Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis

Kavli Affiliate: Arnold R. Kriegstein | Authors: Sajad Hamid Ahanger, Chujing Zhang, Evan R. Semenza, Eugene Gil, Mitchel A. Cole, Li Wang, Arnold R. Kriegstein and Daniel Lim | Summary: The nuclear genome is spatially organized into a three-dimensional (3D) architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina […]


Continue.. Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis

Complete sequencing of ape genomes

Kavli Affiliate: Erich Jarvis | Authors: DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. […]


Continue.. Complete sequencing of ape genomes

Mechanism of neurodegeneration mediated by clonal inflammatory microglia

Kavli Affiliate: Jean-Laurent Casanova | Authors: Rocio Vicario, Stamatina Fragkogianni, Maria Pokrovskii, Carina Mayer, Estibaliz Lopez-Rodrigo, Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay, Isabelle Plu, Veronique Sazdovitch, Sebastien Heritier, Fleur Cohen-Aubart, Natalia Shor, Makoto Miyara, Florence Nguyen-Khac, Agnes Viale, Ahmed Idbaih, Zahir Amoura, Marc Rosenblum, Haochen Zhang, Elias-Ramzey Karnoub, Palash Sashittal, Akhil […]


Continue.. Mechanism of neurodegeneration mediated by clonal inflammatory microglia

Ciliary biology intersects autism and congenital heart disease

Kavli Affiliate: Jeremy Willsey | Authors: Nia Teerikorpi, Micaela C Lasser, Sheng Wang, Elina Kostyanovskaya, Ethel Bader, Nawei Sun, Jeanselle Dea, Tomasz J. Nowakowski, A Jeremy Willsey and Helen Willsey | Summary: Autism spectrum disorder (ASD) commonly co-occurs with congenital heart disease (CHD), but the molecular mechanisms underlying this comorbidity remain unknown. Given that children […]


Continue.. Ciliary biology intersects autism and congenital heart disease

Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses

Kavli Affiliate: Marina Picciotto | Authors: Manoela V Fogaca, Fernanda Daher and Marina Picciotto | Summary: Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), leading to altered synaptic formation and function. Low doses of ketamine rapidly rescue these deficits, inducing fast and sustained antidepressant […]


Continue.. Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses

Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse

Kavli Affiliate: Tejal Desai | Authors: Darnell L Cuylear, Moyu L Fu, Justin C Chau, Bhushan Kharbikar, Galateia Kazakia, Andrew Jheon, Stefan Habelitz, Sunil D Kapila and Tejal A Desai | Summary: Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients’ teeth reverting towards their pretreatment positions, which […]


Continue.. Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse

Control of tongue movements by the Purkinje cells of the cerebellum

Kavli Affiliate: Reza Shadmehr | Authors: Paul Hage, Mohammad Amin Fakharian, Alden M. Shoup, Jay S Pi, Ehsan Sedaghat-Nejad, Simon P Orozco, In Kyu Jang, Vivian Looi, Toren Arginteanu and Reza Shadmehr | Summary: To quantify the cerebellum’s contributions to control of the tongue, we trained head-fixed marmosets to make dexterous movements, harvesting food from […]


Continue.. Control of tongue movements by the Purkinje cells of the cerebellum

Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]


Continue.. Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

A nuclear RNA degradation code for eukaryotic transcriptome surveillance

Kavli Affiliate: Angela Yu | Authors: Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li and Yongsheng Shi | Summary: The RNA exosome plays critical roles in eukaryotic RNA degradation, but it remains unclear how the exosome […]


Continue.. A nuclear RNA degradation code for eukaryotic transcriptome surveillance

Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Xianyu Yang, Samuel Gascoigne, Aldo Compagnoni, Andre Dias, Shripad D Tuljapurkar, Maja Kajin and Roberto Salguero-Gomez | Summary: Forecasting responses of natural populations to increasingly stochastic environments is a major challenge in Ecology and Conservation Biology. We now know that populations can modulate how their vital […]


Continue.. Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity