Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

Posted by dbos NTNU

Kavli Affiliate: Giulia Quattrocolo | Authors: Kristian Moan, Robert P Machold and Giulia Quattrocolo | Summary: Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of the isocortex and allocortex during development, serving an essential role during both prenatal and early postnatal brain development. Notably, these cells disappear from most cortical […]


Continue.. Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Aaron J May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Xiaozhi Lu, Madison Berry, Amanda Newman, Xiao Huang, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, Radha Devkota Adhikari, Priyanka Devkota, Katarzyna Janowska, Yanshun Liu, Garrett Scapellato, Taylor N Spence, Katayoun […]


Continue.. Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins

Monkey See, Model Knew: Large Language Models Accurately Predict Visual Brain Responses in Humans AND Non-Human Primates

Posted by dbos Harvard

Kavli Affiliate: George A. Alvarez | Authors: Colin Conwell, Emalie McMahon, Akshay Jagadeesh, Kasper Vinken, Saloni Sharma, Jacob S. Prince, George Alvarez, Talia Konkle, Margaret Livignstone and Leyla Isik | Summary: Recent progress in multimodal AI and ‘language-aligned’ visual representation learning has rekindled debates about the role of language in shaping the human visual system. […]


Continue.. Monkey See, Model Knew: Large Language Models Accurately Predict Visual Brain Responses in Humans AND Non-Human Primates

CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity

Posted by dbos Hopkins

Kavli Affiliate: Laurent Younes and Donald Geman | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Seungmae Seo, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Definition of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. […]


Continue.. CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity

A multi-institutional investigation of psilocybin’s effects on mouse behavior

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal and Mazen Kheirbek | Authors: Odilia D Lu, Katrina White, Kendall Raymond, Christine Liu, Alexandra S Klein, Nathaniel Green, Sam Vaillancourt, Austin Gallagher, Lena Shindy, Alyssa Li, Ruoxian Li, Mila Zou, Kira Wallquist, Austen B Casey, Lindsay P Cameron, Matthew B Pomrenze, Vikaas Sohal, Mazen A Kheirbek, Andrea M Gomez, Stephan […]


Continue.. A multi-institutional investigation of psilocybin’s effects on mouse behavior

Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami, Nick Belenko, Griffin Dennis, Cuidong Wang, Maria Esterlita Siantoputri, Yurie Maeda, Christina Pressl and Nathaniel Heintz | Summary: Fluorescent imaging enables visualization of the specific molecules of interest with high contrast, and the use of multiple fluorophores in a single tissue sample allows visualization of complex […]


Continue.. Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues

TUCL-Seq for miRNA single molecule sequencing

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Jicai Fan, Zhao Li, Xuejiao You, Lei Liu, Huan Jin, Ping Wu, Yushan Han, Lei Sun, Pengwei Xu, Yongfeng Liu, Jianjun Luo and Qin Yan | Summary: MicroRNAs (miRNAs) are pivotal regulatory molecules in gene expression, and their precise quantification is essential for elucidating their roles in diverse biological […]


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Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Posted by dbos UCSF

Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]


Continue.. Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]


Continue.. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency

Posted by dbos Rockefeller

Kavli Affiliate: Robert B. Darnell | Authors: Maria Skamagki, Cheng Zhang, Ezgi Hacisuleyman, Giuseppe Galleti, Chao Wu, Rajasekhar K Vinagolu, HyoKyeong Cha, Deniz Ata, Jongjin Kim, Taylor Weiskittel, Mame Diop, Thiri Aung, Michael Del Latto, Amanda S. Kim, Zhuoning Li, Matthew Miele, Rui Zhao, Laura H. Tang, Ronald C. Hendrickson, Paul B. Romesser, Jesse Joshua […]


Continue.. Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency