gene regulation

Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

Kavli Affiliate: Dwight Bergles | Authors: Christa Whelan Habela, Shiyu Liu, Arens Taga, Raha Dastgheyb, Norman Haughey, Dwight E Bergles, Hongjun Song, Guo-Li Ming and Nicholas J. Maragakis | Summary: The chromosome 15q11.2 locus is deleted in 1.5% of patients with genetic epilepsy and confers a risk for intellectual disability and schizophrenia. Individuals with this […]


Continue.. Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Kavli Affiliate: Sreekanth Chalasani | Authors: Jessica A Haley, Tianyi Chen, Mikio Aoi and Sreekanth H Chalasani | Summary: Decision-making is a ubiquitous component of animal behavior that is often studied in the context of foraging. Foragers make a series of decisions while locating food (food search), choosing between food types (diet or patch choice), […]


Continue.. Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Lateral prefrontal cortex controls interplay between working memory and actions

Kavli Affiliate: Anastasia Kiyonaga | Authors: Anastasia Kiyonaga, Jacob Miller and Mark D’Esposito | Summary: Humans must often keep multiple task goals in mind, at different levels of priority and immediacy, while also interacting with the environment. We might need to remember information for an upcoming task while engaged in more immediate actions. Consequently, actively […]


Continue.. Lateral prefrontal cortex controls interplay between working memory and actions

Machine-learning convergent melanocytic morphology despite noisy archival slides

Kavli Affiliate: Michael Keiser | Authors: Mikio Tada, Garrett Gaskins, Sina Ghandian, Nicholas Mew, Michael J. Keiser and Elizabeth S. Keiser | Summary: Melanocytic atypia, ranging from benign to malignant, often leads to diagnostic discordance, complicating its prediction by machine learning models. To overcome this, we paired H&E-stained histology images with contiguous or serial sections […]


Continue.. Machine-learning convergent melanocytic morphology despite noisy archival slides

3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Kavli Affiliate: Aniruddha Das | Authors: Jacqueline Salotti, Nida Asif, Srikanta Basu, Aniruddha Das, Mei Yang, Baktiar Karim, Karen Saylor, Nancy Martin, David A Scheiblin, Sweta Misra, Brian Luke, Thorkell Andresson, Stephen Lockett, Lino Tessarollo and Peter F Johnson | Summary: C/EBPβ is a potent regulator of oncogene-induced senescence (OIS) and the SASP. C/EBPβ is […]


Continue.. 3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Kavli Affiliate: John Serences | Authors: Rosanne L Rademaker and John Serences | Summary: People often remember visual information over brief delays while actively engaging with ongoing inputs from the surrounding visual environment. Depending on the situation, one might prioritize mnemonic contents (i.e., remembering details of a past event), or preferentially attend sensory inputs (i.e., […]


Continue.. Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex