Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]
Continue.. Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making