Kavli Affiliate: Dhruv Grover | Authors: Woochan Choi, Shyam Srinivasan and Dhruv Grover | Summary: Learning often requires inference over hidden task structure, including features that predict outcomes. In mammals, prediction-error signaling by midbrain dopamine neurons is considered central to learning, but how these neurons reflect the progression and stability of learning remains unclear. Using […]
Kavli Affiliate: Leslie B. Vosshall | Authors: Umberto Palatini, Stéphanie Dabo, Adriana Rosas-Villegas, Yael N. Tsitohay, Alexandra E. DeFoe, Nadav Shai, Louis Lambrechts and Leslie B. Vosshall | Summary: Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. […]
Kavli Affiliate: Martin Lindquist | Authors: Li-Bo Zhang, Amin Dehghani, Li Hu, Patrick Sadil, Liz Losin, Martin Lindquist and Tor Wager | Summary: Neuroimaging studies typically assume that sensory properties are encoded in response magnitude within fixed neural populations. However, this approach does not capture changes in the spatial extent of activation topography, despite growing […]
Kavli Affiliate: Daniel Mucida | Authors: Patrick W Darcy, Vitoria M Olyntho, Albana Kodra, Zachary Kerner, Maria C.C. Canesso, Sandra Nakandakari-Higa, Gabriel Victora and Daniel Mucida | Summary: Food allergies are associated with progressive gastrointestinal symptoms driven by exacerbated mucosal type-2 immunity. Here, we investigated whether cellular interactions between the gut epithelium and innate immune […]
Kavli Affiliate: Alex Pollen | Authors: Joana Rocha, Runyang Nicolas Lou, Carolina De Lima Adam, Prajna Hebbar, Scott Ferguson, Davide Bolognini, Alison Killilea, Kendra Hoekzema, Andrea Guarracino, Yun Deng, Nicole Soranzo, Benedict Paten, Erik Garrison, Alex Pollen, Evan Eichler, Rori Rohlfs, Matthew Mitchell and Peter H Sudmant | Summary: Complete, haplotype-resolved genome assemblies have provided […]
Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Mercedes F Paredes, Oier Pastor-Alonso, Matthew Heffel, Mohammad S Baig, Jasmine Harris, Susana Gonzalez Granero, Siqian Li, Sol Beccari, Julia Chu, Hannah Lambing, I-Ling Lu, Matthew Varughese, Andrew L Cheng, Jessica Le, Mohini Bhade, JaeYeon Kim, Arantxa Cebrian-Silla, Isabel Torres Cuevas, Kurtis I Auguste, Eric Huang, Arturo Alvarez-Buylla, Jesse […]
Kavli Affiliate: Rafael Yuste | Authors: Dean Geckt, Netanel Ofer, Michael W. Reimann, Rafael Yuste and Idan Segev | Summary: Dendritic spines, small protrusions covering the dendrites of most neurons, are fundamental elements of synaptic connectivity, yet their network-level organization remains poorly understood. Here we leverage the large-scale MICrONS volumetric electron microscopy dataset of mouse […]
Kavli Affiliate: Keri Martinowich | Authors: Jiseok Lee, Hyunggyu Min, Cristine Casingal, Austin T Ledford, Hannah Lee, Won Ma, Yangzhenyu Gao, Hanqian Mao, Eric S McCoy, Lei Xing, Cindy Fang, Sang Ho Kwon, Mark J Zylka, Keri Martinowich, Kristen R Maynard, Stephanie C Hicks, E S Anton and Hyejung Won | Summary: Schizophrenia (SCZ) is […]
Kavli Affiliate: Marina Picciotto | Authors: Oakleigh M Folkes, Meaghan Donahue, Rafael E Perez, Angélica Minier-Toribio, Paola N. Negrón-Moreno, Marina R. Picciotto and Yong-Hui Jiang | Summary: Social behavior deficits are a common symptom of neuropsychiatric disorders, including autism spectrum disorder (ASD), but there are limited pharmacological treatments for these symptoms. Understanding how neurons encode […]
Kavli Affiliate: Rui Costa | Authors: Michael Pereira, Beatriz S. Godinho, Christian K. Machens, Rui M. Costa and Thomas Akam | Summary: Action selection using predictive models of the environment plays a fundamental role in human and animal behaviour, yet is poorly understood at circuit and algorithmic levels. Spatial navigation is an attractive domain for […]