Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics

Kavli Affiliate: Peter Walter | Authors: Kristof Torkenczy, Lucas C Reineke, Sean W Dooling, Benjamin W Henderson, Daniel Itzhak, Benjamin Yang, Dongze He, Richard M Myers, Peter Walter, Stefka Tyanova and Mauro Costa-Mattioli | Summary: Persistent activation of the integrated stress response (ISR) is a major driver of cognitive decline in both neurodevelopmental and neurodegenerative […]


Continue.. Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics

Deconvolution to restore cryo-EM maps with anisotropic resolution

Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]


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Development of an image-guided non-vitrectomy subretinal access approach for trans-scleral cell and gene therapy delivery

Kavli Affiliate: Jin Kang | Authors: Mandeep S Singh, Shoujing Guo, Christopher B Toomey, Minda M McNally, Sarah Harris-Bookman, Kang V Li, Dzhalal Agakishiev, Shuwen Wei, Soohyun Lee, Kathleen Perrino, Kevin C Wolfe and Jin Kang | Summary: Purpose Regenerative therapies for retinal diseases include cell and gene therapy modalities that are targeted to the […]


Continue.. Development of an image-guided non-vitrectomy subretinal access approach for trans-scleral cell and gene therapy delivery

Focus-Tunable Two-Photon Fiberscope Enabling in vivo Imaging at Selected Depths

Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Jiayun Laurie Huang and Xingde Li | Summary: Miniaturized two-photon imaging devices enable real-time in vivo and in situ imaging at subcellular resolution, highly valuable for clinical applications and basic research (such as neuroscience). However, achieving high-quality volumetric imaging at varying depths remains challenging. In this study, […]


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Extracellular matrix proteolysis maintains synapse plasticity during brain development

Kavli Affiliate: Anna Molofsky and Christoph Kirst | Authors: Haruna Nakajo, Ran Cao, Supriya A. Mula, Justin McKetney, Nicholas J. Silva, Muskaan Shah, Indigo V.L. Rose, Martin Kampmann, Danielle L. Swaney, Christoph Kirst and Anna V. Molofsky | Summary: Maintaining a dynamic neuronal synapse pool is critical to brain development. The extracellular matrix (ECM) regulates […]


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Data-driven fine-grained region discovery in the mouse brain with transformers

Kavli Affiliate: Reza Abbasi Asl | Authors: Alex Jihun Lee, Shenqin Yao, Nicholas Lusk, Hongkui Zeng, Bosiljka Tasic and Reza Abbasi-Asl | Summary: Spatial transcriptomics offers unique opportunities to define the spatial organization of tissues and organs, such as the mouse brain. We address a key bottleneck in the analysis of organ-scale spatial transcriptomic data […]


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Dopamine D1 receptor expression in prefrontal parvalbumin neurons influences distractibility across species

Kavli Affiliate: Anirvan Nandy | Authors: Mary Kate P Joyce, Tsvetoslav G Ivanov, Fenna Krienen, Jude Mitchell, Shaojie Ma, Wataru Inoue, Anirvan P Nandy, Dibyadeep Datta, Alvaro Duque, Jon I Arellano, Rahul Gupta, Guillermo Gonzalez-Burgos, David A Lewis, Nenad Sestan, Steven A McCarroll, Julio C Martinez-Trujillo, Seán Froudist-Walsh and Amy FT Arnsten | Summary: Marmosets […]


Continue.. Dopamine D1 receptor expression in prefrontal parvalbumin neurons influences distractibility across species

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

Kavli Affiliate: Pietro De Camilli and Shawn Ferguson | Authors: Xinbo Wang, Peng Xu, Amanda Bentley-DeSousa, William Hancock-Cerutti, Shujun Cai, Benjamin T Johnson, Francesca Tonelli, Lin Shao, Gabriel Talaia, Dario R Alessi, Shawn M Ferguson and Pietro De Camilli | Summary: Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in […]


Continue.. Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

A distinctive subset of microglia positioned at the paraventricular zone are dedicated to cleaning the cerebrospinal fluid

Kavli Affiliate: Li Zhao | Authors: Guoyang Zhou, Jian He, Baojie Mao, Guo Cheng, Rui Zhang, Qiang Wang, Xiaoli Liu, Jiaxin Zheng, Ming Wang, Li Zhao, Peng Shi, Xiao Z Shen and Shu Wan | Summary: The interconnected ventricles in the central nervous system are filled with cerebrospinal fluid (CSF) which serves multifaceted roles including […]


Continue.. A distinctive subset of microglia positioned at the paraventricular zone are dedicated to cleaning the cerebrospinal fluid

Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Kavli Affiliate: Leslie B. Vosshall | Authors: Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih-Che Weng, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti, Adriana Rosas-Villegas, Yael N. Tsitohay, Madison M. Walker, Ben R. Hopkins, Mosquito Cell Atlas Consortium, Omar S. Akbari, Laura B. Duvall, Helen White-Cooper, Trevor R. Sorrells, Roshan Sharma, […]


Continue.. Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito